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STEAP family member 2, metalloreductase

STEAP2, STAMP1, STAMP-I, six-transmembrane epithelial antigen of the prostate 2, six transmembrane protein of prostate 1
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: STEAP, TIARP, Steap3, HAD, ACID
Papers on STEAP2
Characterization of a single b-type heme, FAD, and metal binding sites in the transmembrane domain of six-transmembrane epithelial antigen of the prostate (STEAP) family proteins.
Lawrence et al., Bozeman, United States. In J Biol Chem, Oct 2015
Importantly, the sequence motifs in the transmembrane domain that are associated with the FAD and metal binding sites are not only present in Steap2 and Steap4 but also in Steap1, which lacks the N-terminal oxidoreductase domain.
Molecular mechanisms of non-transferrin-bound and transferring-bound iron uptake in primary hippocampal neurons.
Kosman et al., Buffalo, United States. In J Neurochem, Jun 2015
In this study, we characterized the expression and localization of ferrous iron transporters Zip8, Zip14 and divalent metal transporter 1 (DMT1), and ferrireductases Steap2 and stromal cell-derived receptor 2 in primary rat hippocampal neurons.
Determining differentially expressed miRNAs and validating miRNA--target relationships using the SPRET/Ei mouse strain.
Vandenbroucke et al., Gent, Belgium. In Mamm Genome, Feb 2015
This resulted in the confirmation of six previously unknown miR-target interactions: miR-146a, Zdhhc2; miR-150, Elovl3, Kcnk5, and Nrd1d2; miR-155, Camta1; and miR-592, Steap2.
Whole transcriptome sequencing reveals extensive unspliced mRNA in metastatic castration-resistant prostate cancer.
Li et al., Houston, United States. In Mol Cancer Res, 2015
Using quantitative PCR (qPCR), a series of genes (AR, KLK2, KLK3, STEAP2, CPSF6, and CDK19) were confirmed to have a greater proportion of unspliced RNA in CRPC specimens than in normal prostate epithelium, untreated primary prostate cancer, and cultured prostate cancer cells.
Analysis of tumor necrosis factor α-induced and nuclear factor κB-silenced LNCaP prostate cancer cells by RT-qPCR.
Ogut et al., İzmir, Turkey. In Exp Ther Med, 2014
The apoptosis-related genes p53, p73, caspase 7 and caspase 9 showed statistically significant increases in expression levels while the expression levels of MDM2 and STAMP1 decreased following TNFα induction.
A role for STEAP2 in prostate cancer progression.
Doak et al., Swansea, United Kingdom. In Clin Exp Metastasis, 2014
Furthermore, STEAP2 up-regulation was observed within a small patient cohort and was associated with those that had locally advanced disease.
Identification of a developmental gene expression signature, including HOX genes, for the normal human colonic crypt stem cell niche: overexpression of the signature parallels stem cell overpopulation during colon tumorigenesis.
Boman et al., Newark, United States. In Stem Cells Dev, 2014
Among genes upregulated in the bottom, ∼30% were classified as growth and/or developmental genes including several in the PI3 kinase pathway, a six-transmembrane protein STAMP1, and two homeobox (HOXA4, HOXD10) genes.
STEAP1 protein overexpression is an independent marker for biochemical recurrence in prostate carcinoma.
Rogatto et al., Botucatu, Brazil. In Histopathology, 2013
AIMS: To investigate the prognostic value of expression levels of the genes STEAP1 and STEAP2, and of STEAP1 protein, in prostate carcinomas (PCa).
The STEAP protein family: versatile oxidoreductases and targets for cancer immunotherapy with overlapping and distinct cellular functions.
Matsumoto et al., Paris, France. In Biol Cell, 2012
This concept is supported by the fact that especially STEAP1, and to a lesser extent STEAP2 and -4, are highly over-expressed in many different cancer entities, while being only minimally expressed in a few normal tissues.
STEAP proteins: from structure to applications in cancer therapy.
Santos et al., Covilhã, Portugal. In Mol Cancer Res, 2012
The human 6-transmembrane epithelial antigen of prostate (STEAP) family comprises STEAP1, STEAP2, STEAP3, and STEAP4.
NCI60 cancer cell line panel data and RNAi analysis help identify EAF2 as a modulator of simvastatin and lovastatin response in HCT-116 cells.
Tuzmen et al., Toronto, Canada. In Plos One, 2010
After correction of the p-values for multiple testing using False Discovery Rate, our results identified three genes (NRP1, COL13A1, MRPS31) and six genes (EAF2, ANK2, AKAP7, STEAP2, LPIN2, PARVB) associated with resistance to simvastatin and lovastatin, respectively.
STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer.
Saatcioglu et al., Oslo, Norway. In Cancer Res, 2010
Data suggest that STAMP1 is required for prostate cancer growth.
Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells.
Murphy et al., London, United Kingdom. In Tissue Eng Part A, 2009
STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice.
The Steap proteins are metalloreductases.
Fleming et al., Boston, United States. In Blood, 2006
The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro.
Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer.
Saatcioglu et al., Oslo, Norway. In Oncogene, 2005
Expression of STAMP2, a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 may have a role in cell proliferation.
Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.
Visakorpi et al., Tampere, Finland. In Lab Invest, 2002
STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer.
Evaluation of the predictive value of Her-2/neu overexpression and p53 mutations in high-risk primary breast cancer patients treated with high-dose chemotherapy and autologous stem-cell transplantation.
Jones et al., Denver, United States. In J Clin Oncol, 2000
All patients received the same HDCT regimen, with cyclophosphamide, cisplatin, and carmustine (STAMP-I), followed by autologous stem-cell transplantation.
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