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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

STEAP family member 3, metalloreductase

Steap3, pHyde, TSAP6
induces apoptosis; inhibits prostate tumor growth in some cell lines [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: p53, CAN, STEAP, Transferrin, V1a
Papers on Steap3
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
New
Impact
Geha et al., Boston, United States. In Nat Genet, Jan 2016
We show that STEAP3, a metalloreductase expressed in erythroblasts, associates with TfR1 and partially rescues transferrin uptake in patient-derived fibroblasts, suggesting that STEAP3 may provide an accessory TfR1 endocytosis signal that spares patients from severe anemia.
Characterization of a single b-type heme, FAD, and metal binding sites in the transmembrane domain of six-transmembrane epithelial antigen of the prostate (STEAP) family proteins.
New
Lawrence et al., Bozeman, United States. In J Biol Chem, Oct 2015
Six-transmembrane epithelial antigen of the prostate 3 (Steap3) is the major ferric reductase in developing erythrocytes.
Abnormal erythroid maturation leads to microcytic anemia in the TSAP6/Steap3 null mouse model.
New
Mohandas et al., New York City, United States. In Am J Hematol, Mar 2015
Genetic ablation of the ferrireductase STEAP3, also known as TSAP6, leads to severe microcytic and hypochromic red cells with moderate anemia in the mouse.
Identification of genes and pathways related to lipopolysaccharide signaling in duckling spleens.
Wen et al., Wuhan, China. In Genet Mol Res, 2014
To confirm the RNA-Seq results, we detected CCL4, LBP, CD71, and STEAP3 expression using real-time PCR analysis, and the results were consistent with the RNA-Seq results.
Differential Gene Expression in Colon Tissue Associated With Diet, Lifestyle, and Related Oxidative Stress.
Wolff et al., Salt Lake City, United States. In Plos One, 2014
Recent use of aspirin and/or ibuprofen was associated with differential expression of TMC06, ST8SIA4, and STEAP3 while a summary oxidative balance score (OBS) was associated with SYCP3, HDX, and NRG4 (all up-regulated with greater oxidative balance).
Silencing of human papillomavirus (HPV) E6/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV-positive cancer cells.
Hoppe-Seyler et al., Heidelberg, Germany. In Int J Cancer, 2013
This effect was associated with the reinduction of p53, stimulation of the p53 target genes TSAP6 and CHMP4C that can enhance exosome production and induction of senescence.
Comparative anatomy of chromosomal domains with imprinted and non-imprinted allele-specific DNA methylation.
Tycko et al., New York City, United States. In Plos Genet, 2013
Two index regions (bisulfite PCR amplicons), one between the C3orf27 and RPN1 genes in chromosome band 3q21 and the other near the VTRNA2-1 vault RNA in band 5q31, proved to be new examples of imprinted DMRs (maternal alleles methylated) while a third, between STEAP3 and C2orf76 in chromosome band 2q14, showed non-imprinted haplotype-dependent ASM.
The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site.
Lawrence et al., Bozeman, United States. In J Biol Chem, 2013
Flavin-dependent NADPH oxidase activity that was much greater than the equivalent Steap3 construct was observed for the isolated N-terminal oxidoreductase domain.
Lessons from tumor reversion for cancer treatment.
Review
Telerman et al., Cachan, France. In Curr Opin Oncol, 2013
Differential gene-expression profiling showed that at least 300 genes are implicated in this reversion process such as SIAH-1, PS1, TSAP6, and, most importantly, translationally controlled tumor protein (TPT1/TCTP).
The STEAP protein family: versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions.
Matsumoto et al., Paris, France. In Biol Cell, 2012
Despite their very similar domain organisation, STEAP3 seems to act as a potent metalloreductase essential for physiological iron uptake and turnover, while in particular STEAP4 appears to be rather involved in responses to nutrients and inflammatory stress, fatty acid and glucose metabolism.
STEAP proteins: from structure to applications in cancer therapy.
Review
Santos et al., Covilhã, Portugal. In Mol Cancer Res, 2012
The human 6-transmembrane epithelial antigen of prostate (STEAP) family comprises STEAP1, STEAP2, STEAP3, and STEAP4.
A novel type of congenital hypochromic anemia associated with a nonsense mutation in the STEAP3/TSAP6 gene.
GeneRIF
Heimpel et al., Paris, France. In Blood, 2012
Data show that the STEAP3/TSAP6 is absent in the mouse embryo fibroblasts derived from the STEAP3/TSAP6 knock-out mice (MEFs KO), but present in the wild type MEFs.
Exosome-related multi-pass transmembrane protein TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.
GeneRIF
Wang et al., Beijing, China. In Plos One, 2011
TSAP6 is a target of rhomboid protease RHBDD1-induced proteolysis.
Human STEAP3 maintains tumor growth under hypoferric condition.
GeneRIF
Akashi et al., Fukuoka, Japan. In Exp Cell Res, 2011
findings indicate that STEAP3 maintains iron storage in human malignant cells and tumor proliferation under the hypoferric condition
p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment.
Review
Feng, New Brunswick, United States. In Cold Spring Harb Perspect Biol, 2010
Furthermore, p53 transcribes several critical genes regulating the endosomal compartment, including TSAP6, Chmp4C, Caveolin-1, and DRAM, and increases exosome secretion, the rate of endosomal removal of growth factor receptors (e.g., EGFR) from cell surface, and enhances autophagy.
The molecular programme of tumour reversion: the steps beyond malignant transformation.
Review
Impact
Amson et al., Cachan, France. In Nat Rev Cancer, 2009
Studying these extremely rare events of tumour reversion and deciphering these pathways, which involve SIAH1, presenilin 1, TSAP6 and translationally controlled tumour protein (TCTP), could lead to new avenues in cancer treatment.
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.
GeneRIF
Cornall et al., Oxford, United Kingdom. In Blood, 2009
hypochromic microcytic anemia results from a Y228H substitution in the ferrireductase Steap3 (Steap3(Y288H))
Down-regulated expression of the TSAP6 protein in liver is associated with a transition from cirrhosis to hepatocellular carcinoma.
GeneRIF
Salier et al., Rouen, France. In Histopathology, 2009
Down-regulated expression of the TSAP6 protein in liver is associated with a transition from cirrhosis to hepatocellular carcinoma
Liver iron transport.
Review
Trinder et al., Australia. In World J Gastroenterol, 2007
These include transferrin receptors (TFR1 and 2), a ferrireductase (STEAP3), the transporters divalent metal transporter-1 (DMT1) and ferroportin (FPN) as well as the haemochromatosis protein, HFE and haemojuvelin (HJV), which are signalling molecules.
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells.
Impact
Fleming et al., Boston, United States. In Nat Genet, 2005
Using a positional cloning strategy, we identified a gene, six-transmembrane epithelial antigen of the prostate 3 (Steap3), responsible for the iron deficiency anemia in the mouse mutant nm1054.
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