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SWI3 Swi3p

SWI3, BAF155, SRG3, Swi3p, SMARCC1
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SWI, BRG1, INI1, BAF170, ATPase
Papers using SWI3 antibodies
Tilescope: online analysis pipeline for high-density tiling microarray data.
Copenhaver Gregory P., In PLoS Genetics, 2006
... µg of one of the following antibodies: 1) anti-Ini1 (C-20), Santa Cruz Biotechnology, sc-16189; 2) anti-BAF155 (H-76), Santa Cruz Biotechnology, sc-10756; 3) anti-BAF170 (H-116), ...
Papers on SWI3
BRG1 Governs Nanog Transcription in Early Mouse Embryos and Embryonic Stem Cells via Antagonism of Histone H3 Lysine 9/14 Acetylation.
Knott et al., East Lansing, United States. In Mol Cell Biol, Jan 2016
Biochemical studies demonstrated that HDAC1 was present in BRG1-BAF155 complexes and BRG1-HDAC1 interactions were enriched in the trophoblast lineage.
Knockdown of Brm and Baf170, Components of Chromatin Remodeling Complex, Facilitates Reprogramming of Somatic Cells.
Tian et al., Beltsville, United States. In Stem Cells Dev, Nov 2015
For example, in embryonic stem cells, esBAF contains Brg1 and Baf155, while their homologs, Brm and Baf170, are present in BAF of somatic cells.
Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP.
Gursoy et al., İstanbul, Turkey. In Biophys J, Oct 2015
They further suggest that a BAF60a/BAF155 and/or BAF60a/BAF170 interaction is critical for association between the core and variant subunits.
NKX6.1 functions as a metastatic suppressor through epigenetic regulation of the epithelial-mesenchymal transition.
Lin et al., Taipei, Taiwan. In Oncogene, Sep 2015
NKX6.1 directly enhances the mRNA level of E-cadherin by recruiting BAF155 coactivator and represses that of vimentin and N-cadherin by recruiting RBBP7 (retinoblastoma binding protein 7) corepressor.
Ubiquitous Over-Expression of Chromatin Remodeling Factor SRG3 Ameliorates the T Cell-Mediated Exacerbation of EAE by Modulating the Phenotypes of both Dendritic Cells and Macrophages.
Hong et al., Seoul, South Korea. In Plos One, 2014
Although SWI3-related gene (SRG3), a chromatin remodeling factor, is critical for various biological processes including early embryogenesis and thymocyte development, it is unclear whether SRG3 is involved in the differentiation of CD4+ T cells, the key mediator of adaptive immune responses.
Proteome Analysis of Ground State Pluripotency.
Salekdeh et al., Tehrān, Iran. In Sci Rep, 2014
We observed a number of nuclear proteins which were mostly involved in self-renewal maintenance and were expressed at higher levels in 2i compared to serum - Dnmt1, Map2k1, Parp1, Xpo4, Eif3g, Smarca4/Brg1 and Smarcc1/Baf155.
CARM1 methylates chromatin remodeling factor BAF155 to enhance tumor progression and metastasis.
Xu et al., Madison, United States. In Cancer Cell, 2014
The CARM1 KO cell lines enabled identification of CARM1 substrates, notably the SWI/SNF core subunit BAF155.
CARMA: CARM1 methylation of SWI/SNF in breast cancer.
Roberts et al., Boston, United States. In Cancer Cell, 2014
In this issue of Cancer Cell, Wang and colleagues report that CARM1, a protein arginine methyltransferase, specifically methylates BAF155/SMARCC1, a core subunit of the SWI/SNF chromatin remodeling/tumor suppressor complex.
CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer.
Esteller et al., Barcelona, Spain. In Breast Cancer Res, 2013
In a recent article, Wang and colleagues reported the discovery of a mechanism by which CARM1 regulates the genomic localization of BAF155 (a SWI/SNF subunit involved in chromatin remodeling) through post-translational methylation at R1064 arginine residues.
A hierarchy in reprogramming capacity in different tissue microenvironments: what we know and what we need to know.
Kleger et al., Ulm, Germany. In Stem Cells Dev, 2013
Recently, we have shown that the BAF-complex (BAF155 and Brg1), mediating epigenetic changes during reprogramming, is critical for the increased reprogramming efficiency of liver progenitor cells.
Increased reprogramming capacity of mouse liver progenitor cells, compared with differentiated liver cells, requires the BAF complex.
Rudolph et al., Ulm, Germany. In Gastroenterology, 2012
Liver progenitor cells have intrinsic, cell proliferation-independent characteristics resulting in an increased reprogramming capacity compared to differentiated liver cells which requires the BAF complex.
SRG3/mBAF155 stabilizes the SWI/SNF-like BAF complex by blocking CHFR mediated ubiquitination and degradation of its major components.
Seong et al., Seoul, South Korea. In Biochem Biophys Res Commun, 2012
CHFR interacts with BRG1, SNF5, and BAF60a of the SWI/SNF-like BAF complex and ubiquitinates them to target for degradation through a proteasome-mediated pathway; SRG3 stabilizes these components by blocking their interaction with CHFR.
Identification of a core member of the SWI/SNF complex, BAF155/SMARCC1, as a human tumor suppressor gene.
Weissman et al., Chapel Hill, United States. In Epigenetics, 2011
loss of BAF155 expression represents another mechanism for inactivation of SWI/SNF complex activity in the development in human cancer.
ATP-dependent chromatin remodeling: genetics, genomics and mechanisms.
Crabtree et al., Stanford, United States. In Cell Res, 2011
Recent human genetic screens have revealed that BRG1, ARID1A, BAF155, and hSNF5 are frequently mutated in tumors, indicating that BAF complexes also play a critical role in the initiation or progression of cancer.
Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21(WAF1/CIP1) expression.
Seong et al., Seoul, South Korea. In Oncogene, 2011
Our results establish a novel function of Srg3 in tumor suppression
Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
Masai et al., Tokyo, Japan. In J Biol Chem, 2011
Fission yeast Swi1-Swi3 complex facilitates DNA binding of Mrc1.
Rescuing developing thymocytes from death by neglect.
Seong et al., Seoul, South Korea. In J Biochem Mol Biol, 2002
We will particularly describe the role of the SRG3 protein as a potent modulator of GC-induced apoptosis in the crosstalk.
swi1 and swi3 perform imprinting, pausing, and termination of DNA replication in S. pombe.
Klar et al., Frederick, United States. In Cell, 2000
This work shows (1) that the factors swi1p and swi3p act by pausing the replication fork at the imprinting site; and (2) that swi1p and swi3p are involved in termination at the mat1-proximal polar-terminator of replication (RTS1).
A SWI/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro.
Emerson et al., Los Angeles, United States. In Cell, 1998
E-RC1 contains BRG1, BAF170, BAF155, and INI1 (BAF47) homologs of yeast SWI/SNF subunits, as well as a subunit unique to higher eukaryotes, BAF57, which is critical for chromatin remodeling and transcription with EKLF.
Stimulation of GAL4 derivative binding to nucleosomal DNA by the yeast SWI/SNF complex.
Peterson et al., University Park, United States. In Science, 1994
Here it is shown that the purified SWI/SNF complex is composed of 10 subunits and includes the SWI1, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products.
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