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Signal transducer and activator of transcription 3

STAT3, signal transducer and activator of transcription 3
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, V1a, CAN, JAK2, Akt
Papers using STAT3 antibodies
A novel U-STAT3-dependent mechanism mediates the deleterious effects of chronic nicotine exposure on renal injury
Goumans Marie Jose, In PLoS ONE, 2011
... Fluorescein-5-maleimide was from Pierce Biotechnology (Rockford, lL USA) and recombinant human STAT3 was from OriGene Technologies (Rockville, MD) ...
Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study.
Jagetia Ganesh Chandra, In PLoS ONE, 2010
... Antibodies against phospho-STAT3 (Tyr 705), phospho-AKT (Ser 473), STAT3 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Molecular control of endothelial cell behaviour during blood vessel morphogenesis
Tang Yao Liang, In PLoS ONE, 2010
... LY294002 and antibodies against phosphorylated (p-) STAT3 (Tyr705) and STAT3 were from Cell Signaling Technology (Beverly, MA) ...
The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
Su Wu-Chou et al., In International Journal of Nanomedicine, 2009
... The following antibodies were used: anti-Stat3 (Tyr705), anti-Stat1, anti-α-tubulin (Cell Signaling Technology, Beverly, MA), anti-Stat3 (Santa Cruz Biotechnology, Santa Cruz, CA), and ...
Transcriptomic analysis of mild hypothermia-dependent alterations during endothelial reperfusion injury.
Cheriyath Venugopalan, In PLoS ONE, 2009
... (BETHYL Laboratories, Inc), anti-cleaved PARP, anti-total- and phospho-AKT (Ser473), -ERK1/2 (Thr202/Tyr204), -STAT3, Tyr705) and horseradish peroxidase-conjugated goat anti-mouse or anti-rabbit IgG secondary antibody were from Cell Signaling Technology ...
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Papers on STAT3
Turmeric Sesquiterpenoids: Expeditious Resolution, Comparative Bioactivity, and a New Bicyclic Turmeronoid.
Taglialatela-Scafati et al., Novara, Italy. In J Nat Prod, Feb 2016
The comparative evaluation of these compounds against a series of anti-inflammatory targets (NF-κB, STAT3, Nrf2, HIF-1α) evidenced surprising differences, providing a possible explanation for the contrasting data on the activity of turmeric oil.
STAT3-Ser/Hes3 Signaling: A New Molecular Component of the Neuroendocrine System?
Androutsellis-Theotokis et al., Dresden, Germany. In Horm Metab Res, Feb 2016
The STAT3-Ser/Hes3 Signaling Axis was first identified as a major regulator of neural stem cells and, subsequently, cancer stem cells.
Disruption of CCL20-CCR6 interaction inhibits metastasis of advanced cutaneous T-cell lymphoma.
Tagawa et al., Akita, Japan. In Oncotarget, Feb 2016
We first demonstrated increased STAT3 expression during the progression of primary CTCL.
Strategies and approaches of targeting STAT3 for cancer treatment.
Reigan et al., In Acs Chem Biol, Feb 2016
UNASSIGNED: Signal transducer and activator of transcription 3 (STAT3) is a transcription factor that regulates the expression of genes related to cell cycle, cell survival, and immune response associated with cancer progression and malignancy in a number of cancer types.
The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke.
Yang et al., Zhengzhou, China. In Prog Neurobiol, Jan 2016
Numerous studies have demonstrated the activation of STAT3 in neurological diseases, particularly in cerebral ischemic and hemorrhagic stroke.
Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells.
Cua et al., Palo Alto, United States. In Immunity, Jan 2016
Furthermore, genome-wide occupancy and overexpression studies in Th17 cells revealed that Blimp-1 co-localized with transcription factors RORγt, STAT-3, and p300 at the Il23r, Il17a/f, and Csf2 cytokine loci to enhance their expression.
The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations.
