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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 01 Mar 2015.

Signal transducer and activator of transcription 4

STAT4, signal transducer and activator of transcription 4
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: IL-12, IFN-gamma, STAT6, STAT1, TH2
Papers using STAT4 antibodies
Papers on STAT4
Multiple Genetic Variants Associated with Primary Biliary Cirrhosis in a Han Chinese Population.
Ma et al., Nanjing, China. In Clin Rev Allergy Immunol, 19 Mar 2015
In 1070 PBC patients and 1198 controls, we observed highly significant associations at CD80 (rs2293370, P = 2.67 × 10(-8)) and TNFSF15 (rs4979462, P = 3.86 × 10(-8)) and significant associations at 17q12-21 (rs9303277), PDGFB (rs715505), NF-κB1 (rs7665090), IL12RB2 (rs11209050), and STAT4 (rs7574865; all corrected P values <0.01).
Cutting edge: stage-specific requirement of IL-18 for antiviral NK cell expansion.
Sun et al., New York City, United States. In J Immunol, 15 Mar 2015
IL-12 signaling and STAT4 in activated NK cells increased the expression of the adaptor protein MyD88, which mediates signaling downstream of the IL-18 and IL-1 receptors.
Replication the association of 2q32.2-q32.3 and 14q32.11 with hepatocellular carcinoma.
Sun et al., Hefei, China. In Gene, 06 Mar 2015
We observed that the STAT4 (2q32.2-q32.3)
Genetic basis of rheumatoid arthritis: a current review.
Yamamoto et al., Yokohama, Japan. In Biochem Biophys Res Commun, Oct 2014
In addition, we discuss the pathologic mechanism of the disease by examining the combined findings of genetic and functional studies of individual RA-associated genes, including HLA-DRB1, PADI4, PTPN22, TNFAIP3, STAT4, and CCR6.
Rheumatoid arthritis susceptibility genes: An overview.
Korczowska, Poznań, Poland. In World J Orthop, Oct 2014
These genes include protein tyrosine phosphatase, nonreceptor type 22, Peptidyl Arginine Deiminase type IV, signal transducer and activator of transcription 4, cytotoxic T-lymphocyte-associated protein 4, tumor necrosis factor-receptor associated factor 1/complement component 5, tumor necrosis factor and others.
The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells.
Ueno et al., Dallas, United States. In Nat Immunol, Sep 2014
Here we found that transforming growth factor-β (TGF-β) provided critical additional signals for the transcription factors STAT3 and STAT4 to promote initial TFH differentiation in humans.
Association of STAT4 gene rs7574865G > T polymorphism with ulcerative colitis risk: evidence from 1532 cases and 3786 controls.
Guo et al., Shanghai, China. In Arch Med Sci, Jul 2014
INTRODUCTION: Several studies have reported the relationship between the STAT4 rs7574865G > T polymorphism as a susceptibility factor to ulcerative colitis (UC).
Exacerbating factors induce different gene expression profiles in peripheral blood mononuclear cells from asthmatics, patients with chronic obstructive pulmonary disease and healthy subjects.
Pawliczak et al., Łódź, Poland. In Int Arch Allergy Immunol, 2013
RESULTS: rDer p 1 significantly up-regulated the expression of PLA2G4A, PLA2G6, PLA2G15, CYSLTR1, LB4R2, PTGS1, PTGS2, FOXP1, GATA3, HDAC2, IREB2, PPARG, STAT4, TSLP and CHI3L1 genes in asthmatics in comparison to healthy subjects.
TH1/TH2 cell differentiation and molecular signals.
Sun et al., Shanghai, China. In Adv Exp Med Biol, 2013
IL-12 and IFN-γ make Naive CD4+ T cells highly express T-bet and STAT4 and differentiate to TH1 cells, while IL-4 make Naive CD4+ T cells highly express STAT6 and GATA3 and differentiated to TH2 cells.
Genetic variants of STAT4 are associated with ankylosing spondylitis susceptibility and severity in a Chinese Han population.
Dong et al., Weifang, China. In Int J Clin Exp Med, 2013
OBJECTIVE: Genetic factors play an important role in ankylosing spondylitis (AS) etiology and signal transducer and activator of transcription 4 (STAT4) gene polymorphisms may be involved.
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.
Zhang et al., Beijing, China. In Nat Genet, 2013
Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC).
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
Sivils et al., Oklahoma City, United States. In Nat Genet, 2013
In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)).
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.
Zhao et al., Bethesda, United States. In Nat Immunol, 2013
Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6.
STATs get their move on.
Reich, Stony Brook, United States. In Jakstat, 2013
Nuclear import of STAT1 and STAT4 appears linked to their tyrosine phosphorylation and the formation of parallel dimers via reciprocal phosphotyrosine and Src homology 2 domain interactions.
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
Kastner et al., Bethesda, United States. In Nat Genet, 2013
We identified new associations at CCR1, STAT4 and KLRC4.
Positive association between STAT4 polymorphisms and polymyositis/dermatomyositis in a Japanese population.
Yamanaka et al., Tokyo, Japan. In Ann Rheum Dis, 2012
This is the first study to show a positive association between a STAT4 polymorphism and polymyositis/dermatomyositis
STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection.
Eriksson et al., Göteborg, Sweden. In J Virol, 2012
Mice that lacked STAT4 had impaired HSV-2-specific IFN-gamma production and delayed-type hypersensitivity responses.
Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population.
Cheon et al., Seoul, South Korea. In Life Sci, 2012
Our results indicate that the interaction of specific IL17A, interleukin 23 receptor, and STAT4 modulate susceptibility to intestinal Behcet's disease in the Korean population
The composition and signaling of the IL-35 receptor are unconventional.
Vignali et al., Memphis, United States. In Nat Immunol, 2012
Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4.
The polymorphisms of T cell-specific TBX21 and STAT4 genes may contribute to the susceptibility of Chinese individuals to aplastic anemia.
Feng et al., Tianjin, China. In Hum Immunol, 2012
Results indicate that single nucleotide polymorphisms in TBX21 and STAT4 might contribute to susceptibility to aplastic anemia (AA) in the Chinese population.
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