GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Signal transducer and activator of transcription 1, 91kDa
STAT1, signal transducer and activator of transcription 1
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers using
STAT1
antibodies
Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury.
Supplier
In PLoS ONE, 2009
The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
Supplier
In International Journal of Nanomedicine, 2009
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
Supplier
In PLoS ONE, 2008
... STAT1 and phosphorylated STAT1 antibodies were purchased from Santa Cruz Biotechnology and Cell Signaling, respectively ...
Interferon alpha decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytes
Supplier
In Virology Journal, 2007
Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6
more suppliersSupplier
In Journal of Neuroinflammation, 2006
... Antibodies against vWF-related antigen, STAT1 siRNA [STAT1 p84/p91 shRNA (r) lentiviral particles: sc-61879-V], control shRNA lentiviral particles (sc-108080), and Polybrene® buffer (sc-134220) were purchased from Santa Cruz Biotechnology Inc ...
Papers on
STAT1
TYK2-STAT1-BCL2 Pathway Dependence in T-Cell Acute Lymphoblastic Leukemia.
New
Ad Dānā, Syria. In Cancer Discov, 07 Apr 2013
As a result of two independent RNA interference (RNAi) screens, we identified pathway dependence on a member of the JAK tyrosine kinase family, TYK2, and its downstream effector STAT1 in T-cell acute lymphoblastic leukemia (T-ALL).
Nucleotide Oligomerization Domain 1 Enhances IFN-γ Signaling in Gastric Epithelial Cells during Helicobacter pylori Infection and Exacerbates Disease Severity.
New
Australia. In J Immunol, 04 Apr 2013
In cell culture models, we showed that H. pylori activation of the NOD1 pathway caused enhanced proinflammatory signaling in epithelial cells in response to IFN-γ stimulation through the direct effects of H. pylori on two components of the IFN-γ signaling pathway, STAT1 and IFN regulatory factor 1 (IRF1).
Protective role of synthetic oligodeoxynucleotides expressing immunosuppressive TTAGGG motifs in Concanavalin A-induced hepatitis.
New
Changsha, China. In Immunol Lett, 04 Apr 2013
In the splenic lymphocytes, Western blot analysis showed that suppressive ODNs down-regulated the phosphorylation of signal transducer and activator of transcription 1 (STAT1) and STAT4, and suppressed up-regulation of T-bet, but didn't impact the phosphorylation of STAT6 which are associated with a Th2 phenotype.
Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction.
New
Lyon, France. In Arch Biochem Biophys, 02 Apr 2013
Surprisingly, activity was dependent on heterodimerisation with STAT1 activated by IL-4 and Oncostatin M. Our study paves the way to preclinical stages of a clinical trial with hMSC, and suggests a non-canonical JAK-STAT signaling of unphosphorylated STAT3 in immunomodulatory effects of hMSCs.
T-helper-1-cell cytokines drive cancer into senescence.
New
Impact
Tübingen, Germany. In Nature, 21 Mar 2013
This cytokine-induced senescence strictly requires STAT1 and TNFR1 (also known as TNFRSF1A) signalling in addition to p16INK4a.
CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response.
New
Impact
Vienna, Austria. In Immunity, 21 Mar 2013
Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT) family requires serine phosphorylation within the transactivation domain (TAD).
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus.
New
Impact
Bethesda, United States. In Nat Genet, 28 Feb 2013
Transient overexpression of IFNL4 in a hepatoma cell line induced STAT1 and STAT2 phosphorylation and the expression of interferon-stimulated genes.
The role of hepatic expression of STAT1, SOCS3 and PIAS1 in the response of chronic hepatitis C patients to therapy.
New
In Can J Gastroenterol, 28 Feb 2013
OBJECTIVE: To explore some of the mechanisms of HCV resistance to interferon, the expression of STAT1 and its negative regulators, protein inhibitor of activated STAT (PIAS1) and suppressor of cytokine signalling (SOCS3), in liver tissues of both inteferon responders and nonresponders in chronic HCV patients.
Suppressors of cytokine signaling 2 and 3 diametrically control macrophage polarization.
New
Impact
Lisburn, United Kingdom. In Immunity, 24 Feb 2013
In addition, altered polarization coincided with enhanced interferon-gamma (IFN-γ)-induced signal transducer and activator of transcription-1 (STAT1) activation in Socs2(-/-) macrophages and enhanced interleukin-4 (IL-4) plus IL-13-induced STAT6 phosphorylation in Socs3(Lyz2cre) macrophages.
The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response.
