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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

SWI6 Swi6p

Swi6, Swi6p
Top mentioned proteins: cdc10, CLN2, CAN, PCNA, CLN3
Papers on Swi6
Contribution of the Slt2-regulated transcription factors to echinocandin tolerance in Candida glabrata.
Kohno et al., Nagasaki, Japan. In Fems Yeast Res, 2014
Rlm1 and Swi4-Swi6 cell cycle box binding factor (SBF) are transcription factors downstream of Slt2.
Mutations disrupting histone methylation have different effects on replication timing in S. pombe centromere.
Forsburg et al., Los Angeles, United States. In Plos One, 2012
The fission yeast pericentromere comprises repetitive sequence elements packaged into heterchromatin marked by histone H3K9 methylation and Swi6 binding.
HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts.
GeneRIF
Bühler et al., Basel, Switzerland. In Mol Cell, 2012
HP1(Swi6) mediates the recognition and destruction of heterochromatic RNA transcripts
Ers1 links HP1 to RNAi.
GeneRIF
Madhani et al., San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
Ers1 may promote RNAi by tethering the corresponding enzyme complexes to HP1-coated chromatin, thereby placing them in proximity to the nascent noncoding RNA substrate
Heterochromatin protein 1 homologue Swi6 acts in concert with Ers1 to regulate RNAi-directed heterochromatin assembly.
GeneRIF
Nakayama et al., Kōbe, Japan. In Proc Natl Acad Sci U S A, 2012
Data show that although Ers1 failed to bind Clr4, a direct interaction with Swi6 was detected, and centromeric localization of Swi6 was enhanced by Clr4 overexpression.
Cell cycle regulators interact with pathways that modulate microtubule stability in Saccharomyces cerevisiae.
GeneRIF
Eshel et al., New York City, United States. In Eukaryot Cell, 2011
We found that the transcriptional cofactor Swi6p and activator Swi4p, as well as the G(2)/M-specific cyclin Clb2p, are required in a microtubule-destabilizing environment
Ethanol fermentation driven by elevated expression of the G1 cyclin gene CLN3 in sake yeast.
Shimoi et al., Hiroshima, Japan. In J Biosci Bioeng, 2011
Disruption of the SWI6 gene, a transcriptional coactivator responsible for Cln3p-mediated G(1)/S transition, also resulted in a decreased fermentation rate, whereas whi mutants exhibited significant improvement in the fermentation rate, demonstrating positive roles of Cln3p and its downstream signalling pathway in facilitating ethanol fermentation.
S. pombe replication protein Cdc18 (Cdc6) interacts with Swi6 (HP1) heterochromatin protein: region specific effects and replication timing in the centromere.
GeneRIF
Forsburg et al., Los Angeles, United States. In Cell Cycle, 2011
Mutations in Swi6 that disrupt cdc6 protein interaction disrupt silencing and delay replication in the centromere.
Repeated measures semiparametric regression using targeted maximum likelihood methodology with application to transcription factor activity discovery.
van der Laan et al., Berkeley, United States. In Stat Appl Genet Mol Biol, 2010
We specifically target the importance of SWI4, SWI6, MBP1, MCM1, ACE2, FKH2, NDD1, and SWI5.
Interaction of APC/C-E3 ligase with Swi6/HP1 and Clr4/Suv39 in heterochromatin assembly in fission yeast.
GeneRIF
Singh et al., Chandīgarh, India. In J Biol Chem, 2009
APC and heterochromatin proteins Swi6 and Clr4 play a mutually cooperative role in heterochromatin assembly, thereby ensuring chromosomal integrity, inheritance, and segregation during mitosis and meiosis.
The heterochromatin protein Swi6/HP1 activates replication origins at the pericentromeric region and silent mating-type locus.
Impact
GeneRIF
Masukata et al., Toyonaka, Japan. In Nat Cell Biol, 2009
Swi6, an S. pombe counterpart of heterochromatin protein 1 (HP1), is required for early replication of the pericentromeric region and the mat locus.
Heterochromatin links to centromeric protection by recruiting shugoshin.
Impact
Watanabe et al., Tokyo, Japan. In Nature, 2008
The crucial role of centromeric heterochromatin is still unknown, because even in simpler unicellular organisms such as the fission yeast Schizosaccharomyces pombe, the heterochromatin protein Swi6 (HP1 homologue) has several functions at centromeres, including silencing gene expression and recombination, enriching cohesin, promoting kinetochore assembly, and, ultimately, preventing erroneous microtubule attachment to the kinetochores.
RT-PCR method for selective detection of silent gene transcripts in silencing mutants in homothallic strains of Schizosaccharomyces pombe.
Singh et al., Chandīgarh, India. In Biotechniques, 2008
The results are validated using a known silencing mutant swi6.
SWI6 is a regulatory subunit of two different cell cycle START-dependent transcription factors in Saccharomyces cerevisiae.
Review
Nasmyth et al., Vienna, Austria. In J Cell Sci Suppl, 1991
A different late G1-specific transcription element called the SCB (CACGAAAA) is bound by a factor containing the SWI4 and SWI6 proteins.
Is START a switch?
Review
McKinney et al., New York City, United States. In Ciba Found Symp, 1991
The cell cycle-dependent transcriptional regulators SWI4 and SWI6 may be components of the feedback loop.
The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch.
Impact
Greenwald et al., Princeton, United States. In Nature, 1988
These include extensive overall sequence similarity to the Drosophila Notch protein, which also is involved in cell-cell interactions that specify cell fate; a repeated motif found in proteins encoded by the yeast cell-cycle control genes cdc10 (Schizosaccharomyces pombe) and SWI6 (Saccharomyces cerevisiae); and a repeated motif exemplified by epidermal growth factor, found in many mammalian proteins.
Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila.
Impact
Nasmyth et al., Cambridge, United Kingdom. In Nature, 1987
A repeated promoter element (CACGA4) (refs 7-9) and two trans-acting activators (SWI4 and SWI6) have been identified, which are responsible for the periodic and start-dependent transcription of HO.
Cell cycle control of the yeast HO gene: cis- and trans-acting regulators.
Impact
Nasmyth et al., In Cell, 1987
We also show that, in addition to SWI1 through SWI5, at least five other genes (SWI6 through SWI10) are required for HO transcription.
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