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Malic enzyme 1, NADP

STAT5, Malate Dehydrogenase, MES, Stat5a, STAT5b, MPF
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, STAT3, V1a, HAD
Papers using STAT5 antibodies
progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement.
Damania Blossom, In PLoS Pathogens, 2009
... , STAT5a/b (SC29495, Santa Cruz Biotechnology), COUP-TFII ( ...
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.
Navarro Alfons, In PLoS ONE, 2006
... Rabbit polyclonal antibodies against c-Cbl, Cbl-b, EpoR, Jak2 (C-20 and M-126), and STAT5A as well as a mouse monoclonal antibody against α-tubulin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.
Meurs Eliane F., In PLoS ONE, 2006
... (4921), STAT5 (9358) phosphorylated STAT5 (9356), and the Alexa fluor-conjugated rabbit monoclonal antibody against phosphorylated STAT5 (3939) were obtained from Cell Signaling (Beverly, MA) ...
Antibody response to influenza vaccination in elderly: A quantitative review
Pied Sylviane, In PLoS ONE, 2005
... the reaction was carried out for 20 minutes at room temperature.Afterwards, beads were washed with MES-T buffer using centrifugation at 600 G for 8 minutes on 3-µm Transwell inserts (Life Technologies) assembled on top of ...
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Papers on STAT5
Discovery of 2-((3-amino-4-methylphenyl)amino)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)-4-(methylamino)pyrimidine-5-carboxamide (CHMFL-ABL-053) as a potent, selective and orally available BCR-ABL/SRC/p38 kinase inhibitor for Chronic Myeloid Leukemia.
Liu et al., In J Med Chem, Feb 2016
Through significant suppression of the BCR-ABL auto-phosphorylation (EC50 about 100 nM) and downstream mediators such as STAT5, Crkl and ERK's phosphorylation, 18a inhibited the proliferation of CML cell lines K562 (GI50 = 14 nM), KU812 (GI50 = 25 nM) and MEG-01 (GI50 = 16 nM).
High-resolution antibody array analysis of childhood acute leukemia cells.
Kalina et al., Praha, Czech Republic. In Mol Cell Proteomics, Feb 2016
From non-CD markers, we found DBN1, PAX5, or PTK2 overexpressed in B-cell precursor acute lymphoblastic leukemias, LAT, SH2D1A, or STAT5A overexpressed in T-cell acute lymphoblastic leukemias, and HCK, GLUD1, or SYK overexpressed in acute myeloid leukemias.
Reductive silylation of Cp*UO2((Mes)PDI(Me)) promoted by Lewis bases.
Bart et al., West Lafayette, United States. In Dalton Trans, Feb 2016
UNASSIGNED: Functionalization of the uranyl moiety (UO2(2+)) in Cp*UO2((Mes)PDI(Me)) () ((Mes)PDI(Me) = 2,6-((Mes)N[double bond, length as m-dash]CMe)2C5H3N; Mes = 2,4,6-triphenylmethyl), which bears a reduced, monoanionic pyridine(diimine) ligand, is reported.
The influence of confounding factors on the relationship between muscle contraction level and MF and MPF values of EMG signal: a review.
Roman-Liu, Poland. In Int J Occup Saf Ergon, Jan 2016
UNASSIGNED: The purpose of this paper is to gather results of studies on the relationship between median frequency (MF) and mean power frequency (MPF), and the level of muscle contraction, and to use those results to discuss the differences in the trends according to factors related to measurement technique and subject.
Immune homeostasis enforced by co-localized effector and regulatory T cells.
Germain et al., Bethesda, United States. In Nature, Jan 2016
Here we use multiplex, quantitative imaging in mice to show that, within secondary lymphoid tissues, highly suppressive Treg cells expressing phosphorylated STAT5 exist in discrete clusters with rare IL-2-positive T cells that are activated by self-antigens.
MECHANISMS IN ENDOCRINOLOGY: Novel genetic causes of short stature.
