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Malic enzyme 1, NADP

STAT5, Malate Dehydrogenase, MES, Stat5a, STAT5b, MPF
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, STAT3, ACID, HAD
Papers using STAT5 antibodies
progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement.
Damania Blossom, In PLoS Pathogens, 2009
... , STAT5a/b (SC29495, Santa Cruz Biotechnology), COUP-TFII ( ...
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.
Navarro Alfons, In PLoS ONE, 2006
... Rabbit polyclonal antibodies against c-Cbl, Cbl-b, EpoR, Jak2 (C-20 and M-126), and STAT5A as well as a mouse monoclonal antibody against α-tubulin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.
Meurs Eliane F., In PLoS ONE, 2006
... (4921), STAT5 (9358) phosphorylated STAT5 (9356), and the Alexa fluor-conjugated rabbit monoclonal antibody against phosphorylated STAT5 (3939) were obtained from Cell Signaling (Beverly, MA) ...
Antibody response to influenza vaccination in elderly: A quantitative review
Pied Sylviane, In PLoS ONE, 2005
... the reaction was carried out for 20 minutes at room temperature.Afterwards, beads were washed with MES-T buffer using centrifugation at 600 G for 8 minutes on 3-µm Transwell inserts (Life Technologies) assembled on top of ...
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Papers on STAT5
In vitro steroid-induced meiosis in Rhinella arenarum oocytes: role of pre-MPF activation.
Zelarayán et al., San Miguel de Tucumán, Argentina. In Zygote, 26 Jun 2015
Thus, androgens such as DHEA, T and AD are as competent as P4 to activate pre-MPF.
Differential antigen expression and aberrant signalling via PI3/AKT, MAP/ERK, JAK/STAT and Wnt/β catenin pathways in Lin-/CD38-/CD34+ cells in acute myeloid leukemia (AML).
Madkaikar et al., Mumbai, India. In Eur J Haematol, 23 Jun 2015
Constitutive activation of phospho ERK, AKT and STAT5 in these cells was associated with poor outcome.
Targeting JAK kinase in solid tumors: emerging opportunities and challenges.
Ernst et al., Melbourne, Australia. In Oncogene, 18 Jun 2015
UNASSIGNED: Various human malignancies are characterized by excessive activation of the Janus family of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and STAT5.
Proteomic analysis of differentially expressed proteins in the marine fish parasitic ciliate Cryptocaryon irritans.
Li et al., Guangzhou, China. In Vet Parasitol, 14 Jun 2015
Furthermore, β-tubulin, the metabolic-related protein enolase, NADH-ubiquinone oxidoreductase 75kDa subunit, malate dehydrogenase, as well as polypyrimidine tract-binding protein, glutamine synthetase, protein kinase domain containing protein, TNFR/NGFR cysteine-rich region family protein, and vacuolar ATP synthase catalytic subunit α, were commonly detected by grouper anti-sera.
Review of STAT3 (Signal Transducers and Activators of Transcription) in head and neck cancer.
Mali, India. In Oral Oncol, 24 Apr 2015
In cancer cells, STAT3 and STAT5 activation leads to the increased expression of downstream target genes, leading to increased cell proliferation, cell survival, angiogenesis, and immune system evasion.
ICOS:ICOS-ligand interaction is required for type 2 innate lymphoid cell function, homeostasis, and induction of airway hyperreactivity.
Akbari et al., Los Angeles, United States. In Immunity, 17 Apr 2015
ILC2s expressed both ICOS and ICOS-ligand, and the ICOS:ICOS-ligand interaction promoted cytokine production and survival in ILC2s through STAT5 signaling.
IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance.
Weaver et al., Birmingham, United States. In Nat Immunol, Mar 2015
By repressing expression of the negative regulator SOCS3 dependent on the transcription factor NF-κB, IL-1 increased the amplitude and duration of phosphorylation of the transcription factor STAT3 induced by TH17-polarizing cytokines, which led to an altered balance in the binding of STAT3 and STAT5 to shared consensus sequences in developing T cells.
A cytosolic thioredoxin acts as a molecular chaperone for peroxisome matrix proteins as well as antioxidant in peroxisome.
Cheon et al., Seoul, South Korea. In Mol Cells, Mar 2015
In addition, the chaperone function of GmTRX was demonstrated in in vitro molecular chaperone activity assays including the thermal denaturation assay and malate dehydrogenase aggregation assay.
Impacts of drought stress on soluble carbohydrates and respiratory enzymes in fruit body of Auricularia auricula.
Chen et al., Harbin, China. In Biotechnol Biotechnol Equip, Feb 2015
The activities of phosphoglucose isomerase (PGI), combined glucose-6-phosphate dehydrogenase (G-6-PDH) and 6-phosphogluconate dehydrogenase (6-PGDH), and malate dehydrogenase (MDH), were also determined.
Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression.
Schraenen et al., Leuven, Belgium. In Cell Metab, Jan 2015
Locally secreted hGH binds to prolactin receptors on β cells, activates STAT5 signaling, and induces pregnancy-like changes in gene expression, thereby augmenting pancreatic β cell mass and insulin content.
Signaling pathways in insulin- and IGF-I mediated oocyte maturation in lower vertebrates.
