gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 14 Apr 2015.

Signal transducer and activator of transcription 4

STAT4, signal transducer and activator of transcription 4
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: IL-12, IFN-gamma, STAT6, STAT1, TH2
Papers using STAT4 antibodies
Papers on STAT4
Decreased STAT4 indicates poor prognosis and enhanced cell proliferation in hepatocellular carcinoma.
New
Chen et al., Nantong, China. In World J Gastroenterol, 07 May 2015
AIM: To investigate the role of signal transduction and activation of transcription 4 (STAT4) in the development and progression of human hepatocellular carcinoma (HCC).
STAT4 genetic polymorphisms association with spontaneous clearance of hepatitis B virus infection.
New
Sun et al., Wuhan, China. In Immunol Res, 01 May 2015
UNASSIGNED: STAT4 signal pathway plays an important role in IFN-γ-mediated antiviral activity.
T-bet- and STAT4-dependent IL-33 receptor expression directly promotes antiviral Th1 cell responses.
New
Löhning et al., Berlin, Germany. In Proc Natl Acad Sci U S A, 01 May 2015
ST2 expression on virus-specific Th1 cells depended on the Th1-associated transcription factors T-bet and STAT4.
Silencing of stat4 gene inhibits cell proliferation and invasion of colorectal cancer cells.
New
Zhan et al., Shanghai, China. In J Biol Regul Homeost Agents, Jan 2015
In the present study, we aimed to evaluate the function of STAT4 in human colorectal cancer (CRC).
STAT4 rs7574865 G/T and PTPN22 rs2488457 G/C Polymorphisms Influence the Risk of Developing Juvenile Idiopathic Arthritis in Han Chinese Patients.
New
Yu et al., Nanjing, China. In Plos One, Dec 2014
The protein tyrosine phosphatase nonreceptor 22 (PTPN22) and signal transducer and activator of transcription factor 4 (STAT4) have been recognized as susceptibility genes for numerous autoimmune diseases.
Signal Transducer and Activator of Transcription 4 in Liver Diseases.
Review
New
Wang et al., Beijing, China. In Int J Biol Sci, Dec 2014
UNASSIGNED: STAT4 is a member of the signal transducer and activator of transcription (STAT) family of molecules that localizes to the cytoplasm.
Rheumatoid arthritis susceptibility genes: An overview.
Review
New
Korczowska, Poznań, Poland. In World J Orthop, Oct 2014
These genes include protein tyrosine phosphatase, nonreceptor type 22, Peptidyl Arginine Deiminase type IV, signal transducer and activator of transcription 4, cytotoxic T-lymphocyte-associated protein 4, tumor necrosis factor-receptor associated factor 1/complement component 5, tumor necrosis factor and others.
The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells.
New
Impact
Ueno et al., Dallas, United States. In Nat Immunol, Sep 2014
Here we found that transforming growth factor-β (TGF-β) provided critical additional signals for the transcription factors STAT3 and STAT4 to promote initial TFH differentiation in humans.
Association of susceptible genetic markers and autoantibodies in rheumatoid arthritis.
Review
New
Gopalakrishnan et al., Chennai, India. In J Genet, Aug 2014
A considerable number of confirmed associations with RA and other autoimmune disease susceptibility loci including peptidylarginine deiminase type 4 (PADI4), protein tyrosine phosphatase non-receptor type 22 (PTPN22), signal transducer and activator of transcription (STAT4), cluster of differentiation 244 (CD244) and cytotoxic T lymphocyte-associated antigen 4 (CTLA4), located outside the MHC have been reported recently.
Association of STAT4 gene rs7574865G > T polymorphism with ulcerative colitis risk: evidence from 1532 cases and 3786 controls.
Review
New
Guo et al., Shanghai, China. In Arch Med Sci, Jul 2014
INTRODUCTION: Several studies have reported the relationship between the STAT4 rs7574865G > T polymorphism as a susceptibility factor to ulcerative colitis (UC).
TH1/TH2 cell differentiation and molecular signals.
Review
Sun et al., Shanghai, China. In Adv Exp Med Biol, 2013
IL-12 and IFN-γ make Naive CD4+ T cells highly express T-bet and STAT4 and differentiate to TH1 cells, while IL-4 make Naive CD4+ T cells highly express STAT6 and GATA3 and differentiated to TH2 cells.
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.
Impact
Zhang et al., Beijing, China. In Nat Genet, 2013
Our analysis also confirmed previously reported associations in Europeans in the regions of STAT4, TNFAIP3 and the major histocompatibility complex (MHC).
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.
Impact
Sivils et al., Oklahoma City, United States. In Nat Genet, 2013
In addition to strong association within the human leukocyte antigen (HLA) region at 6p21 (Pmeta = 7.65 × 10(-114)), we establish associations with IRF5-TNPO3 (Pmeta = 2.73 × 10(-19)), STAT4 (Pmeta = 6.80 × 10(-15)), IL12A (Pmeta = 1.17 × 10(-10)), FAM167A-BLK (Pmeta = 4.97 × 10(-10)), DDX6-CXCR5 (Pmeta = 1.10 × 10(-8)) and TNIP1 (Pmeta = 3.30 × 10(-8)).
Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation.
Impact
Zhao et al., Bethesda, United States. In Nat Immunol, 2013
Many were bound and regulated by the key transcription factors T-bet, GATA-3, STAT4 and STAT6.
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
Impact
Kastner et al., Bethesda, United States. In Nat Genet, 2013
We identified new associations at CCR1, STAT4 and KLRC4.
Positive association between STAT4 polymorphisms and polymyositis/dermatomyositis in a Japanese population.
GeneRIF
Yamanaka et al., Tokyo, Japan. In Ann Rheum Dis, 2012
This is the first study to show a positive association between a STAT4 polymorphism and polymyositis/dermatomyositis
STAT4 regulates antiviral gamma interferon responses and recurrent disease during herpes simplex virus 2 infection.
GeneRIF
Eriksson et al., Göteborg, Sweden. In J Virol, 2012
Mice that lacked STAT4 had impaired HSV-2-specific IFN-gamma production and delayed-type hypersensitivity responses.
Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population.
GeneRIF
Cheon et al., Seoul, South Korea. In Life Sci, 2012
Our results indicate that the interaction of specific IL17A, interleukin 23 receptor, and STAT4 modulate susceptibility to intestinal Behcet's disease in the Korean population
The composition and signaling of the IL-35 receptor are unconventional.
Impact
GeneRIF
Vignali et al., Memphis, United States. In Nat Immunol, 2012
Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4.
The polymorphisms of T cell-specific TBX21 and STAT4 genes may contribute to the susceptibility of Chinese individuals to aplastic anemia.
GeneRIF
Feng et al., Tianjin, China. In Hum Immunol, 2012
Results indicate that single nucleotide polymorphisms in TBX21 and STAT4 might contribute to susceptibility to aplastic anemia (AA) in the Chinese population.
share on facebooktweetadd +1mail to friends