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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Stathmin 1

Stathmin, Op18, 19K, oncoprotein 18
This gene belongs to the stathmin family of genes. It encodes a ubiquitous cytosolic phosphoprotein proposed to function as an intracellular relay integrating regulatory signals of the cellular environment. The encoded protein is involved in the regulation of the microtubule filament system by destabilizing microtubules. It prevents assembly and promotes disassembly of microtubules. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, E1A, bcl-2
Papers using Stathmin antibodies
A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals
Supplier
Nguyen Trung P. et al., In Journal of Neuroimmune Pharmacology, 1998
... StathminAbcam ...
Papers on Stathmin
Stathmin reduction and cytoskeleton rearrangement in rat nucleus accumbens in response to clozapine and risperidone treatment - Comparative proteomic study.
New
Dziedzicka-Wasylewska et al., Kraków, Poland. In Neuroscience, Jan 2016
Both antipsychotics influenced the level of microtubule-regulating proteins, i.e., stathmin, and proteins of the collapsin response mediator protein family (CRMPs), and only CLO affected NAD-dependent protein deacetylase sirtuin-2 and septin 6.
A Randomized Multicenter Phase III Study of Single Administration of Mecapegfilgrastim (HHPG-19K), A Pegfilgrastim Biosimilar, for Prophylaxis of Chemotherapy-Induced Neutropenia in Patients With Advanced Non-Small-Cell Lung Cancer (NSCLC).
New
Xia et al., Shanghai, China. In Clin Lung Cancer, Jan 2016
BACKGROUND: Mecapegfilgrastim (code name HHPG-19K) is a biosimilar to pegylated recombinant human granulocyte-colony stimulating factor (PEG-rhG-CSF).
The epidermal growth factor receptor decreases Stathmin 1 and triggers catagen entry in the mouse.
New
Hansen et al., Omaha, United States. In Exp Dermatol, Jan 2016
Similarly, Rcc2-regulated mitotic regulator Stathmin 1 was strikingly reduced in control but not Egfr mutant follicles between P17 and P19.
High expression of stathmin 1 is a strong prognostic marker in oral squamous cell carcinoma patients treated by docetaxel-containing regimens.
New
Ueyama et al., Ube, Japan. In Clin Exp Med, Dec 2015
UNASSIGNED: Stathmin 1 is an oncoprotein that regulates cell cycle by modulating microtubule dynamics and can cause uncontrolled cell proliferation in mutated state.
Evaluation by microarray of the potential safety of Sarracenia purpurea L. (Sarraceniaceae) a traditional medicine used by the Cree of Eeyou Istchee.
New
Arnason et al., Ottawa, Canada. In J Pharm Pharm Sci, Nov 2015
METHODS: Transcriptional activity was profiled using a 19K human cDNA microarray in C2BBe1 cells, clone of Caco-2 intestinal cells, which are a model of first-pass metabolism (1, 2).
Stathmin 1 in normal and malignant hematopoiesis.
Review
Traina et al., Campinas, Brazil. In Bmb Rep, 2014
Stathmin 1 is a microtubule destabilizer that plays an important role in cell cycle progression, segregation of chromosomes, clonogenicity, cell motility and survival.
Stathmin destabilizing microtubule dynamics promotes malignant potential in cancer cells by epithelial-mesenchymal transition.
Review
Yu et al., Shanghai, China. In Hepatobiliary Pancreat Dis Int, 2014
BACKGROUND: Stathmin is a ubiquitous cytosolic regulatory phosphoprotein and is overexpressed in different human malignancies.
Abnormal expression of stathmin 1 in brain tissue of patients with intractable temporal lobe epilepsy and a rat model.
GeneRIF
Wang et al., Chongqing, China. In Synapse, 2012
Stathmin 1 expression was decreased in the experimental animals from 1 to 14 days postseizure and then significantly increased at Days 30 and 60.
Glucose metabolism and pancreatic defects in spinal muscular atrophy.
GeneRIF
Kothary et al., Ottawa, Canada. In Ann Neurol, 2012
The results of this study indicated that defects in glucose metabolism may play an important contributory role in SMA pathogenesis.
Low expression of stathmin in tumor predicts high response to neoadjuvant chemotherapy with docetaxel-containing regimens in locally advanced breast cancer.
GeneRIF
Xie et al., Hangzhou, China. In Genet Test Mol Biomarkers, 2012
ER and stathmin were independent predictive factors for NCT with docetaxel-containing regimens.
Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells.
GeneRIF
Shaw et al., Saint Louis, United States. In J Immunol, 2012
Stathmin phosphorylates the microtubule network during T cell activation, resulting in increased microtubule growth rate dependent on the presence of stathmin.
Stathmin1 plays oncogenic role and is a target of microRNA-223 in gastric cancer.
GeneRIF
To et al., Hong Kong, Hong Kong. In Plos One, 2011
STMN1 knockdown in AGS and MKN7 cell lines suppressed proliferation (p<0.001), reduced monolayer colony formation (p<0.001), inhibited cell invasion and migration ability (p<0.001) and induced G1 phase arrest.
Stathmin: a protein with many tasks. New biomarker and potential target in cancer.
Review
Baldassarre et al., Italy. In Expert Opin Ther Targets, 2011
Several studies then indicated that stathmin is overexpressed in many types of human malignancies, thus deserving the name of Oncoprotein 18 (Op18).
Stathmin 1: a novel therapeutic target for anticancer activity.
Review
Nemunaitis et al., Carrollton, United States. In Expert Rev Anticancer Ther, 2008
Stathmin 1 (STMN1), also known as p17, p18, p19, 19K, metablastin, oncoprotein 18, LAP 18 and Op18, is a 19 kDa cytosolic protein.
Molecular profiling identifies prognostic subgroups of pediatric glioblastoma and shows increased YB-1 expression in tumors.
Impact
Jabado et al., Montréal, Canada. In J Clin Oncol, 2007
Ras and Akt pathway activation was assessed through the phosphorylation of downstream effectors, and gene expression profiles were generated using the University Health Network Human 19K cDNA arrays.
Measurements of stathmin-tubulin interaction in solution.
Review
Carlier, Gif-sur-Yvette, France. In Methods Mol Med, 2006
Stathmin is an important phosphorylation-controlled regulator of microtubule dynamics and plays a crucial role in cell division and cell proliferation.
Stathmin-tubulin interaction gradients in motile and mitotic cells.
Impact
Karsenti et al., Heidelberg, Germany. In Science, 2004
We visualized such intracellular gradients by monitoring the interaction between tubulin and a regulator of microtubule dynamics, stathmin, using a fluorescence resonance energy transfer (FRET) biosensor.
Mitotic chromatin regulates phosphorylation of Stathmin/Op18.
Impact
Karsenti et al., Heidelberg, Germany. In Nature, 1997
It has been shown that Stathmin/Op18 inhibits microtubule polymerization in vitro by interaction with tubulin, and that overexpression in tissue culture cells of non-phosphorylatable mutants of Stathmin/Op18 prevents the assembly of mitotic spindles.
Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules.
Impact
Mitchison et al., San Francisco, United States. In Cell, 1996
Sequence analysis identified this protein as oncoprotein 18 (Op18)/stathmin, a conserved phosphoprotein that is highly expressed in leukemia cells.
Requirement of 19K form of Sonic hedgehog for induction of distinct ventral cell types in CNS explants.
Impact
McMahon et al., Cambridge, United States. In Nature, 1995
Sonic hedgehog (Shh), a vertebrate hedgehog-family member, is processed to generate two peptides (M(r) 19K and 26/27K) which are secreted by both of these organizing centres.
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