Identification of a Th2 and Th17 Skewed Immune Phenotype in Chronic Urticaria with Th22 Reduction Dependent on Autoimmunity and Thyroid Disease Markers.
Boston, United States. In J Cutan Pathol, 20 Feb 2016
METHODS: Biopsies of chronic urticaria (n=11) and normal skin (n=5) were evaluated with immunostains for CD117, CD3 and dual stains for CD4/T-bet, GATA-3, STAT-3, or BNC-2 (transcription factors specific and mutually exclusive for Th1, Th2, Th17, and Th22 cells, respectively).
Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site.
Martinsried, Germany. In Nature, 24 Jan 2016
Here we show that substitution of the conserved glycine 388 residue to a charged arginine residue alters the transmembrane spanning segment and exposes a membrane-proximal cytoplasmic signal transducer and activator of transcription 3 (STAT3) binding site Y(390)-(P)XXQ(393).
Erythropoietin Stimulates Tumor Growth via EphB4.
More papers using
Houston, United States. In Cancer Cell, 09 Dec 2015
Here, we identified EphB4 as an Epo receptor that triggers downstream signaling via STAT3 and promotes rhEpo-induced tumor growth and progression.
Assessing implicit models for nonpolar mean solvation forces: the importance of dispersion and volume terms.
In PLoS ONE, 2005
... 14-3-3σ, 14-3-3θ, 14-3-3β, GAPDH antibodies (Santa Cruz Biotechnology, Santa Cruz, CA), 14-3-3γ, 14-3-3η, Stat3, pY705-Stat3, pS727-Stat3 antibodies (Cell Signaling, Danvers, MA), HA tag, ... Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
In PLoS Biology, 2004
... Antibodies for the following targets were used: STAT1 (BD Biosciences Franklin Lakes, NJ, USA), STAT3 (Santa Cruz Biotech, Santa Cruz, CA, USA), HA (Cell Signaling Technology, Beverly, MA, USA), ... Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
In PLoS ONE, 2003
... phospho (p)-EGFR (Y1068, Y1045), Bcl-xL, Mcl-1, Bid, p-Bad (S112), Bad, PI3K, ERK, p-ERK (T202/Y204), STAT3, p-STAT3 (Y705), aldolase, and H3 (Cell Signaling, Danvers, MA, USA) ...