Regulatory T cell proliferative potential is impaired in human autoimmune disease.
Napoli, Italy. In Nat Med, 31 Jan 2014
Here we report that proliferation of Treg cells after TCR stimulation is impaired in subjects with relapsing-remitting multiple sclerosis (RRMS) because of altered interleukin-2 (IL-2) secretion and IL-2 receptor (IL-2R)-signal transducer and activator of transcription 5 (STAT5) signaling.
Mutant prolactin receptor and familial hyperprolactinemia.
Glasgow, United Kingdom. In N Engl J Med, Dec 2013
This substitution disrupted the high-affinity ligand-binding interface of the prolactin receptor, resulting in a loss of downstream signaling by Janus kinase 2 (JAK2) and signal transducer and activator of transcription 5 (STAT5).
STAT5 in hematopoietic stem cell biology and transplantation.
Atlanta, United States. In Jakstat, Nov 2013
UNLABELLED: Signal transducer and activator of transcription 5 (STAT5) regulates normal lympho-myeloid development through activation downstream of early-acting cytokines, their receptors, and Janus kinases (JAKs).
STATs get their move on.
Stony Brook, United States. In Jakstat, Nov 2013
Distinctly, STAT3, STAT5, and STAT6 are continually imported to the nucleus independent of tyrosine phosphorylation.
[Variations in the protein and enzyme pattern during pollen meiosis and pollen development].
More papers using
Nijmegen, Netherlands. In Planta, 1966
The pattern undergoes a phase-specific variation: every cytological stage shows a specific protein pattern.The fractions could be partially identified by incubation with substrate and by specific enzyme staining of some of the enzymes (phosphorylase, acid phosphatase, peroxydase, thiamine pyrophosphatase, malate dehydrogenase, lactate dehydrogenase).