Gupta et al., In Indian J Biochem Biophys, Dec 2014
Exposure of fully-grown oocytes to steroids or growth factors (insulin/IGFs) initiates various signaling cascade, leading to formation and activation of maturation-promoting factor (MPF), a key enzyme that catalyzes entry into M-phase of meiosis I and II.
A positive feedback loop between prolactin and STAT5 promotes angiogenesis.
Friedl et al., Madison, United States. In Adv Exp Med Biol, Dec 2014
STAT5 activation is necessary and sufficient to induce migration, invasion and tube formation of endothelial cells.
Prolactin-induced prostate tumorigenesis.
Goffin et al., Paris, France. In Adv Exp Med Biol, Dec 2014
Mainly through the activation of its downstream target STAT5, PRL can induce growth and survival of prostate cancer cells and tissues in several experimental settings.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Mullighan et al., Memphis, United States. In N Engl J Med, Oct 2014
Expression of ABL1, ABL2, CSF1R, JAK2, and PDGFRB fusions resulted in cytokine-independent proliferation and activation of phosphorylated STAT5.
Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.
Rudensky et al., New York City, United States. In Cell, Sep 2014
Here, we show that a dedicated Foxp3 intronic element CNS2 maintains Treg cell lineage identity by acting as a sensor of the essential Treg cell growth factor IL-2 and its downstream target STAT5.
Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.
Hamel et al., Toronto, Canada. In Dev Biol, 2012
These data demonstrate that expression of an activated allele of c-src overcomes the block to mammary gland morphogenesis in mice arising due to the loss of the cytoplasmic C-terminal domain of Ptch1.
Expression of phosphorylated signal transducer and activator of transcription 5 is associated with an increased risk of death in acute myeloid leukemia.
Advani et al., Cleveland, United States. In Eur J Haematol, 2012
pSTAT5 expression was significantly associated with an increased risk of death and of relapse after achieving complete remission
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.
Heikenwalder et al., Zürich, Switzerland. In Cancer Cell, 2012
CCL2-induced vascular permeability and metastasis is dependent on JAK2-Stat5 and p38MAPK signaling
Enalapril-induced apoptosis of acute promyelocytic leukaemia cells involves STAT5A.
Saydam et al., İzmir, Turkey. In Anticancer Res, 2012
The expression levels of STAT5A gene were significantly reduced in enalapril-treated HL60 cells as compared to untreated controls.
CCL2, galectin-3, and SMRP combination improves the diagnosis of mesothelioma in pleural effusions.
Gregoire et al., Nantes, France. In J Thorac Oncol, 2012
High SMRP is associated with mesothelioma in pleural effusions.
More papers using STAT5 antibodies
FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
Small Donald et al., In Oncogene, 2003
... Rabbit antihuman FLT3 and anti-STAT5 antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation
Barner Ross et al., In Breast Cancer : Basic and Clinical Research, 2003
... Selected positive and negative tissues were analyzed with alternate antibodies, a polyclonal rabbit antiserum directed against STAT5a (L-20, Santa Cruz Biotechnology Inc, Santa Cruz, CA, ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.
Blagosklonny Mikhail V., In PLoS ONE, 2002
... Antibodies to SRC phospho-Y418, STAT5A phospho-Y694, and STAT5A, were purchased from Cell Signaling Technologies (Danvers, MA) ...
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells
Shemanko Carrie S et al., In Breast Cancer Research : BCR, 2002
... Polyclonal rabbit antibodies against HSP90α were acquired from StressGen (Victoria, BC, Canada), and rabbit anti-STAT5B from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma
Leonard Warren J. et al., In The Journal of Experimental Medicine, 2000
... Stat5a and Stat5b transgenic mice were generated and ...
Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes.
Buday Laszlo, In PLoS ONE, 2000
... P-MAPK, MAPK, and anti-P-STAT5(Y694) for westerns were purchased from Cell Signaling Technology (Danvers, MA) ...
SOCS proteins: negative regulators of cytokine signaling.
Hartl Dominik, In PLoS ONE, 2000
... The following antibodies were used for FACS analyses: Alexa Fluor 647 mouse anti-Stat5 (pY694) (BD Biosciences, Breda, The Netherlands, cat ...
High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin.
Blagosklonny Mikhail, In PLoS ONE, 1996
... Polyclonal anti-EPO (H-162), anti-EPOR (M-20), anti-JAK2 (C-20), anti-phospho-JAK2 (Tyr1007/1008), anti-STAT5 (N-20) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: fact or myth
Desmeules Jules et al., In Basic & Clinical Pharmacology & Toxicology, 1996
... -morpholino)ethane-sulfonic acid (MES) was purchased from AppliChem GmbH (Darmstadt, Germany), penicillin–streptomycin from Sigma Aldrich GmbH (Steinheim, Germany), non-essential ...
FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase
Mellado Mario et al., In The Journal of Cell Biology, 1993
... and anti-STAT5 (Santa Cruz Biotechnology ...
β1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
Brizzi Maria Felice et al., In The Journal of Cell Biology, 1993
... The anti–phospho-STAT5 (tyrosine 694/699) antibody was obtained from Cell Signaling and the anti–phospho-STAT5 (serine725/730) ...
CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.
Lesniak Maciej, In PLoS ONE, 1991
... ) mice, Stat5b transgenic (Stat5-Tg) mice ( ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Schuster Stephan C et al., In BMC Biochemistry, 1969
... Geneticin G 418 and Mes were obtained from Sigma, and sorbitol was from Merck.
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