SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.
Boston, United States. In Nat Med, Dec 2015
Human cancer genome sequencing has recently revealed that genes that encode subunits of SWI/SNF chromatin remodeling complexes are frequently mutated across a wide variety of cancers, and several subunits of the complex have been shown to have bona fide tumor suppressor activity.
The role of TRIB1 in lipid metabolism; from genetics to pathways.
Tochigi, Japan. In Biochem Soc Trans, Nov 2015
Furthermore, novel binding partner, Sin3A (Swi-independent 3A)-associated protein, 18 kDa, was identified, which activates microsomal TG transfer protein (MTTP) expression by binding with MTTP regulatory elements in co-ordination with mSin3A and TRIB1.