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Solute carrier family 23

SVCT2, hSVCT2, SLC23A1, sodium-dependent vitamin C transporter 2, SLC23A2
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, HAD, CAN, V1a, AGE
Papers on SVCT2
Ascorbic acid supplementation improves skeletal muscle oxidative stress and insulin sensitivity in people with type 2 diabetes: Findings of a randomized controlled study.
Wadley et al., Australia. In Free Radic Biol Med, Feb 2016
Antioxidant concentrations, citrate synthase activity and protein abundances of sodium-dependent vitamin C transporter 2 (SVCT2), total Akt and phosphorylated Akt (ser473) were also measured in muscle samples.
SVCT2 Overexpression in Neuroblastoma Cells Induces Cellular Branching that is Associated with ERK Signaling.
Nualart et al., Concepción, Chile. In Mol Neurobiol, Jan 2016
UNASSIGNED: Expression of the sodium and ascorbic acid (AA) cotransporter SVCT2 is induced during the period of cellular arborization and synaptic maturation of early postnatal (P1-P5) rat cerebral neurons.
Sodium-dependent vitamin C transporter-2 mediates vitamin C transport at the cortical nerve terminal.
May et al., Nashville, United States. In J Neurosci Res, Dec 2015
This study investigates the role of the sodium-dependent vitamin C transporter-2 (SVCT2) in transporting VC at the cortical nerve terminal.
Dehydroascorbic Acid Promotes Cell Death in Neurons Under Oxidative Stress: a Protective Role for Astrocytes.
Nualart et al., Concepción, Chile. In Mol Neurobiol, Nov 2015
UNASSIGNED: Ascorbic acid (AA), the reduced form of vitamin C, is incorporated into neurons via the sodium ascorbate co-transporter SVCT2.
Ascorbic acid efflux from human brain microvascular pericytes: Role of re-uptake.
Qu et al., Nashville, United States. In Biofactors, Oct 2015
Microvascular pericytes take up ascorbic acid on the ascorbate transporter SVCT2.
Intracellular dehydroascorbic acid inhibits SVCT2-dependent transport of ascorbic acid in mitochondria.
Cantoni et al., Urbino, Italy. In Pharmacol Res, Sep 2015
Exposure of U937 cells to low concentrations of L-ascorbic acid (AA) is associated with a prompt cellular uptake and a further mitochondrial accumulation of the vitamin.
The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis.
Fulzele et al., Augusta, United States. In Stem Cell Res, Sep 2015
Previously, we reported that vitamin C is transported into bone marrow stromal cells (BMSCs) through the sodium dependent Vitamin C Transporter 2 (SVCT2) and this transporter plays an important role in osteogenic differentiation.
Genetically high plasma vitamin C, intake of fruit and vegetables, and risk of ischemic heart disease and all-cause mortality: a Mendelian randomization study.
Nordestgaard et al., Frederiksberg, Denmark. In Am J Clin Nutr, Jun 2015
DESIGN: We used a Mendelian randomization approach and genotyped for solute carrier family 23 member 1 (SLC23A1) rs33972313 in the sodium-dependent vitamin C transporter 1 in 97,203 white individuals of whom 10,123 subjects had ischemic heart disease, and 8477 subjects died.
Vitamin C in Health and Disease: Its Role in the Metabolism of Cells and Redox State in the Brain.
Rivas-Arancibia et al., Mexico. In Front Physiol, 2014
The distribution and the concentration of vitamin C in the organs depend on the ascorbate requirements of each and on the tissue distribution of sodium-dependent vitamin C transporter 1 and 2 (SVCT1 and SVCT2).
Does vitamin C deficiency affect cognitive development and function?
Lykkesfeldt et al., Copenhagen, Denmark. In Nutrients, 2014
Absence of vitamin C in the brain has been shown to be detrimental to survival in newborn SVCT2(-/-) mice and perinatal deficiency have shown to reduce hippocampal volume and neuron number and cause decreased spatial cognition in guinea pigs, suggesting that maternal vitamin C deficiency could have severe consequences for the offspring.
Ascorbic acid and sodium-dependent vitamin C transporters in the peripheral nervous system: from basic science to clinical trials.
Young et al., Münster, Germany. In Antioxid Redox Signal, 2014
RECENT ADVANCES: Recently, the function of ascorbic acid and SVCT2 in the PNS has been shown in vivo as well.
The sodium-dependent ascorbic acid transporter family SLC23.
Hediger et al., Bern, Switzerland. In Mol Aspects Med, 2013
The human SLC23 family consists of the Na(+)-dependent vitamin C transporters SVCT1 (encoded by the SLC23A1 gene) and SVCT2 (SLC23A2) as well as an orphan transporter SVCT3 (SLC23A3).
Downregulation of vitamin C transporter SVCT-2 in doxorubicin-induced cardiomyocyte injury.
Singal et al., Winnipeg, Canada. In Am J Physiol Cell Physiol, 2012
Expression and localization of sodium-dependent vitamin C transporter-2 in the sarcolemma is reduced by doxorubicin, a change blunted by vitamin C supplementation.
Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.
Rivas et al., Concepción, Chile. In Free Radic Biol Med, 2012
glutathione depletion failed to affect ascorbic acid transport, and SVCT1 and SVCT2 expression in hepatoma cells.
Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against paraquat-induced oxidative damage in lung.
May et al., Nashville, United States. In Plos One, 2011
Increased expression of SVCT2 in a new mouse model raises ascorbic acid in tissues and protects against oxidative stress.
Functional and physiological role of vitamin C transporters.
Hediger et al., Bern, Switzerland. In Curr Top Membr, 2011
The human SLC23 family consists of the Na(+)-dependent vitamin C transporters SVCT1 (SLC23A1) and SVCT2 (SLC23A2) and the orphan transporter SVCT3 (SLC23A3).
Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system.
Young et al., Münster, Germany. In J Neurosci, 2011
Expression of various collagen types is reduced in sciatic nerves of SVCT2(+/-) heterozygous mice compared to wild-type.
Association between a SLC23A2 gene variation, plasma vitamin C levels, and risk of glaucoma in a Mediterranean population.
Corella et al., Valencia, Spain. In Mol Vis, 2010
The rs1279683 single-nucleotide polymorphisms in SLC23A2 was significantly associated with lower plasma concentrations of vitamin C and with higher risk of primary open-angle glaucoma in GG subjects.
Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival.
Nussbaum et al., Bethesda, United States. In Nat Med, 2002
an ascorbic acid transporter essential for vitamin c transport into the brain, and for perinatal survival
A family of mammalian Na+-dependent L-ascorbic acid transporters.
Hediger et al., Boston, United States. In Nature, 1999
Here we describe the isolation of two L-ascorbic acid transporters, SVCT1 and SVCT2, from rat complementary DNA libraries, as the first step in investigating the importance of L-ascorbic acid transport in regulating the supply and metabolism of vitamin C. We find that SVCT1 and SVCT2 each mediate concentrative, high-affinity L-ascorbic acid transport that is stereospecific and is driven by the Na+ electrochemical gradient.
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