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Sterol regulatory element binding transcription factor 1

Sterol Regulatory Element Binding Protein 1, SREBP-1, SREBP-1c, ADD1
This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Insulin, V1a, HAD, AMPK
Papers using Sterol Regulatory Element Binding Protein 1 antibodies
Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin.
Supplier
Schneider-Stock Regine, In PLoS ONE, 2010
... Antibodies against NF-κB, total β-cat, c-Myc, cyclin D1, phosphorylated JNK, SREBP1-c, F4/80 and HO-1 were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
Supplier
Park Hyunsung et al., In Nucleic Acids Research, 2007
... The anti-HIF-1β/Arnt antibody and anti-human-SREBP-1 antibody were purchased from BD Biosciences (Palo Alto, CA, USA) ...
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma
Supplier
Rhodes Christopher J. et al., In Diabetes, 1986
... (Danvers, MA); those against SREBP-1 were from Thermo Scientific (Fremont, CA); and those ...
Papers on Sterol Regulatory Element Binding Protein 1
Betulin alleviated ethanol-induced alcoholic liver injury via SIRT1/AMPK signaling pathway.
New
Nan et al., Yanji, China. In Pharmacol Res, Feb 2016
Betulin suppressed the expression of sterol regulatory element-binding protein-1 (SREBP-1), and genetic deletion of AMPK blocked the effect of betulin on SREBP-1 in ethanol treated LX-2 cells.
ADDing a piece to the puzzle of cognition in schizophrenia.
New
Cavallaro et al., Milano, Italy. In Eur J Med Genet, Jan 2016
In the present study we tested 342 patients with schizophrenia for three common adducins genetic variants, ADD1 rs4961, ADD2 rs4984 and ADD3 rs3731566, reported to have significant effects on circulatory system in humans.
Camphene, a Plant Derived Monoterpene, Exerts Its Hypolipidemic Action by Affecting SREBP-1 and MTP Expression.
New
Hadzopoulou-Cladaras et al., Thessaloníki, Greece. In Plos One, Dec 2015
To evaluate the mode of action of camphene, we examined its effects on the expression of SREBP-1, which affects TG biosynthesis and SREBP-2, which mostly affects sterol synthesis.
Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth.
New
Impact
Guo et al., Columbus, United States. In Cancer Cell, Dec 2015
Here, we delineate a pathway in which EGFR signaling, by increasing glucose uptake, promotes N-glycosylation of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and consequent activation of SREBP-1, an ER-bound transcription factor with central roles in lipid metabolism.
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.
New
Impact
Fernández-Hernando et al., New Haven, United States. In Nat Med, Nov 2015
From this screen we identified and characterized miR-148a as a negative regulator of LDLR expression and activity and defined a sterol regulatory element-binding protein 1 (SREBP1)-mediated pathway through which miR-148a regulates LDL-C uptake.
Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.
New
Willis et al., Chapel Hill, United States. In Cardiovasc Pathol, Nov 2015
At both 3 and 8weeks of fenofibrate treatment, the differentially expressed MuRF1-/- genes most commonly had SREBP-1 and E2F1/E2F promoter regions by TRANSFAC analysis (54 and 50 genes, respectively, of the 111 of the genes >4 and <-4 log fold change; P≤.0004).
Effect of short-chain fatty acids on triacylglycerol accumulation, lipid droplet formation and lipogenic gene expression in goat mammary epithelial cells.
Review
New
Loor et al., China. In Anim Sci J, Sep 2015
The expression of FABP3, SCD1, PPARG, SREBP1, DGAT1, AGPAT6 and ADRP were upregulated by propionate and butyrate treatment.
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.
New
Impact
Wang et al., Beijing, China. In Nature, Sep 2015
Sterol regulatory element-binding protein 1 (SREBP1), an important transcriptional regulator of lipogenesis, is synthesized as an inactive precursor that binds to the endoplasmic reticulum (ER).
Sirtuin 1 signaling and alcoholic fatty liver disease.
Review
New
Wu et al., United States. In Hepatobiliary Surg Nutr, Apr 2015
Chronic ethanol consumption causes steatosis and inflammation in rodents or humans by disturbing several important hepatic transcriptional regulators, including AMP-activated kinase (AMPK), lipin-1, sterol regulatory element binding protein 1 (SREBP-1), PPARγ co-activator-1α (PGC-1α), and nuclear transcription factor-κB (NF-κB).
