This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008] (from
... Rabbit polyclonal antibodies against c-Cbl, Cbl-b, EpoR, Jak2 (C-20 and M-126), and STAT5A as well as a mouse monoclonal antibody against α-tubulin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
... the reaction was carried out for 20 minutes at room temperature.Afterwards, beads were washed with MES-T buffer using centrifugation at 600 G for 8 minutes on 3-µm Transwell inserts (Life Technologies) assembled on top of ...
Isomäki et al., Tampere, Finland. In Clin Exp Immunol, 02 Apr 2015
To this end, PB samples were drawn from 16 patients with active pSS and 16 healthy blood donors, and the phosphorylation of STAT1, STAT3, STAT4, STAT5 and STAT6 proteins was studied in T cells, B cells and monocytes using multicolor flow cytometry.
Weaver et al., Birmingham, United States. In Nat Immunol, 31 Mar 2015
By repressing expression of the negative regulator SOCS3 dependent on the transcription factor NF-κB, IL-1 increased the amplitude and duration of phosphorylation of the transcription factor STAT3 induced by TH17-polarizing cytokines, which led to an altered balance in the binding of STAT3 and STAT5 to shared consensus sequences in developing T cells.
Wolff et al., Sacramento, United States. In Epilepsy Res, 28 Feb 2015
UNASSIGNED: The antiepileptic drug lacosamide [(R)-2-acetamido-N-benzyl-3-methoxypropanamide], a chiral functionalized amino acid, was originally identified by virtue of activity in the mouse and rat maximal electroshock (MES) test.
Schraenen et al., Leuven, Belgium. In Cell Metab, Jan 2015
Locally secreted hGH binds to prolactin receptors on β cells, activates STAT5 signaling, and induces pregnancy-like changes in gene expression, thereby augmenting pancreatic β cell mass and insulin content.
Trautwein et al., Aachen, Germany. In Cell Death Dis, Dec 2014
However, gp130(Δhepa) livers revealed aberrant STAT5 activation and decreased levels of transforming growth factor-β (TGFβ), pSMAD2/3 and SMAD2, whereas phosphorylation of STAT3 at Tyr705 and Ser727 was absent.
Bishop et al., United States. In Nat Immunol, Sep 2014
TRAF3 dampened interleukin 2 (IL-2) signaling by facilitating recruitment of the tyrosine phosphatase TCPTP to the IL-2 receptor complex, which resulted in dephosphorylation of the signaling molecules Jak1 and Jak3 and negative regulation of signaling via Jak and the transcription factor STAT5.
Chiang et al., State College, United States. In Membranes (basel), 2013
When Saccharomyces cerevisiae is starved of glucose, the gluconeogenic enzymes fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase, isocitrate lyase, and malate dehydrogenase, as well as the non-gluconeogenic enzymes glyceraldehyde-3-phosphate dehydrogenase and cyclophilin A, are secreted into the periplasm.