Challenges in developing drugs for primary headache.
Copenhagen, Denmark. In Prog Neurobiol, Feb 2016
Glutamate receptor antagonism whilst efficacious has central side effects and some approaches such as nitric oxide synthase inhibition, substance P antagonism and cortical spreading depression blockade, despite having promising effects in basic pain models, have not delivered efficacy in the clinic.
Mechanism of Action of Spinal Mobilizations: A Systematic Review.
Leioa, Spain. In Spine (phila Pa 1976), Jan 2016
There is limited evidence (one study in each case) to suggest that mobilizations produce increased nociceptive flexion reflex threshold, improved posture, decreased concentration of substance P in saliva, and improved sway index measured in cervical extension.
Acute versus chronic phase mechanisms in a rat model of CRPS.
Palo Alto, United States. In J Neuroinflammation, Dec 2015
The expression of the neuropeptide signaling molecule substance P (SP), NK1 receptor, inflammatory mediators TNFα, IL-1β, and IL-6 and nerve growth factor (NGF) were elevated at 4 weeks in sciatic nerve and/or skin, returning to normal levels by 16 weeks post fracture.