Nuclear and extranuclear effects of vitamin A.
Russia. In Can J Physiol Pharmacol, Dec 2015
These novel scenarios involve: (i) other nuclear receptors such as PPAR β/δ, which regulate the expression of other target genes with other functions; (ii) extranuclear and nontranscriptional effects, such as the activation of kinases, which phosphorylate RARs and other transcription factors, thus expanding the list of the RA-activated genes; (iii) finally, vitamin A is active per se and can work as a cytokine that regulates gene transcription by activating STRA6.
Xanthophyll supplementation regulates carotenoid and retinoid metabolism in hens and chicks.
Fuzhou, China. In Poult Sci, Dec 2015
UNASSIGNED: This study investigated the effects of xanthophylls (containing 40% lutein and 60% zeaxanthin; Juyuan Biochemical Co., Ltd., GuangZhou, China) on gene expression associated with carotenoid cleavage enzymes (β-carotene 15, 15'-monooxygenase, BCMO1; and β-carotene 9', 10'-dioxygenase, BCDO2) and retinoid metabolism (lecithin:retinol acyl transferase (LRAT) and STRA6) of breeding hens and chicks.
STRA6: role in cellular retinol uptake and efflux.
Cleveland, United States. In Hepatobiliary Surg Nutr, Aug 2015
Increasing evidence indicates that this process is mediated by a multidomian membrane protein that is encoded by the stimulated by retinoic acid 6 (STRA6) gene.
Vitamin A and Diabesity: New Insight for Drug Discovery.
Rende, Italy. In Mini Rev Med Chem, Aug 2015
RBP4, interacts with two receptors, the Toll-like receptor 4 (TLR4) and the plasma membrane protein called stimulated by retinoic acid 6 (STRA6) leading to the activation of c-Jun N-terminal protein kinase (JNK) pathways and JAK2/STAT5 cascade, respectively.
The genetic architecture of microphthalmia, anophthalmia and coloboma.
Edinburgh, United Kingdom. In Eur J Med Genet, 2014
This review will focus on MAC phenotypes that are associated with mutation of the genes SOX2, OTX2, PAX6, STRA6, ALDH1A3, RARB, VSX2, RAX, FOXE3, BMP4, BMP7, GDF3, GDF6, ABCB6, ATOH7, C12orf57, TENM3 (ODZ3), and VAX1.