A polysaccharide from mushroom Huaier retards human hepatocellular carcinoma growth, angiogenesis, and metastasis in nude mice.
Wuhan, China. In Tumour Biol, 11 Jan 2015
Keeping in line with this observation, SP1 treatment decreased serum matrix metalloproteinase (MMP) 2 and vascular endothelial growth factor (VEGF) levels, downregulated the protein expression of hypoxia-inducible factor (HIF)-1alpha, VEGF, MMP2, bcl-2, N-cadherin, signal transducer and activator of transcription 3 (STAT3), and metadherin (MTDH), and upregulated bax and NE-cadherin protein expression in tumor tissues.
Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 (APE1/Ref-1) redox function negatively regulates NRF2.
United States. In J Biol Chem, 09 Jan 2015
UNLABELLED: Apurinic/Apyrimidinic endonuclease/Redox factor-1 (APE1/Ref-1) (henceforth referred to as Ref-1) is a multi-functional protein that in addition to its base-excision DNA repair activity exerts redox control of multiple transcription factors, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), STAT3, activator protein-1 (AP-1), hypoxia-inducible factor-1 (HIF-)1 and tumor protein 53 (p53).
Cell signalling pathways underlying induced pluripotent stem cell reprogramming.
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London, United Kingdom. In World J Stem Cells, 26 Dec 2014
In recent years, various groups have endeavoured to interrogate the cell signalling that governs the reprogramming process, including LIF/STAT3, BMP, PI3K, FGF2, Wnt, TGFβ and MAPK pathways, with the aim of increasing our understanding and identifying new mechanisms of improving safety, reproducibility and efficiency.
Assessing implicit models for nonpolar mean solvation forces: the importance of dispersion and volume terms.
In PLoS ONE, 2005
... 14-3-3σ, 14-3-3θ, 14-3-3β, GAPDH antibodies (Santa Cruz Biotechnology, Santa Cruz, CA), 14-3-3γ, 14-3-3η, Stat3, pY705-Stat3, pS727-Stat3 antibodies (Cell Signaling, Danvers, MA), HA tag, ... Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
In PLoS Biology, 2004
... Antibodies for the following targets were used: STAT1 (BD Biosciences Franklin Lakes, NJ, USA), STAT3 (Santa Cruz Biotech, Santa Cruz, CA, USA), HA (Cell Signaling Technology, Beverly, MA, USA), ... Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis.
In PLoS ONE, 2003
... phospho (p)-EGFR (Y1068, Y1045), Bcl-xL, Mcl-1, Bid, p-Bad (S112), Bad, PI3K, ERK, p-ERK (T202/Y204), STAT3, p-STAT3 (Y705), aldolase, and H3 (Cell Signaling, Danvers, MA, USA) ...