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Signal transducer and activator of transcription 3

STAT3, signal transducer and activator of transcription 3
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: V1a, Interleukin-6, CAN, JAK2, Akt
Papers using STAT3 antibodies
A novel U-STAT3-dependent mechanism mediates the deleterious effects of chronic nicotine exposure on renal injury
Supplier
Goumans Marie Jose, In PLoS ONE, 2011
... Fluorescein-5-maleimide was from Pierce Biotechnology (Rockford, lL USA) and recombinant human STAT3 was from OriGene Technologies (Rockville, MD) ...
Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study.
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Jagetia Ganesh Chandra, In PLoS ONE, 2010
... Antibodies against phospho-STAT3 (Tyr 705), phospho-AKT (Ser 473), STAT3 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Molecular control of endothelial cell behaviour during blood vessel morphogenesis
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Tang Yao Liang, In PLoS ONE, 2010
... LY294002 and antibodies against phosphorylated (p-) STAT3 (Tyr705) and STAT3 were from Cell Signaling Technology (Beverly, MA) ...
The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
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Su Wu-Chou et al., In International Journal of Nanomedicine, 2009
... The following antibodies were used: anti-Stat3 (Tyr705), anti-Stat1, anti-α-tubulin (Cell Signaling Technology, Beverly, MA), anti-Stat3 (Santa Cruz Biotechnology, Santa Cruz, CA), and ...
Transcriptomic analysis of mild hypothermia-dependent alterations during endothelial reperfusion injury.
Supplier
Cheriyath Venugopalan, In PLoS ONE, 2009
... (BETHYL Laboratories, Inc), anti-cleaved PARP, anti-total- and phospho-AKT (Ser473), -ERK1/2 (Thr202/Tyr204), -STAT3, Tyr705) and horseradish peroxidase-conjugated goat anti-mouse or anti-rabbit IgG secondary antibody were from Cell Signaling Technology ...
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Papers on STAT3
Revisiting STAT3 signalling in cancer: new and unexpected biological functions.
New
Impact
Jove et al., Duarte, United States. In Nat Rev Cancer, 24 Nov 2014
The Janus kinases (JAKs) and signal transducer and activator of transcription (STAT) proteins, particularly STAT3, are among the most promising new targets for cancer therapy.
Exchange Protein Directly Activated by cAMP (EPAC1) Modulates Regulatory T Cell-Mediated Immune Suppression.
New
Cheng et al., In Biochem J, 23 Nov 2014
Mechanistically, EPAC1 inhibition enhanced activation of the transcription factor STAT3 and up-regulated SMAD7 expression while down-regulating expression of SMAD4.
Autocrine stimulation of IL-10 is critical to the enrichment of IL-10-producing CD40hiCD5+ regulatory B cells in vitro and in vivo.
New
Choi et al., Seoul, South Korea. In Bmb Rep, 23 Nov 2014
The autocrine effect of IL-10 on the CD40 expression was largely suppressed by an inhibitor of JAK/STAT3.
Inflamm-aging: STAT3 Signaling Pushes Muscle Stem Cells off Balance.
New
Impact
Mouchiroud et al., Villeurbanne, France. In Cell Stem Cell, 02 Nov 2014
Both genetic and pharmacologic inhibition of STAT3 signaling improve stem cell homeostasis and physiology of aged and dystrophic muscles.
STAT3 signaling controls satellite cell expansion and skeletal muscle repair.
New
Impact
Sacco et al., Los Angeles, United States. In Nat Med, 31 Oct 2014
The levels of STAT3, a downstream effector of IL-6, are also elevated with muscle wasting, and STAT3 has been implicated in the regulation of self-renewal and stem cell fate in several tissues.
The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors.
New
Impact
Rodriguez et al., New Orleans, United States. In Immunity, 18 Oct 2014
Chop-deficient MDSCs displayed reduced signaling through CCAAT/enhancer-binding protein-β, leading to a decreased production of interleukin-6 (IL-6) and low expression of phospho-STAT3.
Signaling molecules regulating phenotypic conversions of astrocytes and glial scar formation in damaged nerve tissues.
Review
New
Koyama, Ōsaka, Japan. In Neurochem Int, 30 Sep 2014
The transcription factors: STAT3, OLIG2, SMAD, NF-κB, and Sp1 have been suggested to play regulatory roles in astrocytic activation and glial scar formation.
The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells.
New
Impact
Ueno et al., Dallas, United States. In Nat Immunol, 30 Sep 2014
Here we found that transforming growth factor-β (TGF-β) provided critical additional signals for the transcription factors STAT3 and STAT4 to promote initial TFH differentiation in humans.
