Nuclear and extranuclear effects of vitamin A.
Russia. In Can J Physiol Pharmacol, Dec 2015
These novel scenarios involve: (i) other nuclear receptors such as PPAR β/δ, which regulate the expression of other target genes with other functions; (ii) extranuclear and nontranscriptional effects, such as the activation of kinases, which phosphorylate RARs and other transcription factors, thus expanding the list of the RA-activated genes; (iii) finally, vitamin A is active per se and can work as a cytokine that regulates gene transcription by activating STRA6.
Xanthophyll supplementation regulates carotenoid and retinoid metabolism in hens and chicks.
Fuzhou, China. In Poult Sci, Dec 2015
UNASSIGNED: This study investigated the effects of xanthophylls (containing 40% lutein and 60% zeaxanthin; Juyuan Biochemical Co., Ltd., GuangZhou, China) on gene expression associated with carotenoid cleavage enzymes (β-carotene 15, 15'-monooxygenase, BCMO1; and β-carotene 9', 10'-dioxygenase, BCDO2) and retinoid metabolism (lecithin:retinol acyl transferase (LRAT) and STRA6) of breeding hens and chicks.
STRA6: role in cellular retinol uptake and efflux.
Cleveland, United States. In Hepatobiliary Surg Nutr, Aug 2015
Increasing evidence indicates that this process is mediated by a multidomian membrane protein that is encoded by the stimulated by retinoic acid 6 (STRA6) gene.
Vitamin A and Diabesity: New Insight for Drug Discovery.
Rende, Italy. In Mini Rev Med Chem, Aug 2015
RBP4, interacts with two receptors, the Toll-like receptor 4 (TLR4) and the plasma membrane protein called stimulated by retinoic acid 6 (STRA6) leading to the activation of c-Jun N-terminal protein kinase (JNK) pathways and JAK2/STAT5 cascade, respectively.