The JAK-STAT pathway at twenty.
Cleveland, United States. In Immunity, May 2012
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons.
Innate immunity evasion by Dengue virus.
New York City, United States. In Viruses, Mar 2012
Importantly, the ability of the NS5 protein to bind and degrade STAT2 contributes to the limited host tropism of DENV to humans and non-human primates.