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Suppressor of variegation 4-20 homolog 2

Suv4-20h2, KMT5C
SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009] (from NCBI)
Top mentioned proteins: Histone, H4, Suv4-20h, CAN, SUV39H1
Papers on Suv4-20h2
SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3.
New
Matsuura et al., Suita, Japan. In Exp Cell Res, Jun 2015
Reduced H4K20me3 levels in tumor cells are often accompanied by a decrease in the expression of the H4K20-specific methyltransferase, SUV420H2.
NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT.
Bhat-Nakshatri et al., Indianapolis, United States. In Cell Death Dis, 2014
Interestingly, we observed enhanced H4K20 trimethylation and induction of H4K20 trimethylase KMT5C in DMAPT-treated cells independent of NF-κB inhibition.
Molecular basis for substrate recognition by lysine methyltransferases and demethylases.
Review
Trievel et al., Ann Arbor, United States. In Biochim Biophys Acta, 2014
This review explores recent progress in elucidating the molecular basis of these specificities, highlighting structural and functional studies of the methyltransferases SUV4-20H1 (KMT5B), SUV4-20H2 (KMT5C), and ATXR5, and the demethylases UTX (KDM6A), JMJD3 (KDM6B), and JMJD2D (KDM4D).
Dose- and time-dependent epigenetic changes in the livers of Fisher 344 rats exposed to furan.
Pogribny et al., United States. In Toxicol Sci, 2014
These histone modification changes were accompanied by a reduced expression of Suv39h1, Prdm2, and Suv4-20h2 histone methyltransferases and Ep300 and Kat2a histone acetyltransferases.
Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.
Grummt et al., Heidelberg, Germany. In Mol Cell, 2014
In contrast to pericentric or telomeric regions, recruitment of the H4K20 methyltransferase Suv4-20h2 to rRNA genes and IAP elements requires neither trimethylation of H3K9 nor interaction with HP1 proteins but depends on long noncoding RNAs (lncRNAs) that interact with Suv4-20h2.
A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing.
Vertino et al., Atlanta, United States. In J Biol Chem, 2014
In contrast, H4 lysine 20 trimethylation (H4K20me3), mediated by SUV420H2, enforces Pol II pausing by inhibiting MSL recruitment.
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases.
Wilson et al., London, United Kingdom. In Nucleic Acids Res, 2014
We present the structure of the histone H4K20 methyltransferase Suv4-20h2 in complex with its histone H4 peptide substrate and S-adenosyl methionine cofactor.
Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity.
Matsuura et al., In Breast Cancer Res, 2013
We also examined the effect of overexpression or knockdown of the histone H4K20 methyltransferases, SUV420H1 and SUV420H2, on cancer-cell invasion activity in vitro.
Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.
Min et al., In Febs Lett, 2013
SUV420H1 and SUV420H2 are two highly homologous enzymes that methylate lysine 20 of histone H4 (H4K20), a mark that has been implicated in transcriptional regulation.
Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.
Schotta et al., München, Germany. In Genes Dev, 2013
Here we define the histone methyltransferase Suv4-20h2 as a major structural constituent of heterochromatin that mediates chromatin compaction and cohesin recruitment.
Differential effects of garcinol and curcumin on histone and p53 modifications in tumour cells.
Heery et al., Nottingham, United Kingdom. In Bmc Cancer, 2012
Finally, we show that the elevation of H4K20Me3 levels by garcinol correlated with increased expression of SUV420H2, and was prevented by siRNA targeting of SUV420H2.
An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression.
Pogribny et al., United States. In Breast Cancer Res Treat, 2012
The expression of genes, including GLS1, GFPT2, LDHA, HDAC9, MYST2, and SUV420H2, was assessed using RT-PCR.
Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks.
Scully et al., Boston, United States. In Plos One, 2011
This revealed no major requirement for the known H4K20 dimethylases Suv4-20h1 and Suv4-20h2 in 53BP1 recruitment or DSB repair function, but a key role for the H4K20 monomethylase, PR-SET7.
SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation.
GeneRIF
Vertino et al., Atlanta, United States. In Mol Cell Biol, 2011
data indicate that H4K20me3 invokes gene repression by antagonizing hMOF-mediated H4K16Ac
Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells.
GeneRIF
Blasco et al., Madrid, Spain. In Plos One, 2010
Abrogation of Suv4-20h enzymes and loss of heterochromatic mark H4K20me3 at telomeric heterochromatin facilitates telomere reprogramming and provides an increased tumorigenic potential to induced pluripotent stem cells.
Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation.
GeneRIF
Underhill et al., Edmonton, Canada. In Plos One, 2009
SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation
Preferential dimethylation of histone H4 lysine 20 by Suv4-20.
GeneRIF
Mizzen et al., Urbana, United States. In J Biol Chem, 2008
The data indicate that Suv4-20 generates nearly ubiquitous dimethylation that facilitates the DNA damage response and selective trimethylation that is involved in heterochromatin formation.[Suv4-20]
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.
GeneRIF
Blasco et al., Madrid, Spain. In J Cell Biol, 2007
There is a novel role for histone lysine methylation in controlling telomere recombination.
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin.
Impact
Blasco et al., Madrid, Spain. In Nat Cell Biol, 2005
Indeed, we show a direct interaction between the RB1 proteins and the H4K20 tri-methylating enzymes Suv4-20h1 and Suv4-20h2, indicating that the RB1 family has a role in controlling H4K20 tri-methylation by these histone methyltransferases.
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