ORAI Channel-Mediated Ca2+ Signals in Vascular and Airway Smooth Muscle.
United States. In Am J Physiol Cell Physiol, Jan 2016
UNASSIGNED: Orai proteins (Orai1-3) form a family of highly Ca(2+) selective plasma membrane channels that are regulated by stromal interacting molecules (STIM1 and STIM2); STIM proteins are Ca(2+) sensors located in the membrane of the endoplasmic reticulum (ER).
STIM and ORAI proteins in the nervous system.
Leipzig, Germany. In Channels (austin), Oct 2015
STIM2 is required for SOCE in hippocampal synapses and cortical neurons, whereas STIM1 controls calcium store replenishment in cerebellar Purkinje neurons.
Dental enamel cells express functional SOCE channels.
New York City, United States. In Sci Rep, 2014
Investigating primary murine enamel cells, we found that key components of CRAC channels (ORAI1, ORAI2, ORAI3, STIM1, STIM2) were expressed and most abundant during the maturation stage of enamel development.
Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.
Tokyo, Japan. In Immunity, 2013
Here we have used mice lacking the endoplasmic reticulum Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2 to show that STIM-induced store-operated Ca2+ entry is not essential for thymic development of conventional TCRαβ+ T cells but is specifically required for the development of agonist-selected T cells (regulatory T cells, invariant natural killer T cells, and TCRαβ+ CD8αα+ intestinal intraepithelial lymphocytes).