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Signal transducer and activator of transcription 1, 91kDa

STAT1, signal transducer and activator of transcription 1
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: STAT3, V1a, CAN, Interleukin-6, HAD
Papers using STAT1 antibodies
The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
Su Wu-Chou et al., In International Journal of Nanomedicine, 2009
... The following antibodies were used: anti-Stat3 (Tyr705), anti-Stat1, anti-α-tubulin (Cell Signaling Technology, Beverly, MA), anti-Stat3 ...
Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury.
Dalmasso Guillaume, In PLoS ONE, 2009
... Antibodies specific for MLC and phosphorylated MLC (serine 19) (pMLC) and STAT1 (pSTAT1) were from Cell Signaling Technology (Danvers, MA) ...
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
Kremer Eric J., In PLoS ONE, 2008
... STAT1 and phosphorylated STAT1 antibodies were purchased from Santa Cruz Biotechnology and Cell Signaling, respectively ...
Interferon alpha decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytes
Qi Zhong-Tian et al., In Virology Journal, 2007
... MEK, ERK, STAT1, phospho-MEK (Ser217/221), phospho-ERK (Thr202/Tyr204), phospho-SAPK/JNK (Thr183/Tyr185), phospho-p38 MAPK (Thr180/Tyr182), phospho-ATF-2 (Thr71), or phospho-STAT1 (Tyr701) were purchased from Cell Signaling Technology (Beverly, MA) ...
Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6
DeCoster Mark A et al., In Journal of Neuroinflammation, 2006
... Antibodies against vWF-related antigen, STAT1 siRNA [STAT1 p84/p91 shRNA (r) lentiviral particles: sc-61879-V], control shRNA lentiviral particles (sc-108080), and Polybrene® buffer (sc-134220) were purchased from Santa Cruz Biotechnology Inc ...
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Papers on STAT1
S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification.
Rosen et al., Tokyo, Japan. In Proc Natl Acad Sci U S A, Feb 2016
S1PR1 agonist treatment accelerates turnover of IFNAR1, suppresses signal transducer and activator of transcription 1 (STAT1) phosphorylation, and down-modulates total STAT1 levels, thereby inactivating the autoamplification loop.
Progressive Multifocal Leukencephalopathy in Primary Immune Deficiencies: STAT1 Gain of Function and Review of the Literature.
Holland et al., Frederick, United States. In Clin Infect Dis, Feb 2016
One patient with dominant gain of function mutation in signal transducer and activator of transcription 1 (STAT1) with chronic mucocutaneous candidiasis (CMC) and PML was reported previously.
PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non-Small Cell Lung Cancer.
Maehara et al., Fukuoka, Japan. In J Thorac Oncol, Jan 2016
Expression of the PD-L1 protein was significantly reduced by the JAK2 inhibitor TG-101348 and the signal transducer and activator of transcription 3 (STAT-3) inhibitor BP-1-102, but not by the STAT1 inhibitor fludarabine.
Interferon and IL-27 antagonize the function of group 2 innate lymphoid cells and type 2 innate immune responses.
Koyasu et al., Yokohama, Japan. In Nat Immunol, Jan 2016
Both type I and type II interferons and interleukin 27 (IL-27) suppressed ILC2 function in a manner dependent on the transcription factor STAT1. ILC2-mediated lung inflammation was enhanced in the absence of the interferon-γ (IFN-γ) receptor on ILC2 cells in vivo.
Type I interferon restricts type 2 immunopathology through the regulation of group 2 innate lymphoid cells.
Fritz et al., Montréal, Canada. In Nat Immunol, Jan 2016
Type I interferons directly and negatively regulated mouse and human ILC2 cells in a manner dependent on the transcriptional activator ISGF3 that led to altered cytokine production, cell proliferation and increased cell death.
Proinflammatory gene expression in patients undergoing mitral valve surgery and maze ablation for atrial fibrillation.
Yeh et al., Taiwan. In J Thorac Cardiovasc Surg, Jan 2016
Regression analysis showed that increased left atrial diameter was associated with the expression of RHOA and STAT1.
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Holtzman et al., Saint Louis, United States. In Nat Immunol, Dec 2015
In support of this concept, we used a modified form of the transcription factor STAT1 to achieve hyper-responsiveness to interferon without toxicity and markedly improve antiviral function in transgenic mice and transduced human cells.
A STAT inhibitor patent review: progress since 2011.
Gunning et al., Toronto, Canada. In Expert Opin Ther Pat, Dec 2015
Emphasis will be placed on inhibitors of the STAT3, STAT5a/b, and STAT1 proteins for cancer treatment.
The good and the bad faces of STAT1 in solid tumours.
Strobl et al., Vienna, Austria. In Cytokine, Dec 2015
UNASSIGNED: Signal transducer and activator of transcription (STAT) 1 is part of the Janus kinase (JAK)/STAT signalling cascade and is best known for its essential role in mediating responses to all types of interferons (IFN).
Influenza lung injury: mechanisms and therapeutic opportunities.
Kobzik et al., Ban Mae Chan, Thailand. In Am J Physiol Lung Cell Mol Physiol, Dec 2015
The roles of fatty acid binding protein 5, prostaglandin E2, and the interplay between IFN-γ and STAT1 in epithelial signaling during infection have been addressed in vitro.
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.
Diefenbach et al., Mainz, Germany. In Nat Immunol, Jul 2015
Cooperation between the receptor for IL-22 and the receptor for IFN-λ, both of which were 'preferentially' expressed by intestinal epithelial cells (IECs), was required for optimal activation of the transcription factor STAT1 and expression of interferon-stimulated genes (ISGs).
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.
