ORAI Channel-Mediated Ca2+ Signals in Vascular and Airway Smooth Muscle.
United States. In Am J Physiol Cell Physiol, Jan 2016
UNASSIGNED: Orai proteins (Orai1-3) form a family of highly Ca(2+) selective plasma membrane channels that are regulated by stromal interacting molecules (STIM1 and STIM2); STIM proteins are Ca(2+) sensors located in the membrane of the endoplasmic reticulum (ER).
Structural and functional mechanisms of CRAC channel regulation.
Chicago, United States. In J Mol Biol, Feb 2015
Studies in the last two decades have revealed the cellular and molecular choreography of the CRAC channel activation process, and it is now established that opening of CRAC channels is governed through direct interactions between the pore-forming Orai proteins and the endoplasmic reticulum Ca(2+) sensors STIM1 and STIM2.
Dental enamel cells express functional SOCE channels.
New York City, United States. In Sci Rep, 2014
Investigating primary murine enamel cells, we found that key components of CRAC channels (ORAI1, ORAI2, ORAI3, STIM1, STIM2) were expressed and most abundant during the maturation stage of enamel development.
Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry.
Tokyo, Japan. In Immunity, 2013
Here we have used mice lacking the endoplasmic reticulum Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2 to show that STIM-induced store-operated Ca2+ entry is not essential for thymic development of conventional TCRαβ+ T cells but is specifically required for the development of agonist-selected T cells (regulatory T cells, invariant natural killer T cells, and TCRαβ+ CD8αα+ intestinal intraepithelial lymphocytes).