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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Synapsin II

synapsin II, syn-2, synapsin 2
This gene is a member of the synapsin gene family. Synapsins encode neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family encodes a neuron-specific phosphoprotein that selectively binds to small synaptic vesicles in the presynaptic nerve terminal. The TIMP4 gene is located within an intron of this gene and is transcribed in the opposite direction. Mutations in this gene may be associated with abnormal presynaptic function and schizophrenia. Alternative splicing of this gene results in two transcripts. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on synapsin II
Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.
GeneRIF
Valtorta et al., Milano, Italy. In J Neurosci, 2012
Analysis of cultured neurons from wild-type and Syn I,II,III-deficient triple knock-out (TKO) mice shows that synaptic vesicles are severely dispersed in the absence of Syns.
Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation.
GeneRIF
Tsujimoto et al., Kyoto, Japan. In Febs Lett, 2012
Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to G??-PLC?3-ERK1/2-synapsin 2
Synapsins I and II are not required for insulin secretion from mouse pancreatic β-cells.
GeneRIF
Eliasson et al., Malmö, Sweden. In Endocrinology, 2012
We conclude that neither synapsin I nor synapsin II are directly involved in the regulation of glucose-stimulated insulin secretion and Ca(2)-dependent exocytosis in mouse pancreatic beta-cells.
Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder.
GeneRIF
Turecki et al., Montréal, Canada. In Plos One, 2011
Synapsin II is involved in the molecular pathway of lithium treatment in bipolar disorder
A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs.
GeneRIF
Wesseling et al., Pamplona, Spain. In J Neurosci, 2011
The supply rate of vesicle trafficking depresses more rapidly in synapsin knock-outs; the phenotype can be fully explained by changing the value of the single parameter in the model that would specify the size of the local reserve pools.
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