Molybdenum cofactor deficiency.
Houston, United States. In Mol Genet Metab, Jan 2016
MoCD results in deficiency of the molybdenum cofactor dependent enzymes sulfite oxidase, xanthine dehydrogenase, aldehyde oxidase and mitochondrial amidoxime reducing component.
Globins Scavenge Sulfur Trioxide Anion Radical.
Dayton, United States. In J Biol Chem, Dec 2015
Saccharomyces cerevisiae lacking sulfite oxidase and deleted of flavohemoglobin showed an O2-dependent growth impairment with nonfermentable substrates that was exacerbated by sulfide, a precursor to mitochondrial sulfite formation.
Shifting the metallocentric molybdoenzyme paradigm: the importance of pyranopterin coordination.
Edmonton, Canada. In J Biol Inorg Chem, Mar 2015
Enzyme families containing a single pyranopterin dithiolene chelate have been demonstrated to have reactivity towards two (sulfite oxidase, SUOX-fold) and five (xanthine dehydrogenase, XDH-fold) types of substrate, whereas the major family of enzymes containing a bis-pyranopterin dithiolene chelate (dimethylsulfoxide reductase, DMSOR-fold) is reactive towards eight types of substrate.
Genetics of polycystic ovary syndrome.
Boston, United States. In Semin Reprod Med, 2014
The strongest loci in Europeans contain genes for DENND1A and THADA, with additional associations in loci containing the LHCGR and FSHR, YAP1 and RAB5/SUOX.
Molybdenum cofactor biosynthesis and molybdenum enzymes.
Braunschweig, Germany. In Annu Rev Plant Biol, 2005
There are four Mo enzymes in plants: (1) nitrate reductase catalyzes the first and rate-limiting step in nitrate assimilation and is structurally similar to the recently identified, (2) peroxisomal sulfite oxidase that detoxifies excessive sulfite.
With the help of giants.
Durham, United States. In Annu Rev Biochem, 2002
The premier discoveries to emanate from my laboratory have been the sulfite oxidase, the several superoxide dismutases, the manganese catalase, and the catalase/peroxidase.