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Suppressor of variegation 4-20 homolog 1

Suv4-20h, Suv4-20h1, CGI-85
This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The function of this gene has not been determined. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Histone, H4, Suv4-20h2, SET, SET7/9
Papers on Suv4-20h
SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells.
New
Hamamoto et al., Chicago, United States. In Oncotarget, Jan 2016
Here, we demonstrated that the protein lysine methyltransferase SUV420H1 tri-methylated ERK1 at lysines 302 and 361, and that substitution of methylation sites diminished phosphorylation levels of ERK1.
Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation.
New
Impact
Braun et al., Bad Nauheim, Germany. In Cell Stem Cell, Jan 2016
Here, we show that Suv4-20h1, an H4K20 dimethyltransferase, controls MuSC quiescence by promoting formation of facultative heterochromatin (fHC).
Incorporating Functional Information in Tests of Excess De Novo Mutational Load.
New
Allen et al., Durham, United States. In Am J Hum Genet, Sep 2015
Furthermore, our approach provides strong statistical evidence supporting two potentially causal genes: SUV420H1 in autism spectrum disorder and TRIO in a combined analysis of the four neurodevelopmental and neuropsychiatric disorders investigated here.
Genetic alterations of histone lysine methyltransferases and their significance in breast cancer.
New
Yang et al., Detroit, United States. In Oncotarget, Mar 2015
Integrative analysis identified 8 HMTs (SETDB1, SMYD3, ASH1L, SMYD2, WHSC1L1, SUV420H1, SETDB2, and KMT2C) that are dysregulated by genetic alterations, classifying them as candidate therapeutic targets.
EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.
Hung et al., Taiwan. In Dev Cell, 2014
Here, we identify a tyrosine phosphorylation site at Y72 of histone H4, which facilitates recruitment of histone methyltransferases (HMTases), SET8 and SUV4-20H, to enhance its K20 methylation, thereby promoting DNA synthesis and repair.
A novel route to product specificity in the Suv4-20 family of histone H4K20 methyltransferases.
Wilson et al., London, United Kingdom. In Nucleic Acids Res, 2014
Together with supporting biochemical data comparing Suv4-20h1 and Suv4-20h2, we demonstrate that the Suv4-20 family enzymes take a previously mono-methylated H4K20 substrate and generate an exclusively di-methylated product.
PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome.
Feil et al., Cambridge, United States. In Nucleic Acids Res, 2014
Conversely, depletion of ESET (KMT1E) or SUV420H1/H2 (KMT5B/C) affected H3K9me3 and H4K20me3, respectively, without altering H4R3me2s at ICRs.
Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity.
Matsuura et al., In Breast Cancer Res, 2013
We also examined the effect of overexpression or knockdown of the histone H4K20 methyltransferases, SUV420H1 and SUV420H2, on cancer-cell invasion activity in vitro.
Crystal structures of the human histone H4K20 methyltransferases SUV420H1 and SUV420H2.
Min et al., In Febs Lett, 2013
SUV420H1 and SUV420H2 are two highly homologous enzymes that methylate lysine 20 of histone H4 (H4K20), a mark that has been implicated in transcriptional regulation.
H4K20 methylation regulates quiescence and chromatin compaction.
Coller et al., Los Angeles, United States. In Mol Biol Cell, 2013
Overexpression of Suv4-20h1, the enzyme that creates H4K20me2 from H4K20me1, results in G2 arrest, consistent with a role for H4K20me1 in mitosis.
FSHD muscular dystrophy region gene 1 binds Suv4-20h1 histone methyltransferase and impairs myogenesis.
Gabellini et al., Milano, Italy. In J Mol Cell Biol, 2013
Here we show that, when over-expressed, FRG1 binds and interferes with the activity of the histone methyltransferase Suv4-20h1 both in mammals and Drosophila.
Suv4-20h2 mediates chromatin compaction and is important for cohesin recruitment to heterochromatin.
Schotta et al., M√ľnchen, Germany. In Genes Dev, 2013
Suv4-20h mutant cells display an overall reduced chromatin compaction and an altered chromocenter organization in interphase referred to as "chromocenter scattering."
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
Rudan et al., Zagreb, Croatia. In Plos Genet, 2012
Four loci contained genes encoding glycosyltransferases (ST6GAL1, B4GALT1, FUT8, and MGAT3), while the remaining 5 contained genes that have not been previously implicated in protein glycosylation (IKZF1, IL6ST-ANKRD55, ABCF2-SMARCD3, SUV420H1, and SMARCB1-DERL3).
Dissecting the role of H3K64me3 in mouse pericentromeric heterochromatin.
Schneider et al., Freiburg, Germany. In Nat Commun, 2012
Our data suggest that enrichment of H3K64me3 at pericentromeric chromatin foci is dependent on H3K9me3 but independent of a number of central factors such as heterochromatin protein 1, DNA methyltransferases and Suv4-20h histone methyltransferases.
Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells.
GeneRIF
Blasco et al., Madrid, Spain. In Plos One, 2010
Abrogation of Suv4-20h enzymes and loss of heterochromatic mark H4K20me3 at telomeric heterochromatin facilitates telomere reprogramming and provides an increased tumorigenic potential to induced pluripotent stem cells.
Comparative analyses of SUV420H1 isoforms and SUV420H2 reveal differences in their cellular localization and effects on myogenic differentiation.
GeneRIF
Underhill et al., Edmonton, Canada. In Plos One, 2009
SUV420H1 and SUV420H2 isoforms have different in their cellular localization and effects on myogenic differentiation
GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression.
GeneRIF
Rogatsky et al., New York City, United States. In Proc Natl Acad Sci U S A, 2009
dissect the GRIP1:Suv4-20h1 interaction in vitro and in vivo and examine its potential involvement in hormone-dependent transcriptional regulation by GR
Preferential dimethylation of histone H4 lysine 20 by Suv4-20.
GeneRIF
Mizzen et al., Urbana, United States. In J Biol Chem, 2008
The data indicate that Suv4-20 generates nearly ubiquitous dimethylation that facilitates the DNA damage response and selective trimethylation that is involved in heterochromatin formation.[Suv4-20]
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.
GeneRIF
Blasco et al., Madrid, Spain. In J Cell Biol, 2007
There is a novel role for histone lysine methylation in controlling telomere recombination.
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin.
Impact
Blasco et al., Madrid, Spain. In Nat Cell Biol, 2005
Indeed, we show a direct interaction between the RB1 proteins and the H4K20 tri-methylating enzymes Suv4-20h1 and Suv4-20h2, indicating that the RB1 family has a role in controlling H4K20 tri-methylation by these histone methyltransferases.
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