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Synaptojanin 2

synaptojanin 2, SYNJ2
The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: Actin, Rac1, synaptojanin 1, V1a, ACID
Papers on synaptojanin 2
Frequency and amplitude control of cortical oscillations by phosphoinositide waves.
Wu et al., Singapore, Singapore. In Nat Chem Biol, Feb 2016
Here, we identified two phosphoinositide phosphatases, synaptojanin 2 and SHIP1, that function in periodic traveling waves of rat basophilic leukemia (RBL) mast cells.
SYNJ2 variant rs9365723 is associated with colorectal cancer risk in Chinese Han population.
Liu et al., Xi'an, China. In Int J Biol Markers, Dec 2015
CONCLUSIONS: Our results, combined with previous studies, suggest that rs9365723, located on SYNJ2, is associated with the risk of CRC in a Chinese population.
Identification of Differentially Expressed Proteins in the Serum of Colorectal Cancer Patients Using 2D-DIGE Proteomics Analysis.
Jamal et al., Kuala Lumpur, Malaysia. In Pathol Oncol Res, Nov 2015
Five proteins, namely apolipoprotein A1 (APOA1), apolipoprotein E (APOE), complement factor H (CFH), galectin-7 (GAL7) and synaptojanin-2 (SYNJ2) were validated using ELISA and only APOA1 and GAL-7 showed consistent findings.
Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer.
Yarden et al., Israel. In Sci Signal, Feb 2015
In search for similarly targetable genomic aberrations, we identified copy number gains in SYNJ2, which encodes the 5'-inositol lipid phosphatase synaptojanin 2, as well as overexpression in a small fraction of human breast tumors.
Effects of sleep and wake on astrocytes: clues from molecular and ultrastructural studies.
Cirelli et al., Madison, United States. In Bmc Biol, 2014
Sleep upregulates a few select genes, like Cirp and Uba1, whereas wake upregulates many genes related to metabolism, the extracellular matrix and cytoskeleton, including Trio, Synj2 and Gem, which are involved in the elongation of peripheral astrocytic processes.
Transcriptional evidence for the role of chronic venlafaxine treatment in neurotrophic signaling and neuroplasticity including also Glutamatergic [corrected] - and insulin-mediated neuronal processes.
Bagdy et al., Budapest, Hungary. In Plos One, 2013
RESULTS: Chronic VLX administration may have an effect on neurotransmitter release via the regulation of genes involved in vesicular exocytosis and receptor endocytosis (such as Kif proteins, Myo5a, Sv2b, Syn2 or Synj2).
Genetic interactions within inositol-related pathways are associated with longitudinal changes in ventricle size.
Thornton-Wells et al., Nashville, United States. In J Alzheimers Dis, 2013
After Bonferroni correction, we identified four significant interactions in the right ILV (RILV) corresponding to gene-gene pairs SYNJ2-PI4KA, PARD3-MYH2, PDE3A-ABHD12B, and OR2L13-PRKG1 and one significant interaction in the left ILV (LILV) corresponding to SYNJ2-PI4KA.
Analysis of an intronic promoter within Synj2.
Planchart, Raleigh, United States. In Biochem Biophys Res Commun, 2013
Synj2 (synaptojanin 2) encodes an inositol polyphosphate phosphatase that functions in recycling neurotransmitter vesicles and is implicated in spermatogenesis.
Roles of rho GTPases in intracellular transport and cellular transformation.
Chen et al., Fuzhou, China. In Int J Mol Sci, 2012
Rac1 mediates endocytic and exocytic vesicle trafficking by interaction with its effectors, PI3kinase, synaptojanin 2, IQGAP1 and phospholipase D1.
Regulation of synaptojanin 2 5'-phosphatase activity by Src.
Symons et al., North Bay Shore, United States. In Cell Adh Migr, 2012
Synaptojanin 2 (SYNJ2) is a phosphatidylinositol (PI) phosphatase that controls two distinct functions, clathrin-mediated endocytosis and tumor cell invadopodia formation and invasion.
Evolutionary conserved longevity genes and human cognitive abilities in elderly cohorts.
Deary et al., Edinburgh, United Kingdom. In Eur J Hum Genet, 2012
SYNJ2 is a novel gene in which variation is potentially associated with cognitive abilities.
Longevity candidate genes and their association with personality traits in the elderly.
Deary et al., Edinburgh, United Kingdom. In Am J Med Genet B Neuropsychiatr Genet, 2012
Single nucleotide polymorphisms in SYNJ2 are associated with personality disorders.
MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans.
Distelmaier et al., Düsseldorf, Germany. In Exp Gerontol, 2012
It is predicted to be the homolog of human outer mitochondrial membrane protein 25 (OMP25 or synaptojanin-2-binding protein), which is a PDZ domain containing protein with a putative role in cellular stress response pathways.
A micropreparation of mitochondria from cells using magnetic beads with immunoaffinity.
Liu et al., Beijing, China. In Anal Biochem, 2012
Two proteins located on the outer membrane of mitochondria, cytochrome b5 type B (CYB5B) and synaptojanin-2-binding protein (SYNJ2BP), were selected as candidates based on a survey of databases and the literature.
The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
Yaspo et al., Berlin, Germany. In J Biol Chem, 2011
SYNJ2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart.
Dahl et al., Australia. In Plos One, 2010
These results reveal Synj2 as a critical regulator of hair cell survival that is essential for hair cell maintenance and hearing function.
Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells using inhibition of nonsense-mediated decay and microarray analysis.
Ionov et al., Buffalo, United States. In Cancer Genet Cytogenet, 2005
Identification of inactivating mutations in the JAK1, SYNJ2, and CLPTM1 genes in prostate cancer cells
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