Androgen receptor, ccl2, and epithelial-mesenchymal transition: A dangerous affair in the tumor microenvironment.
New
Izumi et al., Taiwan. In Oncoimmunology, Dec 2013
We have recently discovered that inhibiting the androgen receptor (AR) in prostate cancer cells or tumor-infiltrating macrophages results in the upregulation CCL2 and promotes disease progression by activating signal transducer and activator of transcription 3 (STAT3) and by favoring the epithelial-to-mesenchymal transition.
A20--an omnipotent protein in the liver: prometheus myth resolved?
Review
New
Ferran et al., In Adv Exp Med Biol, Dec 2013
The molecular basis for A20's hepatoprotective functions were partially resolved and include blockade of NF-kappaB activation in support of its anti-inflammatory function, inhibition of pro-caspase 8 cleavage in support of its anti-apoptotic function, increasing Peroxisome Proliferator Activated Receptor alpha (PPARalpha) expression in support of its anti-oxidant function, and decreasing Cyclin Dependent Kinase Inhibitor p21 while boosting IL-6/STAT3 proliferative signals as part of its pro-regenerative function.
STAT3: A Novel Molecular Mediator of Resistance to Chemoradiotherapy.
Review
New
Grade et al., Göttingen, Germany. In Cancers (basel), Dec 2013
In this review, we highlight much of the recent evidence suggesting that the signal transducer and activator of transcription 3 (STAT3) plays a prominent role in mediating CRT-resistance, and we outline why inhibition of STAT3 holds great promise for future multimodal treatment concepts in oncology.
Signal transductions and nonalcoholic fatty liver: a mini-review.
Review
New
Zhou et al., Guangzhou, China. In Int J Clin Exp Med, Dec 2013
Different signal transductions such as MAPK, NF-κB, AMPK, JAK2/STAT3, PPAR, PI3K/Akt, TLR were activated by the pathogenic factors to regulate correlative reactions.
Leptin signaling.
Review
New
Ahima et al., Seoul, South Korea. In F1000prime Rep, Dec 2013
The binding of leptin to its specific receptor activates various intracellular signaling pathways, including Janus kinase 2 (JAK2)/ signal transducer and activator of transcription 3 (STAT3), insulin receptor substrate (IRS)/phosphatidylinositol 3 kinase (PI3K), SH2-containing protein tyrosine phosphatase 2 (SHP2)/mitogen-activated protein kinase (MAPK), and 5' adenosine monophosphate-activated protein kinase (AMPK)/ acetyl-CoA carboxylase (ACC), in the central nervous system and peripheral tissues.
The Inhibition of N-Glycosylation of Glycoprotein 130 Molecule Abolishes STAT3 Activation by IL-6 Family Cytokines in Cultured Cardiac Myocytes.
New
Fujio et al., Suita, Japan. In Plos One, Dec 2013
IL-6 cytokines bind to their specific receptors and activate glycoprotein 130 (gp130), a common receptor, followed by further activation of STAT3 and extracellular signal-regulated kinase (ERK)1/2 through janus kinases (JAKs); however the importance of glycosylation of gp130 remains to be elucidated in cardiac myocytes.
The dark side of Toll-like receptor signaling: TLR9 activation limits the efficacy cancer radiotherapy.
New
Pal et al., Duarte, United States. In Oncoimmunology, Dec 2013
We have recently demonstrated that Toll-like receptor 9 (TLR9) jump-starts the signal transduction and activator of transcription 3 (STAT3)-dependent vascularization and regrowth of tumors that recur upon irradiation.
Selective STAT3-α or -β expression reveals spliceform-specific phosphorylation kinetics, nuclear retention and distinct gene expression outcomes.
GeneRIF
Bogoyevitch et al., Melbourne, Australia. In Biochem J, 2012
results highlight STAT3beta as a significant transcriptional regulator in its own right, with additional actions to cross-regulate STAT3alpha phosphorylation and nuclear retention after cytokine stimulation
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
GeneRIF
Egwuagu et al., Bethesda, United States. In J Biol Chem, 2012
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
STAT3 transcription factor promotes instability of nTreg cells and limits generation of iTreg cells during acute murine graft-versus-host disease.
Impact
GeneRIF
Fowler et al., Bethesda, United States. In Immunity, 2012
STAT3 limited FoxP3+ Treg cell numbers following allogeneic bone marrow transplantation by two pathways: instability of natural Treg (nTreg) cells and inhibition of induced Treg (iTreg) cell polarization from naive CD4+ T cells.
The stat3/socs3a pathway is a key regulator of hair cell regeneration in zebrafish. [corrected].
