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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Stanniocalcin 1

STC, stanniocalcin-1, STC1, Stanniocalcin
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, ACID, Cholecystokinin, V1a
Papers on STC
H3K27 Demethylase JMJD3 Employs the NF-κB and BMP Signaling Pathways to Modulate the Tumor Microenvironment and Promote Melanoma Progression and Metastasis.
New
Kim et al., Taejŏn, South Korea. In Cancer Res, Feb 2016
Mechanistic investigations demonstrated that JMJD3 transcriptionally upregulated several targets of NF-κB and BMP signaling, including stanniocalcin 1 (STC1) and chemokine (C-C motif) ligand 2 (CCL2), which functioned as downstream effectors of JMJD3 in self-renewal and macrophage recruitment, respectively.
Empagliflozin/linagliptin single-tablet combination: first-in-class treatment option.
Review
New
Woo, Winnipeg, Canada. In Int J Clin Pract, Dec 2015
BACKGROUND: The availability of a dual sodium glucose co-transporter 2/dipeptidyl peptidase-4 inhibitor combination in a single-tablet combination (STC) represents a new therapeutic option for patients with type 2 diabetes.
Effects of thymosin β4 on a rat model of severe acute pancreatitis.
New
Wang et al., Wuhan, China. In Exp Ther Med, Dec 2015
UNASSIGNED: The aim of the present study was to investigate the effects of thymosin β4 on a rat model of severe acute pancreatitis (SAP) induced by sodium taurocholate (STC) and the underlying mechanism.
The oncogenetic role of stanniocalcin 1 in lung adenocarcinoma: a promising serum candidate biomarker for tracking lung adenocarcinoma progression.
New
Gao et al., Shanghai, China. In Tumour Biol, Dec 2015
UNASSIGNED: Stanniocalcin 1 (STC1) is reported to functionally participate in the development of several cancers.
[Effect of Qingyi Granule on HMGB1 Expression in Liver and Renal Tissues of Severe Acute Pancreatitis Rats].
New
Wang et al., In Zhongguo Zhong Xi Yi Jie He Za Zhi, Nov 2015
Rats in the SAP group were induced by injecting 5% sodium taurocholate (STC).
Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B.
Sajikumar et al., Singapore, Singapore. In Sci Rep, 2014
Late long-term potentiation (late-LTP), a cellular correlate of memory and its associative mechanisms such as synaptic tagging and capture (STC) were studied in the CA1 area of hippocampal slices from 82-84 week old rats.
Osmoregulation in zebrafish: ion transport mechanisms and functional regulation.
Review
Hwang et al., Taipei, Taiwan. In Excli J, 2014
Several hormones, namely isotocin, prolactin, cortisol, stanniocalcin-1, calcitonin, endothelin-1, vitamin D, parathyorid hormone 1, catecholamines, and the renin-angiotensin-system, have been demonstrated to positively or negatively regulate ion transport through specific receptors at different ionocytes stages, at either the transcriptional/translational or posttranslational level.
Myriad Functions of Stanniocalcin-1 (STC1) Cover Multiple Therapeutic Targets in the Complicated Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF).
Review
Kurosawa et al., Sendai, Japan. In Clin Med Insights Circ Respir Pulm Med, 2014
In this review, we introduce a humoral factor, stanniocalcin-1 (STC1), which has myriad functions, including the maintenance of calcium homeostasis, the promotion of early wound healing, uncoupling respiration (aerobic glycolysis), reepithelialization in damaged tissues, the inhibition of vascular leakage, and the regulation of macrophage functions to keep epithelial and endothelial homeostasis, which may adequately cover the myriad therapeutic targets of IPF.
Transcriptome analysis identifies genes involved in adventitious branches formation of Gracilaria lichenoides in vitro.
Fang et al., Xiamen, China. In Sci Rep, 2014
However, STC lags behind that of higher plants because of the paucity of genomic information.
Stanniocalcin-1 inhibits thrombin-induced signaling and protects from bleomycin-induced lung injury.
Sheikh-Hamad et al., Houston, United States. In Sci Rep, 2014
Stanniocalcin-1 (STC1) activates anti-oxidant pathways, inhibits inflammation and provides cytoprotection; hence, we hypothesized that STC1 will inhibit thrombin/PAR1 signaling and protect from bleomycin-induced pneumonitis.
Investigation of the mechanism of soft tissue conduction explains several perplexing auditory phenomena.
Review
Sohmer et al., In J Basic Clin Physiol Pharmacol, 2014
Soft tissue conduction (STC) is a recently expounded mode of auditory stimulation in which the clinical bone vibrator delivers auditory frequency vibratory stimuli to skin sites on the head, neck, and thorax.
Mechanisms of epithelial repair and regeneration after acute kidney injury.
Review
Moeller et al., Aachen, Germany. In Semin Nephrol, 2014
Thus, the STC phenotype is a transient, graded, and specific transcriptional program facilitating tubular regeneration.
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
Impact
Gieger et al., Freiburg, Germany. In Nat Genet, 2013
By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4).
Stanniocalcin supports the functional adaptation of adult-sized kidneys transplanted into the pediatric recipients.
GeneRIF
Sarwal et al., San Francisco, United States. In Transplantation, 2012
Stanniocalcin (STC1) plays an important role in functional adaption in pediatric kidney transplantation.
Assessment of stanniocalcin-1 as a prognostic marker in human esophageal squamous cell carcinoma.
GeneRIF
Doki et al., Suita, Japan. In Oncol Rep, 2012
Overexpression of STC1 was an independent prognostic factor in patients with esophageal cancer who had undergone curative surgery.
crinkled reveals a new role for Wingless signaling in Drosophila denticle formation.
GeneRIF
Chao et al., Durham, United States. In Development, 2012
Data suggest that Crinkled acts in concert with Wingless targets to orchestrate the proper shaping of denticles in the Drosophila embryonic epidermis.
Human stanniocalcin-1 suppresses angiotensin II-induced superoxide generation in cardiomyocytes through UCP3-mediated anti-oxidant pathway.
GeneRIF
Sheikh-Hamad et al., Houston, United States. In Plos One, 2011
STC1 activates a novel anti-oxidant pathway in cardiac myocytes through induction of UCP3
Expression of stanniocalcin 1 as a potential biomarker of gastric cancer.
GeneRIF
Natsugoe et al., Kagoshima, Japan. In Oncology, 2011
STC1 is a potentially useful blood marker for predicting biological tumor aggressiveness in patients with gastric cancer
Multiple loci associated with indices of renal function and chronic kidney disease.
Impact
Fox et al., Baltimore, United States. In Nat Genet, 2009
We identified significant SNP associations (P < 5 × 10(-8)) with CKD at the UMOD locus, with eGFRcrea at UMOD, SHROOM3 and GATM-SPATA5L1, and with eGFRcys at CST and STC1.
Phosphatidylinositol (3,4,5)P3 interacts with SH2 domains and modulates PI 3-kinase association with tyrosine-phosphorylated proteins.
Impact
Cantley et al., Boston, United States. In Cell, 1996
The SH2 domain of pp60C-STC also specifically bound Ptdlns (3,4,5)P3, and the binding was competed by a phosphopeptide specific for the Src SH2 domain.
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