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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tachykinin, precursor 1

substance P, Neurokinin-1, neurokinin A
This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Neuropeptide, Calcitonin, HAD, V1a
Papers using substance P antibodies
Substance P: Structure, Function and Therapuetics
Supplier
Koch Karl-Wilhelm, In PLoS ONE, 2003
... FAM (Fluorescein amidite) labeled Substance P was purchased from Anaspec Inc ...
Transmission of chronic nociception by spinal neurons expressing the substance P receptor
Supplier
MacDermott Amy B et al., In Molecular Pain, 1998
... Some TMR-substance P was synthesized and purchased from AnaSpec, Inc ...
Papers on substance P
Substance P, Hemokinin-1, CRH, TNF and IL-6 are increased in serum of patients with Fibromyalgia Syndrome and may serve both as biomarkers and targets for treatment.
New
Theoharides et al., Logan, United States. In J Pharmacol Exp Ther, Feb 2016
Here we report for the first time that the neuropeptides corticotropin-releasing hormone (CRH), substance P (SP) and its structurally related Hemokinin-1 (HK-1) were significantly (p=0.026,
Synthesis and biological evaluation of novel orally available 1-phenyl-6-aminouracils containing dimethyldihydrobenzofuranol structure for the treatment of allergic skin diseases.
New
Isobe et al., Suita, Japan. In Bioorg Med Chem Lett, Feb 2016
In addition, compound 13d, having potent hydroxyl radical-scavenging activity, showed more potent suppressive effect on substance P-induced pruritus in mice than oxatomide.
Changes in the Disposition of Substance P in the Rostral Ventromedial Medulla after Inflammatory Injury in the Rat.
New
Hammond et al., Iowa City, United States. In Neuroscience, Feb 2016
UNASSIGNED: This study examined whether peripheral inflammatory injury increases the levels or changes the disposition of substance P (SubP) in the rostral ventromedial medulla (RVM), which serves as a central relay in bulbospinal pathways of pain modulation.
Challenges in developing drugs for primary headache.
Review
New
Ashina et al., Copenhagen, Denmark. In Prog Neurobiol, Feb 2016
Glutamate receptor antagonism whilst efficacious has central side effects and some approaches such as nitric oxide synthase inhibition, substance P antagonism and cortical spreading depression blockade, despite having promising effects in basic pain models, have not delivered efficacy in the clinic.
Trichodynia: a review of the literature.
Review
New
Rebora, Genova, Italy. In Int J Dermatol, Jan 2016
Trichodynia seems to be related to the release of substance P and is present in alopecia areata.
Control of arousal through neuropeptide afferents of the locus coeruleus.
Review
New
Zitnik, Philadelphia, United States. In Brain Res, Jan 2016
These neuropeptides include: corticotropin releasing factor (CRF), orexin (ORX), endogenous opioids, substance P (SP), melanin-concentrating hormone (MCH), neuropeptide Y (NPY) and somatostatin (SS).
Role of substance P in the cardiovascular system.
Review
New
Chottova Dvorakova et al., Praha, Czech Republic. In Neuropeptides, Jan 2016
Substance P is an undecapeptide originating from TAC1 gen and belonging to the tachykinin family.
Acute versus chronic phase mechanisms in a rat model of CRPS.
New
Clark et al., Palo Alto, United States. In J Neuroinflammation, Dec 2015
The expression of the neuropeptide signaling molecule substance P (SP), NK1 receptor, inflammatory mediators TNFα, IL-1β, and IL-6 and nerve growth factor (NGF) were elevated at 4 weeks in sciatic nerve and/or skin, returning to normal levels by 16 weeks post fracture.
The immediate effect of traditional Malay massage on substance P, inflammatory mediators, pain scale and functional outcome among patients with low back pain: study protocol of a randomised controlled trial.
New
Ming et al., Shah Alam, Malaysia. In Bmc Complement Altern Med, Dec 2015
The aim of this study is to investigate the immediate effect of traditional Malay massage on the pain scale, substance P, inflammatory mediators, and functional outcomes among low back pain patients.
Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of cisplatin-based highly emetogenic chemotherapy in patients with cancer: two randomised, active-controlled, double-blind, phase 3 trials.