GeneRIF
Burgess et al., Bethesda, United States. In J Neurosci, 2012
The results of this study suggested that the stat3/socs3 pathway is a key response in all tissue regeneration in zebrafish.
Activation of Stat3 in endothelial cells following hypoxia-reoxygenation is mediated by Rac1 and protein Kinase C.
GeneRIF
Becker et al., Baltimore, United States. In Biochim Biophys Acta, 2012
Stat3 forms a multiprotein complex with Rac1 and PKC in an hypoxia-reoxygenation-dependent manner.
More papers using STAT3 antibodies
STAT3 transcriptional factor activated by reactive oxygen species induces IL6 in starvation-induced autophagy of cancer cells
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Viola Joao P. B., In PLoS ONE, 2009
... Anti-STAT3 and anti-p-STAT3 (Y705) were purchased from Cell Signaling.
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
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Fagard Remi et al., In BMC Cell Biology, 2008
... with binding buffer, complexes were separated on SDS-polyacrylamide (8%) gel, subjected to immunoblotting using an anti-phospho-STAT3 antibody (Cell Signaling); input was determined by ...
Plasma and urine biomarkers in acute viral hepatitis E.
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Tavis John E., In PLoS ONE, 2008
... The antibodies to phospho-Akt, Akt, HNF4, PARP and STAT3 were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Notch1 signaling stimulates proliferation of immature cardiomyocytes
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Giacca Mauro et al., In The Journal of Cell Biology, 2007
... anti–GATA-4 antibodies were obtained from Santa Cruz Biotechnology, Inc.; anti–cleaved Notch-1 (Val1744), anti–phospho-p38 MAPK, and anti–phospho-STAT3 (Tyr705) were obtained from Cell Signaling Technology; antisarcomeric α-actinin (EA-53) ...
Spatially and temporally controlled electroporation of early chick embryos.
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Najbauer Joseph, In PLoS ONE, 2007
... Jak I inhibitor 0.6 µM (Calbiochem) was used to block LIF-Stat3 pathway; SB431542 10 µM (Tocris Bioscience) and rhNoggin 500 ...
Rho GTPase activation assays.
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Beaudoin Claude, In PLoS ONE, 2007
... Antibodies to total and phosphorylated STAT3 were from Cell Signaling Technology (Danvers, MA, USA) ...
The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation
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Chang Zhijie et al., In Breast Cancer Research : BCR, 2006
... Anti-Myc (9E10), anti-HA (F-7), anti-GFP (FL), anti-pSTAT3(Tyr705, B-7), anti-pSTAT3(Ser727), anti-STAT3 (F-2) and anti-STAT3 (C-20) antibodies, and protein G/A plus agarose beads were purchased from Santa Cruz Biotechnology, and anti-β-Actin (AC-15) antibody ...
Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6
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DeCoster Mark A et al., In Journal of Neuroinflammation, 2006
... The antibodies against β-actin, phospho-JAK3, phospho-STAT3, JAK3, and STAT3 were purchased from Cell Signaling Technology Inc ...
The expression of the von Hippel-Lindau gene product and its impact on invasiveness of human breast cancer cells
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Rozakis-Adcock M et al., In Oncogene, 2006
... Antibodies to phospho-Met Y1234/5, phospho-Akt Ser 473, Akt, phospho-STAT3, STAT3, phosphotyrosine residues (4G10) and HRP-linked secondary antibodies were purchased from Cell Signaling Technologies (Beverly, MA, USA) ...
STAT3 polymorphism predicts interferon-alfa response in patients with metastatic renal cell carcinoma
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Bauer Joseph Alan, In PLoS ONE, 2006
... For fluorescence polarization assays, STAT3 protein (>90% purity) was purchased from Abcam (Cambridge, MA) ...
The effect of bovine serum albumin on the membrane potential and reactive oxygen species generation in succinate-supported isolated brain mitochondria.
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Combs Colin, In PLoS ONE, 2006
... Primary antibody to GFAP was from Dako (rabbit, Carpenteria, CA), to tyrosine705-phosphorylated STAT3 (pSTAT3) was from Cell Signaling Technology, Inc ...
Raf kinase inhibitory protein knockout mice: expression in the brain and olfaction deficit.
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Yamaoka Yoshio, In PLoS ONE, 2006
... The antibodies to STAT3 pS727 and pY705 and PARP were purchased from Cell Signaling Technology (Beverly, MA) and ...
The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1
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Benistant Christine et al., In The Journal of Cell Biology, 2005
... Stat3 from Cell Signaling Technology, anti-Stat3 from Millipore, ...
