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Malic enzyme 1, NADP

STAT5, Malate Dehydrogenase, MES, Stat5a, STAT5b, MPF
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, STAT3, ACID, HAD
Papers using STAT5 antibodies
progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement.
Damania Blossom, In PLoS Pathogens, 2009
... , STAT5a/b (SC29495, Santa Cruz Biotechnology), COUP-TFII ( ...
Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta.
Navarro Alfons, In PLoS ONE, 2006
... Rabbit polyclonal antibodies against c-Cbl, Cbl-b, EpoR, Jak2 (C-20 and M-126), and STAT5A as well as a mouse monoclonal antibody against α-tubulin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Alpha E beta 7 integrin interaction with E-cadherin promotes antitumor CTL activity by triggering lytic granule polarization and exocytosis.
Meurs Eliane F., In PLoS ONE, 2006
... (4921), STAT5 (9358) phosphorylated STAT5 (9356), and the Alexa fluor-conjugated rabbit monoclonal antibody against phosphorylated STAT5 (3939) were obtained from Cell Signaling (Beverly, MA) ...
Antibody response to influenza vaccination in elderly: A quantitative review
Pied Sylviane, In PLoS ONE, 2005
... the reaction was carried out for 20 minutes at room temperature.Afterwards, beads were washed with MES-T buffer using centrifugation at 600 G for 8 minutes on 3-µm Transwell inserts (Life Technologies) assembled on top of ...
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Papers on STAT5
Increase in peroxisome number and the gene expression of putative glyoxysomal enzymes in Chlamydomonas cells supplemented with acetate.
Watanabe et al., Niigata, Japan. In J Plant Res, 21 Dec 2014
The transcript levels of genes encoding malate synthase, malate dehydrogenase, isocitrate lyase, and citrate synthase increased when Chlamydomonas cells were grown on minimal culture medium supplemented with acetate.
Producing GM-CSF: a unique T helper subset?
Flavell et al., New Haven, United States. In Cell Res, 21 Dec 2014
An article by Sheng et al. recently published by Cell Research now suggests that the differentiation program of GM-CSF-producing cells from naïve CD4 T cells is distinct from that of Th1 and Th17 cells, and is regulated by the IL-7-STAT5 axis.
In Vivo Maintenance of Human Regulatory T Cells during CD25 Blockade.
Fontenot et al., Cambridge, United States. In J Immunol, 21 Dec 2014
In the presence of daclizumab, IL-2 serum concentrations increased and IL-2Rβγ signaling induced STAT5 phosphorylation and sustained FOXP3 expression.
Mechanisms of Resistance to Cabazitaxel.
Sikic et al., Stanford, United States. In Mol Cancer Ther, 21 Dec 2014
Among multidrug resistant (MDR) variants, cabazitaxel was relatively less cross-resistant than paclitaxel and docetaxel (15 vs. 200-fold in MES-SA/Dx5 and 9 vs. 60-fold in MCF-7/TxT50, respectively).
Nanomolar-Potency Small Molecule Inhibitor of STAT5 Protein.
Gunning et al., Toronto, Canada. In Acs Med Chem Lett, 13 Dec 2014
UNLABELLED: We herein report the design and synthesis of the first nanomolar binding inhibitor of STAT5 protein.
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Mullighan et al., Memphis, United States. In N Engl J Med, 11 Oct 2014
Expression of ABL1, ABL2, CSF1R, JAK2, and PDGFRB fusions resulted in cytokine-independent proliferation and activation of phosphorylated STAT5.
The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2.
Bishop et al., United States. In Nat Immunol, Sep 2014
TRAF3 dampened interleukin 2 (IL-2) signaling by facilitating recruitment of the tyrosine phosphatase TCPTP to the IL-2 receptor complex, which resulted in dephosphorylation of the signaling molecules Jak1 and Jak3 and negative regulation of signaling via Jak and the transcription factor STAT5.
Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus.