Bauman et al., Pittsburgh, United States. In Oral Oncol, Jan 2016
Aberrant regulation of the STAT3 oncogene contributes to tumor formation and progression in many cancers, including head and neck squamous cell carcinoma (HNSCC), where hyperactivation of STAT3 is implicated in both treatment resistance and immune escape.
Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration.
Hanash et al., New York City, United States. In Nature, Jan 2016
IL-22 induced STAT3 phosphorylation in Lgr5(+) ISCs, and STAT3 was crucial for both organoid formation and IL-22-mediated regeneration.
Germline variant FGFR4  p.G388R exposes a membrane-proximal STAT3 binding site.
Ullrich et al., Martinsried, Germany. In Nature, Jan 2016
Here we show that substitution of the conserved glycine 388 residue to a charged arginine residue alters the transmembrane spanning segment and exposes a membrane-proximal cytoplasmic signal transducer and activator of transcription 3 (STAT3) binding site Y(390)-(P)XXQ(393).
Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder.
Berk et al., Toronto, Canada. In Psychiatry Res, Jan 2016
We also validated protein expression levels of the main complex I regulators by immunohistochemistry. Upon reviewing the literature, we found PARK-7, STAT-3, SIRT-3 and IMP-2 play an important role in regulating complex I activity.
JAK/STAT3 signaling pathway mediates endothelial-like differentiation of immature dendritic cells.
Dong et al., Zhengzhou, China. In Oncol Lett, Dec 2015
During the ELD of iDCs, sustained activation of JAK (janus tyrosine kinase)/STAT3 (signal transducer and activator of transcription 3) signaling was detected.
The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation.
Yin et al., Beijing, China. In Nat Immunol, Dec 2015
DUSP2 was directly associated with the signal transducer and transcription activator STAT3 and attenuated its activity through dephosphorylation of STAT3 at Tyr705 and Ser727.
The significance of microRNA-184 on JAK2/STAT3 signaling pathway in the formation mechanism of glioblastoma.
Zhai et al., Linyi, China. In Oncol Lett, Dec 2015
The aim of the present study was to examine the expression of microRNA (miR)-184 in Janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway in the mechanism of glioblastoma formation, thus providing a new basis for the mechanism of glioblastoma induction.
Erythropoietin Stimulates Tumor Growth via EphB4.
Sood et al., Houston, United States. In Cancer Cell, Dec 2015
Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo-induced tumor growth and progression.
Saw Palmetto Extract Inhibits Metastasis and Antiangiogenesis through STAT3 Signal Pathway in Glioma Cell.
Che et al., Shenyang, China. In Evid Based Complement Alternat Med, 2014
Signal transducer and activator of transcription factor 3 (STAT3) plays an important role in the proliferation and angiogenesis in human glioma.
Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes.
Bogoyevitch et al., Melbourne, Australia. In Biochem J, 2012
results highlight STAT3beta as a significant transcriptional regulator in its own right, with additional actions to cross-regulate STAT3alpha phosphorylation and nuclear retention after cytokine stimulation
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
Egwuagu et al., Bethesda, United States. In J Biol Chem, 2012
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.
Fowler et al., Bethesda, United States. In Immunity, 2012
STAT3 limited FoxP3+ Treg cell numbers following allogeneic bone marrow transplantation by two pathways: instability of natural Treg (nTreg) cells and inhibition of induced Treg (iTreg) cell polarization from naive CD4+ T cells.
The stat3/socs3a pathway is a key regulator of hair cell regeneration in zebrafish. [corrected].
Burgess et al., Bethesda, United States. In J Neurosci, 2012
The results of this study suggested that the stat3/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Activation of Stat3 in endothelial cells following hypoxia-reoxygenation is mediated by Rac1 and protein Kinase C.
Becker et al., Baltimore, United States. In Biochim Biophys Acta, 2012
Stat3 forms a multiprotein complex with Rac1 and PKC in an hypoxia-reoxygenation-dependent manner.
