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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 27 Jun 2015.

Signal transducer and activator of transcription 4

STAT4, signal transducer and activator of transcription 4
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: IL-12, IFN-gamma, STAT6, STAT1, TH2
Papers using STAT4 antibodies
Papers on STAT4
Fischer et al., Düsseldorf, Germany. In Haematologica, 25 Jul 2015
Interleukin-12 and -23 signaling was completely abrogated as demonstrated by deficient STAT4 phosphorylation and interferone γ production.
Adipose tissue-derived mesenchymal stem cells attenuate staphylococcal enterotoxin A-induced toxic shock.
Nakane et al., Hirosaki, Japan. In Infect Immun, 22 Jul 2015
On the other hand, the expression of IL-12 receptor and STAT4 decreased by ASC administration.
CCR1, KLRC4, IL12A-ASN1, STAT4, and ERAP1 are associated with Behçet's disease in Iranian.
Oliveira et al., Lisbon, Portugal. In Arthritis Rheumatol, 19 Jul 2015
RESULTS: In decreasing order of significance, rs7616215 (located 38 kilobases downstream of CCR1), rs2617170 (p.Asn104Ser) in KLRC4, rs17810546 in IL12A-AS1, rs7574070 in STAT4, and rs10050860 (p.Asp575Asn) and rs13154629 in ERAP1 were nominally associated with BD in both allelic (5.05x10(-9) ≤Pallele ≤7.55x10(-3) ) and gender-adjusted genotypic (6.01x10(-9) ≤Padj ≤1.30x10(-2) ) tests of association.
Disease susceptibility genes shared by primary biliary cirrhosis and Crohn's disease in the Japanese population.
Nakamura et al., Ōmura, Japan. In J Hum Genet, 18 Jul 2015
Three PBC susceptibility genes, CXCR5 rs6421571, STAT4 rs7574865 and NFKB1 rs230534, were nominally associated with susceptibility to CD (P=2.82 × 10(-2), P=3.88 × 10(-2) and P=2.04 × 10(-2), respectively).
Invasive Surgery Impairs the Regulatory Function of Human CD56bright Natural Killer Cells in Response to Staphylococcus aureus. Suppression of Interferon-γ Synthesis.
Flohé et al., Essen, Germany. In Plos One, Dec 2014
CD56bright NK cells displayed reduced levels of the IL-12Rβ1 chain whereas the phosphorylation of STAT4, the key transcription factor for the Ifng gene was not diminished.
Signal transducer and activator of transcription 4 in liver diseases.
Wang et al., Beijing, China. In Int J Biol Sci, Dec 2014
STAT4 is a member of the signal transducer and activator of transcription (STAT) family of molecules that localizes to the cytoplasm.
Strategies for evaluating idiopathic inflammatory myopathy disease susceptibility genes.
Chinoy et al., Manchester, United Kingdom. In Curr Rheumatol Rep, Oct 2014
Candidate gene studies have identified novel risk associations in non-Europeans, such as STAT4 and HLA-DRB1 in the Japanese population.
Rheumatoid arthritis susceptibility genes: An overview.
Korczowska, Poznań, Poland. In World J Orthop, Oct 2014
These genes include protein tyrosine phosphatase, nonreceptor type 22, Peptidyl Arginine Deiminase type IV, signal transducer and activator of transcription 4, cytotoxic T-lymphocyte-associated protein 4, tumor necrosis factor-receptor associated factor 1/complement component 5, tumor necrosis factor and others.
The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells.
Ueno et al., Dallas, United States. In Nat Immunol, Sep 2014
Here we found that transforming growth factor-β (TGF-β) provided critical additional signals for the transcription factors STAT3 and STAT4 to promote initial TFH differentiation in humans.
Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis.
Gopalakrishnan et al., Chennai, India. In J Genet, Aug 2014
A considerable number of confirmed associations with RA and other autoimmune disease susceptibility loci including peptidylarginine deiminase type 4 (PADI4), protein tyrosine phosphatase non-receptor type 22 (PTPN22), signal transducer and activator of transcription (STAT4), cluster of differentiation 244 (CD244) and cytotoxic T lymphocyte-associated antigen 4 (CTLA4), located outside the MHC have been reported recently.
TH1/TH2 cell differentiation and molecular signals.
Sun et al., Shanghai, China. In Adv Exp Med Biol, 2013
IL-12 and IFN-γ make Naive CD4+ T cells highly express T-bet and STAT4 and differentiate to TH1 cells, while IL-4 make Naive CD4+ T cells highly express STAT6 and GATA3 and differentiated to TH2 cells.
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.
Zhang et al., Beijing, China. In Nat Genet, 2013
Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC).
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
Sivils et al., Oklahoma City, United States. In Nat Genet, 2013
In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)).
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.
Zhao et al., Bethesda, United States. In Nat Immunol, 2013
Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6.
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
Kastner et al., Bethesda, United States. In Nat Genet, 2013
We identified new associations at CCR1, STAT4 and KLRC4.
Positive association between STAT4 polymorphisms and polymyositis/dermatomyositis in a Japanese population.
Yamanaka et al., Tokyo, Japan. In Ann Rheum Dis, 2012
This is the first study to show a positive association between a STAT4 polymorphism and polymyositis/dermatomyositis
STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection.
Eriksson et al., Göteborg, Sweden. In J Virol, 2012
Mice that lacked STAT4 had impaired HSV-2-specific IFN-gamma production and delayed-type hypersensitivity responses.
Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population.
Cheon et al., Seoul, South Korea. In Life Sci, 2012
Our results indicate that the interaction of specific IL17A, interleukin 23 receptor, and STAT4 modulate susceptibility to intestinal Behcet's disease in the Korean population
The composition and signaling of the IL-35 receptor are unconventional.
Vignali et al., Memphis, United States. In Nat Immunol, 2012
Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4.
The polymorphisms of T cell-specific TBX21 and STAT4 genes may contribute to the susceptibility of Chinese individuals to aplastic anemia.
Feng et al., Tianjin, China. In Hum Immunol, 2012
Results indicate that single nucleotide polymorphisms in TBX21 and STAT4 might contribute to susceptibility to aplastic anemia (AA) in the Chinese population.
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