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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Vang-like 2

Strabismus
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: AGE, HAD, CAN, OUT, iMpact
Papers on Strabismus
Strabismus, a preventable barrier to social participation: a short report.
New
Australian Cerebral Palsy Register Group et al., Perth, Australia. In Dev Med Child Neurol, Feb 2016
UNASSIGNED: Isolated strabismus does not significantly impair visual functionality and has traditionally been considered a primarily cosmetic defect of little importance.
Treatment of exophthalmos and strabismus surgery in thyroid-associated orbitopathy.
New
Clauser et al., Ferrara, Italy. In Int J Oral Maxillofac Surg, Feb 2016
UNASSIGNED: Endocrine orbitopathy (EO) can have important consequences, such as exophthalmos and restrictive strabismus.
Botulinum toxin uses in strabismus: A review of the injections performed during one year in a general hospital.
New
García Gil de Bernabé et al., Madrid, Spain. In Arch Soc Esp Oftalmol, Jan 2016
OBJECTIVE: To analyse the indications, dosage and efficacy of botulinum toxin A injection performed in patients in a Strabismus Department.
Evaluation and validity of the Danish version of the Adult Strabismus Questionnaire AS-20.
New
Mortzos et al., Roskilde, Denmark. In Clin Ophthalmol, Dec 2015
PURPOSE: Assessing health-related quality of life in patients with strabismus is important in evaluating the clinical benefits of strabismus treatment.
Strabismus.
Review
New
DeBenedictis et al., Philadelphia, United States. In Prim Care, Sep 2015
Defining the type of strabismus creates a framework for work-up and management.
Periosteal Fixation Procedures in the Management of Incomitant Strabismus.
Review
New
Pinto et al., New Delhi, India. In Middle East Afr J Ophthalmol, Jul 2015
Managing a case of incomitant strabismus from nerve palsy or extraocular muscle loss is a major challenge.
An Approach to Some Aspects of Strabismus from Ocular and Orbital Trauma.
Review
New
Murray, Cape Town, South Africa. In Middle East Afr J Ophthalmol, Jul 2015
Strabismus caused by ocular or orbital trauma can be the result of localized acute soft tissue swelling or may follow orbital fractures, partial or complete loss of extraocular muscle (EOM) and/or cranial nerve function, or damage to surrounding tissues causing mechanical restriction.
[Interpretation the consensus of strabismus classification].
Review
New
Zhang, Tianjin, China. In Zhonghua Yan Ke Za Zhi, Jun 2015
Strabismus is a deviation of the visual axes relative to each other and is a very common eye disease.
Aligning Strabismus Surgery with Duane Syndrome.
Review
Kelly et al., In Insight, 2014
Initial consideration for surgical intervention tends to be resection and recession of affected muscles for strabismus.
[Strabismus Sursoabductorius (put into the Context of eighteen Years of Strabismus Surgery Analysis)].
Krásný, In Cesk Slov Oftalmol, 2014
AIM: To familiarize with the form of combined horizontal and vertical deviations and its development and put it into the context of eighteen years of strabismus surgery analysis.
Dissecting the molecular bridges that mediate the function of Frizzled in planar cell polarity.
GeneRIF
Lawrence et al., New York City, United States. In Development, 2012
We deduce that each cell has a mechanism to estimate and compare the numbers of asymmetric bridges, made between Stan and Stan plus Fz, that link it with its neighbouring cells.
The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.
GeneRIF
Chandrasekhar et al., Columbia, United States. In Dev Biol, 2012
loss of Dvl2 function in Vangl2(Lp/+) embryos did not exacerbate the Vangl2(Lp/+) neuronal migration phenotype
VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration.
GeneRIF
Jessen et al., Nashville, United States. In J Cell Sci, 2012
VANGL2 regulates the endocytosis and cell-surface availability of MMP14 in a manner that is dependent on focal adhesion kinase.
Nitric oxide sustains long-term skeletal muscle regeneration by regulating fate of satellite cells via signaling pathways requiring Vangl2 and cyclic GMP.
GeneRIF
Clementi et al., Milano, Italy. In Stem Cells, 2012
These results identify nitric oxide as a key messenger in satellite cells maintenance and expand the significance of the Vangl2-dependent Wnt noncanonical pathway in myogenesis.
Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development.
GeneRIF
Deans et al., Baltimore, United States. In Plos One, 2011
A vangl2 knockout mouse was compared for the severity of the knockout and Looptail mutant phenotypes.
Planar cell polarity signalling couples cell division and morphogenesis during neurulation.
Impact
Schier et al., New York City, United States. In Nature, 2006
Mouse and frog models for these birth defects have indicated that Van Gogh-like 2 (Vangl2, also known as Strabismus) and other components of planar cell polarity (PCP) signalling might control neurulation by promoting the convergence of neural progenitors to the midline.
Planar cell polarity signalling controls cell division orientation during zebrafish gastrulation.
Impact
Fraser et al., Pasadena, United States. In Nature, 2004
Establishment of this animal-vegetal polarity requires the Wnt pathway components Silberblick/Wnt11, Dishevelled and Strabismus.
Discs-Large and Strabismus are functionally linked to plasma membrane formation.
Impact
GeneRIF
Cho et al., Houston, United States. In Nat Cell Biol, 2003
role in development of cell boundaries for cell nuclei in Drosophila embryos in conjunction with Discs-Large protein
Identification of Vangl2 and Scrb1 as planar polarity genes in mammals.
Impact
GeneRIF
Kelley et al., Rockville, United States. In Nature, 2003
mutation in Vangl2 results in significant disruptions in the polarization of stereociliary bundles in mouse cochlea due to defects in the direction of movement and/or anchoring of the kinocilium within each hair cell
Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements.
Impact
GeneRIF
Solnica-Krezel et al., Nashville, United States. In Nat Cell Biol, 2002
The vangl2 gene product mediates cellular interactions that confer directionality on distinct movements during vertebrate embryogenesis.
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