More papers using STAT3 antibodies
STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells
Viola Joao P. B., In PLoS ONE, 2009
... Anti-STAT3 and anti-p-STAT3 (Y705) were purchased from Cell Signaling.
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
Fagard Remi et al., In BMC Cell Biology, 2008
... with binding buffer, complexes were separated on SDS-polyacrylamide (8%) gel, subjected to immunoblotting using an anti-phospho-STAT3 antibody (Cell Signaling); input was determined by ...
Plasma and urine biomarkers in acute viral hepatitis E.
Tavis John E., In PLoS ONE, 2008
... The antibodies to phospho-Akt, Akt, HNF4, PARP and STAT3 were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Notch1 signaling stimulates proliferation of immature cardiomyocytes
Giacca Mauro et al., In The Journal of Cell Biology, 2007
... anti–GATA-4 antibodies were obtained from Santa Cruz Biotechnology, Inc.; anti–cleaved Notch-1 (Val1744), anti–phospho-p38 MAPK, and anti–phospho-STAT3 (Tyr705) were obtained from Cell Signaling Technology; antisarcomeric α-actinin (EA-53) ...
Spatially and temporally controlled electroporation of early chick embryos.
Najbauer Joseph, In PLoS ONE, 2007
... Jak I inhibitor 0.6 µM (Calbiochem) was used to block LIF-Stat3 pathway; SB431542 10 µM (Tocris Bioscience) and rhNoggin 500 ...
Rho GTPase activation assays.
Beaudoin Claude, In PLoS ONE, 2007
... Antibodies to total and phosphorylated STAT3 were from Cell Signaling Technology (Danvers, MA, USA) ...
The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation
Chang Zhijie et al., In Breast Cancer Research : BCR, 2006
... Anti-Myc (9E10), anti-HA (F-7), anti-GFP (FL), anti-pSTAT3(Tyr705, B-7), anti-pSTAT3(Ser727), anti-STAT3 (F-2) and anti-STAT3 (C-20) antibodies, and protein G/A plus agarose beads were purchased from Santa Cruz Biotechnology, and anti-β-Actin (AC-15) antibody ...
Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6
DeCoster Mark A et al., In Journal of Neuroinflammation, 2006
... The antibodies against β-actin, phospho-JAK3, phospho-STAT3, JAK3, and STAT3 were purchased from Cell Signaling Technology Inc ...
The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells
Rozakis-Adcock M et al., In Oncogene, 2006
... Antibodies to phospho-Met Y1234/5, phospho-Akt Ser 473, Akt, phospho-STAT3, STAT3, phosphotyrosine residues (4G10) and HRP-linked secondary antibodies were purchased from Cell Signaling Technologies (Beverly, MA, USA) ...
STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma
Bauer Joseph Alan, In PLoS ONE, 2006
... For fluorescence polarization assays, STAT3 protein (>90% purity) was purchased from Abcam (Cambridge, MA) ...
The effect of bovine serum albumin on the membrane potential and reactive oxygen species generation in succinate-supported isolated brain mitochondria.
Combs Colin, In PLoS ONE, 2006
... Primary antibody to GFAP was from Dako (rabbit, Carpenteria, CA), to tyrosine705-phosphorylated STAT3 (pSTAT3) was from Cell Signaling Technology, Inc ...
Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit.
Yamaoka Yoshio, In PLoS ONE, 2006
... The antibodies to STAT3 pS727 and pY705 and PARP were purchased from Cell Signaling Technology (Beverly, MA) and ...
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
Benistant Christine et al., In The Journal of Cell Biology, 2005
... Stat3 from Cell Signaling Technology, anti-Stat3 from Millipore, ...
Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice
Bromberg Jacqueline et al., In Breast Cancer Research : BCR, 2005
... ] by using a radiolabeled high-affinity m67 DNA binding probe and an anti-Stat3 antibody for supershifting (Stat3 (K-15): sc-483 X, Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Assessing implicit models for nonpolar mean solvation forces: the importance of dispersion and volume terms.
