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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Mar 2015.

Signal transducer and activator of transcription 1, 91kDa

STAT1, signal transducer and activator of transcription 1
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: STAT3, V1a, CAN, Interleukin-6, HAD
Papers using STAT1 antibodies
The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
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Su Wu-Chou et al., In International Journal of Nanomedicine, 2009
... The following antibodies were used: anti-Stat3 (Tyr705), anti-Stat1, anti-α-tubulin (Cell Signaling Technology, Beverly, MA), anti-Stat3 ...
Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury.
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Dalmasso Guillaume, In PLoS ONE, 2009
... Antibodies specific for MLC and phosphorylated MLC (serine 19) (pMLC) and STAT1 (pSTAT1) were from Cell Signaling Technology (Danvers, MA) ...
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
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Kremer Eric J., In PLoS ONE, 2008
... STAT1 and phosphorylated STAT1 antibodies were purchased from Santa Cruz Biotechnology and Cell Signaling, respectively ...
Interferon alpha decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytes
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Qi Zhong-Tian et al., In Virology Journal, 2007
... MEK, ERK, STAT1, phospho-MEK (Ser217/221), phospho-ERK (Thr202/Tyr204), phospho-SAPK/JNK (Thr183/Tyr185), phospho-p38 MAPK (Thr180/Tyr182), phospho-ATF-2 (Thr71), or phospho-STAT1 (Tyr701) were purchased from Cell Signaling Technology (Beverly, MA) ...
Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6
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DeCoster Mark A et al., In Journal of Neuroinflammation, 2006
... Antibodies against vWF-related antigen, STAT1 siRNA [STAT1 p84/p91 shRNA (r) lentiviral particles: sc-61879-V], control shRNA lentiviral particles (sc-108080), and Polybrene® buffer (sc-134220) were purchased from Santa Cruz Biotechnology Inc ...
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Papers on STAT1
STAT1 Attenuates Murine Allergen-Induced Airway Remodeling and Exacerbation by Carbon Nanotubes.
New
Bonner et al., Raleigh, United States. In Am J Respir Cell Mol Biol, 25 Apr 2015
STAT1 is a transcription factor that maintains Th1 cell development.
Activation of JNK pathway in spinal astrocytes contributes to acute ultra-low dose morphine thermal hyperalgesia.
New
Galeotti et al., Florence, Italy. In Pain, 23 Apr 2015
Conversely, phosphorylation of cAMP response element-binding protein (CREB) and signal transducer and activator of transcription-1 (STAT-1) was not elevated, and nuclear factor kappa B (NF-κB) levels remained unmodified.
Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus.
New
Ahn et al., Suwŏn, South Korea. In Plos Pathog, 31 Mar 2015
PML was required for accumulation of activated STAT1 and STAT2, interacted with them and HDAC1 and HDAC2, and was associated with ISG promoters after HCMV infection.
Immunological loss-of-function due to genetic gain-of-function in humans: autosomal dominance of the third kind.
Review
New
Casanova et al., New York City, United States. In Curr Opin Immunol, 02 Mar 2015
Remarkably, six of the 17 genes concerned also harbor monoallelic (STAT3), biallelic (C3, CFB, CARD11, PIK3R1) or both monoallelic and biallelic (STAT1) LOF alleles in patients with other clinical phenotypes.
Diabetic Nephropathy and Proximal Tubular Damage.
Review
New
Lai et al., Hong Kong, Hong Kong. In J Ren Nutr, 08 Feb 2015
Peroxisome proliferator-activated receptor-γ attenuates STAT-1 activation and has shown promise in renoprotection.
Mendelian susceptibility to mycobacterial disease: genetic, immunological, and clinical features of inborn errors of IFN-γ immunity.
Review
New
Casanova et al., New York City, United States. In Semin Immunol, Dec 2014
Since 1996, nine MSMD-causing genes, including seven autosomal (IFNGR1, IFNGR2, STAT1, IL12B, IL12RB1, ISG15, and IRF8) and two X-linked (NEMO, and CYBB) genes have been discovered.
STAT1-Mediated Down-Regulation of Bcl-2 Expression Is Involved in IFN-γ/TNF-α-Induced Apoptosis in NIT-1 Cells.
New
Zhang et al., Chongqing, China. In Plos One, Dec 2014
In this study, we treated the murine beta-cell line NIT-1 with TNF-α and IFN-γ and then investigated the regulation of signal transducer and activator of transcription-1 (STAT-1) and expression of the members of the Bcl-2 family in this apoptotic pathway.
EphrinB2 controls vessel pruning through STAT1-JNK3 signalling.
New
Tosato et al., Bethesda, United States. In Nat Commun, Dec 2014
This regulation depends upon phosphotyrosine-EphrinB2 signalling repressing c-jun N-terminal kinase 3 activity via STAT1.
Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling.
New
Impact
Esko et al., San Diego, United States. In Cell Metab, Dec 2014
Motif analysis of promoters of upregulated genes suggested increased type I interferon signaling, which was confirmed by elevation of STAT1 phosphorylation induced by IFN-β.
Apoptosis of beta cells in diabetes mellitus.
Review
New
Rani et al., Hyderābād, India. In Dna Cell Biol, Nov 2014
Cytokines induce the expression of Fas and tumor necrosis factor-alpha (TNF-α) by activating the transcription factor, nuclear factor-κb, and signal transducer and activator of transcription 1 (STAT-1) in the β cells in the extrinsic pathway of apoptosis.
Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways.
New
Impact
Minn et al., Philadelphia, United States. In Cell, Nov 2014
RNA within exosomes, which are largely noncoding transcripts and transposable elements, stimulates the pattern recognition receptor RIG-I to activate STAT1-dependent antiviral signaling.
