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Sucrase, sucrase-isomaltase
This gene encodes a sucrase-isomaltase enzyme that is expressed in the intestinal brush border. The encoded protein is synthesized as a precursor protein that is cleaved by pancreatic proteases into two enzymatic subunits sucrase and isomaltase. These two subunits heterodimerize to form the sucrose-isomaltase complex. This complex is essential for the digestion of dietary carbohydrates including starch, sucrose and isomaltose. Mutations in this gene are the cause of congenital sucrase-isomaltase deficiency.[provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: Lac, ACID, HAD, CAN, aminopeptidase
Papers on Sucrase
Characterization of the first α-(1→3) branching sucrases of GH70 family.
Remaud-Siméon et al., Toulouse, France. In J Biol Chem, Feb 2016
To date, BRS-B is the first reported α-(1→3) branching sucrase.
Inhibition by Seeds of Phalaris canariensis Extracts of Key Enzymes Linked to Obesity.
Cruz Victoria et al., In Altern Ther Health Med, Jan 2016
The inhibitory activity of rat intestinal sucrase was determined by measuring the glucose released.
Alligators and Crocodiles Have High Paracellular Absorption of Nutrients, But Differ in Digestive Morphology and Physiology.
Christian et al., Darwin, Australia. In Integr Comp Biol, Dec 2015
Since there are few comparative studies of crocodilian digestive physiology to help explain these differences, we investigated young Alligator mississippiensis and Crocodylus porosus in terms of (1) gross and microscopic morphology of the intestine, (2) activity of the membrane-bound digestive enzymes aminopeptidase-N, maltase, and sucrase, and (3) nutrient absorption by carrier-mediated and paracellular pathways.
[Expression and purification of human sucrase protein in E.coli].
Ge et al., Zhuhai, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, Dec 2015
Objective To construct prokaryotic expression vector pET-28a(+)-human sucrase (hSUC) and express hSUC fusion protein in E.coli.
Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3.
Huber et al., Innsbruck, Austria. In J Cell Biol, Dec 2015
The brush border enzymes DPPIV and sucrase-isomaltase still correctly localize at the apical plasma membrane independent of this pathway.
Propolis aqueous extract preserves functional integrity of murine intestinal mucosa after exposure to ionizing radiation.
El-Ghazaly et al., Cairo, Egypt. In Environ Toxicol Pharmacol, Nov 2015
Irradiation led to a rise in the histological damage score, a rise in tissue TNF-α and TBARS, and a decrease in sucrase, alkaline phosphatase, GSH and cholecystokinin as well as a decrease in plasma citrulline.
Probiotic Pediococcus pentosaceus strain GS4 alleviates azoxymethane-induced toxicity in mice.
Khuda-Bukhsh et al., Vellore, India. In Nutr Res, Oct 2015
Probiotic GS4 intervention reduced the intestinal structural deformities as evident from the elevated brush border membrane-associated disaccharidases (sucrase, lactase) and intestinal alkaline phosphatase activities, which were found disrupted by AOM intoxication.
An in vivo model of human small intestine using pluripotent stem cells.
Helmrath et al., Cincinnati, United States. In Nat Med, 2014
In vivo transplantation resulted in marked expansion and maturation of the epithelium and mesenchyme, as demonstrated by differentiated intestinal cell lineages (enterocytes, goblet cells, Paneth cells, tuft cells and enteroendocrine cells), presence of functional brush-border enzymes (lactase, sucrase-isomaltase and dipeptidyl peptidase 4) and visible subepithelial and smooth muscle layers when compared with HIOs in vitro.
Drinking problems on a 'simple' diet: physiological convergence in nectar-feeding birds.
Fleming et al., Pretoria, South Africa. In J Exp Biol, 2014
These birds show similar dependence of sugar preferences on nectar concentration, high intestinal sucrase activity and rapid absorption of hexoses via mediated and paracellular routes.
Naturally occurring sulfonium-ion glucosidase inhibitors and their derivatives: a promising class of potential antidiabetic agents.
Pinto et al., Canada. In Acc Chem Res, 2014
Then two retaining exoglucosidases, maltase-glucoamylase (MGAM) and sucrase-isomaltase (SI), convert those molecules into glucose in the small intestine.
Possible effects of dietary polyphenols on sugar absorption and digestion.
Williamson, Leeds, United Kingdom. In Mol Nutr Food Res, 2013
Anthocyanidins and catechin oxidation products, such as theaflavins and theasinsensins, inhibit maltase; sucrase is less strongly inhibited but anthocyanidins seem somewhat effective.
[Synthetic medicinal chemistry of the biomolecular components mimics].
Takahata, In Yakugaku Zasshi, 2012
Among them, the inhibitory activity towards intestinal sucrase of α-1-C-L-butylarabinoiminofuranose was quite strong towards intestinal sucrase compared to the above commercial drugs.
Determination of the transient period of the EIS complex and investigation of the suppression of blood glucose levels by L-arabinose in healthy adults.
Houda et al., Kashihara, Japan. In Eur J Nutr, 2011
investigation of EIS (enzyme-inhibitor-substrate) complex of sucrase: kinetic studies of complex formation/stability; role of complex in prevention of hyperglycemia by L-arabinose
Core2 O-glycan structure is essential for the cell surface expression of sucrase isomaltase and dipeptidyl peptidase-IV during intestinal cell differentiation.
Fukuda et al., Los Angeles, United States. In J Biol Chem, 2010
Core2 O-glycan structure is essential for expression of SI and DDP-IV during intestinal cell differentiation.
Induction of histone acetylation on the sucrase-isomaltase gene in the postnatal rat jejunum.
Goda et al., Shizuoka, Japan. In Biosci Biotechnol Biochem, 2009
An abrupt jejunal induction of histone acetylation changes on the sucrase-isomaltase gene during this period may be concerned with the expression of the gene.
Compound heterozygous mutations affect protein folding and function in patients with congenital sucrase-isomaltase deficiency.
Naim et al., Hannover, Germany. In Gastroenterology, 2009
The effects of mutations in the sucrase domain of SIC1229Y and SIF1745C indicate the importance of a direct interaction between isomaltase and sucrose and the role of sucrose as an intermolecular chaperone in the intracellular transport of SI
Effect of harmaline on rat intestinal brush border sucrase activity.
Mahmood et al., Chandīgarh, India. In Indian J Biochem Biophys, 2002
harmaline has an effect on rat intestinal brush border sucrase activity
Homozygosity mapping of the gene for alkaptonuria to chromosome 3q2.
Seidman et al., Boston, United States. In Nat Genet, 1993
Coinheritance of either neonatal severe hyperparathyroidism or sucrase-isomaltase deficiency and alkaptonuria provided a candidate location for the mutated genes on chromosome 3. Homozygosity mapping with polymorphic loci identified a 16 centiMorgan region on chromosome 3q2 that contains the alkaptonuria gene.
A study of the molecular pathology of sucrase-isomaltase deficiency. A defect in the intracellular processing of the enzyme.
Olsen et al., In N Engl J Med, 1987
The intestinal brush-border enzyme sucrase-isomaltase splits sucrose into its component monosaccharides, glucose and fructose.
The sucrase-isomaltase complex: primary structure, membrane-orientation, and evolution of a stalked, intrinsic brush border protein.
Lodish et al., In Cell, 1986
The complete primary structure (1827 amino acids) of rabbit intestinal pro-sucrase-isomaltase (pro-SI) was deduced from the sequence of a nearly full-length cDNA.
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