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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

STE2 Ste2p

STE2, Ste2p
Top mentioned proteins: CAN, GPCR, ACID, HAD, FUS
Papers on STE2
Evidence of a role for S. cerevisiae α-arrestin Art1 (Ldb19) in mating projection and zygote formations.
New
Loewen et al., Saskatoon, Canada. In Cell Biol Int, Jan 2016
Now, with the recent demonstration of a role for α-arrestins in internalization of the yeast pheromone GPCR, Ste2p, the possibility of arrestin-mediated alternate GPCR functionalities in yeast also follows.
Quantification of mutation-derived bias for alternate mating functionalities of the Saccharomyces cerevisiae Ste2p pheromone receptor.
New
Loewen et al., Saskatoon, Canada. In J Biochem, Jan 2016
Although well documented for mammalian G-protein-coupled receptors, alternate functionalities and associated alternate signalling remain to be unequivocally established for the Saccharomyces cerevisiae pheromone Ste2p receptor.
The N-terminus of the yeast G protein-coupled receptor Ste2p plays critical roles in surface expression, signaling, and negative regulation.
New
Becker et al., Knoxville, United States. In Biochim Biophys Acta, Jan 2016
The yeast Ste2p protein, the receptor for the thirteen amino acid peptide pheromone α-factor, has been used extensively as a model to study GPCR structure and function.
Novobiocin and peptide analogs of α-factor are positive allosteric modulators of the yeast G protein-coupled receptor Ste2p.
New
Becker et al., Knoxville, United States. In Biochim Biophys Acta, Apr 2015
The purpose of this study was to investigate the nature of the interaction between putative allosteric modulators and Ste2p, a model GPCR expressed in the yeast Saccharomyces cerevisiae that binds the tridecapeptide mating pheromone α-factor.
The mapping of yeast's G-protein coupled receptor with an atomic force microscope.
New
Kondo et al., Kōbe, Japan. In Nanoscale, Apr 2015
In this study, Ste2p, one of the G protein-coupled receptors (GPCRs), was chosen as the target receptor.
Identification of destabilizing and stabilizing mutations of Ste2p, a G protein-coupled receptor in Saccharomyces cerevisiae.
New
Dumont et al., Rochester, United States. In Biochemistry, Apr 2015
We have pursued a strategy for the identification of stabilized variants of the yeast α-factor receptor Ste2p.
Structural characterization of triple transmembrane domain containing fragments of a yeast G protein-coupled receptor in an organic : aqueous environment by solution-state NMR spectroscopy.
New
Naider et al., New York City, United States. In J Pept Sci, Mar 2015
This report summarizes recent biophysical and protein expression experiments on polypeptides containing the N-terminus, the first, second, and third transmembrane (TM) domains and the contiguous loops of the α-factor receptor Ste2p, a G protein-coupled receptor.
Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids.
Del Poeta et al., Stony Brook, United States. In Mbio, 2014
Deep-sequencing analysis of drug-resistant mutants revealed that four protein products, encoded by genes APL5, COS111, MKK1, and STE2, which are involved in vesicular transport and cell cycle progression, are targeted by BHBM.
A Novel Screening Approach for Optimal and Functional Fusion of T4 Lysozyme in GPCRs.
Dumont et al., Rochester, United States. In Methods Enzymol, 2014
When applied to the yeast α-factor receptor, Ste2p, this approach allowed recovery of well-expressed receptor variants containing internally fused T4L that retained nearly normal signaling function.
Identifying functionally important conformational changes in proteins: activation of the yeast α-factor receptor Ste2p.
GeneRIF
Dumont et al., Rochester, United States. In J Mol Biol, 2012
the identification of disulfide bonds that stabilize the active state of the yeast alpha-mating pheromone receptor Ste2p
Multiple regulatory roles of the carboxy terminus of Ste2p a yeast GPCR.
GeneRIF
Becker et al., Kwangju, South Korea. In Pharmacol Res, 2012
C-terminus contains multiple functional domains with differential and interdependent roles in regulating Ste2p function.
Yeast pheromone receptor genes STE2 and STE3 are differently regulated at the transcription and polyadenylation level.
GeneRIF
Tocchini-Valentini et al., Roma, Italy. In Proc Natl Acad Sci U S A, 2011
a cryptic polyadenylation site is present inside the coding region of the a-specific STE2 gene, encoding the receptor for the alpha-factor
Changes in conformation at the cytoplasmic ends of the fifth and sixth transmembrane helices of a yeast G protein-coupled receptor in response to ligand binding.
GeneRIF
Becker et al., Knoxville, United States. In Biochemistry, 2011
study provides new information about role of specific residues of STE2, a GPCR, in signal transduction and how peptide ligand binding activates the receptor
Differential interactions of fluorescent agonists and antagonists with the yeast G protein coupled receptor Ste2p.
GeneRIF
Dumont et al., Rochester, United States. In J Mol Biol, 2011
These results suggest that receptor--agonist interactions, such as those involving Ste2p, involve at least two sites, of which only one is specific for the activated conformation of the receptor.
The alpha-factor mating pheromone of Saccharomyces cerevisiae: a model for studying the interaction of peptide hormones and G protein-coupled receptors.
Review
Becker et al., New York City, United States. In Peptides, 2004
This review summarizes the use of the alpha-factor (WHWLQLKPGQPMY)--GPCR (Ste2p) interaction as a paradigm to understand the recognition between medium-sized peptide hormones and their cognate receptors.
Fab1p PtdIns(3)P 5-kinase function essential for protein sorting in the multivesicular body.
Impact
Emr et al., San Diego, United States. In Cell, 1999
We demonstrate that the membrane glycoprotein carboxypeptidase S and the G protein-coupled receptor Ste2p are targeted into the vacuole lumen, and this process requires a subset of VPS gene products essential for normal endosome function.
Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis.
Impact
Riezman et al., Basel, Switzerland. In Cell, 1996
Binding of alpha factor to Ste2p, a G protein-coupled plasma membrane receptor, activates a signal transduction pathway and stimulates endocytosis of the receptor-ligand complex.
DNA repair gene RAD3 of S. cerevisiae is essential for transcription by RNA polymerase II.
Impact
Prakash et al., Rochester, United States. In Nature, 1994
Messenger RNA levels of all the genes examined, HIS3, TRP3, STE2, MET19, RAD23, CDC7, CDC9 and ACT1, decline rapidly upon loss of RAD3 activity.
Binding of alpha-factor pheromone to yeast a cells: chemical and genetic evidence for an alpha-factor receptor.
Impact
Hartwell et al., In Cell, 1983
The alpha-factor binding activity associated with five temperature-sensitive ste2 mutants was thermolabile, suggesting that the STE2 gene encodes the receptor for alpha-factor.
Induction of yeast mating pheromone a-factor by alpha cells.
Impact
MacKay et al., In Nature, 1983
This induction of a-factor may result from increased synthesis or increased secretion of a-factor, as opposed to modification or stabilization of preexisting a-factor, as part of the a cell response to alpha-factor, as an a ste2 mutant (which cannot respond to alpha-factor) is not induced by alpha-factor.
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