Inhibition of interleukin-6 with CNTO328, an anti-interleukin-6 monoclonal antibody, inhibits conversion of androgen-dependent prostate cancer to an androgen-independent phenotype in orchiectomized mice
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Bromberg Jacqueline et al., In Breast Cancer Research : BCR, 2005
... ] by using a radiolabeled high-affinity m67 DNA binding probe and an anti-Stat3 antibody for supershifting (Stat3 (K-15): sc-483 X, Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
Assessing implicit models for nonpolar mean solvation forces: the importance of dispersion and volume terms.
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Schneider-Stock Regine, In PLoS ONE, 2005
... 14-3-3σ, 14-3-3θ, 14-3-3β, GAPDH antibodies (Santa Cruz Biotechnology, Santa Cruz, CA), 14-3-3γ, 14-3-3η, Stat3, pY705-Stat3, pS727-Stat3 antibodies (Cell Signaling, Danvers, MA), HA tag, ...
Targeting signal-transducer-and-activator-of-transcription-3 for prevention and therapy of cancer: modern target but ancient solution
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Claret Francois X et al., In Breast Cancer Research : BCR, 2005
... The following antibodies were used in the study: C/EBP-α (N-19), C/EBP-β (C-19), GATA-1 (H-200), and Stat3 (C-20) (Santa Cruz Biotechnology, Santa Cruz, CA, USA) ...
The signal transduction networks required for phosphorylation of STAT1 at Ser727 in mouse epidermal JB6 cells in the UVB response and inhibitory mechanisms of tea polyphenols
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Verma Ajit K. et al., In Oncogene, 2004
... pStat3Tyr705, Bcl-xL, COX-2, β-actin, donkey anti-goat immunoglobulin (IgG)-FITC for PKCε and donkey anti-rabbit IgG-rhodamine for Stat3 (Santa Cruz Biotechnology, Santa Cruz, CA); and ...
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
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Virgin Skip W., In PLoS Biology, 2004
... Antibodies for the following targets were used: STAT1 (BD Biosciences Franklin Lakes, NJ, USA), STAT3 (Santa Cruz Biotech, Santa Cruz, CA, USA), HA (Cell Signaling Technology, Beverly, MA, USA), ...
The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing.
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Bunting Kevin D., In PLoS ONE, 2003
... Phospho-STAT3 (Tyr705) D3A7 rabbit monoclonal antibody, Cell Signaling Technology (CST) #9145 ...
Transformation fingerprint: induced STAT3-C, v-Src and Ha-Ras cause small initial changes but similar established profiles in mRNA.
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Zimmer Jacques, In PLoS ONE, 2003
TLR4 (clone UT41), CD25 Abs and Stat3 inhibitory peptide (Stat3I) were from eBioscience (San Diego, CA) ...
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
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Schneider Guenter, In PLoS ONE, 2003
... phospho (p)-EGFR (Y1068, Y1045), Bcl-xL, Mcl-1, Bid, p-Bad (S112), Bad, PI3K, ERK, p-ERK (T202/Y204), STAT3, p-STAT3 (Y705), aldolase, and H3 (Cell Signaling, Danvers, MA, USA) ...
Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis.
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Singh Rana Pratap, In PLoS ONE, 2003
... -pSTAT3 and STAT3 were purchased from Cell Signaling Technology (Beverly,MA) ...
Thrombin Up-regulates Tissue Factor Pathway Inhibitor-2 Synthesis through a Cyclooxygenase-2-dependent, Epidermal Growth Factor Receptor-independent Mechanism
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Rosenbaum Jean et al., In Comparative Hepatology, 2003
... mAb B-R3 was from Diaclone (Besançon, France), anti-gp80 mAb M91 was from Coulter-Immunotech (Marseille, France), anti-phospho-STAT-3 (Tyr705) was from Cell Signaling Technology (Beverly, MA) ...
Apoptosis pathway in cancer and cancer therapy
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Fahmy Hesham et al., In Marine Drugs, 2003
... Mouse monoclonal antibodies against β-actin, Cdk4 and STAT-3, rabbit antibodies against cycline D1 and D2, goat anti-mouse and goat anti-rabbit both horseradish-conjugated (HRP) secondary antibodies were purchased from Santa Cruz Biotechnology, Inc ...
Matrix metalloproteinase activity and immunohistochemical profile of matrix metalloproteinase-2 and -9 and tissue inhibitor of metalloproteinase-1 during human dermal wound healing
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He Shaoheng et al., In BMC Cell Biology, 2003
... AG490, LY294002, phospho-p44/42 MAPK antibody, unphospho-p44/42 MAPK antibody, phospho-Akt antibody, unphospho-Akt antibody, phospho-STAT3 antibody and unphospho-STAT3 antibody were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.
