CCR1, KLRC4, IL12A-ASN1, STAT4, and ERAP1 are associated with Behçet's disease in Iranian.
Lisbon, Portugal. In Arthritis Rheumatol, 19 Jul 2015
RESULTS: In decreasing order of significance, rs7616215 (located 38 kilobases downstream of CCR1), rs2617170 (p.Asn104Ser) in KLRC4, rs17810546 in IL12A-AS1, rs7574070 in STAT4, and rs10050860 (p.Asp575Asn) and rs13154629 in ERAP1 were nominally associated with BD in both allelic (5.05x10(-9) ≤Pallele ≤7.55x10(-3) ) and gender-adjusted genotypic (6.01x10(-9) ≤Padj ≤1.30x10(-2) ) tests of association.
Rheumatoid arthritis susceptibility genes: An overview.
Poznań, Poland. In World J Orthop, Oct 2014
These genes include protein tyrosine phosphatase, nonreceptor type 22, Peptidyl Arginine Deiminase type IV, signal transducer and activator of transcription 4, cytotoxic T-lymphocyte-associated protein 4, tumor necrosis factor-receptor associated factor 1/complement component 5, tumor necrosis factor and others.
Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis.
Chennai, India. In J Genet, Aug 2014
A considerable number of confirmed associations with RA and other autoimmune disease susceptibility loci including peptidylarginine deiminase type 4 (PADI4), protein tyrosine phosphatase non-receptor type 22 (PTPN22), signal transducer and activator of transcription (STAT4), cluster of differentiation 244 (CD244) and cytotoxic T lymphocyte-associated antigen 4 (CTLA4), located outside the MHC have been reported recently.
TH1/TH2 cell differentiation and molecular signals.
Shanghai, China. In Adv Exp Med Biol, 2013
IL-12 and IFN-γ make Naive CD4+ T cells highly express T-bet and STAT4 and differentiate to TH1 cells, while IL-4 make Naive CD4+ T cells highly express STAT6 and GATA3 and differentiated to TH2 cells.