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Malic enzyme 1, NADP

STAT5, Malate Dehydrogenase, MES, Stat5a, STAT5b, MPF
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, STAT3, V1a, ACID, HAD
Papers using STAT5 antibodies
progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement.
Damania Blossom, In PLoS Pathogens, 2009
... , STAT5a/b (SC29495, Santa Cruz Biotechnology), COUP-TFII ( ...
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.
Navarro Alfons, In PLoS ONE, 2006
... Rabbit polyclonal antibodies against c-Cbl, Cbl-b, EpoR, Jak2 (C-20 and M-126), and STAT5A as well as a mouse monoclonal antibody against α-tubulin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.
Meurs Eliane F., In PLoS ONE, 2006
... (4921), STAT5 (9358) phosphorylated STAT5 (9356), and the Alexa fluor-conjugated rabbit monoclonal antibody against phosphorylated STAT5 (3939) were obtained from Cell Signaling (Beverly, MA) ...
Antibody response to influenza vaccination in elderly: A quantitative review
Pied Sylviane, In PLoS ONE, 2005
... the reaction was carried out for 20 minutes at room temperature.Afterwards, beads were washed with MES-T buffer using centrifugation at 600 G for 8 minutes on 3-µm Transwell inserts (Life Technologies) assembled on top of ...
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Papers on STAT5
Gene expression of different adipose tissues of severely obese women with or without a dysmetabolic profile.
Richard et al., Québec, Canada. In J Physiol Biochem, 10 Nov 2015
We thus compared, by quantitative PCR, the expression profile of a number of genes in the SCABD, omental (OME), and mesenteric (MES) depots of severely obese women with (DYS; n = 25) or without (NDYS; n = 23) a dysmetabolic profile.
UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.
Mulloy et al., Cincinnati, United States. In Leukemia, 09 Nov 2015
Mechanistically, loss of CBL function confers hyper-responsiveness to thrombopoietin and enhances STAT5/AKT/ERK/Src signaling in AML1-ETO cells.
An autoregulatory enhancer controls mammary-specific STAT5 functions.
Hennighausen et al., Bethesda, United States. In Nucleic Acids Res, 07 Nov 2015
Although STAT5A is expressed in most tissues it remains to be understood why its premier, non-redundant functions are restricted to prolactin-induced mammary gland development and function.
GroEL of the nitrogen-fixing cyanobacterium Anabaena sp. strain L-31 exhibits GroES and ATP-independent refolding activity.
Apte et al., Mumbai, India. In J Biochem, 07 Nov 2015
Anabaena GroEL formed stable higher oligomer (>12-mer) in the presence of K(+) and prevented thermal aggregation of Malate Dehydrogenase (MDH).
Influenza Transmission in the Mother-Infant Dyad Leads to Severe Disease, Mammary Gland Infection, and Pathogenesis by Regulating Host Responses.
Kelvin et al., Toronto, Canada. In Plos Pathog, 31 Oct 2015
To understand the molecular mechanisms of mammary gland infection, we performed global transcript analysis which showed downregulation of milk production genes such as Prolactin and increased breast involution pathways indicated by a STAT5 to STAT3 signaling shift.
Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists.
Leboulch et al., Fontenay-aux-Roses, France. In Nature, 17 Oct 2015
We found that activation of PPARγ by the glitazones decreases expression of STAT5 and its downstream targets HIF2α and CITED2, which are key guardians of the quiescence and stemness of CML LSCs.
Exome sequencing identifies somatic mutations of DDX3X in natural killer/T-cell lymphoma.
Chen et al., Shanghai, China. In Nat Genet, 30 Sep 2015
Recurrent mutations were most frequently located in the RNA helicase gene DDX3X (21/105 subjects, 20.0%), tumor suppressors (TP53 and MGA), JAK-STAT-pathway molecules (STAT3 and STAT5B) and epigenetic modifiers (MLL2, ARID1A, EP300 and ASXL3).
Out-of-Sequence Signal 3 Paralyzes Primary CD4(+) T-Cell-Dependent Immunity.
Murphy et al., Sacramento, United States. In Immunity, 18 Sep 2015
This suppression targeted naive CD4(+) but not CD8(+) T cells and was mediated through transient suppressor of cytokine signaling-3 (SOCS3) inhibition of the STAT5b transcription factor signaling pathway.
Hypoxia-Mediated Increases in l-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.
Loscalzo et al., Boston, United States. In Cell Metab, 04 Sep 2015
L2HG is a metabolite of unknown function produced by the reduction of mitochondrial 2-oxoglutarate by malate dehydrogenase.
Novel Therapy to Treat Corneal Epithelial Defects: A Hypothesis with Growth Hormone.
Ding et al., Salt Lake City, United States. In Ocul Surf, Jul 2015
In a recent study, HGH was shown to activate signal transducer and activators of transcription-5 (STAT5) signaling and promote corneal wound healing by enhancing corneal epithelial migration in a co-culture system of corneal epithelial cells and fibroblasts.
The growth hormone receptor.
Waters, Australia. In Growth Horm Igf Res, Jul 2015
This brings the two kinase domains into position for trans-activation and initiates tyrosine phosphorylation of the receptor cytoplasmic domain and other substrates such as STAT5, the key transcription factor mediating most genomic actions of GH.
Adaptations of protein structure and function to temperature: there is more than one way to 'skin a cat'.
