Ers1 links HP1 to RNAi.
San Francisco, United States. In Proc Natl Acad Sci U S A, 2012
Ers1 may promote RNAi by tethering the corresponding enzyme complexes to HP1-coated chromatin, thereby placing them in proximity to the nascent noncoding RNA substrate
Ethanol fermentation driven by elevated expression of the G1 cyclin gene CLN3 in sake yeast.
Hiroshima, Japan. In J Biosci Bioeng, 2011
Disruption of the SWI6 gene, a transcriptional coactivator responsible for Cln3p-mediated G(1)/S transition, also resulted in a decreased fermentation rate, whereas whi mutants exhibited significant improvement in the fermentation rate, demonstrating positive roles of Cln3p and its downstream signalling pathway in facilitating ethanol fermentation.
Heterochromatin links to centromeric protection by recruiting shugoshin.
Tokyo, Japan. In Nature, 2008
The crucial role of centromeric heterochromatin is still unknown, because even in simpler unicellular organisms such as the fission yeast Schizosaccharomyces pombe, the heterochromatin protein Swi6 (HP1 homologue) has several functions at centromeres, including silencing gene expression and recombination, enriching cohesin, promoting kinetochore assembly, and, ultimately, preventing erroneous microtubule attachment to the kinetochores.
Is START a switch?
New York City, United States. In Ciba Found Symp, 1991
The cell cycle-dependent transcriptional regulators SWI4 and SWI6 may be components of the feedback loop.