CLEC-2 activates Syk through dimerizationmore suppliers
In Cellular and Molecular Life Sciences, 2009
... Dimethyl BAPTA (DM-BAPTA), Fura-2 and Fura-Red acetoxymethyl esters were from Molecular Probes, while Syk inhibitor II and IV were from Merck Biosciences ...
High-resolution antibody array analysis of childhood acute leukemia cells.
Praha, Czech Republic. In Mol Cell Proteomics, Feb 2016
From non-CD markers, we found DBN1, PAX5, or PTK2 overexpressed in B-cell precursor acute lymphoblastic leukemias, LAT, SH2D1A, or STAT5A overexpressed in T-cell acute lymphoblastic leukemias, and HCK, GLUD1, or SYK overexpressed in acute myeloid leukemias.
The role of B-cell receptor inhibitors in the treatment of patients with chronic lymphocytic leukemia.
Bethesda, United States. In Haematologica, Dec 2015
Spleen tyrosine kinase, Bruton's tyrosine kinase, and the phosphatidylinositol 3-kinase (PI3K) δ isoform are essential for B-cell receptor signal transduction but also mediate the effect of other pathways engaged in chronic lymphocytic leukemia cells in the tissue-microenvironment. Orally bioavailable inhibitors of spleen tyrosine kinase, Bruton's tyrosine kinase, or PI3Kδ, induce high rates of durable responses.
[Treatment Progress of Immune Thrombocytopenia].
More papers using
Lanzhou, China. In Zhongguo Shi Yan Xue Ye Xue Za Zhi, Aug 2015
New methods, such as anti-CD154 antibody, FcγRIIb and Syk (spleen tyrosine kinase) inhibitor, can target at certain key steps in the disease process, showing the potential to limite systemic side effects and to decrease the morbidity and mortality of ITP patients.