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SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

SWI, ISWI, SNF2h
This gene encodes a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: BRG1, Histone, ATPase, CAN, INI1
Papers using SWI antibodies
UBF levels determine the number of active ribosomal RNA genes in mammals
Supplier
Hannan Ross D. et al., In The Journal of Cell Biology, 1994
... Anti–trimethyl H3K9, anti–dimethyl H3K9, anti–trimethyl H3K4, anti–dimethyl H3K4, anti-H4, and anti-SNF2H antibodies were obtained from Abcam.
Papers on SWI
ARID1A gene mutation in ovarian and endometrial cancers (Review).
Review
New
Aoki et al., Tokyo, Japan. In Oncol Rep, Feb 2016
The AT-rich interacting domain‑containing protein 1A gene (ARID1A) encodes ARID1A, a member of the SWI/SNF chromatin remodeling complex.
Biofilm formation in Candida glabrata: What have we learnt from functional genomics approaches?
Review
New
Janbon et al., Paris, France. In Fems Yeast Res, Feb 2016
In particular, the Yak1 kinase and the Swi/Snf chromatin remodeling complex have been shown to relieve the repression exerted by subtelomeric silencing on the expression of the EPA6 and EPA7 genes, thus allowing the encoded adhesins to exert their key roles in biofilm formation.
Regulation of antisense transcription by NuA4 histone acetyltransferase and other chromatin regulatory factors.
New
Bhaumik et al., Carbondale, United States. In Mol Cell Biol, Feb 2016
Like NuA4 KAT, histone H3 K4/36 methyltransferases and histone H2B ubiquitin conjugase facilitate GAL10 antisense transcription, while the Swi/Snf and SAGA chromatin remodeling/modification factors are dispensable for antisense, but not sense, transcription of GAL10.
A mutation in the Cc.arp9 gene encoding a putative actin-related protein causes defects in fruiting initiation and asexual development in the agaricomycete Coprinopsis cinerea.
New
Nakahori et al., Kyoto, Japan. In Curr Genet, Feb 2016
Dikaryon formation in agaricomycetes, which is followed by fruiting development, is governed by the mating type loci, A and B. Recently, mutations in the Cc.snf5 gene, which encodes a putative component of the chromatin remodeling complex switch/sucrose non-fermentable (SWI/SNF), were shown to cause defects in A-regulated clamp cell morphogenesis, as well as in fruiting initiation.
Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas.
New
Lee et al., Vancouver, Canada. In Mod Pathol, Feb 2016
We performed targeted sequencing of eight dedifferentiated carcinomas and identified somatic frameshift/nonsense mutations in SMARCA4, a core ATPase of the switch/sucrose non-fermenting (SWI/SNF) complex, in the undifferentiated components of four tumors.
Novel missense mutations in a conserved loop between ERCC6 (CSB) helicase motifs V and VI: Insights into Cockayne syndrome.
New
Sutton et al., Newcastle upon Tyne, United Kingdom. In Am J Med Genet A, Feb 2016
Indeed, the amino acid sequence of this loop is more highly conserved than the adjacent helicase motifs V and VI, suggesting that this is a crucial structural component of the SWI/SNF family of proteins, to which ERCC6 (CSB) belongs.
FOXD3 Regulates Pluripotent Stem Cell Potential by Simultaneously Initiating and Repressing Enhancer Activity.
New
Impact
Blelloch et al., San Francisco, United States. In Cell Stem Cell, Feb 2016
It recruited the SWI/SNF chromatin remodeling complex ATPase BRG1 to promote nucleosome removal while concurrently inhibiting maximal activation of the same enhancers by recruiting histone deacetylases1/2.
Chromatin modification and NBS1: their relationship in DNA double-strand break repair.
Review
New
Kobayashi et al., Kyoto, Japan. In Genes Genet Syst, Feb 2016
Its recently identified binding partner RNF20 is an E3 ubiquitin ligase that facilitates the monoubiquitination of histone H2B, a process that is crucial for recruitment of the chromatin remodeler SNF2h to DSB damage sites.