Somero et al., Lancaster, United States. In J Exp Biol, Jun 2015
A series of studies using two structurally and catalytically related enzymes, A4-lactate dehydrogenase (A4-LDH) and cytosolic malate dehydrogenase (cMDH) have been especially valuable in determining the functional attributes of enzymes most sensitive to temperature, and identifying amino acid substitutions that lead to changes in those attributes.
Investigating the Role of JAK/STAT Pathway on Dasatinib-Induced Apoptosis for CML Cell Model K562.
Saydam et al., İzmir, Turkey. In Clin Lymphoma Myeloma Leuk, Jun 2015
mRNA and protein levels of STAT5A and STAT5B genes were significantly reduced in dasatinib-treated K562 cells.
Targeting JAK kinase in solid tumors: emerging opportunities and challenges.
Ernst et al., Melbourne, Australia. In Oncogene, Jun 2015
UNASSIGNED: Various human malignancies are characterized by excessive activation of the Janus family of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and STAT5.
ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.
Akbari et al., Los Angeles, United States. In Immunity, Apr 2015
ILC2s expressed both ICOS and ICOS-ligand, and the ICOS:ICOS-ligand interaction promoted cytokine production and survival in ILC2s through STAT5 signaling.
Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.
Hamel et al., Toronto, Canada. In Dev Biol, 2012
These data demonstrate that expression of an activated allele of c-src overcomes the block to mammary gland morphogenesis in mice arising due to the loss of the cytoplasmic C-terminal domain of Ptch1.
Expression of phosphorylated signal transducer and activator of transcription 5 is associated with an increased risk of death in acute myeloid leukemia.
Advani et al., Cleveland, United States. In Eur J Haematol, 2012
pSTAT5 expression was significantly associated with an increased risk of death and of relapse after achieving complete remission
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.
Heikenwalder et al., Zürich, Switzerland. In Cancer Cell, 2012
CCL2-induced vascular permeability and metastasis is dependent on JAK2-Stat5 and p38MAPK signaling
Enalapril-induced apoptosis of acute promyelocytic leukaemia cells involves STAT5A.
Saydam et al., İzmir, Turkey. In Anticancer Res, 2012
The expression levels of STAT5A gene were significantly reduced in enalapril-treated HL60 cells as compared to untreated controls.
CCL2, galectin-3, and SMRP combination improves the diagnosis of mesothelioma in pleural effusions.
Gregoire et al., Nantes, France. In J Thorac Oncol, 2012
High SMRP is associated with mesothelioma in pleural effusions.
More papers using STAT5 antibodies
FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
Small Donald et al., In Oncogene, 2003
... Rabbit antihuman FLT3 and anti-STAT5 antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation
Barner Ross et al., In Breast Cancer : Basic and Clinical Research, 2003
... Selected positive and negative tissues were analyzed with alternate antibodies, a polyclonal rabbit antiserum directed against STAT5a (L-20, Santa Cruz Biotechnology Inc, Santa Cruz, CA, ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.
Blagosklonny Mikhail V., In PLoS ONE, 2002
... Antibodies to SRC phospho-Y418, STAT5A phospho-Y694, and STAT5A, were purchased from Cell Signaling Technologies (Danvers, MA) ...
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells
Shemanko Carrie S et al., In Breast Cancer Research : BCR, 2002
... Polyclonal rabbit antibodies against HSP90α were acquired from StressGen (Victoria, BC, Canada), and rabbit anti-STAT5B from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma
Leonard Warren J. et al., In The Journal of Experimental Medicine, 2000
... Stat5a and Stat5b transgenic mice were generated and ...
Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes.
Buday Laszlo, In PLoS ONE, 2000
... P-MAPK, MAPK, and anti-P-STAT5(Y694) for westerns were purchased from Cell Signaling Technology (Danvers, MA) ...
SOCS proteins: negative regulators of cytokine signaling.
Hartl Dominik, In PLoS ONE, 2000
... The following antibodies were used for FACS analyses: Alexa Fluor 647 mouse anti-Stat5 (pY694) (BD Biosciences, Breda, The Netherlands, cat ...
High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin.
Blagosklonny Mikhail, In PLoS ONE, 1996
... Polyclonal anti-EPO (H-162), anti-EPOR (M-20), anti-JAK2 (C-20), anti-phospho-JAK2 (Tyr1007/1008), anti-STAT5 (N-20) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: fact or myth
Desmeules Jules et al., In Basic & Clinical Pharmacology & Toxicology, 1996
... -morpholino)ethane-sulfonic acid (MES) was purchased from AppliChem GmbH (Darmstadt, Germany), penicillin–streptomycin from Sigma Aldrich GmbH (Steinheim, Germany), non-essential ...
FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase
Mellado Mario et al., In The Journal of Cell Biology, 1993
... and anti-STAT5 (Santa Cruz Biotechnology ...
β1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
Brizzi Maria Felice et al., In The Journal of Cell Biology, 1993
... The anti–phospho-STAT5 (tyrosine 694/699) antibody was obtained from Cell Signaling and the anti–phospho-STAT5 (serine725/730) ...
CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.
Lesniak Maciej, In PLoS ONE, 1991
... ) mice, Stat5b transgenic (Stat5-Tg) mice ( ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Schuster Stephan C et al., In BMC Biochemistry, 1969
... Geneticin G 418 and Mes were obtained from Sigma, and sorbitol was from Merck.
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