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Signal transducer and activator of transcription 6, interleukin-4 induced

STAT6, signal transducer and activator of transcription 6
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] (from NCBI)
Top mentioned proteins: IL-4, TH2, IL-13, CAN, V1a
Papers using STAT6 antibodies
Cell cycle: bistability is needed for robust cycling.
Unutmaz Derya, In PLoS ONE, 2004
... Antibodies against the phospho-proteins Stat1 Y701 (4A), Stat3 Y705 (4), Stat5 Y694 (47), Stat6 Y641 (J71-773.58.11) conjugated to Alexa 488 or Alexa 647 were also provided by BD Biosciences.
The SH3–SAM Adaptor HACS1 is Up-regulated in B Cell Activation Signaling Cascades
Stewart A. Keith et al., In The Journal of Experimental Medicine, 2002
... Rapamycin (FRAP/mTOR inhibitor), PD98059 (MEK1 inhibitor), anti–phospho-Akt, anti-Akt, anti–phospho-PKCζ, and anti-STAT6 were from Cell Signaling Technology ...
Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells
Murphy Kenneth M. et al., In The Journal of Experimental Medicine, 1998
... Wild-type and Stat6-deficient DO11.10 α/β− TCR transgenic mice have been described ...
Functional Inactivation of CXC Chemokine Receptor 4–mediated Responses through SOCS3 Up-regulation
Mellado Mario et al., In The Journal of Experimental Medicine, 1993
... , anti-STAT1 to -STAT6, anti-pol II (Santa Cruz Biotechnology, Inc.), and anti–β-actin (Sigma-Aldrich) ...
Papers on STAT6
Analysis of changes in expression of IL-4/IL-13/STAT6 pathway and correlation with the selected clinical parameters in patients with atopic asthma.
Brzeziańska-Lasota et al., Łódź, Poland. In Int J Immunopathol Pharmacol, Feb 2016
INTRODUCTION: Asthma is associated with activation of interleukin-4 (IL-4)/interleukin-13 (IL-13)/signal transducer and activator of transcription factor-6(STAT6) inflammatory response via overexpression of all pathway components: IL-4, IL-13, and STAT6.
IL-4 Modulates CCL11 and CCL20 Productions from IL-1β-Stimulated Human Periodontal Ligament Cells.
Matsuo et al., Tokushima, Japan. In Cell Physiol Biochem, Feb 2016
Akt and STAT6 inhibitors decreased CCL11 production, but enhanced CCL20 production in HPDLCs stimulated with IL-4 and IL-1β.
Luteolin inhibits recruitment of monocytes and migration of Lewis lung carcinoma cells by suppressing chemokine (C-C motif) ligand 2 expression in tumor-associated macrophage.
Ha et al., Yangsan, South Korea. In Biochem Biophys Res Commun, Feb 2016
Luteolin inhibited phosphorylation of signal transducer and activator of transcription 6 (STAT6), a main downstream signal of IL-4, and reduced the expression of the M2-associated genes.
Airway inflammation in asthma: key players beyond the Th2 pathway.
KleinJan, Rotterdam, Netherlands. In Curr Opin Pulm Med, Jan 2016
PURPOSE OF REVIEW: The Th2 pathway starts with the binding of IL-4 to the IL-4 receptor followed by the phosphorylation of signal transducer and activator of transcription 6 and the activation of GATA3.
Solitary fibrous tumor of the breast: report of a case with emphasis on diagnostic role of STAT6 immunostaining.
Palazzo et al., Catania, Italy. In Pathol Res Pract, Jan 2016
As STAT6 nuclear immunoexpression is the result of the inv12(q13q13)-derived NAB2-STAT6 fusion, which characterizes SFT, we analyzed immunohistochemically our case with a commercially available anti-STAT6 antibody.
IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation.
Ballestar et al., Barcelona, Spain. In Genome Biol, Dec 2015
Most importantly, activation of the JAK3-STAT6 pathway, downstream of IL-4, is required for the acquisition of the dendritic-cell-specific demethylation and expression signature, following STAT6 binding.
Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy.
Wang et al., Cincinnati, United States. In Immunity, Nov 2015
Repeated intragastric antigen challenge induced MMC9 development that required T cells, IL-4, and STAT6 transcription factor, but not IL-9 signals.
The genetic basis of eosinophilic esophagitis.
Hakonarson et al., Philadelphia, United States. In Best Pract Res Clin Gastroenterol, Oct 2015
The information gained from GWAS has been of value in elucidating the pathways involved, such as IL4/STAT6, and more unexpected pathways such as epithelial apical transport and wound healing.
Enteric nematodes and the path to up-regulation of type 2 cytokines IL-4 and IL-13.
Zhao et al., Baltimore, United States. In Cytokine, Sep 2015
Protective immunity against enteric parasitic nematodes is dependent on IL-4, IL-13 activation of their exclusive transcription factor STAT6.
Pleural neoplastic pathology.
Froudarakis et al., Ioánnina, Greece. In Respir Med, Aug 2015
Solitary fibrous tumor, the commonest primary pleural mesenchymal tumor is characterized by STAT6 overexpression.
Role of IL-25 in Immunity.
Parizad et al., Īlām, Iran. In J Clin Diagn Res, Apr 2015
Reaction between IL-25 and IL-17BR leads to activation of transcription factors, such as NF-KB, STAT6, GATA3, NF-ATC1, JUNNB, MAPK, and JNK.
Regulatory T cell reprogramming toward a Th2-cell-like lineage impairs oral tolerance and promotes food allergy.
Chatila et al., Boston, United States. In Immunity, Apr 2015
We show that disease-susceptible (Il4ra(F709)) mice with enhanced interleukin-4 receptor (IL-4R) signaling exhibited STAT6-dependent impaired generation and function of mucosal allergen-specific Treg cells.
Coinfection. Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation.
Artis et al., Philadelphia, United States. In Science, 2014
Helminth coinfection resulted in impaired antiviral immunity and was associated with changes in the microbiota and STAT6-dependent helminth-induced alternative activation of macrophages.
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.
Zhao et al., Bethesda, United States. In Nat Immunol, 2013
Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6.
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis.
Wirtz et al., Erlangen, Germany. In Immunity, 2013
We identified ILC2-derived IL-13, acting through type-II IL-4 receptor-dependent signaling via the transcription factor STAT6 and hepatic stellate-cell activation, as a critical downstream cytokine of IL-33-dependent pathologic tissue remodeling and fibrosis.
Polymorphisms of STAT6 and specific serum IgE levels in patients with penicillin allergy.
Qiao et al., Zhengzhou, China. In Int J Clin Pharmacol Ther, 2012
STAT6 in2SNP3 is associated with penicillin allergy, but has no effect on the specific IgE levels of patients with penicillin allergy.
Astrocytes, but not microglia, rapidly sense H₂O₂via STAT6 phosphorylation, resulting in cyclooxygenase-2 expression and prostaglandin release.
Jou et al., Suwŏn, South Korea. In J Immunol, 2012
STAT6 in astrocytes is much more sensitive to reactive oxygen species (ROS)-dependent phosphorylation than is microglial STAT6; therefore, astrocytes may function as ROS sensors.
Anti-apoptotic effects of SERPIN B3 and B4 via STAT6 activation in macrophages after infection with Toxoplasma gondii.
Nam et al., Seoul, South Korea. In Korean J Parasitol, 2012
Toxoplasma gondii induces SERPIN B3/B4 expression via STAT6 activation to inhibit the apoptosis of infected cells for survival of the parasites.
A molecular model for the differential activation of STAT3 and STAT6 by the herpesviral oncoprotein tip.
Ensser et al., Erlangen, Germany. In Plos One, 2011
model for the differential activation of STAT3 or STAT6 by two distinct regions of the viral Tip protein
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells.
Misawa et al., Tokyo, Japan. In Pharmacol Rep, 2011
the STAT6 phosphorylation/activation induced by IL-13 is mediated by an activation of JAK1 in cultured human bronchial smooth muscle cells.
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