GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Malic enzyme 1, NADP
STAT5, Malate Dehydrogenase, MES, Stat5a, STAT5b, MPF
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers using
STAT5
antibodies
progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement.
Supplier
In PLoS Pathogens, 2009
... , STAT5a/b (SC29495, Santa Cruz Biotechnology), COUP-TFII ( ...
Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.
Supplier
In PLoS ONE, 2006
Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling.
Supplier
In PLoS ONE, 2006
... ), STAT3, STAT5, and AMPKα were purchased from Santa Cruz Biotechnology Inc ...
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.
Supplier
In PLoS ONE, 2006
... Rabbit polyclonal antibodies against c-Cbl, Cbl-b, EpoR, Jak2 (C-20 and M-126), and STAT5A as well as a mouse monoclonal antibody against α-tubulin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Antibody response to influenza vaccination in elderly: A quantitative review
more suppliersSupplier
In PLoS ONE, 2005
... the reaction was carried out for 20 minutes at room temperature.Afterwards, beads were washed with MES-T buffer using centrifugation at 600 G for 8 minutes on 3-µm Transwell inserts (Life Technologies) assembled on top of ...
Papers on
STAT5
The effects of training intensities on motor recovery and gait symmetry in a rat model of ischemia.
New
Guangzhou, China. In Brain Inj, 08 Apr 2013
These results were reflected in the increase in the EMG burst duration and increase in EMG mean power frequency (MPF) drop rate on the affected side in the MTG.
Spatial and functional organization of mitochondrial protein network.
New
South Korea. In Sci Rep, 07 Apr 2013
Here, we characterized the functional and spatial organization of mitochondrial proteins by assessing their position in the Mitochondrial Protein Functional (MPF) network.
The Cytokines IL-21 and GM-CSF Have Opposing Regulatory Roles in the Apoptosis of Conventional Dendritic Cells.
New
Impact
Bethesda, United States. In Immunity, 26 Mar 2013
ChIP-Seq analysis revealed genome-wide binding competition between GM-CSF-induced STAT5 and IL-21-induced STAT3.
The transcription factor STAT5 is critical in dendritic cells for the development of T(H)2 but not T(H)1 responses.
New
Impact
Seattle, United States. In Nat Immunol, 24 Mar 2013
We found here that DC-specific deletion of the transcription factor STAT5 was not critical for development but was required for T helper type 2 (T(H)2), but not T(H)1, allergic responses in both the skin and lungs.
Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP.
New
Impact
Indianapolis, United States. In Immunity, 21 Mar 2013
In primary cell cultures, the addition of TSLP led to an increase in IL-9 production from human and mouse Th9 cells, and induced an increase in signal transducer and activator of transcription 5 (STAT5) activation and binding to the Il9 promoter.
CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response.
New
Impact
Vienna, Austria. In Immunity, 21 Mar 2013
Here, we show that the cyclin-dependent kinase 8 (CDK8) module of the Mediator complex phosphorylated regulatory sites within the TADs of STAT1, STAT3, and STAT5, including S727 within the STAT1 TAD in the interferon (IFN) signaling pathway.
An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development.
New
Impact
Würzburg, Germany. In Nat Immunol, 28 Feb 2013
Although the transcription factor STAT5 is an important component of IL-7 signaling, differences in the phenotypes of mice deficient in STAT5, IL-7, IL-7 receptor alpha (IL-7rα) or the kinase Jak3 suggest the existence of STAT5-independent IL-7 signaling.
Malate and Fumarate Extend Lifespan in Caenorhabditis elegans.
New
Tampa, United States. In Plos One, Dec 2012
Malate, the tricarboxylic acid (TCA) cycle metabolite, increased lifespan and thermotolerance in the nematode Malate can be synthesized from fumarate by the enzyme fumarase and further oxidized to oxaloacetate by malate dehydrogenase with the accompanying reduction of NAD.
Characterisation of P2Y12 Receptor Responsiveness to Cysteinyl Leukotrienes.
New
London, United Kingdom. In Plos One, Dec 2012
In contrast, selective P2Y agonists ADP and 2-MeS-ADP induced specific calcium flux in cells expressing P2Y+ Gα.
STAT6-dependent and -independent mechanisms in Th2 polarization.
Review
New
Salzburg, Austria. In Eur J Immunol, Nov 2012
This article gives an overview on STAT6-dependent and -independent mechanisms involved in the process of Th2 polarization, including Notch, mTORC2, IL-2/STAT5, and Wnt.
Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species.
Review
New
Debrecen, Hungary. In J Allergy Clin Immunol, Nov 2012
Recent research on primary immunodeficiency disorders and the identification of patients carrying germline mutations in STAT1, STAT3, and STAT5B have highlighted the role of human STATs in host defense against various viruses, bacteria, and fungi.
An intrinsically disordered protein, CP12: jack of all trades and master of the Calvin cycle.
Review
New
Marseille, France. In Biochem Soc Trans, Oct 2012
CP12 is promiscuous and interacts with other enzymes such as aldolase and malate dehydrogenase.
Basophil modulation by cytokine instruction.
