Rheumatoid arthritis in Latin Americans enriched for Amerindian ancestry is associated with loci in chromosomes 1, 12,13, and HLA class II region.
Granada, Spain. In Arthritis Rheum, 04 Apr 2013
We identified onenovel putative association in ENOX1onchromosome 13 (p= 7.0 × 10-7 ).Previously reported RA associations were observed, with moderate p values (>x10-5 ), including STAT4, IRF5, IL2RA, SPRED2, CCL21 and PTPN22.Adjustment for Amerindian ancestryimproved the association of a novel locus in chromosome 12, atC12orf30 (NNA25) (p= 3.9 × 10-6 ).
Primary Sjögren's syndrome and the type I interferon system.
Uppsala, Sweden. In Curr Pharm Biotechnol, Aug 2012
Polymorphisms in the interferon regulatory factor 5 (IRF5) and signal transducer and activator of transcription 4 (STAT4) genes in the type I IFN system, are associated with increased risk for pSS.
Transcriptional mechanisms that regulate T helper 1 cell differentiation.
Seattle, United States. In Curr Opin Immunol, Apr 2012
In particular, studies examining the transcription factors T-bet, STAT1, and STAT4 have elucidated their roles in regulating Th1 signature genes, including Ifng, and have started to address their contributions to the epigenetic states in Th1 cells.
Natural killer cell functional dichotomy: a feature of chronic viral hepatitis?
Pavia, Italy. In Front Immunol, 2011
In chronic HCV infection this appears to be caused by altered IFN-α signaling resulting from increased signal transducer and activator of transcription 1 (STAT1) phosphorylation, which polarizes NK cells toward cytotoxicity, and a concomitantly reduced IFN-α induced STAT4 phosphorylation yielding reduced IFN-γ mRNA levels.