STATs get their move on.
Stony Brook, United States. In Jakstat, Nov 2013
Following STAT2 tyrosine phosphorylation, it can form dimers with STAT1 to affect nuclear import as the trimeric complex (ISGF3).
STAT2 phosphorylation and signaling.
Philadelphia, United States. In Jakstat, Nov 2013
Evidence of additional STAT2 phosphorylation sites has emerged as well as novel roles for STAT2 separate from the classical ISGF3-signaling.
STAT2 and IRF9: Beyond ISGF3.
Montréal, Canada. In Jakstat, Nov 2013
Among STATs, STAT2 is classically known to dimerize with STAT1 and together with IRF9 forms the ISGF3 transcription factor complex that has long been considered a hallmark of activation by type I and type III interferons.
Transcriptional regulation by STAT1 and STAT2 in the interferon JAK-STAT pathway.
Evanston, United States. In Jakstat, Aug 2013
While many aspects of ISGF3-mediated gene regulation are thought to be common features applicable to several ISGs, there are also many reports of distinct cases of non-canonical STAT1 or STAT2 signaling events and distinct patterns of co-regulators that contribute to gene-specific transcription.
Paramyxovirus evasion of innate immunity: Diverse strategies for common targets.
Australia. In World J Virol, Jun 2013
Although paramyxovirus IFN antagonists generally target common factors of the IFN system, including melanoma differentiation associated factor 5, retinoic acid-inducible gene-I, signal transducers and activators of transcription (STAT)1 and STAT2, and IFN regulatory factor 3, the mechanisms of antagonism show remarkable diversity between different genera and even individual members of the same genus; the reasons for this diversity, however, are not currently understood.
The JAK-STAT pathway at twenty.
Cleveland, United States. In Immunity, 2012
We look back on the discoveries that the tyrosine kinases TYK2 and JAK1 and the transcription factors STAT1, STAT2, and IRF9 are required for the cellular response to type I interferons.