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Stimulated by retinoic acid gene 6 homolog

STRA6
The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] (from NCBI)
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Top mentioned proteins: ACID, RBP, CAN, Insulin, HAD
Papers on STRA6
Vitamin A in regulation of insulin responsiveness: mini review.
New
Noy, Cleveland, United States. In Proc Nutr Soc, Feb 2016
At some tissues, retinol-bound (holo-) RBP4 is recognised by a receptor termed stimulated by retinoic acid 6 (STRA6) which transports retinol into cells.
A novel mutation in two Hmong families broadens the range of STRA6-related malformations to include contractures and camptodactyly.
New
Care4Rare Canada Consortium et al., Ottawa, Canada. In Am J Med Genet A, Jan 2016
The disorder is caused by mutations in STRA6, an important regulator of vitamin A and retinoic acid metabolism.
Nuclear and extranuclear effects of vitamin A.
New
Rochette-Egly et al., Russia. In Can J Physiol Pharmacol, Dec 2015
These novel scenarios involve: (i) other nuclear receptors such as PPAR β/δ, which regulate the expression of other target genes with other functions; (ii) extranuclear and nontranscriptional effects, such as the activation of kinases, which phosphorylate RARs and other transcription factors, thus expanding the list of the RA-activated genes; (iii) finally, vitamin A is active per se and can work as a cytokine that regulates gene transcription by activating STRA6.
Xanthophyll supplementation regulates carotenoid and retinoid metabolism in hens and chicks.
New
Bi et al., Fuzhou, China. In Poult Sci, Dec 2015
UNASSIGNED: This study investigated the effects of xanthophylls (containing 40% lutein and 60% zeaxanthin; Juyuan Biochemical Co., Ltd., GuangZhou, China) on gene expression associated with carotenoid cleavage enzymes (β-carotene 15, 15'-monooxygenase, BCMO1; and β-carotene 9', 10'-dioxygenase, BCDO2) and retinoid metabolism (lecithin:retinol acyl transferase (LRAT) and STRA6) of breeding hens and chicks.
The effect of retinol binding protein on the proteome of C2C12 muscle cells.
New
Findlay et al., Ireland. In Diabetes Metab Res Rev, Dec 2015
BACKGROUND: Retinol binding protein (RBP) and its membrane receptor, STRA6, are vital for the management of vitamin A in the body.
STRA6: role in cellular retinol uptake and efflux.
Review
New
von Lintig et al., Cleveland, United States. In Hepatobiliary Surg Nutr, Aug 2015
Increasing evidence indicates that this process is mediated by a multidomian membrane protein that is encoded by the stimulated by retinoic acid 6 (STRA6) gene.
Is retinol binding protein 4 a link between adiposity and cancer?
Review
New
Berger et al., In Horm Mol Biol Clin Investig, Aug 2015
In addition to its function as a transport protein, RBP4 serves as a signaling molecule which, by binding to the membrane receptor STRA6, triggers downstream activation of pro-oncogenic pathways including JAK2/STAT3/5.
Vitamin A and Diabesity: New Insight for Drug Discovery.
New
Genchi et al., Rende, Italy. In Mini Rev Med Chem, Aug 2015
RBP4, interacts with two receptors, the Toll-like receptor 4 (TLR4) and the plasma membrane protein called stimulated by retinoic acid 6 (STRA6) leading to the activation of c-Jun N-terminal protein kinase (JNK) pathways and JAK2/STAT5 cascade, respectively.
Biochemical Basis for Dominant Inheritance, Variable Penetrance, and Maternal Effects in RBP4 Congenital Eye Disease.
New
Impact
Glaser et al., Ann Arbor, United States. In Cell, May 2015
The disease mutations greatly reduce retinol binding to RBP, yet paradoxically increase the affinity of RBP for its cell surface receptor, STRA6.
Retinol binding protein 4 and its membrane receptors: a metabolic perspective.
Review
New
Schupp et al., In Horm Mol Biol Clin Investig, Apr 2015
We pay special attention to the involvement of RBP4 membrane receptors that were identified during these years, such as 'stimulated by retinoic acid 6' (STRA6), and whose identification added another layer of complexity to RBP4's diverse actions.
Vitamin A Transport Mechanism of the Multitransmembrane Cell-Surface Receptor STRA6.
Review
Sun et al., Los Angeles, United States. In Membranes (basel), 2014
This "drug delivery system" is mediated by plasma retinol binding protein (RBP), the principle and specific vitamin A carrier protein in the blood, and STRA6, the cell-surface receptor for RBP that mediates cellular vitamin A uptake.
The genetic architecture of microphthalmia, anophthalmia and coloboma.
Review
FitzPatrick et al., Edinburgh, United Kingdom. In Eur J Med Genet, 2014
This review will focus on MAC phenotypes that are associated with mutation of the genes SOX2, OTX2, PAX6, STRA6, ALDH1A3, RARB, VSX2, RAX, FOXE3, BMP4, BMP7, GDF3, GDF6, ABCB6, ATOH7, C12orf57, TENM3 (ODZ3), and VAX1.
Cross talk between signaling and vitamin A transport by the retinol-binding protein receptor STRA6.
GeneRIF
Noy et al., Cleveland, United States. In Mol Cell Biol, 2012
STRA6 orchestrates a multicomponent machinery that couples vitamin A homeostasis and metabolism to activation of a signaling cascade and that, in turn, STRA6 signaling regulates the cellular uptake of the vitamin.
Oral vitamin A and retinoic acid supplementation stimulates antibody production and splenic Stra6 expression in tetanus toxoid-immunized mice.
GeneRIF
Ross et al., United States. In J Nutr, 2012
The effects of vitamin A, retinoic acid, and polyinosinic acid:polycytidylic acid on the systemic antigen-specific antibody response in mice vaccinated with tetanus toxoids are reported.
First implication of STRA6 mutations in isolated anophthalmia, microphthalmia, and coloboma: a new dimension to the STRA6 phenotype.
GeneRIF
Ennis et al., Dublin, Ireland. In Hum Mutat, 2011
STRA6 mutations can cause isolated eye malformations in addition to the congenital anomalies observed in MWS.
Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population.
GeneRIF
Anilkumar et al., Quilon, India. In Plos One, 2009
SNPs in STRA6, gene coding the cell surface receptor for RBP4, were significantly associated with type 2 diabetes and further genetic and functional studies are required to understand and ascertain its role in the manifestation of type 2 diabetes.
Phenotypic spectrum of STRA6 mutations: from Matthew-Wood syndrome to non-lethal anophthalmia.
GeneRIF
Calvas et al., Toulouse, France. In Hum Mutat, 2009
Six novel mutations were identified in STRA6.
RBP4 disrupts vitamin A uptake homeostasis in a STRA6-deficient animal model for Matthew-Wood syndrome.
Impact
GeneRIF
von Lintig et al., Freiburg, Germany. In Cell Metab, 2008
In fibroboasts, STRA6 transports retinol bidirectionally in an RBP4 dependent manner.
STRA6, a cell-surface receptor for retinol-binding protein: the plot thickens.
Impact
Blaner, New York City, United States. In Cell Metab, 2007
How retinol (vitamin A) is taken up by cells has been an area of active research since the first report of a cell-surface receptor for retinol-binding protein (RBP) in the mid-1970s.
A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A.
Impact
GeneRIF
Sun et al., Los Angeles, United States. In Science, 2007
STRA6 was identified in retinal pigment epithelium cells as a specific membrane receptor for retinol binding protein (RBP); STRA6 binds to RBP with high affinity and has robust vitamin A uptake activity from the vitamin A-RBP complex
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