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
Review
New
Zhou et al., Shijiazhuang, China. In Alcohol Alcohol, Mar 2015
RESULT: Ethanol could increase the expression of lipin-1 through the AMPK-SREBP-1 signaling and dramatically increase the ratio of Lpin1β to Lpin1α by SIRT1-SFRS10-Lpin1β/α axis in the liver.
Linking diet to acne metabolomics, inflammation, and comedogenesis: an update.
Review
Melnik, Osnabrück, Germany. In Clin Cosmet Investig Dermatol, 2014
FoxO1 is a negative coregulator of androgen receptor, peroxisome proliferator-activated receptor-γ (PPARγ), liver X receptor-α, and sterol response element binding protein-1c (SREBP-1c), crucial transcription factors of sebaceous lipogenesis.
mTORC1 signaling activates NRF1 to increase cellular proteasome levels.
Review
Manning et al., Boston, United States. In Cell Cycle, 2014
Activation of mTORC1 genetically, through loss of the tuberous sclerosis complex (TSC) tumor suppressors, or physiologically, through growth factors or feeding, stimulates a transcriptional program involving the sterol-regulatory element binding protein 1 (SREBP1) and nuclear factor erythroid-derived 2-related factor 1 (NRF1; also known as NFE2L1) transcription factors leading to an increase in cellular proteasome content.
Hawthorn leaf flavonoids alleviate nonalcoholic fatty liver disease by enhancing the adiponectin/AMPK pathway.
Ji et al., Shanghai, China. In Int J Clin Exp Med, 2014
Moreover, adenosine monophosphate (AMP)-activated protein kinase (AMPK) was also activated, as well as AMPK-mediated alteration of sterol regulatory element binding protein-1c (SREBP-1c), peroxisome proliferator-activated receptor α (PPARα) and their downstream targets.
Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.
Impact
Sassone-Corsi et al., Irvine, United States. In Cell, 2014
Moreover, SIRT6 controls circadian chromatin recruitment of SREBP-1, resulting in the cyclic regulation of genes implicated in fatty acid and cholesterol metabolism.
Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance.
Impact
Tontonoz et al., Los Angeles, United States. In Cell Metab, 2013
LXRs are essential for obesity-driven SREBP-1c and ChREBP activity in liver, but not fat.
Endoplasmic reticulum factor ERLIN2 regulates cytosolic lipid content in cancer cells.
GeneRIF
Zhang et al., Detroit, United States. In Biochem J, 2012
ERLIN2 regulates activation of SREBP (sterol regulatory element-binding protein) 1c, the key regulator of de novo lipogenesis, in cancer cells
Evaluation of Fbxw7 expression and its correlation with expression of SREBP-1 in a mouse model of NAFLD.
GeneRIF
Liu et al., Xi'an, China. In Mol Med Report, 2012
The mRNA and protein expression of SREBP-1 was significantly increased, indicating that the Fbxw7-SREBP-1 axis may play a key pathological role in the development of NAFLD.
The Gly460Trp polymorphism of alpha-adducin gene as a predictor of renal function decline over 4 years of follow-up in an apparently healthy Chinese population.
GeneRIF
Sheu et al., Kao-hsiung, Taiwan. In Transl Res, 2012
The alpha-adducin Gly460Trp gene polymorphism might modulate renal function decline in the Chinese.
Repression of endometrial tumor growth by targeting SREBP1 and lipogenesis.
GeneRIF
Wang et al., Jinan, China. In Cell Cycle, 2012
SREBP1 is essential for EC cell growth both in vitro and in vivo, suggesting that SREBP1 activity may be a novel therapeutic target for endometrial cancers.
[Association of sterol regulatory element binding protein-1c genetic polymorphisms rs2297508 and rs11868035 with type 2 diabetes mellitus in Gansu Han and Dongxiang population].
GeneRIF
Liu et al., Lanzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
The genotypic and allelic frequencies of sterol regulatory element binding protein-1c rs2297508 and rs11868035 polymorphisms did not differ significantly in the control groups of Han and Dongxiang ethnics (P> 0.05).
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