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Signal transducer and activator of transcription 1, 91kDa

STAT1, signal transducer and activator of transcription 1
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: STAT3, V1a, CAN, Interleukin-6, HAD
Papers using STAT1 antibodies
The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
Su Wu-Chou et al., In International Journal of Nanomedicine, 2009
... The following antibodies were used: anti-Stat3 (Tyr705), anti-Stat1, anti-α-tubulin (Cell Signaling Technology, Beverly, MA), anti-Stat3 ...
Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury.
Dalmasso Guillaume, In PLoS ONE, 2009
... Antibodies specific for MLC and phosphorylated MLC (serine 19) (pMLC) and STAT1 (pSTAT1) were from Cell Signaling Technology (Danvers, MA) ...
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
Kremer Eric J., In PLoS ONE, 2008
... STAT1 and phosphorylated STAT1 antibodies were purchased from Santa Cruz Biotechnology and Cell Signaling, respectively ...
Interferon alpha decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytes
Qi Zhong-Tian et al., In Virology Journal, 2007
... MEK, ERK, STAT1, phospho-MEK (Ser217/221), phospho-ERK (Thr202/Tyr204), phospho-SAPK/JNK (Thr183/Tyr185), phospho-p38 MAPK (Thr180/Tyr182), phospho-ATF-2 (Thr71), or phospho-STAT1 (Tyr701) were purchased from Cell Signaling Technology (Beverly, MA) ...
Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6
DeCoster Mark A et al., In Journal of Neuroinflammation, 2006
... Antibodies against vWF-related antigen, STAT1 siRNA [STAT1 p84/p91 shRNA (r) lentiviral particles: sc-61879-V], control shRNA lentiviral particles (sc-108080), and Polybrene® buffer (sc-134220) were purchased from Santa Cruz Biotechnology Inc ...
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Papers on STAT1
A novel JAK-STAT inhibitor, 2-[(3-Carbamoyl-2-thienyl)amino]-2-oxoethyl(2,6-dichlorophenyl)acetate, suppresses helper T cell differentiation in vitro and in collagen-induced arthritis in vivo.
Yoshimura et al., Tokyo, Japan. In Biochem Biophys Res Commun, 09 Dec 2015
In HEK293T cells and primary T cells, JI069 suppressed STAT3 activation as efficiently as other STATs, including STAT1, STAT5, and STAT6.
Mutations in the linker domain affect phospho-STAT3 function and suggest targets for interrupting STAT3 activity.
Darnell et al., New York City, United States. In Proc Natl Acad Sci U S A, 09 Dec 2015
UNASSIGNED: Crystallography of the cores of phosphotyrosine-activated dimers of STAT1 (132-713) and STAT3 (127-722) bound to a similar double-stranded deoxyoligonucleotide established the domain structure of the STATs and the structural basis for activation through tyrosine phosphorylation and dimerization.
Anti-inflammatory effects of Saururus chinensis aerial parts in murine macrophages via induction of heme oxygenase-1.
Kang et al., South Korea. In Exp Biol Med (maywood), 08 Dec 2015
SCF4 also suppressed the phosphorylation of signal transducers and activators of transcription 1 (p-STAT1).
Cigarette smoke-mediated oxidative stress induces apoptosis via the MAPKs/STAT1 pathway in mouse lung fibroblasts.
Yang et al., Ch'unch'ŏn, South Korea. In Toxicol Lett, 04 Dec 2015
Moreover, CSE induced the phosphorylation of STAT1 at Tyr701/Ser727 and increased the activation of ERK1/2, p38, and JNK in the MAPK pathway.
The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells.
Menu et al., Brussels, Belgium. In Oncotarget, 02 Dec 2015
Moreover, these exosomes directly induced the survival of MDSCs through activating STAT3 and STAT1 pathways and increasing the anti-apoptotic proteins Bcl-xL and Mcl-1.
PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Holtzman et al., Saint Louis, United States. In Nat Immunol, 19 Nov 2015
In support of this concept, we used a modified form of the transcription factor STAT1 to achieve hyper-responsiveness to interferon without toxicity and markedly improve antiviral function in transgenic mice and transduced human cells.
Host susceptibility to non-tuberculous mycobacterial infections.
Holland et al., Bethesda, United States. In Lancet Infect Dis, Aug 2015
So far, at least seven autosomal mutations (in IL12B, IL12RB1, ISG15, IFNGR1, IFNGR2, STAT1, and IRF8) and two X-linked mutations (in IKBKG and CYBB), mostly presenting in childhood, have been reported to confer susceptibility to disseminated non-tuberculous mycobacterial infection.
Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection.
Diefenbach et al., Mainz, Germany. In Nat Immunol, Jul 2015
Cooperation between the receptor for IL-22 and the receptor for IFN-λ, both of which were 'preferentially' expressed by intestinal epithelial cells (IECs), was required for optimal activation of the transcription factor STAT1 and expression of interferon-stimulated genes (ISGs).
Asymmetric Action of STAT Transcription Factors Drives Transcriptional Outputs and Cytokine Specificity.
O'Shea et al., Bethesda, United States. In Immunity, Jun 2015
To evaluate the specificity and redundancy for these cytokines, we quantified their global transcriptomic changes and determined the relative contributions of STAT1 and STAT3 using genetic models and chromatin immunoprecipitation-sequencing (ChIP-seq) approaches.
The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity.
Means et al., United States. In Nat Immunol, May 2015
Macrophages from Treml4(-/-) mice were hyporesponsive to TLR7 agonists and failed to produce type I interferons due to impaired phosphorylation of the transcription factor STAT1 by the mitogen-activated protein kinase p38 and decreased recruitment of the adaptor MyD88 to TLR7.
