GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Signal transducer and activator of transcription 2, 113kDa
STAT2
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010] (from
NCBI)
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Papers on
STAT2
Porcine Reproductive and Respiratory Syndrome Virus Nsp1β Inhibits Interferon-Activated JAK/STAT Signal Transduction by Inducing Karyopherin-α1 Degradation.
New
College Park, United States. In J Virol, 28 Mar 2013
Type I interferons (IFNs) induce the expression of IFN-stimulated genes by activating phosphorylation of both the signal transducer and activator of transcription 1 (STAT1) and STAT2, which form heterotrimers (ISGF3) with IRF9 and translocate to the nucleus.
STAT2 deficiency and susceptibility to viral illness in humans.
New
Newcastle upon Tyne, United Kingdom. In Proc Natl Acad Sci U S A, 19 Mar 2013
Patient fibroblasts were indeed abnormally permissive for viral replication in vitro, associated with profound failure of type I IFN signaling and absence of STAT2 protein.
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.
New
Impact
Bethesda, United States. In Nat Genet, 28 Feb 2013
Transient overexpression of IFNL4 in a hepatoma cell line induced STAT1 and STAT2 phosphorylation and the expression of interferon-stimulated genes.
Neandertal origin of genetic variation at the cluster of OAS immunity genes.
New
Tucson, United States. In Mol Biol Evol, 12 Feb 2013
This is the second locus in the human genome, after STAT2, carrying distinct haplotypes that appear to have introgressed separately from both Neandertals and Denisova.
Detection and cellular localization of phospho-STAT2 in the central nervous system by immunohistochemical staining.
New
Odense, Denmark. In Methods Mol Biol, Dec 2012
Here we describe immunohistochemical staining procedures for detection and identification of the cellular localization of phospho-STAT2 in the central nervous system (CNS) of mice.
Morbillivirus v proteins exhibit multiple mechanisms to block type 1 and type 2 interferon signalling pathways.
New
United Kingdom. In Plos One, Dec 2012
The ability to block type II IFN-induced gene transcription correlated with co-precipitation of STAT1 with the respective V protein, but there was no correlation between co-precipitation of either STAT1 or STAT2 and the abilities of the V proteins to block type I IFN-induced gene transcription or the creation of the antiviral state.
The V protein of Tioman virus is incapable of blocking type I interferon signaling in human cells.
New
Paris, France. In Plos One, Dec 2012
Here we show that in contrast to the V protein of MuV, the V protein of TioV (TioV-V) hardly interacts with human STAT2, does not degrade STAT1, and cannot block IFN-α/β signaling in human cells.
The JAK-STAT pathway at twenty.
Review
New
Impact
Cleveland, United States. In Immunity, May 2012
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons.
The role of signal transducer and activator of transcription-2 in the interferon response.
Review
New
Philadelphia, United States. In J Interferon Cytokine Res, Mar 2012
The signal transducer and activator of transcription-2 (STAT2) was discovered as a cellular component of the DNA binding complex known as interferon (IFN) stimulated gene factor-3.
Innate immunity evasion by Dengue virus.
Review
New
New York City, United States. In Viruses, Mar 2012
Importantly, the ability of the NS5 protein to bind and degrade STAT2 contributes to the limited host tropism of DENV to humans and non-human primates.
Deletion of Kaposi's sarcoma-associated herpesvirus FLICE inhibitory protein, vFLIP, from the viral genome compromises the activation of STAT1-responsive cellular genes and spindle cell formation in endothelial cells.
GeneRIF
Hannover, Germany. In J Virol, 2011
These findings highlight the role of Kaposi's sarcoma herpesvirus vFLIP in the activation of STAT1/STAT2 and STAT-responsive cellular genes in endothelial cells.
NLRX1 protein attenuates inflammatory responses to infection by interfering with the RIG-I-MAVS and TRAF6-NF-κB signaling pathways.
Impact
Chapel Hill, United States. In Immunity, 2011
We showed that Nlrx1(-/-) mice exhibited increased expression of antiviral signaling molecules IFN-β, STAT2, OAS1, and IL-6 after influenza virus infection.
Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2.
GeneRIF
Roma, Italy. In J Biol Chem, 2011
Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2.
p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor.
GeneRIF
Roma, Italy. In Oncogene, 2011
Data show that, in response to IFNalpha, STAT2 is recruited onto the endogenous P2p73 promoter together with the polycomb group protein Ezh2.
Identification of DNA-damage DNA-binding protein 1 as a conditional essential factor for cytomegalovirus replication in interferon-γ-stimulated cells.
GeneRIF
Düsseldorf, Germany. In Plos Pathog, 2011
In a constructive process, pM27 recruits DDB1 to exploit ubiquitin ligase complexes catalyzing the obstruction of the STAT2-dependent antiviral state of cells to permit viral replication.
PCBP2 enhances the antiviral activity of IFN-α against HCV by stabilizing the mRNA of STAT1 and STAT2.
GeneRIF
Beijing, China. In Plos One, 2010
PCBP2 stabilizes the mRNA of STAT1 and STAT2 through binding the 3'Untranslated Region (UTR) of these two molecules.
Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression.
Impact
Vienna, Austria. In Immunity, 2010
Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing STAT1, STAT2, and IRF9 subunits) and NF-kappaB to the transcriptional induction of the Nos2 gene in macrophages infected with the intracellular bacterial pathogen Listeria monocytogenes.
STAT1 and pathogens, not a friendly relationship.
Review
Bobigny, France. In Biochimie, 2010
STAT1 belongs to the STAT family of transcription factors, which comprises seven factors: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6.
Evasion of interferon responses by Ebola and Marburg viruses.
Review
New York City, United States. In J Interferon Cytokine Res, 2009
Notably, the Marburg virus VP24 protein does not detectably block STAT1 nuclear import, and, unlike EBOV, MARV infection inhibits STAT1 and STAT2 phosphorylation.
Acetylation-dependent signal transduction for type I interferon receptor.
Impact
Providence, United States. In Cell, 2007
IRF9 interacts with the acetyl-Lys399 motif by means of its IRF homology2 (IH2) domain, leading to formation of the ISGF3 complex that includes IRF9, STAT1, and STAT2.
