Interferon alpha decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytesmore suppliers
In Virology Journal, 2007
... MEK, ERK, STAT1, phospho-MEK (Ser217/221), phospho-ERK (Thr202/Tyr204), phospho-SAPK/JNK (Thr183/Tyr185), phospho-p38 MAPK (Thr180/Tyr182), phospho-ATF-2 (Thr71), or phospho-STAT1 (Tyr701) were purchased from Cell Signaling Technology (Beverly, MA) ...
The good and the bad faces of STAT1 in solid tumours.
Vienna, Austria. In Cytokine, Dec 2015
UNASSIGNED: Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase (JAK)/STAT signalling cascade and is best known for its essential role in mediating responses to all types of interferons (IFN).
Host susceptibility to non-tuberculous mycobacterial infections.
Bethesda, United States. In Lancet Infect Dis, Aug 2015
So far, at least seven autosomal mutations (in IL12B, IL12RB1, ISG15, IFNGR1, IFNGR2, STAT1, and IRF8) and two X-linked mutations (in IKBKG and CYBB), mostly presenting in childhood, have been reported to confer susceptibility to disseminated non-tuberculous mycobacterial infection.
The Evolving View of IL-17-Mediated Immunity in Defense Against Mucocutaneous Candidiasis in Humans.
Debrecen, Hungary. In Int Rev Immunol, 2014
Inborn errors of immunity affecting IL-17+ T cell differentiation have recently been defined, such as deficiencies of signal transducer and activator of transcription (STAT)3, STAT1, IL-12Rβ1 and IL-12p40, and caspase recruitment domain 9. Impaired receptor-ligand coupling was identified in patients with IL-17F and IL-17 receptor A (IL17RA) deficiency and autoimmune polyendocrine syndrome (APS) type 1. Mutation in the nuclear factor kappa B activator (ACT) 1 was described as a cause of impaired IL-17R-mediated signaling.
Herpes in STAT1 gain-of-function mutation [corrected].
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Debrecen, Hungary. In Lancet, 2012
individuals carrying STAT1 mutations might also be susceptible to viral diseases. The mechanism underlying reactivation disease in patients with STAT1 mutations and chronic mucocutaneous candidosis could involve the impairment of memory T cells