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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

T-cell lymphoma invasion and metastasis 2

STEF, TIAM2, T-cell lymphoma invasion and metastasis 2
This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tiam1, Rac1, Rhodopsin, Akt, Cdc42
Papers on STEF
Sp1-mediated ectopic expression of T-cell lymphoma invasion and metastasis 2 in hepatocellular carcinoma.
New
Sun et al., Tainan City, Taiwan. In Cancer Med, Feb 2016
UNASSIGNED: T-cell lymphoma invasion and metastasis 2 (TIAM2) is a neuron-specific protein that has been found ectopically expressed in hepatocellular carcinoma (HCC).
ATF3 is a novel regulator of mouse neutrophil migration.
Karp et al., In Blood, 2014
Global gene expression analysis identified ablated Tiam2 expression in ATF3(-/-) neutrophils.
Clinical impact of genetically determined platelet reactivity.
Review
Bonello et al., Marseille, France. In J Cardiovasc Transl Res, 2013
Other genetic polymorphisms have also been correlated with HTPR: ABCB1, ATP2B2, and TIAM2.
TIAM2 enhances non-small cell lung cancer cell invasion and motility.
Cheng et al., Tianjin, China. In Asian Pac J Cancer Prev, 2012
BACKGROUND: TIAM2, a Rac guanine nucleotide exchange factor, is closely associated with cell adherence and migration.
Expression of T-cell lymphoma invasion and metastasis 2 (TIAM2) promotes proliferation and invasion of liver cancer.
GeneRIF
Sun et al., Tainan City, Taiwan. In Int J Cancer, 2012
TIAM2 expression was undetectable in normal human liver but was induced in all HCC cell lines and in 86% (78/91) of HCC biopsies.
Dlx6 regulates molecular properties of the striatum and central nucleus of the amygdala.
Rubenstein et al., San Francisco, United States. In J Comp Neurol, 2011
For instance, we observed reduced of Golf, RXRγ, and Tiam2 expression in the striatum, and reduced Dlx5 expression in the central nucleus of the amygdala.
Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells.
Nakamura et al., Kyoto, Japan. In Mol Biol Cell, 2011
dbcAMP-induced Rac1 activation was principally mediated by protein kinase A (PKA) and Sif- and Tiam1-like exchange factor (STEF)/Tiam2.
Distinct ligand specificity of the Tiam1 and Tiam2 PDZ domains.
GeneRIF
Fuentes et al., Iowa City, United States. In Biochemistry, 2011
specificity of PDZ domain and the molecular origin
The Rac activator STEF (Tiam2) regulates cell migration by microtubule-mediated focal adhesion disassembly.
GeneRIF
Malliri et al., Manchester, United Kingdom. In Embo Rep, 2010
The findings suggest a new role for STEF in Focal adhesion disassembly and cell migration through microtubules-mediated mechanisms.
The PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding module.
GeneRIF
Hakoshima et al., Ikoma, Japan. In Embo J, 2010
Crystal structures of the PH-CC-Ex regions revealed a single globular domain, PHCCEx domain, comprising a conventional PH subdomain associated with an antiparallel coiled coil of CC subdomain and a novel three-helical globular Ex subdomain.
A longitudinal study of functional magnetic resonance imaging in upper-limb hemiplegia after stroke treated with constraint-induced movement therapy.
Lin et al., Beijing, China. In Brain Inj, 2009
MAIN OUTCOMES: Compared with the baseline, Upper Extremity Function Test (UEFT) of the patient's upper limb increased by 29.1% and Simple Test for Evaluating Hand Function (STEF) increased by 18.4%.
Crystallographic characterization of the membrane-targeting domains of the Rac-specific guanine nucleotide-exchange factors Tiam1 and Tiam2.
GeneRIF
Hakoshima et al., Nara, Japan. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2008
Results describe the purification, crystallization and X-ray data collection of the Tiam1 and Tiam2 PH-CC-Ex regions.
Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation.
Kaibuchi et al., Nagoya, Japan. In Dev Cell, 2008
PAR-3 directly interacts with Tiam1/Taim2 (STEF), Rac1-specific guanine nucleotide exchange factors, and forms a complex with aPKC-PAR-6-Cdc42*GTP, leading to Rac1 activation.
Epac signaling pathway involves STEF, a guanine nucleotide exchange factor for Rac, to regulate APP processing.
Zugaza et al., Spain. In Febs Lett, 2008
We now report that Rap1 can physically and specifically associate with the guanine nucleotide exchange factor (GEF) STEF through its TSS region.
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
Impact
Kaibuchi et al., Nagoya, Japan. In Nat Cell Biol, 2005
Here, we found that PAR-3 directly interacted with STEF/Tiam1, which are Rac-specific guanine nucleotide-exchange factors, and that STEF formed a complex with PAR-3-aPKC-PAR-6-Cdc42-GTP.
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