CLEC-2 activates Syk through dimerizationmore suppliers
In Cellular and Molecular Life Sciences, 2009
... Dimethyl BAPTA (DM-BAPTA), Fura-2 and Fura-Red acetoxymethyl esters were from Molecular Probes, while Syk inhibitor II and IV were from Merck Biosciences ...
High-resolution antibody array analysis of childhood acute leukemia cells.
Praha, Czech Republic. In Mol Cell Proteomics, Feb 2016
From non-CD markers, we found DBN1, PAX5, or PTK2 overexpressed in B-cell precursor acute lymphoblastic leukemias, LAT, SH2D1A, or STAT5A overexpressed in T-cell acute lymphoblastic leukemias, and HCK, GLUD1, or SYK overexpressed in acute myeloid leukemias.
The role of B-cell receptor inhibitors in the treatment of patients with chronic lymphocytic leukemia.
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Bethesda, United States. In Haematologica, Dec 2015
Spleen tyrosine kinase, Bruton's tyrosine kinase, and the phosphatidylinositol 3-kinase (PI3K) δ isoform are essential for B-cell receptor signal transduction but also mediate the effect of other pathways engaged in chronic lymphocytic leukemia cells in the tissue-microenvironment. Orally bioavailable inhibitors of spleen tyrosine kinase, Bruton's tyrosine kinase, or PI3Kδ, induce high rates of durable responses.