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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Synaptotagmin II

Synaptotagmin II, Syt2, synaptotagmin 2
component of synaptic vesicle membranes; may have important role in vesicle trafficking to the active zone of the synapse and in exocytosis; may be the crucial calcium sensor in neurotransmitter release [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: SYT-SSX, CAN, ACID, C2A, HAD
Papers on Synaptotagmin II
Cortical PGC-1α-Dependent Transcripts are Reduced in Postmortem Tissue From Patients With Schizophrenia.
New
Cowell et al., Birmingham, United States. In Schizophr Bull, Jan 2016
Experiments in mice have revealed a set of developmentally-regulated cortical PGC-1α-dependent transcripts involved in calcium buffering (parvalbumin, PV), synchronous neurotransmitter release (synaptotagmin 2, Syt2; complexin 1, Cplx1) and axonal integrity (neurofilamaent heavy chain, Nefh).
Arabidopsis Synaptotagmin 2 Participates in Pollen Germination and Tube Growth and Is Delivered to Plasma Membrane via Conventional Secretion.
New
Zhao et al., Beijing, China. In Mol Plant, Jan 2016
Arabidopsis synaptotagmin 2 (SYT2) has been reported to participate in an unconventional secretory pathway in somatic cells.
Electrophysiologic features of SYT2 mutations causing a treatable neuromuscular syndrome.
New
Lochmüller et al., Newcastle upon Tyne, United Kingdom. In Neurology, Jan 2016
OBJECTIVES: To describe the clinical and electrophysiologic features of synaptotagmin II (SYT2) mutations, a novel neuromuscular syndrome characterized by foot deformities and fatigable ocular and lower limb weakness, and the response to modulators of acetylcholine release.
Effects of PIP2 on membrane fusion between mast cell SNARE liposomes mediated by synaptotagmin 2.
New
Hirashima et al., Nagoya, Japan. In Biochim Biophys Acta, Oct 2015
Moreover, we found that synaptotagmin 2, a candidate Ca2+ sensor for mast cell exocytosis, enhanced SNARE-mediated membrane fusion via Ca2+ and phosphatidylserine.
DNA methylation in the medial prefrontal cortex regulates alcohol-induced behavior and plasticity.
New
Heilig et al., Linköping, Sweden. In J Neurosci, May 2015
Specifically, RG108 treatment directly reversed both downregulation of synaptotagmin 2 (Syt2) gene expression and hypermethylation on CpG#5 of its first exon.
An epigenetic hypothesis for the genomic memory of pain.
Szyf et al., Palo Alto, United States. In Front Cell Neurosci, 2014
In support of this hypothesis, we show here that up-regulation of a gene involved with synaptic function, Synaptotagmin II (syt2), in the PFC in a chronic pain model is associated with long-term changes in DNA methylation.
Development of aequorin-based mast cell nanosensor for rapid identification of botulinum neurotoxin type B.
Wang et al., In J Biomed Nanotechnol, 2014
This was achieved by fusing the Fc region of IgE antibody to a 21-amino acid peptide (p21) derived from residues 40-60 of synaptotagmin II (Syt II), the protein receptor of botulinum neurotoxin type B (BoNT/B).
Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.
Impact
Reinisch et al., In Nature, 2014
Here we present at 2.44 Å resolution the crystal structure of a fragment of human extended synaptotagmin 2 (E-SYT2), including an SMP domain and two adjacent C2 domains.
Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity.
GeneRIF
Rummel et al., Hannover, Germany. In Febs Lett, 2012
synaptotagmin-II is not a high affinity receptor for BoNT/B and G due to a phenylalanine to leucine mutation in its luminal domain present only in humans and chimpanzees
Synaptotagmin-2 is a reliable marker for parvalbumin positive inhibitory boutons in the mouse visual cortex.
GeneRIF
Levelt et al., Amsterdam, Netherlands. In Plos One, 2011
Syt2 make it an excellent marker for analyzing the development and plasticity of perisomatic inhibitory innervations onto both excitatory and inhibitory neurons in the visual cortex.
Synaptotagmins I and II in the developing rat auditory brainstem: Synaptotagmin I is transiently expressed in glutamate-releasing immature inhibitory terminals.
GeneRIF
Gillespie et al., Hamilton, Canada. In J Comp Neurol, 2011
Data suggest that immature medial nucleus of the trapezoid body terminals may contain two populations of synaptic vesicles, one expressing VGLUT3 with synaptotagmin 2 and another expressing VGLUT3 with synaptotagmin 1.
Synaptotagmin increases the dynamic range of synapses by driving Ca²+-evoked release and by clamping a near-linear remaining Ca²+ sensor.
GeneRIF
Schneggenburger et al., Lausanne, Switzerland. In Neuron, 2011
Syt2 increases the dynamic range of synapses by driving release with a high Ca(2)+ cooperativity, as well as by suppressing a remaining, near-linear Ca(2)+ sensor.
Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells.
GeneRIF
Dulon et al., Bordeaux, France. In J Neurosci, 2010
Transient expression of Syt2 is no longer detected in cochlear inner hair cells (IHCs) after the onset of hearing, indicating that the most common calcium-sensors in central nervous system synapses are not involved in mature IHC ribbon synapse.
Synaptotagmin-mediated vesicle fusion regulates cell migration.
Impact
GeneRIF
Luster et al., Boston, United States. In Nat Immunol, 2010
SYT2 was a negative regulator of chemotaxis
Immune recognition of BoNTs A and B: how anti-toxin antibodies that bind to the heavy chain obstruct toxin action.
Review
Atassi, Houston, United States. In Toxicon, 2009
On BoNT/B, Ab-binding regions overlapped with the sites that bind to mouse and rat synaptotagmin II or to ganglioside, thereby explaining Ab blocking of BoNT/B action.
Location matters: synaptotagmin helps place vesicles near calcium channels.
Review
Wu et al., Bethesda, United States. In Neuron, 2009
In this issue of Neuron, Young and Neher find that synaptotagmin 2 helps to align readily releasable vesicles near calcium channels at nerve terminals.
Regulated airway goblet cell mucin secretion.
Review
Dickey et al., Chapel Hill, United States. In Annu Rev Physiol, 2007
Emerging data from Munc13-2- and synaptotagmin 2-deficient mouse models represent the first direct, molecular-level manipulations of proteins involved in regulated secretory cell mucin secretion.
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse.
Impact
Südhof et al., Dallas, United States. In Nature, 2007
We show that deletion of synaptotagmin 2 (Syt2) in mice selectively abolishes synchronous release, allowing us to study pure asynchronous release in isolation.
Structural basis of cell surface receptor recognition by botulinum neurotoxin B.
Impact
Stevens et al., Los Angeles, United States. In Nature, 2007
Here we report the crystal structure of full-length BoNT/B in complex with the synaptotagmin II (Syt-II) recognition domain at 2.6 A resolution.
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity.
Impact
GeneRIF
Brunger et al., Stanford, United States. In Nature, 2007
the structure of a BoNT in complex with its protein receptor: the receptor-binding domain of botulinum neurotoxin serotype B (BoNT/B) bound to the luminal domain of synaptotagmin II, determined at 2.15 A resolution
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