Diabetic nephropathy and proximal tubular damage.
Lai et al., Hong Kong, Hong Kong. In J Ren Nutr, Mar 2015
Peroxisome proliferator-activated receptor-γ attenuates STAT-1 activation and has shown promise in renoprotection.
Immunological loss-of-function due to genetic gain-of-function in humans: autosomal dominance of the third kind.
Casanova et al., New York City, United States. In Curr Opin Immunol, Feb 2015
Remarkably, six of the 17 genes concerned also harbor monoallelic (STAT3), biallelic (C3, CFB, CARD11, PIK3R1) or both monoallelic and biallelic (STAT1) LOF alleles in patients with other clinical phenotypes.
Transcriptional regulation of chemokine genes: a link to pancreatic islet inflammation?
Collier et al., Baton Rouge, United States. In Biomolecules, Dec 2014
In this review, we highlight what is known about the signals and mechanisms that govern the transcription of genes encoding specific chemokine proteins in pancreatic islet β-cells, which include contributions from the NF-κB and STAT1 pathways.
Interleukin-27 in T cell immunity.
Yamamoto et al., Tokyo, Japan. In Int J Mol Sci, Dec 2014
IL-27 induces expansion of Th1 cells by activating signal transducer and activator of transcription (STAT) 1-mediated T-bet signaling pathway.
Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling.
Esko et al., San Diego, United States. In Cell Metab, Dec 2014
Motif analysis of promoters of upregulated genes suggested increased type I interferon signaling, which was confirmed by elevation of STAT1 phosphorylation induced by IFN-β.
Extended JAK activation and delayed STAT1 dephosphorylation contribute to the distinct signaling profile of CNS neurons exposed to interferon-gamma.
Rose et al., Easton, United States. In J Neuroimmunol, 2012
Experimental inactivation of JAK1/JAK2 in neurons after IFN-gamma treatment did not reverse the extended STAT1 phosphorylation phenotype.
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain.
Ariga et al., Sapporo, Japan. In J Immunol, 2012
This is the first report of a mutation affecting the DNA-binding domain of STAT1 as the genetic cause of sporadic chronic mucocutaneous candidiasis in two unrelated Japanese patients.
Herpes in STAT1 gain-of-function mutation [corrected].
Maródi et al., Debrecen, Hungary. In Lancet, 2012
individuals carrying STAT1 mutations might also be susceptible to viral diseases. The mechanism underlying reactivation disease in patients with STAT1 mutations and chronic mucocutaneous candidosis could involve the impairment of memory T cells
Mathematical modelling unravels regulatory mechanisms of interferon-γ-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells.
Rateitschak et al., Rostock, Germany. In Iet Syst Biol, 2012
In addition, our results propose that unphosphorylated or serine-phosphorylated STAT1 can act as transcription factors of MUC4.
Involvement of Stat1 in the phagocytosis of M. avium.
Brandi et al., Urbino, Italy. In Clin Dev Immunol, 2011
we demonstrate that opsonized live M. avium is phagocytosed by macrophages involving membrane receptors not related with JAK/STAT1 signalling pathway.
More papers using STAT1 antibodies
Computational processing and error reduction strategies for standardized quantitative data in biological networks
Jaster Robert et al., In Molecular Cancer, 2004
... Primary antibodies were from BD Biosciences (Franklin Lakes, NJ, USA; anti-pY701-STAT1; mouse monoclonal), Upstate Cell Signaling Solutions (Billerica, MA, USA; ...
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
Virgin Skip W., In PLoS Biology, 2004
... Antibodies for the following targets were used: STAT1 (BD Biosciences Franklin Lakes, NJ, USA), ...
Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas
Kirchmair Rudolf, In PLoS ONE, 2003
... ) and STAT1(total and Y701P), were from New England Biolabs (Herts, UK), MMP-14 (AB8221), ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
Ploplis Victoria A et al., In Vascular Cell, 2002
... rabbit anti-human-total paxillin, rabbit anti-human-phospho-FAK, rabbit anti-human RhoA, rabbit anti-human Rac1/2/3 (L129), and rabbit anti-human STAT1 were from Cell Signaling Technology (Danvers, MA) ...
Using the transcriptome to annotate the genome.
Rénia Laurent, In PLoS ONE, 2001
... heterozygous (N = 19); LMP2 knockout/IFNγ transgenic (N = 46); LMP2 heterozygous/IFNγ transgenic (N = 19); LMP7 knockout/IFNγ transgenic (N = 5); and STAT1 knockout/IFNγ transgenic (N = 3) ...
Arsenic alters the function of the glucocorticoid receptor as a transcription factor.
Mellone Barbara, In PLoS ONE, 2000
... Plasmid STAT1-YFP was generated by inserting cDNA encoding the human STAT1 protein into pEYFP-C1 (BD Biosciences Clontech, Palo ...
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.
Linden Rafael, In PLoS ONE, 2000
... The antisera used were: anti-signal transducer and activator of transcription 1 (STAT1) and phospho-STAT1 (Tyr 701) from Cell Signaling (Beverly, MA), anti- LC3 ...
Signal transduction and transcription factors in rheumatic disease
Peng Daizhi et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1998
... Mouse anti-STAT1 monoclonal antibodies were obtained from BioLegend (CA, USA) ...
Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)
Marrack Philippa et al., In The Journal of Experimental Medicine, 1987
... ), and phospho-Stat1 (Tyr701) rabbit polyclonal anti–mouse antibodies were from New England Biolabs.
Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages
Corbett John A. et al., In The Journal of General Virology, 1987
... and rabbit anti-STAT1 antiserum from Santa Cruz Biotechnology, mouse monoclonal anti-Src (clone ...
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