GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Jun 2013.
Malic enzyme 1, NADP
STAT5, Malate Dehydrogenase, MES, Stat5a, STAT5b, MPF
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008] (from
NCBI)
Sponsored links
Papers using
STAT5
antibodies
progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement.
Supplier
In PLoS Pathogens, 2009
... , STAT5a/b (SC29495, Santa Cruz Biotechnology), COUP-TFII ( ...
Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.
Supplier
In PLoS ONE, 2006
Identification of SH2B2beta as an inhibitor for SH2B1- and SH2B2alpha-promoted Janus kinase-2 activation and insulin signaling.
Supplier
In PLoS ONE, 2006
... ), STAT3, STAT5, and AMPKα were purchased from Santa Cruz Biotechnology Inc ...
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.
Supplier
In PLoS ONE, 2006
... Rabbit polyclonal antibodies against c-Cbl, Cbl-b, EpoR, Jak2 (C-20 and M-126), and STAT5A as well as a mouse monoclonal antibody against α-tubulin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Antibody response to influenza vaccination in elderly: A quantitative review
more suppliersSupplier
In PLoS ONE, 2005
... the reaction was carried out for 20 minutes at room temperature.Afterwards, beads were washed with MES-T buffer using centrifugation at 600 G for 8 minutes on 3-µm Transwell inserts (Life Technologies) assembled on top of ...
Papers on
STAT5
Mutational Landscape of Basal Cell Carcinomas by Whole Exome Sequencing.
New
Roanoke, United States. In J Invest Dermatol, 17 Jul 2013
After correction for multiple hypotheses testing, InVEx identified only PTCH1 as having a significant functional mutation burden.
RHPN2 Drives Mesenchymal Transformation in Malignant Glioma by Triggering RhoA Activation.
New
Colombia. In Cancer Res, 17 Jul 2013
Mesenchymal (MES) transformation is the hallmark feature that determines aggressiveness of human glioblastoma (GBM).
Age-related changes and nutritional regulation of myosin heavy-chain composition in longissimus dorsi of commercial pigs.
New
Hangzhou, China. In Animal, 14 Jul 2013
We analysed the composition (%) of myosin heavy-chain (MyHC) mRNA according to the absolute copies of each MyHC (I, IIa, IIb and IIx) mRNA, and the activities of succinate dehydrogenase (SDH) and malate dehydrogenase (MDH) in the longissimus muscle.
Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma.
New
Beijing, China. In Leuk Res, 11 Jul 2013
We evaluated the association between genetic polymorphisms (SNPs) in 12 JAK/STAT pathway genes (JAK3, STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6, SCOS1, SCOS2, SCOS3, and SCOS4) and NHL risk in a population-based case-control study of Connecticut women.
The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation.
New
Impact
Houston, United States. In Nat Immunol, 02 Jul 2013
Here we found that the SOCS protein CIS, which was substantially induced by interleukin 4 (IL-4), negatively regulated the activation of STAT3, STAT5 and STAT6 in T cells.
Differentiating the roles of STAT5B and STAT5A in human CD4(+) T cells.
New
Stanford, United States. In Clin Immunol, 05 Jun 2013
STAT5A and STAT5B are highly homologous proteins whose distinctive roles in human immunity remain unclear.
MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.
New
Impact
Lausanne, Switzerland. In Immunity, 18 May 2013
miRNA-155 deficiency resulted in accumulation of suppressor of cytokine signaling-1 (SOCS-1) causing defective cytokine signaling through STAT5.
Anti-GM-CSF autoantibodies in patients with cryptococcal meningitis.
Review
New
Bethesda, United States. In J Immunol, 15 May 2013
Plasma from all patients prevented GM-CSF-induced STAT5 phosphorylation and MIP-1α production in normal PBMCs.
The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses.
New
Impact
Seattle, United States. In Nat Immunol, Apr 2013
We found here that DC-specific deletion of the transcription factor STAT5 was not critical for development but was required for T helper type 2 (TH2), but not TH1, allergic responses in both the skin and lungs.
The cytokines IL-21 and GM-CSF have opposing regulatory roles in the apoptosis of conventional dendritic cells.
New
Impact
Bethesda, United States. In Immunity, Apr 2013
ChIP-Seq analysis revealed genome-wide binding competition between GM-CSF-induced STAT5 and IL-21-induced STAT3.
Interleukin-9 is required for allergic airway inflammation mediated by the cytokine TSLP.
New
Impact
Indianapolis, United States. In Immunity, Mar 2013
In primary cell cultures, the addition of TSLP led to an increase in IL-9 production from human and mouse Th9 cells, and induced an increase in signal transducer and activator of transcription 5 (STAT5) activation and binding to the Il9 promoter.
Erythropoietin: multiple targets, actions, and modifying influences for biological and clinical consideration.
Review
New
Indianapolis, United States. In J Exp Med, Mar 2013
Ligation of EPORs triggers various signaling pathways, including the JAK2-STAT5 and MAPK-NF-κB pathways, depending both on the receptor and the target cell type.