Kant et al., Leiden, Netherlands. In Eur J Endocrinol, Dec 2015
Besides well-defined causes of GH insensitivity (GHR, STAT5B, IGFALS, IGF1 defects), disorders of NFκB signalling, STAT3 and IGF2 have recently been discovered.
Advances in peptidic and peptidomimetic-based approaches to inhibit STAT signaling in human diseases.
Hans et al., Poznań, Poland. In Curr Protein Pept Sci, Dec 2015
Novel strategies involve screening of high-complexity libraries of random peptides, as specific STAT3 or STAT5 DNA-binding inhibitors, to construct cell permeable peptide aptamers and aptides for cancer therapy.
Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.
Cantor et al., Boston, United States. In Science, Nov 2015
Helios-deficient T(regs) develop an unstable phenotype during inflammatory responses characterized by reduced FoxP3 expression and increased effector cytokine expression secondary to diminished activation of the STAT5 pathway.
Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists.
Leboulch et al., Fontenay-aux-Roses, France. In Nature, Oct 2015
We found that activation of PPARγ by the glitazones decreases expression of STAT5 and its downstream targets HIF2α and CITED2, which are key guardians of the quiescence and stemness of CML LSCs.
Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity.
Murphy et al., Sacramento, United States. In Immunity, Sep 2015
This suppression targeted naive CD4(+) but not CD8(+) T cells and was mediated through transient suppressor of cytokine signaling-3 (SOCS3) inhibition of the STAT5b transcription factor signaling pathway.
Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.
Loscalzo et al., Boston, United States. In Cell Metab, Sep 2015
L2HG is a metabolite of unknown function produced by the reduction of mitochondrial 2-oxoglutarate by malate dehydrogenase.
Effects of different dwarfing interstocks on key enzyme activities and the expression of genes related to malic acid metabolism in Red Fuji apples.
Xu et al., Baoding, China. In Genet Mol Res, 2014
The malate dehydrogenase (NAD-MDH) activity in apples on interstock No. 53 was highest on Day 30, Day 100, and Day 160 after bloom, and the malic enzyme (NADP-ME) activity in apples on interstock No. 111 was higher than in the interstock No. 53 fruit from Day 70 to Day 100 after bloom.
Integrative Modeling of Macromolecular Assemblies from Low to Near-Atomic Resolution.
Ivanov et al., Atlanta, United States. In Comput Struct Biotechnol J, 2014
Second, we describe hybrid molecular dynamics, Rosetta Monte-Carlo and minimum ensemble search (MES) methods that can be used to incorporate SAXS into pseudoatomic structural models.
Unraveling the in vitro secretome of the phytopathogen Botrytis cinerea to understand the interaction with its hosts.
Jorrín-Novo et al., Ciudad Juárez, Mexico. In Front Plant Sci, 2014
By using proteomics as experimental approach, many secreted proteins by B. cinerea have been identified from in vitro experiments, and belonging to different functional categories: (i) cell wall-degrading enzymes such as pectinesterases and endo-polygalacturonases; (ii) proteases involved in host protein degradation such as an aspartic protease; (iii) proteins related to the oxidative burst such as glyoxal oxidase; (iv) proteins which may induce the plant hypersensitive response such as a cerato-platanin domain-containing protein; and (v) proteins related to production and secretion of toxins such as malate dehydrogenase.
Selection of reference genes for expression analyses of red-fleshed sweet orange (Citrus sinensis).
Latado et al., Piracicaba, Brazil. In Genet Mol Res, 2014
Phosphatase, malate dehydrogenase, and ACT were the most stable genes in the leaf samples of infected plants.
Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.
Hamel et al., Toronto, Canada. In Dev Biol, 2012
These data demonstrate that expression of an activated allele of c-src overcomes the block to mammary gland morphogenesis in mice arising due to the loss of the cytoplasmic C-terminal domain of Ptch1.