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Buday Laszlo, In PLoS ONE, 2002
... : Antibodies against pStat3, Stat3 (Cell Signaling), against IL-10R1 (polyclonal, C20 ...
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation
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Parker Peter J. et al., In The Journal of Cell Biology, 2001
... were the following: anti–phospho–c-Met (Tyrosine 1349 or Tyrosine 1234/1235), pan-ERK, phospho-p42/p44 ERK, mouse monoclonal anti–pan-STAT3, phospho-STAT3 (Y706; S727), PKCα (BD Biosciences), anti–pan-STAT3, and chc (Santa ...
BMPs signal alternately through a SMAD or FRAP–STAT pathway to regulate fate choice in CNS stem cells
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McKay Ronald D.G. et al., In The Journal of Cell Biology, 2001
... DakoCytomation; monoclonal anti-SMA and anti-FLAG from Sigma-Aldrich; polyclonal anti-HA from BABCO; monoclonal anti-FKBP12, anti-FRAP, and anti-Stat3 from Transduction Laboratories; polyclonal anti-phosphoStat3 (Tyr705 and Ser727) from Santa Cruz Biotechnology, Inc.; monoclonal anti–BMPR-IA from ...
Processing of gene expression data generated by quantitative real-time RT-PCR.
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Harhaj Edward, In PLoS ONE, 2001
... Anti-phospho-Stat1 (Tyr701) and anti-phospho-Stat3 (Tyr705) were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
SOCS proteins: negative regulators of cytokine signaling.
Supplier
Hartl Dominik, In PLoS ONE, 2000
... 9205), phospho-STAT3 (Tyr705) (Cell Signaling, Cat ...
A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube
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Farrar William L et al., In Molecular Cancer, 1999
... LFM-A13 (Tocris, Ellisville, MO), MEK inhibitor PD98059 (Gibco, Carlsbad, CA), JAK inhibitor AG490 (Gibco), and STAT3 inhibitor Stattic (Sigma Aldrich, St ...
Generalized lacZ expression with the ROSA26 Cre reporter strain.
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O'Rahilly Stephen, In PLoS Biology, 1998
... was purchased from Santa Cruz, anti-JAK2 antibody from Invitrogen, anti-phosphotyrosine antibody from Upstate, anti-P-Stat3 and anti-Stat3 antibodies from Cell Signaling, and anti-actin antibody from ...
Rat embryo fibroblasts transformed by c-Jun display highly metastatic and angiogenic activities in vivo and deregulate gene expression of both angiogenic and antiangiogenic factors
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Gibson Spencer B et al., In BMC Cancer, 1998
... and total Erk1/2, XIAP and STAT3 antibodies, as well as siRNA for c-Jun (#6203) and Stat3 siRNA I (#6580) and control siRNA (#6201 fluorescein conjugate) were purchased from Cell Signaling Technology, VEGF antibody was ...
Signal transduction and transcription factors in rheumatic disease
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Peng Daizhi et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1998
... Rabbit anti-phospho-Jak2 (Tyr1007/1008), anti-STAT3 polyclonal antibodies were purchased from Biovision (CA, USA) ...
STAT3 mediates the survival signal in oncogenic ras-transfected intestinal epithelial cells
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Asano T et al., In British Journal of Cancer, 1997
... The antibodies used in this study were antibodies against phospho-STAT3 (p-STAT3, Cell Signaling Technology Inc., Beverly, MA, ...
Signal transduction via platelet-derived growth factor receptors.
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Samuel Jane-Lise, In PLoS ONE, 1997
... kinase 1/2 (ERK1/2), Akt, glycogen synthase kinase-3β (GSK-3β) and signal transducer and activator of transcription 3 (STAT3) were obtained from Cell Signaling technology (Danvers, MA) ...
Functional Inactivation of CXC Chemokine Receptor 4–mediated Responses through SOCS3 Up-regulation
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Mellado Mario et al., In The Journal of Experimental Medicine, 1993
... For immunostaining, we used anti-STAT3 and -phospho-STAT3 antibody (New England Biolabs, Inc.) ...
Anaesthesia techniques for midazolam and flumazenil-an overview
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Iida Hiroki et al., In Journal of Neuroinflammation, 1989
... SAPK/JNK, phospho-specific inhibitory kappa B (IκB), IκB, phospho-specific signal transducer and activator of transcription (STAT)3 and STAT3 antibodies were purchased from Cell Signaling (Beverly, MA) ...
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