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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Symplekin

SYM, Symplekin
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: NOD, ACID, CAN, HAD, V1a
Papers on SYM
The polyadenylation complex of Trypanosoma brucei: characterization of the functional poly(A) polymerase.
New
Preußer et al., Gießen, Germany. In Rna Biol, Feb 2016
Based on tandem-affinity purification with tagged CPSF160 and mass spectrometry, we identified ten associated components of the trypanosome polyadenylation complex, including homologues to all four CPSF subunits, Fip1, CstF50/6;4, and Symplekin, as well as two hypothetical proteins.
Pomeron Eigenvalue at Three Loops in N=4 Supersymmetric Yang-Mills Theory.
New
Sizov et al., London, United Kingdom. In Phys Rev Lett, Jan 2016
We obtain an analytical expression for the next-to-next-to-leading order of the Balitsky-Fadin-Kuraev-Lipatov (BFKL) Pomeron eigenvalue in planar N=4 SYM using quantum spectral curve (QSC) integrability-based method.
Pontibacter ummariensis sp. nov., isolated from a hexachlorocyclohexane contaminated soil.
New
Lal et al., Delhi, India. In Int J Syst Evol Microbiol, Jan 2016
Sym-Homospermidine was found to be the major polyamine and menaquinone-7 (MK-7) was the major respiratory quinone for strain NKM1T.
Effect of volatiles versus exudates released by germinating spores of Gigaspora margarita on lateral root formation.
New
Tang et al., China. In Plant Physiol Biochem, Dec 2015
We conclude that volatile organic compounds released by the germinating AM fungal spores may stimulate LRF in a symbiosis signaling pathway (SYM)- and host-independent way, whereas GSEs stimulate LRF in a SYM- and host-dependent way.
Positive modulation of a neutral declarative memory by a threatening social event.
New
Pedreira et al., Buenos Aires, Argentina. In Neurobiol Learn Mem, Dec 2015
Memories can be altered by negative or arousing experiences due to the activation of the stress-responsive sympatho-adrenal-medullary axis (SYM).
In vivo characterization of the Drosophila mRNA 3' end processing core cleavage complex.
New
Steiniger et al., Saint Louis, United States. In Rna, Aug 2015
A core cleavage complex (CCC) consisting of CPSF73, CPSF100, and Symplekin is required for cotranscriptional 3' end processing of all metazoan pre-mRNAs, yet little is known about the in vivo molecular interactions within this complex.
TANG1, Encoding a Symplekin_C Domain-Contained Protein, Influences Sugar Responses in Arabidopsis.
New
Jing et al., Beijing, China. In Plant Physiol, Jul 2015
The TANG1 gene was isolated by a map-based cloning approach and encodes a previously uncharacterized unique protein with a predicted Symplekin tight-junction protein C terminus.
The influence of working memory load on semantic priming.
New
De Deyne et al., Montana, Bulgaria. In J Exp Psychol Learn Mem Cogn, May 2015
To disentangle prospective and retrospective processes, prime-target pairs were selected such that they were symmetrically associated (e.g., answer-question; SYM) or asymmetrically associated in either the forward direction (e.g., panda-bear; FA) or the backward direction (e.g., ball-catch; BA).
Association between health-related quality of life and symptoms in patients with chronic constipation: an integrated analysis of three phase 3 trials of prucalopride.
New
Kerstens et al., Leuven, Belgium. In Neurogastroenterol Motil, Mar 2015
Relationships were investigated between Patient Assessment of Constipation Quality of Life (PAC-QOL) scores, Patient Assessment of Constipation Symptoms (PAC-SYM) scores, bowel movement frequency (assessed using daily diaries), and treatment.
FBN-1, a fibrillin-related protein, is required for resistance of the epidermis to mechanical deformation during C. elegans embryogenesis.
Fay et al., Laramie, United States. In Elife, 2014
The conserved SYM-3/FAM102A and SYM-4/WDR44 proteins, which are linked to protein trafficking, function as additional components of this network.
DiscML: an R package for estimating evolutionary rates of discrete characters using maximum likelihood.
Hao et al., Detroit, United States. In Bmc Bioinformatics, 2013
It gives users options to customize the instantaneous transition rate matrices, or to choose pre-determined matrices from models such as birth-and-death (BD), birth-death-and-innovation (BDI), equal rates (ER), symmetric (SYM), general time-reversible (GTR) and all rates different (ARD).
Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions.
Duronio et al., Chapel Hill, United States. In Nucleus, 2013
The scaffolding protein Symplekin is part of multiple complexes involved in generating and modifying the 3' end of mRNAs, including cleavage-polyadenylation, histone pre-mRNA processing and cytoplasmic polyadenylation.
Symbiosis and the social network of higher plants.
Review
Ané et al., Madison, United States. In Curr Opin Plant Biol, 2013
Almost all plants indulge in developing social networks with microbes, in particular with arbuscular mycorrhizal fungi, and emerging evidence indicates that most employ an ancient and widespread central 'social media' pathway made of signaling molecules within what is called the SYM pathway.
Expression and distribution of symplekin regulates the assembly and function of the epithelial tight junction.
GeneRIF
Cao et al., Kunming, China. In Histochem Cell Biol, 2012
Symplekin expression regulates the assembly of tight junctions, thus helps to maintain the integrity of the epithelial monolayer and cellular polarity.
Symplekin specifies mitotic fidelity by supporting microtubule dynamics.
GeneRIF
Whitehurst et al., Chapel Hill, United States. In Mol Cell Biol, 2010
Symplekin supports faithful mitosis by contributing to the formation of a bipolar spindle apparatus. Depletion of symplekin attenuates microtubule polymerization as well as expression of the critical microtubule polymerization protein CKAP5 (TOGp).
Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex.
Impact
GeneRIF
Tong et al., New York City, United States. In Nature, 2010
crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplekin in a ternary complex with the Pol II carboxy-terminal domain (CTD) Ser 5 phosphatase Ssu72 and a CTD Ser 5 phosphopeptide
Water-tolerant legume nodulation.
Review
Holsters et al., Norwich, United Kingdom. In J Exp Bot, 2010
For intercellular invasion, Nodulation Factor (NF) signalling recruits an ethylene-dependent, common Sym gene-independent pathway, leading to local cell death.
Symplekin promotes tumorigenicity by up-regulating claudin-2 expression.
GeneRIF
Hollande et al., Montpellier, France. In Proc Natl Acad Sci U S A, 2010
Data show that claudin-2 expression was reduced following symplekin down-regulation, and siRNA-mediated claudin-2 down-regulation increased the transepithelial resistance and decreased cyclin D1 expression and ZONAB nuclear localization.
The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1.
GeneRIF
Hollande et al., Montpellier, France. In Gastroenterology, 2009
The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1.
Gibberellin: inhibitor of an inhibitor of...?
Review
Richards et al., Norwich, United Kingdom. In Bioessays, 1998
Sym Soc.
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