Schneider-Stock Regine, In PLoS ONE, 2005
... 14-3-3σ, 14-3-3θ, 14-3-3β, GAPDH antibodies (Santa Cruz Biotechnology, Santa Cruz, CA), 14-3-3γ, 14-3-3η, Stat3, pY705-Stat3, pS727-Stat3 antibodies (Cell Signaling, Danvers, MA), HA tag, ...
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution
Claret Francois X et al., In Breast Cancer Research : BCR, 2005
... The following antibodies were used in the study: C/EBP-α (N-19), C/EBP-β (C-19), GATA-1 (H-200), and Stat3 (C-20) (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols
Verma Ajit K. et al., In Oncogene, 2004
... pStat3Tyr705, Bcl-xL, COX-2, β-actin, donkey anti-goat immunoglobulin (IgG)-FITC for PKCε and donkey anti-rabbit IgG-rhodamine for Stat3 (Santa Cruz Biotechnology, Santa Cruz, CA); and ...
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
Virgin Skip W., In PLoS Biology, 2004
... Antibodies for the following targets were used: STAT1 (BD Biosciences Franklin Lakes, NJ, USA), STAT3 (Santa Cruz Biotech, Santa Cruz, CA, USA), HA (Cell Signaling Technology, Beverly, MA, USA), ...
The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing.
Bunting Kevin D., In PLoS ONE, 2003
... Phospho-STAT3 (Tyr705) D3A7 rabbit monoclonal antibody, Cell Signaling Technology (CST) #9145 ...
Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA.
Zimmer Jacques, In PLoS ONE, 2003
TLR4 (clone UT41), CD25 Abs and Stat3 inhibitory peptide (Stat3I) were from eBioscience (San Diego, CA) ...
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
Schneider Guenter, In PLoS ONE, 2003
... phospho (p)-EGFR (Y1068, Y1045), Bcl-xL, Mcl-1, Bid, p-Bad (S112), Bad, PI3K, ERK, p-ERK (T202/Y204), STAT3, p-STAT3 (Y705), aldolase, and H3 (Cell Signaling, Danvers, MA, USA) ...
Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis.
Singh Rana Pratap, In PLoS ONE, 2003
... -pSTAT3 and STAT3 were purchased from Cell Signaling Technology (Beverly,MA) ...
Thrombin Up-regulates Tissue Factor Pathway Inhibitor-2 Synthesis through a Cyclooxygenase-2-dependent, Epidermal Growth Factor Receptor-independent Mechanism
Rosenbaum Jean et al., In Comparative Hepatology, 2003
... mAb B-R3 was from Diaclone (Besançon, France), anti-gp80 mAb M91 was from Coulter-Immunotech (Marseille, France), anti-phospho-STAT-3 (Tyr705) was from Cell Signaling Technology (Beverly, MA) ...
Apoptosis pathway in cancer and cancer therapy
Fahmy Hesham et al., In Marine Drugs, 2003
... Mouse monoclonal antibodies against β-actin, Cdk4 and STAT-3, rabbit antibodies against cycline D1 and D2, goat anti-mouse and goat anti-rabbit both horseradish-conjugated (HRP) secondary antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Matrix metalloproteinase activity and immunohistochemical profile of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 during human dermal wound healing
He Shaoheng et al., In BMC Cell Biology, 2003
... AG490, LY294002, phospho-p44/42 MAPK antibody, unphospho-p44/42 MAPK antibody, phospho-Akt antibody, unphospho-Akt antibody, phospho-STAT3 antibody and unphospho-STAT3 antibody were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.
Buday Laszlo, In PLoS ONE, 2002
... : Antibodies against pStat3, Stat3 (Cell Signaling), against IL-10R1 (polyclonal, C20 ...