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.
New
Impact
Roberts et al., Boston, United States. In Nat Med, Dec 2015
Human cancer genome sequencing has recently revealed that genes that encode subunits of SWI/SNF chromatin remodeling complexes are frequently mutated across a wide variety of cancers, and several subunits of the complex have been shown to have bona fide tumor suppressor activity.
Loss of Tumor Suppressor ARID1A Protein Expression Correlates with Poor Prognosis in Patients with Primary Breast Cancer.
New
Lee et al., Ch'ŏnan, South Korea. In J Breast Cancer, Dec 2015
PURPOSE: Somatic mutations of the chromatin remodeling AT-rich interactive domain 1A (SWI-like) gene (ARID1A) have been identified in many human cancers, including breast cancer.
DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.
New
Impact
Radlwimmer et al., Leipzig, Germany. In Nat Genet, Nov 2015
Integrative pathway analyses of regions differentially methylated in Burkitt and follicular lymphomas implicated DNA methylation as cooperating with somatic mutation of sphingosine phosphate signaling, as well as the TCF3-ID3 and SWI/SNF complexes, in a large fraction of Burkitt lymphomas.
Chromatin-remodeling and the initiation of transcription.
Review
New
Kornberg et al., Stanford, United States. In Q Rev Biophys, Nov 2015
Repression is relieved by the SWI/SNF-RSC family of chromatin-remodeling complexes.
G1/S Inhibitors and the SWI/SNF Complex Control Cell-Cycle Exit during Muscle Differentiation.
New
Impact
van den Heuvel et al., Utrecht, Netherlands. In Cell, Aug 2015
Combined lineage-specific gene inactivation and genetic screening revealed extensive redundancies between previously identified cell-cycle inhibitors and the SWI/SNF chromatin-remodeling complex.
The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling.
New
Impact
Fan et al., Beijing, China. In Cell Stem Cell, May 2015
Mechanistically, lncTCF7 recruits the SWI/SNF complex to the promoter of TCF7 to regulate its expression, leading to activation of Wnt signaling.
ADNP: in search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration.
Review
Ivashko-Pachima et al., Tel Aviv-Yafo, Israel. In Front Aging Neurosci, 2014
ADNP is a member of the SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeling complex also associated with alternative splicing, including tau transcript splicing.
Histone H3 lysine 36 methylation targets the Isw1b remodeling complex to chromatin.
GeneRIF
Howe et al., Vancouver, Canada. In Mol Cell Biol, 2012
Histone H3 lysine 36 methylation promoted the chromatin interaction of the Isw1b chromatin-remodeling complex in Saccharomyces cerevisiae.
Chromatin remodelers Isw1 and Chd1 maintain chromatin structure during transcription by preventing histone exchange.
GeneRIF
Workman et al., Kansas City, United States. In Nat Struct Mol Biol, 2012
Deletion of ISW1 and CHD1 causes widespread intragenic transcription.
Nucleosome remodeler SNF2L suppresses cell proliferation and migration and attenuates Wnt signaling.
GeneRIF
Becker et al., München, Germany. In Mol Cell Biol, 2012
The effect of SNF2L depletion on gene expression portray the cell in a state of activated Wnt signaling with increased proliferation and locomotion. High levels of SNF2L expression in normal melanocytes contrast with undetectable expression in melanoma.
Human CCAAT/enhancer-binding protein β interacts with chromatin remodeling complexes of the imitation switch subfamily.
GeneRIF
Gutiérrez et al., Concepción, Chile. In Biochemistry, 2012
Functional interaction is characterized between C/EBPbeta and SNF2H/ACF1, involving mainly suppression of C/EBPbeta transactivation activity in the presence of SNF2H and ACF1.
Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer.
GeneRIF
Pollack et al., Stanford, United States. In Proc Natl Acad Sci U S A, 2012
expression profiling analyses revealed that SWI/SNF likely antagonizes Polycomb repressive complex 2, implicating this as one possible mechanism of tumor suppression
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