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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Surfeit 4

This gene is located in the surfeit gene cluster, which is comprised of very tightly linked housekeeping genes that do not share sequence similarity. The encoded protein is a conserved integral membrane protein containing multiple putative transmembrane regions. In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). The specific function of this protein has not been determined but its yeast homolog is directly required for packaging glycosylated pro-alpha-factor into COPII vesicles. This gene uses multiple polyadenylation sites, resulting in transcript length variation. The existence of alternatively spliced transcript variants has been suggested, but their validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, c-Myc, V1a, carboxypeptidase, SURF1
Papers on Surf-4
Positive diversifying selection on the Plasmodium falciparum surf4.1 gene in Thailand.
Kaneko et al., Nagasaki, Japan. In Trop Med Health, 2012
Plasmodium falciparum SURFIN(4.1) is a type I transmembrane protein thought to locate on the merozoite surface and to be responsible for a reversible adherence to the erythrocyte before invasion.
Surf4 modulates STIM1-dependent calcium entry.
Baba et al., Yokohama, Japan. In Biochem Biophys Res Commun, 2012
These findings suggest the modulatory function of Surf4 for STIM1-mediated store-operated Ca(2+) entry.
The cargo receptors Surf4, endoplasmic reticulum-Golgi intermediate compartment (ERGIC)-53, and p25 are required to maintain the architecture of ERGIC and Golgi.
Hauri et al., Basel, Switzerland. In Mol Biol Cell, 2008
Silencing Surf4 together with ERGIC-53 or silencing the p24 family member p25 induced an identical phenotype characterized by a reduced number of ERGIC clusters and fragmentation of the Golgi apparatus without effect on anterograde transport.
SURFIN4.1, a schizont-merozoite associated protein in the SURFIN family of Plasmodium falciparum.
Wahlgren et al., Stockholm, Sweden. In Malar J, 2007
Bioinformatic tools were used to study the structure of the surf4.1 gene.
Membrane topology of the endoplasmic reticulum to Golgi transport factor Erv29p.
Otte et al., Chicago, United States. In Mol Membr Biol, 2007
It is conserved across species, with one ortholog found in each genome studied, including the surf-4 protein in mammals.
The surf-4 gene encodes a novel 30 kDa integral membrane protein.
Fried et al., London, United Kingdom. In Mol Membr Biol, 1995
We show that the surf-4 coding sequence is conserved between mouse and human.
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