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Stanniocalcin 2

STC2, stanniocalcin 2
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: STC, CD45, HAD, CAN, ACID
Papers on STC2
Secretome profiling of oral squamous cell carcinoma-associated fibroblasts reveals organization and disassembly of extracellular matrix and collagen metabolic process signatures.
Coletta et al., Piracicaba, Brazil. In Tumour Biol, Feb 2016
Among the upregulated proteins were fibronectin type III domain-containing 1 (FNDC1), serpin peptidase inhibitor type 1 (SERPINE1), and stanniocalcin 2 (STC2), the upregulation of which was validated by quantitative PCR and ELISA in an independent set of CAF cell lines.
Stanniocalcin 2 enhances mesenchymal stem cell survival by suppressing oxidative stress.
Cho et al., Taejŏn, South Korea. In Bmb Rep, Dec 2015
To overcome the disadvantages of stem cell-based cell therapy like low cell survival at the disease site, we used stanniocalcin 2 (STC2), a family of secreted glycoprotein hormones that function to inhibit apoptosis and oxidative damage and to induce proliferation.
Stanniocalcin 2 promotes cell proliferation and cisplatin resistance in cervical cancer.
Tan et al., Harbin, China. In Biochem Biophys Res Commun, Nov 2015
We found in this study that stanniocalcin 2 (STC2) expression was upregulated in both cervical cancer tissues and cell lines.
Stanniocalcin-1 Potently Inhibits the Proteolytic Activity of the Metalloproteinase Pregnancy-associated Plasma Protein-A.
Oxvig et al., Århus, Denmark. In J Biol Chem, Oct 2015
It has recently been found that the homologous STC2 inhibits PAPP-A proteolytic activity, and that this depends on the formation of a covalent complex between the inhibitor and the proteinase, mediated by Cys-120 of STC2.
STC2 overexpression mediated by HMGA2 is a biomarker for aggressiveness of high-grade serous ovarian cancer.
Wei et al., Hangzhou, China. In Oncol Rep, Sep 2015
Based on the gene profiling analysis, we found that the potent EMT gene, stanniocalcin 2 (STC2), was highly correlated with HMGA2 expression.
Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease.
Van Laere et al., Rotterdam, Netherlands. In Mol Oncol, Jun 2015
RESULTS: A metagene of six genes including the genes encoding for 4-aminobutyrate aminotransferase (ABAT) and Stanniocalcin-2 (STC2) were identified to distinguish 22 ER+ IBC from 43 ER+ nIBC patients and remained discriminatory in an independent series of 136 patients.
[The correlation between stanniocalcin 2 expression and prognosis in laryngeal squamous cell cancer].
Peng et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, 2015
OBJECTIVE: In this study, we have detected the expression of STC2 protein in laryngeal cancer and The safe incisal margin by immunohistochemical staining, to evaluate its correlation with clinical features and the prognosis value in laryngeal squamous cell cancer.
Stanniocalicin 2 suppresses breast cancer cell migration and invasion via the PKC/claudin-1-mediated signaling.
Yang et al., Shanghai, China. In Plos One, 2014
STC2, a member of STC family, has been reported to be associated with tumor development.
Hair follicle transcriptome profiles during the transition from anagen to catagen in Cashmere goat (Capra hircus).
Li et al., Hohhot, China. In Genet Mol Res, 2014
Many of these up-regulated genes, such as STC2, VEGFR, and ROR2, are known to be transfactors in the process of cell differentiation and in the cell cycle.
MicroRNA-485-5p suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting stanniocalcin 2.
Ren et al., Kaifeng, China. In Int J Clin Exp Pathol, 2014
Results from the dual-luciferase reporter gene assays and western blot further showed that stanniocalcin 2 was a direct target of miR-485-5p.
Stanniocalcin 2, forms a complex with heme oxygenase 1, binds hemin and is a heat shock protein.
Andersson et al., Helsinki, Finland. In Biochem Biophys Res Commun, 2012
These findings point to three novel functions of STC2, and suggest that STC2 interacts with HO1 to form a eukaryotic 'stressosome' involved in the degradation of heme.
Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells.
Takeda et al., Tokushima, Japan. In Bone, 2012
These results suggest that the up-regulation of STC2 gene expression resulting from abnormal alpha-klotho-Fgf23 signaling may contribute to limitation of ectopic calcification.
Evolution and roles of stanniocalcin.
Wong et al., Hong Kong, Hong Kong. In Mol Cell Endocrinol, 2012
The recent identification and study of mammalian STCs (STC1 and STC2) revealed that the hormones are made in virtually all tissues and they act primarily as paracrine/autocrine factors to regulate various biological functions.
Stanniocalcin 2 is a negative modulator of store-operated calcium entry.
Thinakaran et al., Chicago, United States. In Mol Cell Biol, 2011
These results define a novel molecular function for STC2 as a negative modulator of Store-Operated Calcium Entry and provide the first direct evidence for the regulation of Ca2+ homeostasis by mammalian STC2.
STC2: a predictive marker for lymph node metastasis in esophageal squamous-cell carcinoma.
Mori et al., Beppu, Japan. In Ann Surg Oncol, 2011
High STC2 is associated with lymph node metastases in squamous cell esophageal carcinoma.
Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice.
Pin et al., London, Canada. In Bmc Cell Biol, 2010
STC2 is linked to PERK signalling in acinar cells and has a role in limiting damage during pancreatic injury.
[Progress in the research of stanniocalcin].
Zhu et al., Beijing, China. In Sheng Li Ke Xue Jin Zhan, 2008
Stanniocalcin is also identified in human and mammals and is named STC1 and STC2 by the sequence of finding.
The stanniocalcin family of proteins.
Dimattia et al., London, Canada. In J Exp Zool A Comp Exp Biol, 2006
Perhaps the most significant of these has been the discovery of a second gene encoding stanniocalcin-related protein, or STC-2, first in mammals and subsequently in fish.
Mammalian stanniocalcins and cancer.
Reddel et al., Westmead, Australia. In Endocr Relat Cancer, 2003
The related mammalian proteins, STC1 and STC2, are expressed in a wide variety of tissues.
Prospect of a stanniocalcin endocrine/paracrine system in mammals.
Imai et al., Tochigi, Japan. In Am J Physiol Renal Physiol, 2002
More recently, a human gene encoding the second stanniocalcin-like protein, STC2, was identified.
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