Interferon alpha decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytesmore suppliers
In Virology Journal, 2007
... MEK, ERK, STAT1, phospho-MEK (Ser217/221), phospho-ERK (Thr202/Tyr204), phospho-SAPK/JNK (Thr183/Tyr185), phospho-p38 MAPK (Thr180/Tyr182), phospho-ATF-2 (Thr71), or phospho-STAT1 (Tyr701) were purchased from Cell Signaling Technology (Beverly, MA) ...
Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity.
New York City, United States. In Semin Immunol, Dec 2014
Since 1996, nine MSMD-causing genes, including seven autosomal (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1, ISG15, and IRF8) and two X-linked (NEMO, and CYBB) genes have been discovered.
Different pathways of macrophage activation and polarization.
Gdańsk, Poland. In Postepy Hig Med Dosw (online), Dec 2014
Mediators of M1 macrophage TLR-dependent polarization include transcription factors such as NF-κB, AP-1, PU.1, CCAAT/enhancer-binding protein α (C/EBP-α), STAT1 as well as interferon regulatory factor 5 (IRF5), while the transcription factors which promote M2 activation include IRF4, C/EBP-β, Krüppel-like factor 4 (KLF4), STAT6 and PPARγ receptor.
Apoptosis of beta cells in diabetes mellitus.
Hyderābād, India. In Dna Cell Biol, Nov 2014
Cytokines induce the expression of Fas and tumor necrosis factor-alpha (TNF-α) by activating the transcription factor, nuclear factor-κb, and signal transducer and activator of transcription 1 (STAT-1) in the β cells in the extrinsic pathway of apoptosis.
Activated STING in a vascular and pulmonary syndrome.
Bethesda, United States. In N Engl J Med, Sep 2014
Mutant STING leads to increased phosphorylation of signal transducer and activator of transcription 1 (STAT1), so we tested the effect of Janus kinase (JAK) inhibitors on STAT1 phosphorylation in lymphocytes from the affected children and controls.
Diminazene aceturate (Berenil), a new use for an old compound?
Canada. In Int Immunopharmacol, Aug 2014
Instead, Berenil significantly downregulated phosphorylation of mitogen activated protein kinases (MAPKs, including ERK, p38 and JNK), signal transducer and activator of transcription (STAT) proteins (including STAT1 and STAT3) and NFκB p65 subunit, key signaling molecules and transcription factors involved in the production of proinflammatory cytokines.
Herpes in STAT1 gain-of-function mutation [corrected].
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Debrecen, Hungary. In Lancet, 2012
individuals carrying STAT1 mutations might also be susceptible to viral diseases. The mechanism underlying reactivation disease in patients with STAT1 mutations and chronic mucocutaneous candidosis could involve the impairment of memory T cells