New
Impact
Navari et al., Johannesburg, South Africa. In Lancet Oncol, Sep 2015
Guidelines recommend use of a neurokinin-1 (NK-1) receptor antagonist in conjunction with a 5-HT3 receptor antagonist and corticosteroid in patients receiving highly emetogenic chemotherapy.
Safety and efficacy of rolapitant for prevention of chemotherapy-induced nausea and vomiting after administration of moderately emetogenic chemotherapy or anthracycline and cyclophosphamide regimens in patients with cancer: a randomised, active-controlled, double-blind, phase 3 trial.
New
Impact
Schnadig et al., Memphis, United States. In Lancet Oncol, Sep 2015
We aimed to assess the neurokinin-1 receptor antagonist rolapitant, in combination with a serotonin (5-HT3) receptor antagonist and dexamethasone, for the prevention of chemotherapy-induced nausea and vomiting in patients with cancer after administration of moderately emetogenic chemotherapy or regimens containing an anthracycline and cyclophosphamide.
Aprepitant for the prevention of chemotherapy-induced nausea and vomiting in children: a randomised, double-blind, phase 3 trial.
New
Impact
Zwaan et al., Seoul, South Korea. In Lancet Oncol, Apr 2015
BACKGROUND: Oral aprepitant, a neurokinin-1 receptor antagonist, is recommended in combination with other anti-emetic agents for the prevention of nausea and vomiting associated with moderately or highly emetogenic chemotherapy in adults, but its efficacy and safety in paediatric patients are unknown.
Neurologic Regulation and Orthodontic Tooth Movement.
Review
Faber et al., In Front Oral Biol, 2014
Various types of nerves are found in the periodontium, including thinly myelinated and unmyelinated sensory fibers that express the neuropeptides substance P and calcitonin gene-related peptide among others.
Tachykinins and their receptors: contributions to physiological control and the mechanisms of disease.
Review
Impact
Bunnett et al., In Physiol Rev, 2014
In clinical trials there is a singular success: neurokinin 1 receptor antagonists to treat nausea and vomiting.
Randomized, double-blind, placebo-controlled, phase III cross-over study evaluating the oral neurokinin-1 antagonist aprepitant in combination with a 5HT3 receptor antagonist and dexamethasone in patients with germ cell tumors receiving 5-day cisplatin combination chemotherapy regimens: a hoosier oncology group study.
Impact
Einhorn et al., Indianapolis, United States. In J Clin Oncol, 2012
PURPOSE: Aprepitant, a 5-HT3 receptor antagonist (5HT3-RA), and dexamethasone are standard antiemetic therapy for prevention of single-day, cisplatin-induced nausea and vomiting.
Glutamate receptors in tendinopathic patients.
GeneRIF
Ackermann et al., Stockholm, Sweden. In J Orthop Res, 2012
The unique co-existence of SP and phospho-NMDAR1 in tendinopathy presumably reflects a tissue proliferative and nociceptive role.
Cerebrospinal fluid substance P-like immunoreactivity correlates with aggression in personality disordered subjects.
GeneRIF
Nemeroff et al., Chicago, United States. In Biol Psychiatry, 2012
These data suggest a direct relationship between central nervous system substance P containing neural circuits and aggression in human subjects
Role for substance p-based nociceptive signaling in progenitor cell activation and angiogenesis during ischemia in mice and in human subjects.
GeneRIF
Madeddu et al., Bristol, United Kingdom. In Circulation, 2012
Human progenitor cells (PC) express NK1, and substance p-induced migration provides enrichment for proangiogenic PC
Serum levels of calcitonin gene-related peptide and substance P are decreased in patients with diabetes mellitus and coronary artery disease.
GeneRIF
Sun et al., Hangzhou, China. In J Int Med Res, 2011
CGRP and SP may have a role in the pathogenesis of coronary artery disease in patients with diabetes.
Substance P and neprilysin in chronic pancreatitis.
GeneRIF
di Sebastiano et al., San Giovanni Rotondo, Italy. In Eur Surg Res, 2011
Tissue and serum levels of substance P were increased in chronic pancreatitis, while neprilysin levels remained unaltered.
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