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STV1 Stv1p

STV1, Stv1p, TJ6, RPL24
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24E family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as ribosomal protein L30 because the encoded protein shares amino acid identity with the L30 ribosomal proteins from S. cerevisiae; however, its official name is ribosomal protein L24. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ATPase, A-4, V-ATPase, HAD, CAN
Papers on STV1
Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis.
Rajender et al., Lucknow, India. In Plos One, 2014
Some transcripts were specific to the normozoospermic group (up-regulated: CAPNS1, FAM153C, ARF1, CFL1, RPL19, USP22; down-regulated: ZNF90, SMNDC1, c14orf126, HNRNPK), while some were specific to the asthenozoospermic group (up-regulated: RPL24, HNRNPM, RPL4, PRPF8, HTN3, RPL11, RPL28, RPS16, SLC25A3, C2orf24, RHOA, GDI2, NONO, PARK7; down-regulated: HNRNPC, SMARCAD1, RPS24, RPS24, RPS27A, KIFAP3).
RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth.
Benz et al., Novato, United States. In Oncotarget, 2014
Partial loss of large ribosomal subunit protein 24 (RPL24) function is known to protect mice against Akt or Myc-driven cancers, in part via translational inhibition of a subset of cap(eIF4E)-dependently translated mRNAs.
The RAVE complex is an isoform-specific V-ATPase assembly factor in yeast.
Kane et al., Syracuse, United States. In Mol Biol Cell, 2014
STV1 overexpression suppressed the growth defects of both rav1 and rav1vph1, and allowed RAVE-independent assembly of active Stv1p-containing V-ATPases in vacuoles.
Drug resistance effects of ribosomal protein L24 overexpression in hepatocellular carcinoma HepG2 cells.
Tan et al., Jining, China. In Asian Pac J Cancer Prev, 2013
Ribosomal protein L24 has been reported to be a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cell growth of cancer.
Essential role for vacuolar acidification in Candida albicans virulence.
Rao et al., Baltimore, United States. In J Biol Chem, 2013
To dissect their separate roles in Candida albicans pathogenicity we generated knock-out strains for the V0 subunit a genes VPH1 and STV1, which target the vacuole and secretory pathway, respectively.
Deletion of vacuolar proton-translocating ATPase V(o)a isoforms clarifies the role of vacuolar pH as a determinant of virulence-associated traits in Candida albicans.
Parra et al., Albuquerque, United States. In J Biol Chem, 2013
V-ATPase subunit a of the Vo domain (Voa) is present as two fungal isoforms: Stv1p (Golgi) and Vph1p (vacuole).
The global translation profile in a ribosomal protein mutant resembles that of an eIF3 mutant.
von Arnim et al., Knoxville, United States. In Bmc Biol, 2012
To identify additional features of the global landscape of translational control, we used microarray analysis of polysomal as well as non-polysomal mRNAs to examine the defects in translation in a poly(A) binding protein mutant, pab2 pab8, as well as in a mutant of a large ribosomal subunit protein, rpl24b/shortvalve1.
Overexpression, purification, and pharmacologic evaluation of anticancer activity of ribosomal protein L24 from the giant panda (Ailuropoda melanoleuca).
Zhong et al., Nanchong, China. In Genet Mol Res, 2012
The ribosomal protein L24 (RPL24) belongs to the L24E family of ribosomal proteins and is located in the cytoplasm.
Sorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1p.
GeneRIF
Stevens et al., Eugene, United States. In J Biol Chem, 2012
This evolutionary intermediate includes an endogenous W(83)KY sorting motif and is sufficient to compete with sorting of the native yeast Stv1p V-ATPase isoform.
Abortion-prone mating influences alteration of systemic a2 vacuolar ATPase expression in spleen and blood immune cells.
GeneRIF
Beaman et al., North Chicago, United States. In Am J Reprod Immunol, 2012
Deceased expression of Atp6v0a2 in the various immune cell populations of the spleen and blood suggests that the maternal environment is not supportive to fetus and leads to poor pregnancy outcome in the abortion-prone mating model
V-ATPase upregulation during early pregnancy: a possible link to establishment of an inflammatory response during preimplantation period of pregnancy.
GeneRIF
Beaman et al., North Chicago, United States. In Reproduction, 2012
Report Atp6v0a2 up-regulation/inflammatory response during preimplantation period of pregnancy may lead to successful pregnancy outcome.
The function of RH22, a DEAD RNA helicase, in the biogenesis of the 50S ribosomal subunits of Arabidopsis chloroplasts.
Zhang et al., Beijing, China. In Plant Physiol, 2012
In addition, RH22 interacted with the 50S ribosomal protein RPL24 through yeast two-hybrid and pull-down assays, and it was also bound to a small 23S rRNA fragment encompassing RPL24-binding sites.
Placental ATPase expression is a link between multiple causes of spontaneous abortion in mice.
GeneRIF
Beaman et al., North Chicago, United States. In Biol Reprod, 2011
a2V regulates the delicate cytokine and chemokine networks that coordinate the recruitment of macrophages for successful placental development and growth at the feto-maternal interface.
The reconstructed ancestral subunit a functions as both V-ATPase isoforms Vph1p and Stv1p in Saccharomyces cerevisiae.
Stevens et al., Eugene, United States. In Mol Biol Cell, 2011
Incorporation of Vph1p or Stv1p into the V-ATPase dictates the localization of the V-ATPase to the vacuole or late Golgi/endosome, respectively.
Consequences of loss of Vph1 protein-containing vacuolar ATPases (V-ATPases) for overall cellular pH homeostasis.
Kane et al., Syracuse, United States. In J Biol Chem, 2011
In yeast cells, subunit a of the vacuolar proton pump (V-ATPase) is encoded by two organelle-specific isoforms, VPH1 and STV1.
Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO.
GeneRIF
Marshansky et al., Boston, United States. In Biochim Biophys Acta, 2010
Specific motifs of the V-ATPase a2-subunit isoform interact with catalytic and regulatory domains of ARNO.
Translation reinitiation and development are compromised in similar ways by mutations in translation initiation factor eIF3h and the ribosomal protein RPL24.
von Arnim et al., Knoxville, United States. In Bmc Plant Biol, 2009
The RPL24B protein of the large ribosomal subunit, which is encoded by SHORT VALVE1, likewise fosters translation of uORF-containing mRNAs, for example mRNAs for auxin response transcription factors (ARFs).
TJ6: the pregnancy-associated cytokine.
Review
Gilman-Sachs et al., Chicago, United States. In Am J Reprod Immunol, 1996
These studies have demonstrated that TJ6m protein can be measured in women prior to a spontaneous abortion based on expression of TJ6 on CD56-positive NK cells.
Evidence for a conserved 95-120 kDa subunit associated with and essential for activity of V-ATPases.
Review
Jones et al., Pittsburgh, United States. In J Exp Biol, 1992
Vph1p has 42% identity to the 116 kDa polypeptide of the rat clathrin-coated vesicles/synaptic vesicle proton pump, 42% identity to the TJ6 mouse immune suppressor factor, 42% identity to the Caenorhabditis elegans proton pump homologue and 54% identity to the predicted polypeptide encoded by the yeast gene STV1 (Similar To VPH1, identified as an open reading frame next to the BUB2 gene.
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