An epigenetic hypothesis for the genomic memory of pain.
Palo Alto, United States. In Front Cell Neurosci, 2014
In support of this hypothesis, we show here that up-regulation of a gene involved with synaptic function, Synaptotagmin II (syt2), in the PFC in a chronic pain model is associated with long-term changes in DNA methylation.
Regulated airway goblet cell mucin secretion.
Chapel Hill, United States. In Annu Rev Physiol, 2007
Emerging data from Munc13-2- and synaptotagmin 2-deficient mouse models represent the first direct, molecular-level manipulations of proteins involved in regulated secretory cell mucin secretion.