Rudensky et al., New York City, United States. In Cell, Sep 2014
Here, we show that a dedicated Foxp3 intronic element CNS2 maintains Treg cell lineage identity by acting as a sensor of the essential Treg cell growth factor IL-2 and its downstream target STAT5.
The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.
Walzer et al., Lyon, France. In Nat Immunol, Aug 2014
Here we found that the metabolic checkpoint kinase mTOR was activated and boosted bioenergetic metabolism after exposure of NK cells to high concentrations of IL-15, whereas low doses of IL-15 triggered only phosphorylation of the transcription factor STAT5. mTOR stimulated the growth and nutrient uptake of NK cells and positively fed back on the receptor for IL-15.
Long-lived charge separation and applications in artificial photosynthesis.
Suenobu et al., Suita, Japan. In Acc Chem Res, Jun 2014
Our most successful example, 9-mesityl-10-methylacridinium ion (Acr(+)-Mes), can undergo a fast photoinduced ET from the mesityl (Mes) moiety to the singlet excited state of the acridinium ion moiety (Acr(+)) with extremely slow back ET.
Retinoic acid signaling and mouse embryonic stem cells differentiation: Cross talk between genomic and non-genomic effects of RA.
Rochette-Egly, Illkirch-Graffenstaden, France. In Biochim Biophys Acta, May 2014
In order to investigate the relevance of RARs phosphorylation in cell differentiation, mouse embryonic stem (mES) cells were used as a model.
Balancing Proliferation with Igκ Recombination during B-lymphopoiesis.
Clark et al., Chicago, United States. In Front Immunol, Dec 2013
Remarkably, the principal downstream proliferative effectors of the IL-7R, STAT5 and cyclin D3, directly repress Igκ accessibility through very divergent yet complementary mechanisms.
Exocytosis and Endocytosis of Small Vesicles across the Plasma Membrane in Saccharomyces cerevisiae.
Chiang et al., State College, United States. In Membranes (basel), Dec 2013
When Saccharomyces cerevisiae is starved of glucose, the gluconeogenic enzymes fructose-1,6-bisphosphatase (FBPase), phosphoenolpyruvate carboxykinase, isocitrate lyase, and malate dehydrogenase, as well as the non-gluconeogenic enzymes glyceraldehyde-3-phosphate dehydrogenase and cyclophilin A, are secreted into the periplasm.
Mulberry ( sang shèn zǐ) and its bioactive compounds, the chemoprevention effects and molecular mechanisms in vitro and in vivo.
Wang et al., T'ai-chung-shih, Taiwan. In J Tradit Complement Med, 2013
This review thus focuses on the recent advances of mulberry extracts (MEs) and their applications in the prevention and treatment of human cancer, liver disease, obesity, diabetes, and cardiovascular disease.
Evaluation of Signaling Pathways Involved in γ-Globin Gene Induction Using Fetal Hemoglobin Inducer Drugs.
Mousakhani et al., Ahvāz, Iran. In Int J Hematol Oncol Stem Cell Res, 2012
Several studies suggest that activating P38 MAPK, RAS and STAT5 signaling pathways result in efficient HbF induction.
Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1.
Hamel et al., Toronto, Canada. In Dev Biol, 2012
These data demonstrate that expression of an activated allele of c-src overcomes the block to mammary gland morphogenesis in mice arising due to the loss of the cytoplasmic C-terminal domain of Ptch1.
Expression of phosphorylated signal transducer and activator of transcription 5 is associated with an increased risk of death in acute myeloid leukemia.
Advani et al., Cleveland, United States. In Eur J Haematol, 2012
pSTAT5 expression was significantly associated with an increased risk of death and of relapse after achieving complete remission
Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.
Heikenwalder et al., Zürich, Switzerland. In Cancer Cell, 2012
CCL2-induced vascular permeability and metastasis is dependent on JAK2-Stat5 and p38MAPK signaling
Enalapril-induced apoptosis of acute promyelocytic leukaemia cells involves STAT5A.
Saydam et al., İzmir, Turkey. In Anticancer Res, 2012
The expression levels of STAT5A gene were significantly reduced in enalapril-treated HL60 cells as compared to untreated controls.