Growth hormone and cell growth.
Review
Australia. In Endocr Dev, 2011
GH acts via its cell membrane receptor to initiate a range of signalling pathways, with JAK2 kinase activation of STAT5 being the most important.
Spectrum of insulin-like growth factor deficiency.
Review
Leiden, Netherlands. In Endocr Dev, 2011
Of the three GH signal transduction defects, a STAT5B defect is well established, but abnormalities in the MAPK pathway (such as PTPN11 mutations in Noonan syndrome) and NF-ĸB pathway (IĸBα mutation) may also cause IGFD.
The role of microRNA in metastatic colorectal cancer and its significance in cancer prognosis and treatment.
Review
Łódź, Poland. In Acta Biochim Pol, 2011
microRNA levels may serve as a predictive CRC marker, which was confirmed by the serum level of miR-29a targeting KLF4, a marker of cell stemness, and the plasma level of miR-221 down-regulating c-Kit, Stat5A and ETS1, which are signal transducers and transcription factor, respectively.
Phenotypic spectrum associated with CASK loss-of-function mutations.
GeneRIF
Heidelberg, Germany. In J Med Genet, 2011
Heterozygous mutations in the CASK gene are described in 20 female patients that are associated with distinct brain malformations and phenotypes of remarkably varying degrees.
Association of copy number loss of CDKN2B and PTCH1 with poor overall survival in patients with pulmonary squamous cell carcinoma.
GeneRIF
Harbin, China. In Clin Lung Cancer, 2011
2 genes of loss, CDKN2B and PTCH1, are associated with poor overall survival in patients with squamous cell carcinoma of the lung and may be useful as prognostic markers
Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression.
GeneRIF
Houston, United States. In Mol Cancer, 2010
Mesothelin confers pancreatic cancer cell resistance to TNF-alpha-induced apoptosis through Akt/PI3K/NF-kappa-B activation and IL-6/Mcl-1 overexpression
The hedgehog receptor patched is involved in cholesterol transport.
GeneRIF
Nice, France. In Plos One, 2010
Patched may contribute to cholesterol efflux from cells
Ectopic proliferation contributes to retinal dysplasia in the juvenile zebrafish patched2 mutant eye.
More papers using
STAT5
antibodies
GeneRIF
Austin, United States. In Invest Ophthalmol Vis Sci, 2010
Results demonstrate a direct link between overproliferation and retinal dysplasia in the ptc2-/- juvenile retina and establish ectopic proliferation as the likely cellular underpinning of retinal dysplasia in juvenile ptc2-/- mutants.
FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
Supplier
In Oncogene, 2003
... Rabbit antihuman FLT3 and anti-STAT5 antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation
Supplier
In Breast Cancer : Basic and Clinical Research, 2003
... Selected positive and negative tissues were analyzed with alternate antibodies, a polyclonal rabbit antiserum directed against STAT5a (L-20, Santa Cruz Biotechnology Inc, Santa Cruz, CA, ...
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells
Supplier
In Breast Cancer Research : BCR, 2002
... Polyclonal rabbit antibodies against HSP90α were acquired from StressGen (Victoria, BC, Canada), and rabbit anti-STAT5B from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.
Supplier
In PLoS ONE, 2002
Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma
Supplier
In The Journal of Experimental Medicine, 2000
... Stat5a and Stat5b transgenic mice were generated and ...
SOCS proteins: negative regulators of cytokine signaling.
Supplier
In PLoS ONE, 2000
... The following antibodies were used for FACS analyses: Alexa Fluor 647 mouse anti-Stat5 (pY694) (BD Biosciences, Breda, The Netherlands, cat ...
Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes.
Supplier
In PLoS ONE, 2000
... P-MAPK, MAPK, and anti-P-STAT5(Y694) for westerns were purchased from Cell Signaling Technology (Danvers, MA) ...
High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin.
Supplier
In PLoS ONE, 1996
... Polyclonal anti-EPO (H-162), anti-EPOR (M-20), anti-JAK2 (C-20), anti-phospho-JAK2 (Tyr1007/1008), anti-STAT5 (N-20) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: fact or myth
Supplier
In Basic & Clinical Pharmacology & Toxicology, 1996
... -morpholino)ethane-sulfonic acid (MES) was purchased from AppliChem GmbH (Darmstadt, Germany), penicillin–streptomycin from Sigma Aldrich GmbH (Steinheim, Germany), non-essential ...
β1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
Supplier
In The Journal of Cell Biology, 1993
FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase
Supplier
In The Journal of Cell Biology, 1993
... and anti-STAT5 (Santa Cruz Biotechnology ...
CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.
Supplier
In PLoS ONE, 1991
... ) mice, Stat5b transgenic (Stat5-Tg) mice ( ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Supplier
In BMC Biochemistry, 1969
... Geneticin G 418 and Mes were obtained from Sigma, and sorbitol was from Merck.
