Lessons from tumor reversion for cancer treatment.
Cachan, France. In Curr Opin Oncol, 2013
Differential gene-expression profiling showed that at least 300 genes are implicated in this reversion process such as SIAH-1, PS1, TSAP6, and, most importantly, translationally controlled tumor protein (TPT1/TCTP).
p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment.
New Brunswick, United States. In Cold Spring Harb Perspect Biol, 2010
Furthermore, p53 transcribes several critical genes regulating the endosomal compartment, including TSAP6, Chmp4C, Caveolin-1, and DRAM, and increases exosome secretion, the rate of endosomal removal of growth factor receptors (e.g., EGFR) from cell surface, and enhances autophagy.
Liver iron transport.
Australia. In World J Gastroenterol, 2007
These include transferrin receptors (TFR1 and 2), a ferrireductase (STEAP3), the transporters divalent metal transporter-1 (DMT1) and ferroportin (FPN) as well as the haemochromatosis protein, HFE and haemojuvelin (HJV), which are signalling molecules.