CCL2, galectin-3, and SMRP combination improves the diagnosis of mesothelioma in pleural effusions.
Gregoire et al., Nantes, France. In J Thorac Oncol, 2012
High SMRP is associated with mesothelioma in pleural effusions.
More papers using STAT5 antibodies
FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells
Small Donald et al., In Oncogene, 2003
... Rabbit antihuman FLT3 and anti-STAT5 antibody were obtained from Santa Cruz Biotechnology (Santa Cruz, CA) ...
A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation
Barner Ross et al., In Breast Cancer : Basic and Clinical Research, 2003
... Selected positive and negative tissues were analyzed with alternate antibodies, a polyclonal rabbit antiserum directed against STAT5a (L-20, Santa Cruz Biotechnology Inc, Santa Cruz, CA, ...
Evaluation of multidimensional chromatography coupled with tandem mass spectrometry (LC/LC-MS/MS) for large-scale protein analysis: the yeast proteome.
Blagosklonny Mikhail V., In PLoS ONE, 2002
... Antibodies to SRC phospho-Y418, STAT5A phospho-Y694, and STAT5A, were purchased from Cell Signaling Technologies (Danvers, MA) ...
The heat shock protein 90 inhibitor geldanamycin and the ErbB inhibitor ZD1839 promote rapid PP1 phosphatase-dependent inactivation of AKT in ErbB2 overexpressing breast cancer cells
Shemanko Carrie S et al., In Breast Cancer Research : BCR, 2002
... Polyclonal rabbit antibodies against HSP90α were acquired from StressGen (Victoria, BC, Canada), and rabbit anti-STAT5B from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Stat5 Synergizes with T Cell Receptor/Antigen Stimulation in the Development of Lymphoblastic Lymphoma
Leonard Warren J. et al., In The Journal of Experimental Medicine, 2000
... Stat5a and Stat5b transgenic mice were generated and ...
Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes.
Buday Laszlo, In PLoS ONE, 2000
... P-MAPK, MAPK, and anti-P-STAT5(Y694) for westerns were purchased from Cell Signaling Technology (Danvers, MA) ...
SOCS proteins: negative regulators of cytokine signaling.
Hartl Dominik, In PLoS ONE, 2000
... The following antibodies were used for FACS analyses: Alexa Fluor 647 mouse anti-Stat5 (pY694) (BD Biosciences, Breda, The Netherlands, cat ...
High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin.
Blagosklonny Mikhail, In PLoS ONE, 1996
... Polyclonal anti-EPO (H-162), anti-EPOR (M-20), anti-JAK2 (C-20), anti-phospho-JAK2 (Tyr1007/1008), anti-STAT5 (N-20) antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA) ...
In vitro permeability across Caco-2 cells (colonic) can predict in vivo (small intestinal) absorption in man: fact or myth
Desmeules Jules et al., In Basic & Clinical Pharmacology & Toxicology, 1996
... -morpholino)ethane-sulfonic acid (MES) was purchased from AppliChem GmbH (Darmstadt, Germany), penicillin–streptomycin from Sigma Aldrich GmbH (Steinheim, Germany), non-essential ...
FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase
Mellado Mario et al., In The Journal of Cell Biology, 1993
... and anti-STAT5 (Santa Cruz Biotechnology ...
β1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation
Brizzi Maria Felice et al., In The Journal of Cell Biology, 1993
... The anti–phospho-STAT5 (tyrosine 694/699) antibody was obtained from Cell Signaling and the anti–phospho-STAT5 (serine725/730) ...
CD8+ T cells specific for a single nonamer epitope of Listeria monocytogenes are protective in vivo.
Lesniak Maciej, In PLoS ONE, 1991
... ) mice, Stat5b transgenic (Stat5-Tg) mice ( ...
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Schuster Stephan C et al., In BMC Biochemistry, 1969
... Geneticin G 418 and Mes were obtained from Sigma, and sorbitol was from Merck.
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