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Signal transducer and activator of transcription 4

STAT4, signal transducer and activator of transcription 4
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: IL-12, IFN-gamma, STAT6, STAT1, TH2
Papers using STAT4 antibodies
Papers on STAT4
A114: Methylprednisolone-Induced Inhibition of miR-155 Expression Increases SOCS1-Driven Suppression of Cytokine Signaling.
Tsokos et al., Boston, United States. In Arthritis Rheumatol, Mar 2014
Steroids through blocking the IL-12/STAT4 pathway inhibit Th1 differentiation.
Systemic Lupus Erythematosus: Old and New Susceptibility Genes versus Clinical Manifestations.
S et al., Recife, Brazil. In Curr Genomics, Feb 2014
IRF5, PTPN22, CTLA4, STAT4 and BANK1).
STAT4 gene polymorphisms are associated with susceptibility and ANA status in primary biliary cirrhosis.
Ota et al., Matsumoto, Japan. In Dis Markers, Dec 2013
Here, we performed an association analysis between IL12A, IL12RB, and signal transducer and activator of transcription 4 (STAT4) genetic variations and susceptibility to PBC.
Association between a C8orf13-BLK polymorphism and polymyositis/dermatomyositis in the Japanese population: an additive effect with STAT4 on disease susceptibility.
Yamanaka et al., Tokyo, Japan. In Plos One, Dec 2013
A possible gene-gene interaction between C8orf13-BLK and STAT4, which we recently showed to be associated with Japanese polymyositis/dermatomyositis, was also analyzed.
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
Sivils et al., Oklahoma City, United States. In Nat Genet, Nov 2013
In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)).
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.
Zhao et al., Bethesda, United States. In Nat Immunol, Nov 2013
Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6.
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.
Zhang et al., Beijing, China. In Nat Genet, Nov 2013
Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC).
STATs get their move on.
Reich, Stony Brook, United States. In Jakstat, Nov 2013
Nuclear import of STAT1 and STAT4 appears linked to their tyrosine phosphorylation and the formation of parallel dimers via reciprocal phosphotyrosine and Src homology 2 domain interactions.
The genetics of complex cholestatic disorders.
Mason et al., Birmingham, United Kingdom. In Gastroenterology, Jun 2013
In contrast, studies have associated primary biliary cirrhosis and primary sclerosing cholangitis with genes encoding major histocompatibility complex proteins and identified loci associated with microbial sensing and immune regulatory pathways outside this region, such as genes encoding IL12, STAT4, IRF5, IL2 and its receptor (IL2R), CD28, and CD80.
Behçet's syndrome: a critical digest of the 2012-2013 literature.
Hamuryudan et al., İstanbul, Turkey. In Clin Exp Rheumatol, May 2013
Imputation analyses of genome wide association studies revealed new associations such as ERAP-1, CCR1-CCR3, KLRC4 and STAT4.
Variants in the IFNγ transcription factor genes TBET, STAT1, STAT4, and HLX and the risk of pulmonary tuberculosis in a Colombian population: a case-control study.
Barrera et al., Medellín, Colombia. In Biomedica, Apr 2013
OBJECTIVE: To investigate the relationships of genetic variants in the transcription factors TBET, STAT1, STAT4, and HLX to susceptibility/resistance to pulmonary TB.
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
Kastner et al., Bethesda, United States. In Nat Genet, Feb 2013
We identified new associations at CCR1, STAT4 and KLRC4.
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
Yu et al., Shanghai, China. In Nat Genet, 2013
The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, P(meta) = 2.48 × 10(-10), odds ratio (OR) = 1.21; and rs9275319 at HLA-DQ, P(meta) = 2.72 × 10(-17), OR = 1.49.
The role of type 1 interferon in systemic sclerosis.
Assassi et al., Houston, United States. In Front Immunol, 2012
IRFs and STAT4 proteins are key activators of type I IFN signaling pathways.
Positive association between STAT4 polymorphisms and polymyositis/dermatomyositis in a Japanese population.
Yamanaka et al., Tokyo, Japan. In Ann Rheum Dis, 2012
This is the first study to show a positive association between a STAT4 polymorphism and polymyositis/dermatomyositis
STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection.
Eriksson et al., Göteborg, Sweden. In J Virol, 2012
Mice that lacked STAT4 had impaired HSV-2-specific IFN-gamma production and delayed-type hypersensitivity responses.
Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population.
Cheon et al., Seoul, South Korea. In Life Sci, 2012
Our results indicate that the interaction of specific IL17A, interleukin 23 receptor, and STAT4 modulate susceptibility to intestinal Behcet's disease in the Korean population
The composition and signaling of the IL-35 receptor are unconventional.
Vignali et al., Memphis, United States. In Nat Immunol, 2012
Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4.
The polymorphisms of T cell-specific TBX21 and STAT4 genes may contribute to the susceptibility of Chinese individuals to aplastic anemia.
Feng et al., Tianjin, China. In Hum Immunol, 2012
Results indicate that single nucleotide polymorphisms in TBX21 and STAT4 might contribute to susceptibility to aplastic anemia (AA) in the Chinese population.
[Analysis of disease-pathway by identifying susceptible genes to primary biliary cirrhosis].
Makamura et al., Nagasaki, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2011
Among 21 non-HLA susceptibility loci for PBC identified in GWASs of European descent, 10 loci (CD80, IKZF3, IL7R, NFKB1, STAT4, TNFAIP2, CXCR5, MAP3K7IP1, rs6974491, DENND1B) showed significant associations in the Japanese population.
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