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Malic enzyme 1, NADP

STAT5, Malate Dehydrogenase, MES, Stat5a, STAT5b, MPF
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, V1a, STAT3, HAD
Papers using STAT5 antibodies
progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement.
Supplier
Damania Blossom, In PLoS Pathogens, 2009
... , STAT5a/b (SC29495, Santa Cruz Biotechnology), COUP-TFII ( ...
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.
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Navarro Alfons, In PLoS ONE, 2006
... Rabbit polyclonal antibodies against c-Cbl, Cbl-b, EpoR, Jak2 (C-20 and M-126), and STAT5A as well as a mouse monoclonal antibody against α-tubulin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.
Supplier
Meurs Eliane F., In PLoS ONE, 2006
... (4921), STAT5 (9358) phosphorylated STAT5 (9356), and the Alexa fluor-conjugated rabbit monoclonal antibody against phosphorylated STAT5 (3939) were obtained from Cell Signaling (Beverly, MA) ...
Antibody response to influenza vaccination in elderly: A quantitative review
Supplier
Pied Sylviane, In PLoS ONE, 2005
... the reaction was carried out for 20 minutes at room temperature.Afterwards, beads were washed with MES-T buffer using centrifugation at 600 G for 8 minutes on 3-µm Transwell inserts (Life Technologies) assembled on top of ...
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Papers on STAT5
Systematic analysis of intracellular mechanisms of propanol production in the engineered Thermobifida fusca B6 strain.
New
Fong et al., Wuxi, China. In Appl Microbiol Biotechnol, 31 Aug 2015
Further, the transcriptome suggested a pathway for synthesizing succinyl-CoA: oxaloacetate to malate (by malate dehydrogenase), malate to fumarate (by fumarate hydratase), and fumarate to succinate (by succinate dehydrogenase/fumarate reductase) which was ultimately converted to succinyl-CoA by succinyl-CoA synthetase.
Natural variation in IL-2 sensitivity influences regulatory T cell frequency and function in individuals with long-standing type 1 diabetes.
New
Tree et al., San Diego, United States. In Diabetes, 29 Aug 2015
IL-2 responsiveness, measured by STAT5a phosphorylation, was found to be a very stable phenotype within individuals, but exhibited considerable inter-individual variation and was influenced by T1D-associated PTPN2 gene polymorphisms.
Crosstalk between Growth Hormone-regulated Transcription Factors HNF6 and CUX2 in Adult Mouse Liver.
New
Waxman et al., Boston, United States. In Mol Endocrinol, 28 Aug 2015
UNASSIGNED: HNF6 and CUX2 are growth hormone and STAT5-regulated homeobox transcription factors.
Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity.
New
Impact
Murphy et al., Sacramento, United States. In Immunity, 28 Aug 2015
This suppression targeted naive CD4(+) but not CD8(+) T cells and was mediated through transient suppressor of cytokine signaling-3 (SOCS3) inhibition of the STAT5b transcription factor signaling pathway.
Hypoxia-Mediated Increases in l-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.
New
Impact
Loscalzo et al., Boston, United States. In Cell Metab, 22 Aug 2015
L2HG is a metabolite of unknown function produced by the reduction of mitochondrial 2-oxoglutarate by malate dehydrogenase.
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.
New
Impact
Chen et al., Shanghai, China. In Nat Genet, 20 Aug 2015
Recurrent mutations were most frequently located in the RNA helicase gene DDX3X (21/105 subjects, 20.0%), tumor suppressors (TP53 and MGA), JAK-STAT-pathway molecules (STAT3 and STAT5B) and epigenetic modifiers (MLL2, ARID1A, EP300 and ASXL3).
Novel Therapy to Treat Corneal Epithelial Defects: A Hypothesis with Growth Hormone.
Review
New
Ding et al., Salt Lake City, United States. In Ocul Surf, 31 Jul 2015
In a recent study, HGH was shown to activate signal transducer and activators of transcription-5 (STAT5) signaling and promote corneal wound healing by enhancing corneal epithelial migration in a co-culture system of corneal epithelial cells and fibroblasts.
The growth hormone receptor.
Review
New
Waters, Australia. In Growth Horm Igf Res, 07 Jul 2015
This brings the two kinase domains into position for trans-activation and initiates tyrosine phosphorylation of the receptor cytoplasmic domain and other substrates such as STAT5, the key transcription factor mediating most genomic actions of GH.
Adaptations of protein structure and function to temperature: there is more than one way to 'skin a cat'.
Review
New
Somero et al., Lancaster, United States. In J Exp Biol, Jun 2015
A series of studies using two structurally and catalytically related enzymes, A4-lactate dehydrogenase (A4-LDH) and cytosolic malate dehydrogenase (cMDH) have been especially valuable in determining the functional attributes of enzymes most sensitive to temperature, and identifying amino acid substitutions that lead to changes in those attributes.
Targeting JAK kinase in solid tumors: emerging opportunities and challenges.
Review
New
Ernst et al., Melbourne, Australia. In Oncogene, Jun 2015
UNASSIGNED: Various human malignancies are characterized by excessive activation of the Janus family of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and STAT5.
Emerging EPO and EPO receptor regulators, and signal transducers.
Review
New
Wojchowski et al., West Scarborough, United States. In Blood, May 2015
Early investigations defined basic mechanisms for Hypoxia-Inducible Factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical JAK2/STAT5, RAS/MEK/ERK and PI3K pathways.
ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.
New
Impact
Akbari et al., Los Angeles, United States. In Immunity, Apr 2015
ILC2s expressed both ICOS and ICOS-ligand, and the ICOS:ICOS-ligand interaction promoted cytokine production and survival in ILC2s through STAT5 signaling.
