Soypeptide lunasin in cytokine immunotherapy for lymphoma.
Indianapolis, United States. In Cancer Immunol Immunother, 31 Mar 2014
We have previously reported that post-transplant lymphoma patients have an acquired deficiency of signal transducer and activator of transcription 4, which results in defective IFNγ production during clinical immunotherapy.
Association of rheumatoid arthritis susceptibility gene with lipid profiles in patients with rheumatoid arthritis.
Omaha, United States. In Rheumatology (oxford), 03 Mar 2014
Patients (n = 763) enrolled in the Veterans Affairs RA registry who were not on hydroxymethylglutaryl-CoA reductase inhibitor were genotyped for human leukocyte antigen shared epitope (HLA-DRB1-SE) and SNPs in the following genes: CTLA-4 (cytotoxic T-lymphocyte antigen 4), IL-10, PTPN22 (protein tyrosine phosphatase, non-receptor type 22), REL (c-Rel), STAT4 (signal transducer and activator of transcription protein), TNF-α and TRAF1 (TNF receptor-associated factor 1).
STATs get their move on.
Stony Brook, United States. In Jakstat, Nov 2013
Nuclear import of STAT1 and STAT4 appears linked to their tyrosine phosphorylation and the formation of parallel dimers via reciprocal phosphotyrosine and Src homology 2 domain interactions.
The genetics of complex cholestatic disorders.
Birmingham, United Kingdom. In Gastroenterology, Jun 2013
In contrast, studies have associated primary biliary cirrhosis and primary sclerosing cholangitis with genes encoding major histocompatibility complex proteins and identified loci associated with microbial sensing and immune regulatory pathways outside this region, such as genes encoding IL12, STAT4, IRF5, IL2 and its receptor (IL2R), CD28, and CD80.
[Analysis of disease-pathway by identifying susceptible genes to primary biliary cirrhosis].
Nagasaki, Japan. In Nihon Rinsho Meneki Gakkai Kaishi, 2011
Among 21 non-HLA susceptibility loci for PBC identified in GWASs of European descent, 10 loci (CD80, IKZF3, IL7R, NFKB1, STAT4, TNFAIP2, CXCR5, MAP3K7IP1, rs6974491, DENND1B) showed significant associations in the Japanese population.