Review
New
Erlangen, Germany. In Eur J Immunol, Oct 2012
IL-3, GM-CSF, and thymic stromal lymphopoietin activate the STAT5 pathway that promotes proliferation, activation, and cytokine secretion but also induces a negative feedback loop via Pim-1 and SOCS proteins.
Semicarbazone - a versatile therapeutic pharmacophore for fragment based anticonvulsant drug design.
New
In Acta Pharm, Oct 2012
4-(4-Flurophenoxy) benzaldehyde semicarbazone (C0102862, V102862) was discovered as a lead molecule and is being developed as a potent antiepileptic drug, with maximal electroshock (MES) ED50 of i.p. 12.9 mg kg-1.
Myeloid-derived suppressor cells adhere to physiologic STAT3- vs STAT5-dependent hematopoietic programming, establishing diverse tumor-mediated mechanisms of immunologic escape.
Review
Scottsdale, United States. In Immunol Invest, 2011
The presence or absence of GM-CSF is likely the major determinant in each compartment, given that GM-CSF's capacity to preempt STAT3-dependent with dominant STAT5-dependent hematopoietic programming confers sunitinib resistance and redirects differentiation from the n-MDSC lineage to the more versatile monocytoid (m-MDSC) lineage.
Phenotypic spectrum associated with CASK loss-of-function mutations.
GeneRIF
Heidelberg, Germany. In J Med Genet, 2011
Heterozygous mutations in the CASK gene are described in 20 female patients that are associated with distinct brain malformations and phenotypes of remarkably varying degrees.
Association of copy number loss of CDKN2B and PTCH1 with poor overall survival in patients with pulmonary squamous cell carcinoma.
GeneRIF
Harbin, China. In Clin Lung Cancer, 2011
2 genes of loss, CDKN2B and PTCH1, are associated with poor overall survival in patients with squamous cell carcinoma of the lung and may be useful as prognostic markers
Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression.
GeneRIF
Houston, United States. In Mol Cancer, 2010
Mesothelin confers pancreatic cancer cell resistance to TNF-alpha-induced apoptosis through Akt/PI3K/NF-kappa-B activation and IL-6/Mcl-1 overexpression
The hedgehog receptor patched is involved in cholesterol transport.
GeneRIF
Nice, France. In Plos One, 2010
Patched may contribute to cholesterol efflux from cells
Ectopic proliferation contributes to retinal dysplasia in the juvenile zebrafish patched2 mutant eye.
More papers using
STAT5
antibodies
GeneRIF
Austin, United States. In Invest Ophthalmol Vis Sci, 2010
Results demonstrate a direct link between overproliferation and retinal dysplasia in the ptc2-/- juvenile retina and establish ectopic proliferation as the likely cellular underpinning of retinal dysplasia in juvenile ptc2-/- mutants.
FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
Supplier
In Oncogene, 2003
... Rabbit antihuman FLT3 and anti-STAT5 antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation
Supplier
In Breast Cancer : Basic and Clinical Research, 2003
... Selected positive and negative tissues were analyzed with alternate antibodies, a polyclonal rabbit antiserum directed against STAT5a (L-20, Santa Cruz Biotechnology Inc, Santa Cruz, CA, ...
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells
Supplier
In Breast Cancer Research : BCR, 2002
... Polyclonal rabbit antibodies against HSP90α were acquired from StressGen (Victoria, BC, Canada), and rabbit anti-STAT5B from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.
Supplier
In PLoS ONE, 2002
Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma
Supplier
In The Journal of Experimental Medicine, 2000
... Stat5a and Stat5b transgenic mice were generated and ...
SOCS proteins: negative regulators of cytokine signaling.
Supplier
In PLoS ONE, 2000
... The following antibodies were used for FACS analyses: Alexa Fluor 647 mouse anti-Stat5 (pY694) (BD Biosciences, Breda, The Netherlands, cat ...
Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes.
Supplier
In PLoS ONE, 2000
... P-MAPK, MAPK, and anti-P-STAT5(Y694) for westerns were purchased from Cell Signaling Technology (Danvers, MA) ...
High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin.
Supplier
In PLoS ONE, 1996
... Polyclonal anti-EPO (H-162), anti-EPOR (M-20), anti-JAK2 (C-20), anti-phospho-JAK2 (Tyr1007/1008), anti-STAT5 (N-20) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: fact or myth
Supplier
In Basic & Clinical Pharmacology & Toxicology, 1996
... -morpholino)ethane-sulfonic acid (MES) was purchased from AppliChem GmbH (Darmstadt, Germany), penicillin–streptomycin from Sigma Aldrich GmbH (Steinheim, Germany), non-essential ...
β1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
Supplier
In The Journal of Cell Biology, 1993
FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase
Supplier
In The Journal of Cell Biology, 1993
... and anti-STAT5 (Santa Cruz Biotechnology ...
CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.
Supplier
In PLoS ONE, 1991
... ) mice, Stat5b transgenic (Stat5-Tg) mice ( ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Supplier
In BMC Biochemistry, 1969
... Geneticin G 418 and Mes were obtained from Sigma, and sorbitol was from Merck.