Activated STING in a vascular and pulmonary syndrome.
New
Impact
Goldbach-Mansky et al., Bethesda, United States. In N Engl J Med, Sep 2014
Mutant STING leads to increased phosphorylation of signal transducer and activator of transcription 1 (STAT1), so we tested the effect of Janus kinase (JAK) inhibitors on STAT1 phosphorylation in lymphocytes from the affected children and controls.
The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells.
New
Impact
Apetoh et al., Dijon, France. In Nat Immunol, Aug 2014
Under TH9-skewing conditions, interleukin 1β (IL-1β) induced phosphorylation of the transcription factor STAT1 and subsequent expression of IRF1, which bound to the promoters of Il9 and Il21 and enhanced secretion of the cytokines IL-9 and IL-21 from TH9 cells.
Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKε kinase-mediated antiviral response.
New
Impact
García-Sastre et al., New York City, United States. In Immunity, Jul 2014
TRIM6 and the E2-ubiquitin conjugase UbE2K cooperated in the synthesis of unanchored K48-linked polyubiquitin chains, which activated IKKε for subsequent STAT1 phosphorylation.
Interferons and their stimulated genes in the tumor microenvironment.
Review
New
Stark et al., Cleveland, United States. In Semin Oncol, Apr 2014
Induction of the gene products by both unphosphorylated and phosphorylated STAT1 after ligand binding results in alterations in tumor cell survival, inhibition of angiogenesis, and augmentation of actions of T, natural killer (NK), and dendritic cells.
Extended JAK activation and delayed STAT1 dephosphorylation contribute to the distinct signaling profile of CNS neurons exposed to interferon-gamma.
GeneRIF
Rose et al., Easton, United States. In J Neuroimmunol, 2012
Experimental inactivation of JAK1/JAK2 in neurons after IFN-gamma treatment did not reverse the extended STAT1 phosphorylation phenotype.
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain.
GeneRIF
Ariga et al., Sapporo, Japan. In J Immunol, 2012
This is the first report of a mutation affecting the DNA-binding domain of STAT1 as the genetic cause of sporadic chronic mucocutaneous candidiasis in two unrelated Japanese patients.
Herpes in STAT1 gain-of-function mutation [corrected].
Impact
GeneRIF
Maródi et al., Debrecen, Hungary. In Lancet, 2012
individuals carrying STAT1 mutations might also be susceptible to viral diseases. The mechanism underlying reactivation disease in patients with STAT1 mutations and chronic mucocutaneous candidosis could involve the impairment of memory T cells
Mathematical modelling unravels regulatory mechanisms of interferon-γ-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells.
GeneRIF
Rateitschak et al., Rostock, Germany. In Iet Syst Biol, 2012
In addition, our results propose that unphosphorylated or serine-phosphorylated STAT1 can act as transcription factors of MUC4.
Involvement of Stat1 in the phagocytosis of M. avium.
GeneRIF
Brandi et al., Urbino, Italy. In Clin Dev Immunol, 2011
we demonstrate that opsonized live M. avium is phagocytosed by macrophages involving membrane receptors not related with JAK/STAT1 signalling pathway.
More papers using STAT1 antibodies
Computational processing and error reduction strategies for standardized quantitative data in biological networks
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Jaster Robert et al., In Molecular Cancer, 2004
... Primary antibodies were from BD Biosciences (Franklin Lakes, NJ, USA; anti-pY701-STAT1; mouse monoclonal), Upstate Cell Signaling Solutions (Billerica, MA, USA; ...
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
Supplier
Virgin Skip W., In PLoS Biology, 2004
... Antibodies for the following targets were used: STAT1 (BD Biosciences Franklin Lakes, NJ, USA), ...
Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas
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Kirchmair Rudolf, In PLoS ONE, 2003
... ) and STAT1(total and Y701P), were from New England Biolabs (Herts, UK), MMP-14 (AB8221), ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
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Ploplis Victoria A et al., In Vascular Cell, 2002
... rabbit anti-human-total paxillin, rabbit anti-human-phospho-FAK, rabbit anti-human RhoA, rabbit anti-human Rac1/2/3 (L129), and rabbit anti-human STAT1 were from Cell Signaling Technology (Danvers, MA) ...
Using the transcriptome to annotate the genome.
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Rénia Laurent, In PLoS ONE, 2001
... heterozygous (N = 19); LMP2 knockout/IFNγ transgenic (N = 46); LMP2 heterozygous/IFNγ transgenic (N = 19); LMP7 knockout/IFNγ transgenic (N = 5); and STAT1 knockout/IFNγ transgenic (N = 3) ...
Arsenic alters the function of the glucocorticoid receptor as a transcription factor.
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Mellone Barbara, In PLoS ONE, 2000
... Plasmid STAT1-YFP was generated by inserting cDNA encoding the human STAT1 protein into pEYFP-C1 (BD Biosciences Clontech, Palo ...
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.
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Linden Rafael, In PLoS ONE, 2000
... The antisera used were: anti-signal transducer and activator of transcription 1 (STAT1) and phospho-STAT1 (Tyr 701) from Cell Signaling (Beverly, MA), anti- LC3 ...
Signal transduction and transcription factors in rheumatic disease
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Peng Daizhi et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1998
... Mouse anti-STAT1 monoclonal antibodies were obtained from BioLegend (CA, USA) ...
Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)
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Marrack Philippa et al., In The Journal of Experimental Medicine, 1987
... ), and phospho-Stat1 (Tyr701) rabbit polyclonal anti–mouse antibodies were from New England Biolabs.
Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages
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Corbett John A. et al., In The Journal of General Virology, 1987
... and rabbit anti-STAT1 antiserum from Santa Cruz Biotechnology, mouse monoclonal anti-Src (clone ...
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