Expression of phosphorylated signal transducer and activator of transcription 5 is associated with an increased risk of death in acute myeloid leukemia.
Advani et al., Cleveland, United States. In Eur J Haematol, 2012
pSTAT5 expression was significantly associated with an increased risk of death and of relapse after achieving complete remission
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.
Heikenwalder et al., Zürich, Switzerland. In Cancer Cell, 2012
CCL2-induced vascular permeability and metastasis is dependent on JAK2-Stat5 and p38MAPK signaling
Enalapril-induced apoptosis of acute promyelocytic leukaemia cells involves STAT5A.
Saydam et al., İzmir, Turkey. In Anticancer Res, 2012
The expression levels of STAT5A gene were significantly reduced in enalapril-treated HL60 cells as compared to untreated controls.
CCL2, galectin-3, and SMRP combination improves the diagnosis of mesothelioma in pleural effusions.
Gregoire et al., Nantes, France. In J Thorac Oncol, 2012
High SMRP is associated with mesothelioma in pleural effusions.
More papers using STAT5 antibodies
FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
Small Donald et al., In Oncogene, 2003
... Rabbit antihuman FLT3 and anti-STAT5 antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation
Barner Ross et al., In Breast Cancer : Basic and Clinical Research, 2003
... Selected positive and negative tissues were analyzed with alternate antibodies, a polyclonal rabbit antiserum directed against STAT5a (L-20, Santa Cruz Biotechnology Inc, Santa Cruz, CA, ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.
Blagosklonny Mikhail V., In PLoS ONE, 2002
... Antibodies to SRC phospho-Y418, STAT5A phospho-Y694, and STAT5A, were purchased from Cell Signaling Technologies (Danvers, MA) ...
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells
Shemanko Carrie S et al., In Breast Cancer Research : BCR, 2002
... Polyclonal rabbit antibodies against HSP90α were acquired from StressGen (Victoria, BC, Canada), and rabbit anti-STAT5B from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma
Leonard Warren J. et al., In The Journal of Experimental Medicine, 2000
... Stat5a and Stat5b transgenic mice were generated and ...
Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes.
Buday Laszlo, In PLoS ONE, 2000
... P-MAPK, MAPK, and anti-P-STAT5(Y694) for westerns were purchased from Cell Signaling Technology (Danvers, MA) ...
SOCS proteins: negative regulators of cytokine signaling.
Hartl Dominik, In PLoS ONE, 2000
... The following antibodies were used for FACS analyses: Alexa Fluor 647 mouse anti-Stat5 (pY694) (BD Biosciences, Breda, The Netherlands, cat ...
High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin.
Blagosklonny Mikhail, In PLoS ONE, 1996
... Polyclonal anti-EPO (H-162), anti-EPOR (M-20), anti-JAK2 (C-20), anti-phospho-JAK2 (Tyr1007/1008), anti-STAT5 (N-20) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: fact or myth
Desmeules Jules et al., In Basic & Clinical Pharmacology & Toxicology, 1996
... -morpholino)ethane-sulfonic acid (MES) was purchased from AppliChem GmbH (Darmstadt, Germany), penicillin–streptomycin from Sigma Aldrich GmbH (Steinheim, Germany), non-essential ...
FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase
Mellado Mario et al., In The Journal of Cell Biology, 1993
... and anti-STAT5 (Santa Cruz Biotechnology ...
β1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
Brizzi Maria Felice et al., In The Journal of Cell Biology, 1993
... The anti–phospho-STAT5 (tyrosine 694/699) antibody was obtained from Cell Signaling and the anti–phospho-STAT5 (serine725/730) ...
CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.
Lesniak Maciej, In PLoS ONE, 1991
... ) mice, Stat5b transgenic (Stat5-Tg) mice ( ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Schuster Stephan C et al., In BMC Biochemistry, 1969
... Geneticin G 418 and Mes were obtained from Sigma, and sorbitol was from Merck.
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