O'Shea et al., Bethesda, United States. In Immunity, Jun 2015
To evaluate the specificity and redundancy for these cytokines, we quantified their global transcriptomic changes and determined the relative contributions of STAT1 and STAT3 using genetic models and chromatin immunoprecipitation-sequencing (ChIP-seq) approaches.
Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review.
Hassa et al., Zürich, Switzerland. In Mol Cancer, 2014
A special focus is given on STAT1, ARTD9, DTX3L and ARTD8 (also known as PARP14) as novel potential drug targets in distinct molecular subsets of DLBCL.
Role of Baicalin in Anti-Influenza Virus A as a Potent Inducer of IFN-Gamma.
Wang et al., Beijing, China. In Biomed Res Int, 2014
Moreover, BA can directly induce IFN-γ production in human CD4(+) and CD8(+) T cells and NK cells, and activate JAK/STAT-1 signaling pathway.
Differential signaling of inducible nitric oxide synthase induction in Mycobacterium tuberculosis infected alveolar epithelial cell line A549 in response to cytokines IFN-γ, TNF-α and IL-1β.
Bose et al., Delhi, India. In Int J Mycobacteriol, 2014
RESULTS: Nuclear extracts prepared from M. tuberculosis infected A549 cells alone or stimulated with IFN-γ or a combination of three cytokines (IFN-γ, TNF-α and IL-1β) formed DNA protein complexes with probes from both -5.2kb region (specific for binding of STAT-1 protein) and -5.8kb region (specific for binding of both STAT-1 and NF-κB) of the iNOS promoter.
Extended JAK activation and delayed STAT1 dephosphorylation contribute to the distinct signaling profile of CNS neurons exposed to interferon-gamma.
Rose et al., Easton, United States. In J Neuroimmunol, 2012
Experimental inactivation of JAK1/JAK2 in neurons after IFN-gamma treatment did not reverse the extended STAT1 phosphorylation phenotype.
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain.
Ariga et al., Sapporo, Japan. In J Immunol, 2012
This is the first report of a mutation affecting the DNA-binding domain of STAT1 as the genetic cause of sporadic chronic mucocutaneous candidiasis in two unrelated Japanese patients.
Herpes in STAT1 gain-of-function mutation [corrected].
Maródi et al., Debrecen, Hungary. In Lancet, 2012
individuals carrying STAT1 mutations might also be susceptible to viral diseases. The mechanism underlying reactivation disease in patients with STAT1 mutations and chronic mucocutaneous candidosis could involve the impairment of memory T cells
Mathematical modelling unravels regulatory mechanisms of interferon-γ-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells.
Rateitschak et al., Rostock, Germany. In Iet Syst Biol, 2012
In addition, our results propose that unphosphorylated or serine-phosphorylated STAT1 can act as transcription factors of MUC4.
Involvement of Stat1 in the phagocytosis of M. avium.
Brandi et al., Urbino, Italy. In Clin Dev Immunol, 2011
we demonstrate that opsonized live M. avium is phagocytosed by macrophages involving membrane receptors not related with JAK/STAT1 signalling pathway.
More papers using STAT1 antibodies
Computational processing and error reduction strategies for standardized quantitative data in biological networks
Jaster Robert et al., In Molecular Cancer, 2004
... Primary antibodies were from BD Biosciences (Franklin Lakes, NJ, USA; anti-pY701-STAT1; mouse monoclonal), Upstate Cell Signaling Solutions (Billerica, MA, USA; ...
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
Virgin Skip W., In PLoS Biology, 2004
... Antibodies for the following targets were used: STAT1 (BD Biosciences Franklin Lakes, NJ, USA), ...
Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas
Kirchmair Rudolf, In PLoS ONE, 2003
... ) and STAT1(total and Y701P), were from New England Biolabs (Herts, UK), MMP-14 (AB8221), ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
Ploplis Victoria A et al., In Vascular Cell, 2002
... rabbit anti-human-total paxillin, rabbit anti-human-phospho-FAK, rabbit anti-human RhoA, rabbit anti-human Rac1/2/3 (L129), and rabbit anti-human STAT1 were from Cell Signaling Technology (Danvers, MA) ...
Using the transcriptome to annotate the genome.
Rénia Laurent, In PLoS ONE, 2001
... heterozygous (N = 19); LMP2 knockout/IFNγ transgenic (N = 46); LMP2 heterozygous/IFNγ transgenic (N = 19); LMP7 knockout/IFNγ transgenic (N = 5); and STAT1 knockout/IFNγ transgenic (N = 3) ...
Arsenic alters the function of the glucocorticoid receptor as a transcription factor.
Mellone Barbara, In PLoS ONE, 2000
... Plasmid STAT1-YFP was generated by inserting cDNA encoding the human STAT1 protein into pEYFP-C1 (BD Biosciences Clontech, Palo ...
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.
Linden Rafael, In PLoS ONE, 2000
... The antisera used were: anti-signal transducer and activator of transcription 1 (STAT1) and phospho-STAT1 (Tyr 701) from Cell Signaling (Beverly, MA), anti- LC3 ...
Signal transduction and transcription factors in rheumatic disease
Peng Daizhi et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1998
... Mouse anti-STAT1 monoclonal antibodies were obtained from BioLegend (CA, USA) ...
Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)
Marrack Philippa et al., In The Journal of Experimental Medicine, 1987
... ), and phospho-Stat1 (Tyr701) rabbit polyclonal anti–mouse antibodies were from New England Biolabs.
Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages
Corbett John A. et al., In The Journal of General Virology, 1987
... and rabbit anti-STAT1 antiserum from Santa Cruz Biotechnology, mouse monoclonal anti-Src (clone ...
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