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Sad1 and UNC84 domain containing 2

SUN2, Rpn3
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010] (from NCBI)
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Top mentioned proteins: CAN, Actin, Sad1, nesprin-2, V1a
Papers using SUN2 antibodies
Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes.
Supplier
Hotchin Neil A., In PLoS ONE, 2003
... The entire coding region of SUN2 was PCR-amplified by Elongase Enzyme (Life Technologies) using specific primers ...
Papers on SUN2
Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators.
New
Feng et al., Beijing, China. In Structure, Feb 2016
Here, we found that the two coiled-coil domains (CC1 and CC2) of SUN2 exhibit distinct oligomeric states.
Inner nuclear envelope protein SUN1 plays a prominent role in mammalian mRNA export.
New
Noegel et al., Köln, Germany. In Nucleic Acids Res, Dec 2015
The results indicate that both SUN1 and SUN2 interact with heterogeneous nuclear ribonucleoprotein (hnRNP) F/H and hnRNP K/J.
Global loss of a nuclear lamina component, lamin A/C, and LINC complex components SUN1, SUN2, and nesprin-2 in breast cancer.
New
Matsuura et al., Suita, Japan. In Cancer Med, Oct 2015
The linker of nucleoskeleton and cytoskeleton (LINC) complex, a nuclear envelope protein complex consisting mainly of the SUN and nesprin proteins, connects nuclear lamina and cytoskeletal filaments and helps to regulate the size and shape of the nucleus.
SUN anchors pollen WIP-WIT complexes at the vegetative nuclear envelope and is necessary for pollen tube targeting and fertility.
New
Meier et al., Columbus, United States. In J Exp Bot, Oct 2015
To explore this question, a SUN2 lumenal domain that was targeted to the ER specifically in pollen was over-expressed.
A Disulfide Bond Is Required for the Transmission of Forces through SUN-KASH Complexes.
New
Mofrad et al., Berkeley, United States. In Biophys J, Sep 2015
Herein, using molecular dynamics, we examine the effect of tension on the human SUN2-KASH2 complex and show that it is remarkably stable under physiologically relevant tensile forces and large strains.
Diffusion and retention are major determinants of protein targeting to the inner nuclear membrane.
New
Kutay et al., Zürich, Switzerland. In J Cell Biol, Jul 2015
Using human LBR, SUN2, and LAP2β as model substrates, we show that INM targeting is energy-dependent but distinct from import of soluble cargo.
Nuclear-cytoskeletal linkages facilitate cross talk between the nucleus and intercellular adhesions.
New
King et al., New Haven, United States. In J Cell Biol, Jun 2015
In this paper, we demonstrate that the LINC complex component SUN2 contributes to the mechanical integrity of intercellular adhesions between mammalian epidermal keratinocytes.
Plant nuclear shape is independently determined by the SUN-WIP-WIT2-myosin XI-i complex and CRWN1.
Meier et al., Columbus, United States. In Nucleus, 2014
Recently, an interaction between Arabidopsis SUN1 and SUN2 proteins and CRWN1, a plant analog of lamins, has been reported.
SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer.
Sang et al., Nanchang, China. In Sci Rep, 2014
SUN2, a key component of LINC (linker of nucleoskeleton and cytoskeleton) complex located at the inner nuclear membrane, plays unknown role in lung cancer.
Nuclear envelope-associated endosomes deliver surface proteins to the nucleus.
Bard et al., Singapore, Singapore. In Nat Commun, 2014
RNAi screening further revealed that NAE-mediated transfer depends on the nuclear envelope proteins SUN1 and SUN2, as well as the Sec61 translocon complex.
LINC complexes form by binding of three KASH peptides to domain interfaces of trimeric SUN proteins.
Impact
GeneRIF
Schwartz et al., Cambridge, United States. In Cell, 2012
Study presents crystal structures of the human SUN2-KASH1/2 complex, i.e. SUN2 complexed with the C-terminal 29 residues of human Nesprin-1 or -2 (the core of the LINC complex).
Structure of Sad1-UNC84 homology (SUN) domain defines features of molecular bridge in nuclear envelope.
GeneRIF
Wang et al., Philadelphia, United States. In J Biol Chem, 2012
the crystal structure of the SUN2 protein SUN domain
The LINC complex and human disease.
Review
Wehnert et al., Greifswald, Germany. In Biochem Soc Trans, 2011
The LINC components emerin, lamin A/C, SUN1, SUN2, nesprin-1 and nesprin-2 interact with each other at the NE and also with other binding partners including actin filaments and B-type lamins.
A proteasome assembly defect in rpn3 mutants is associated with Rpn11 instability and increased sensitivity to stress.
GeneRIF
Madura et al., United States. In J Mol Biol, 2011
Data show that the availability of Rpn11 is important for maintaining adequate levels of intact proteasomes, as its depletion caused growth and proteolytic defects in rpn3.
A diverse range of gene products are effectors of the type I interferon antiviral response.
Impact
Rice et al., New York City, United States. In Nature, 2011
Broadly acting effectors included IRF1, C6orf150 (also known as MB21D1), HPSE, RIG-I (also known as DDX58), MDA5 (also known as IFIH1) and IFITM3, whereas more targeted antiviral specificity was observed with DDX60, IFI44L, IFI6, IFITM2, MAP3K14, MOV10, NAMPT (also known as PBEF1), OASL, RTP4, TREX1 and UNC84B (also known as SUN2).
KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.
GeneRIF
Han et al., Shanghai, China. In Hum Mol Genet, 2011
Syne-2, SUN1 and SUN2 play critical roles during interkinetic nuclear migration and photoreceptor cell migration in the mouse retina development.
Subcellular localization of SUN2 is regulated by lamin A and Rab5.
GeneRIF
Chan et al., Hong Kong, Hong Kong. In Plos One, 2010
Data found that expression of lamin A but not lamin C partly restored the nuclear envelope localization of SUN2.
Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement.
Impact
Gundersen et al., New York City, United States. In Science, 2010
We found that linear arrays of outer (nesprin2G) and inner (SUN2) nuclear membrane proteins assembled on and moved with retrogradely moving dorsal actin cables during nuclear movement in polarizing fibroblasts.
On the physiological role of casein kinase II in Saccharomyces cerevisiae.
Review
Glover, Athens, United States. In Prog Nucleic Acid Res Mol Biol, 1997
Consistent with this, isolation of multicopy suppressors of conditional cka mutations has identified three genes that have a known or potential role in either the cell cycle or cell polarity: CDC37, which is required for cell cycle progression in both G1 and G2/M; ZDS1 and 2, which appear to have a function in cell polarity; and SUN2, which encodes a protein of the regulatory component of the 26S protease.
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