Mutant prolactin receptor and familial hyperprolactinemia.
Glasgow, United Kingdom. In N Engl J Med, 21 Dec 2013
This substitution disrupted the high-affinity ligand-binding interface of the prolactin receptor, resulting in a loss of downstream signaling by Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5).
Nucleic acid-based approaches to STAT inhibition.
Pittsburgh, United States. In Jakstat, Nov 2012
Among the STAT proteins, especially STAT3, followed by STAT5, are the most frequently activated oncogenic STATs, which have emerged as plausible therapeutic cancer targets.
STAT transcription in the ischemic heart.
More papers using
London, United Kingdom. In Jakstat, May 2012
Prolonged activation of STAT3, however, is strongly implicated in the post-infarction remodeling of the heart which leads to heart failure, where, possibly together with STAT5, it augments activation of the renin-angiotensin system.