The genetic basis of eosinophilic esophagitis.
Philadelphia, United States. In Best Pract Res Clin Gastroenterol, Oct 2015
The information gained from GWAS has been of value in elucidating the pathways involved, such as IL4/STAT6, and more unexpected pathways such as epithelial apical transport and wound healing.
Pleural neoplastic pathology.
Ioánnina, Greece. In Respir Med, Aug 2015
Solitary fibrous tumor, the commonest primary pleural mesenchymal tumor is characterized by STAT6 overexpression.
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis.
Erlangen, Germany. In Immunity, 2013
We identified ILC2-derived IL-13, acting through type-II IL-4 receptor-dependent signaling via the transcription factor STAT6 and hepatic stellate-cell activation, as a critical downstream cytokine of IL-33-dependent pathologic tissue remodeling and fibrosis.