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation
Parker Peter J. et al., In The Journal of Cell Biology, 2001
... were the following: anti–phospho–c-Met (Tyrosine 1349 or Tyrosine 1234/1235), pan-ERK, phospho-p42/p44 ERK, mouse monoclonal anti–pan-STAT3, phospho-STAT3 (Y706; S727), PKCα (BD Biosciences), anti–pan-STAT3, and chc (Santa ...
BMPs signal alternately through a SMAD or FRAP–STAT pathway to regulate fate choice in CNS stem cells
McKay Ronald D.G. et al., In The Journal of Cell Biology, 2001
... DakoCytomation; monoclonal anti-SMA and anti-FLAG from Sigma-Aldrich; polyclonal anti-HA from BABCO; monoclonal anti-FKBP12, anti-FRAP, and anti-Stat3 from Transduction Laboratories; polyclonal anti-phosphoStat3 (Tyr705 and Ser727) from Santa Cruz Biotechnology, Inc.; monoclonal anti–BMPR-IA from ...
Processing of gene expression data generated by quantitative real-time RT-PCR.
Harhaj Edward, In PLoS ONE, 2001
... Anti-phospho-Stat1 (Tyr701) and anti-phospho-Stat3 (Tyr705) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
SOCS proteins: negative regulators of cytokine signaling.
Hartl Dominik, In PLoS ONE, 2000
... 9205), phospho-STAT3 (Tyr705) (Cell Signaling, Cat ...
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
Farrar William L et al., In Molecular Cancer, 1999
... LFM-A13 (Tocris, Ellisville, MO), MEK inhibitor PD98059 (Gibco, Carlsbad, CA), JAK inhibitor AG490 (Gibco), and STAT3 inhibitor Stattic (Sigma Aldrich, St ...
Generalized lacZ expression with the ROSA26 Cre reporter strain.
O'Rahilly Stephen, In PLoS Biology, 1998
... was purchased from Santa Cruz, anti-JAK2 antibody from Invitrogen, anti-phosphotyrosine antibody from Upstate, anti-P-Stat3 and anti-Stat3 antibodies from Cell Signaling, and anti-actin antibody from ...
Rat embryo fibroblasts transformed by c-Jun display highly metastatic and angiogenic activities in vivo and deregulate gene expression of both angiogenic and antiangiogenic factors
Gibson Spencer B et al., In BMC Cancer, 1998
... and total Erk1/2, XIAP and STAT3 antibodies, as well as siRNA for c-Jun (#6203) and Stat3 siRNA I (#6580) and control siRNA (#6201 fluorescein conjugate) were purchased from Cell Signaling Technology, VEGF antibody was ...
Signal transduction and transcription factors in rheumatic disease
Peng Daizhi et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1998
... Rabbit anti-phospho-Jak2 (Tyr1007/1008), anti-STAT3 polyclonal antibodies were purchased from Biovision (CA, USA) ...
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells
Asano T et al., In British Journal of Cancer, 1997
... The antibodies used in this study were antibodies against phospho-STAT3 (p-STAT3, Cell Signaling Technology Inc., Beverly, MA, ...
Signal transduction via platelet-derived growth factor receptors.
Samuel Jane-Lise, In PLoS ONE, 1997
... kinase 1/2 (ERK1/2), Akt, glycogen synthase kinase-3β (GSK-3β) and signal transducer and activator of transcription 3 (STAT3) were obtained from Cell Signaling technology (Danvers, MA) ...
Functional Inactivation of CXC Chemokine Receptor 4–mediated Responses through SOCS3 Up-regulation
Mellado Mario et al., In The Journal of Experimental Medicine, 1993
... For immunostaining, we used anti-STAT3 and -phospho-STAT3 antibody (New England Biolabs, Inc.) ...
Anaesthesia techniques for midazolam and flumazenil-an overview
Iida Hiroki et al., In Journal of Neuroinflammation, 1989
... SAPK/JNK, phospho-specific inhibitory kappa B (IκB), IκB, phospho-specific signal transducer and activator of transcription (STAT)3 and STAT3 antibodies were purchased from Cell Signaling (Beverly, MA) ...
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