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Signal transducer and activator of transcription 4

STAT4, signal transducer and activator of transcription 4
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: IL-12, IFN-gamma, STAT6, STAT1, TH2
Papers using STAT4 antibodies
Papers on STAT4
Therapeutic implication of genetic variants of IL13 and STAT4 in airway remodelling with bronchial asthma.
Yamauchi et al., Chinju, South Korea. In Clin Exp Allergy, 14 Feb 2016
OBJECTIVE: We determined the effects of high-dose inhaled corticosteroids (ICSs) on decreased pulmonary function in asthmatic Japanese patients with variants of IL13 and STAT4 during long-term treatments with low to mild doses of ICS.
Polymorphisms in STAT4 and IRF5 increase the risk of systemic sclerosis: a meta-analysis.
Yang et al., Beijing, China. In Int J Dermatol, 29 Jan 2016
The aim of this study was to investigate the association of signal transducer and activator of transcription 4 (STAT4) rs7574865 and interferon regulatory factor 5 (IRF5) rs2004640 polymorphisms with risk of SSc.
Genetic variation in STAT4 predicts response to interferon-α therapy for hepatitis B e antigen-positive chronic hepatitis B.
Xu et al., Shanghai, China. In Hepatology, 24 Jan 2016
A genetic variant, rs7574865 in STAT4, was recently reported to be associated with risk of developing CHB and hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC).
Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I.
Cao et al., Beijing, China. In J Immunol, 22 Jan 2016
In this study, we report that STAT family member STAT4 promotes RIG-I-triggered type I IFN production in antiviral innate immunity.
Application of Various Statistical Models to Explore Gene-Gene Interactions in Folate, Xenobiotic, Toll-Like Receptor and STAT4 Pathways that Modulate Susceptibility to Systemic Lupus Erythematosus.
Kutala et al., Hyderābād, India. In Mol Diagn Ther, 21 Jan 2016
INTRODUCTION: In view of our previous studies showing an independent association of genetic polymorphisms in folate, xenobiotic, and toll-like receptor (TLR) pathways with the risk for systemic lupus erythematosus (SLE), we have developed three statistical models to delineate complex gene-gene interactions between folate, xenobiotic, TLR, and signal transducer and activator of transcription 4 (STAT4) signaling pathways in association with the molecular pathophysiology of SLE.
Identification of a systemic lupus erythematosus risk locus spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
Tsao et al., Oklahoma City, United States. In Arthritis Rheumatol, 14 Jan 2016
We replicated ten previously established SLE risk loci: STAT1-STAT4, TNFSF4, TNFAIP3, IKZF1, HIP1, IRF5, BLK, WDFY4, ETS1 and IRAK1-MECP2.
Genetic variants associated with non-typhoidal Salmonella bacteraemia in African children.
Wellcome Trust Case Control Consortium 2 et al., Kilifi, Kenya. In Lancet, Mar 2015
An intronic variant in STAT4 was associated (recessive model) with NTS in both Kenyan and Malawian children (Kenya p=5·6 × 10(-9), Malawi p=0·02, combined p=1·4 × 10(-9); odds ratio 7·2, 95% CI 3·8-13·5).
Role of retinoic acid in the stability of the T-helper-type 1 lineage and implications for autoimmunity.
Noelle et al., New York City, United States. In Lancet, Mar 2015
Abrogation of retinoic acid signalling in Th1 cells resulted in loss of T-bet expression and STAT4 activity.
Activity of JAK/STAT and NF-kB in patients with axial spondyloarthritis.
Wiland et al., Wrocław, Poland. In Postepy Hig Med Dosw (online), 2014
The expression of NF-κB, STAT1, STAT3, STAT4, STAT5, STAT6, and JAK3 in peripheral blood leukocytes was assessed.
Meta-analysis of STAT4 and IFIH1 polymorphisms in type 1 diabetes mellitus patients with autoimmune polyglandular syndrome type III.
Brandão et al., Recife, Brazil. In Genet Mol Res, 2014
Signal transducer and activator of transcription 4 (STAT4) is a well-known regulator of proinflammatory cytokines, and interferon-induced with helicase C domain 1 (IFIH1) is activated in the interferon type I response.
Single Nucleotide Polymorphisms in STAT3 and STAT4 and Risk of Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B.
Tangkijvanich et al., Bangkok, Thailand. In Asian Pac J Cancer Prev, 2014
Recent studies demonstrated that single nucleotide polymorphisms (SNPs) rs2293152 in signal transducer and activator of transcription 3 (STAT3) and rs7574865 in signal transducer and activator of transcription 4 (STAT4) are associated with chronic hepatitis B (CHB)-related HCC in the Chinese population.
Network-assisted analysis of primary Sjögren's syndrome GWAS data in Han Chinese.
Wang et al., Beijing, China. In Sci Rep, 2014
Of these pSS candidates, 14 genes had been reported to be associated with any of pSS, RA, and SLE, including STAT4, GTF2I, HLA-DPB1, HLA-DRB1, PTTG1, HLA-DQB1, MBL2, TAP2, CFLAR, NFKBIE, HLA-DRA, APOM, HLA-DQA2 and NOTCH4.
The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells.
Ueno et al., Dallas, United States. In Nat Immunol, 2014
Here we found that transforming growth factor-β (TGF-β) provided critical additional signals for the transcription factors STAT3 and STAT4 to promote initial TFH differentiation in humans.
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
Sivils et al., Oklahoma City, United States. In Nat Genet, 2013
In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)).
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.
Zhang et al., Beijing, China. In Nat Genet, 2013
Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC).
Positive association between STAT4 polymorphisms and polymyositis/dermatomyositis in a Japanese population.
Yamanaka et al., Tokyo, Japan. In Ann Rheum Dis, 2012
This is the first study to show a positive association between a STAT4 polymorphism and polymyositis/dermatomyositis
STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection.
Eriksson et al., Göteborg, Sweden. In J Virol, 2012
Mice that lacked STAT4 had impaired HSV-2-specific IFN-gamma production and delayed-type hypersensitivity responses.
Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population.
Cheon et al., Seoul, South Korea. In Life Sci, 2012
Our results indicate that the interaction of specific IL17A, interleukin 23 receptor, and STAT4 modulate susceptibility to intestinal Behcet's disease in the Korean population
The composition and signaling of the IL-35 receptor are unconventional.
Vignali et al., Memphis, United States. In Nat Immunol, 2012
Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4.
The polymorphisms of T cell-specific TBX21 and STAT4 genes may contribute to the susceptibility of Chinese individuals to aplastic anemia.
Feng et al., Tianjin, China. In Hum Immunol, 2012
Results indicate that single nucleotide polymorphisms in TBX21 and STAT4 might contribute to susceptibility to aplastic anemia (AA) in the Chinese population.
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