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
New
Impact
Weaver et al., Birmingham, United States. In Nat Immunol, Mar 2015
By repressing expression of the negative regulator SOCS3 dependent on the transcription factor NF-κB, IL-1 increased the amplitude and duration of phosphorylation of the transcription factor STAT3 induced by TH17-polarizing cytokines, which led to an altered balance in the binding of STAT3 and STAT5 to shared consensus sequences in developing T cells.
Aqueous extract of Caesalpinia sappan decelerates allograft rejection by inducing imbalance between CD4(+) CD25(+) T cells and Th17 cells.
New
Si et al., Jining, China. In Int J Clin Exp Med, Dec 2014
RESULTS: CSE prolonged skin allograft survival, increased the percentage and number of CD4(+) CD25(+) T cells, the expression of Foxp3 and STAT5 in spleen cells, the serum levels of IL-10 and TGF-β1, whereas reduced the percentage and number of Th17 cells and serum IL-17 level in Balb/c recipients.
IL-35 Is Involved in the Pathogenesis of Guillain-Barré Syndrome Through Its Influence on the Function of CD4+ T Cells.
New
Li et al., Changsha, China. In Immunol Invest, Dec 2014
In contrast, the levels of STAT5 and STAT6 proteins and GATA3, Foxp3, IL-4 and TGF-β1 mRNAs were decreased in GBS patients in comparison with those of HCs.
Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.
GeneRIF
Hamel et al., Toronto, Canada. In Dev Biol, 2012
These data demonstrate that expression of an activated allele of c-src overcomes the block to mammary gland morphogenesis in mice arising due to the loss of the cytoplasmic C-terminal domain of Ptch1.
Expression of phosphorylated signal transducer and activator of transcription 5 is associated with an increased risk of death in acute myeloid leukemia.
GeneRIF
Advani et al., Cleveland, United States. In Eur J Haematol, 2012
pSTAT5 expression was significantly associated with an increased risk of death and of relapse after achieving complete remission
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.
Impact
GeneRIF
Heikenwalder et al., Zürich, Switzerland. In Cancer Cell, 2012
CCL2-induced vascular permeability and metastasis is dependent on JAK2-Stat5 and p38MAPK signaling
Enalapril-induced apoptosis of acute promyelocytic leukaemia cells involves STAT5A.
GeneRIF
Saydam et al., İzmir, Turkey. In Anticancer Res, 2012
The expression levels of STAT5A gene were significantly reduced in enalapril-treated HL60 cells as compared to untreated controls.
CCL2, galectin-3, and SMRP combination improves the diagnosis of mesothelioma in pleural effusions.
GeneRIF
Gregoire et al., Nantes, France. In J Thorac Oncol, 2012
High SMRP is associated with mesothelioma in pleural effusions.
More papers using STAT5 antibodies
FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
Supplier
Small Donald et al., In Oncogene, 2003
... Rabbit antihuman FLT3 and anti-STAT5 antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation
Supplier
Barner Ross et al., In Breast Cancer : Basic and Clinical Research, 2003
... Selected positive and negative tissues were analyzed with alternate antibodies, a polyclonal rabbit antiserum directed against STAT5a (L-20, Santa Cruz Biotechnology Inc, Santa Cruz, CA, ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.
Supplier
Blagosklonny Mikhail V., In PLoS ONE, 2002
... Antibodies to SRC phospho-Y418, STAT5A phospho-Y694, and STAT5A, were purchased from Cell Signaling Technologies (Danvers, MA) ...
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells
Supplier
Shemanko Carrie S et al., In Breast Cancer Research : BCR, 2002
... Polyclonal rabbit antibodies against HSP90α were acquired from StressGen (Victoria, BC, Canada), and rabbit anti-STAT5B from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma
Supplier
Leonard Warren J. et al., In The Journal of Experimental Medicine, 2000
... Stat5a and Stat5b transgenic mice were generated and ...
Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes.
Supplier
Buday Laszlo, In PLoS ONE, 2000
... P-MAPK, MAPK, and anti-P-STAT5(Y694) for westerns were purchased from Cell Signaling Technology (Danvers, MA) ...
SOCS proteins: negative regulators of cytokine signaling.
Supplier
Hartl Dominik, In PLoS ONE, 2000
... The following antibodies were used for FACS analyses: Alexa Fluor 647 mouse anti-Stat5 (pY694) (BD Biosciences, Breda, The Netherlands, cat ...
High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin.
Supplier
Blagosklonny Mikhail, In PLoS ONE, 1996
... Polyclonal anti-EPO (H-162), anti-EPOR (M-20), anti-JAK2 (C-20), anti-phospho-JAK2 (Tyr1007/1008), anti-STAT5 (N-20) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: fact or myth
Supplier
Desmeules Jules et al., In Basic & Clinical Pharmacology & Toxicology, 1996
... -morpholino)ethane-sulfonic acid (MES) was purchased from AppliChem GmbH (Darmstadt, Germany), penicillin–streptomycin from Sigma Aldrich GmbH (Steinheim, Germany), non-essential ...
FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase
Supplier
Mellado Mario et al., In The Journal of Cell Biology, 1993
... and anti-STAT5 (Santa Cruz Biotechnology ...
β1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
Supplier
Brizzi Maria Felice et al., In The Journal of Cell Biology, 1993
... The anti–phospho-STAT5 (tyrosine 694/699) antibody was obtained from Cell Signaling and the anti–phospho-STAT5 (serine725/730) ...
CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.
Supplier
Lesniak Maciej, In PLoS ONE, 1991
... ) mice, Stat5b transgenic (Stat5-Tg) mice ( ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Supplier
Schuster Stephan C et al., In BMC Biochemistry, 1969
... Geneticin G 418 and Mes were obtained from Sigma, and sorbitol was from Merck.
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