New
Impact
Edinburgh, United Kingdom. In Immunity, 24 Feb 2013
Here we report a cellular antiviral role for macrophage production of 25-hydroxycholesterol (cholest-5-en-3β,25-diol, 25HC) as a component of the sterol metabolic network linked to the IFN response via Stat1.
STAT signaling in glioma cells.
Review
New
Warsaw, Poland. In Adv Exp Med Biol, Dec 2012
While STAT1 is believed to play an important role in growth arrest and apoptosis, and to act as a tumor suppressor, STAT3 and 5 are involved in promoting cell cycle progression, cellular transformation, and preventing apoptosis.
Molecular mechanisms of mucocutaneous immunity against Candida and Staphylococcus species.
Review
New
Debrecen, Hungary. In J Allergy Clin Immunol, Nov 2012
Signal transducer and activator of transcription (STAT) proteins are key components of the innate and adaptive immune responses to pathogenic microorganisms.
Managing macrophages in rheumatoid arthritis by reform or removal.
Review
New
Birmingham, United States. In Curr Rheumatol Rep, Oct 2012
Major targets that are related to macrophage development and apoptosis include TNF-α, IL-1, IL-6, GM-CSF, M-CSF, death receptor 5 (DR5), Fas, and others, as listed in Table 1.
Immunity to infection in IL-17-deficient mice and humans.
Review
New
New York City, United States. In Eur J Immunol, Sep 2012
Heterozygosity for gain-of-function mutations in STAT1 in additional patients with CMC was recently shown to inhibit the development of IL-17 T cells.
Keratin 17 as a therapeutic target for the treatment of psoriasis.
Review
New
Xi'an, China. In J Dermatol Sci, Sep 2012
Moreover, these effects are partially blocked with STAT1- and STAT3-specific inhibitors, as well as small interfering RNA (siRNA) targeting STAT1 and STAT3.
A novel disrupter of telomere silencing 1-like (DOT1L) interaction is required for signal transducer and activator of transcription 1 (STAT1)-activated gene expression.
GeneRIF
Charlottesville, United States. In J Biol Chem, 2012
a novel STAT1-DOT1L interaction that is required for the regulation JAK-STAT-inducible gene expression
Functional genomics reveals an essential and specific role for Stat1 in protection of the central nervous system following herpes simplex virus corneal infection.
GeneRIF
United States. In J Virol, 2011
These results indicated an essential role for normal Stat1-dependent signaling in mediating a nonpathological immune response to herpes simplex virus central nervous system infection.
Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation.
GeneRIF
Brussels, Belgium. In J Biol Chem, 2011
Cytokines tumor necrosis factor-alpha and interferon-gamma induce pancreatic beta-cell apoptosis through STAT1-mediated Bim protein activation.
Transcriptional regulation of macrophage polarization: enabling diversity with identity.
Impact
GeneRIF
Marseille, France. In Nat Rev Immunol, 2011
Studies indicate that the M1 macrophage phenotype is controlled by STAT1 and IRF5, whereas STAT6, IRF4 and PPARgamma regulate M2 macrophage polarization.
PCBP2 enhances the antiviral activity of IFN-α against HCV by stabilizing the mRNA of STAT1 and STAT2.
More papers using
STAT1
antibodies
GeneRIF
Beijing, China. In Plos One, 2010
PCBP2 stabilizes the mRNA of STAT1 and STAT2 through binding the 3'Untranslated Region (UTR) of these two molecules.
Computational processing and error reduction strategies for standardized quantitative data in biological networks
Supplier
In Molecular Cancer, 2004
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
Supplier
In PLoS Biology, 2004
... Antibodies for the following targets were used: STAT1 (BD Biosciences Franklin Lakes, NJ, USA), ...
Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas
Supplier
In PLoS ONE, 2003
... ) and STAT1(total and Y701P), were from New England Biolabs (Herts, UK), MMP-14 (AB8221), ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
Supplier
In Vascular Cell, 2002
... rabbit anti-human-total paxillin, rabbit anti-human-phospho-FAK, rabbit anti-human RhoA, rabbit anti-human Rac1/2/3 (L129), and rabbit anti-human STAT1 were from Cell Signaling Technology (Danvers, MA) ...
Using the transcriptome to annotate the genome.
Supplier
In PLoS ONE, 2001
... heterozygous (N = 19); LMP2 knockout/IFNγ transgenic (N = 46); LMP2 heterozygous/IFNγ transgenic (N = 19); LMP7 knockout/IFNγ transgenic (N = 5); and STAT1 knockout/IFNγ transgenic (N = 3) ...
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.
Supplier
In PLoS ONE, 2000
... The antisera used were: anti-signal transducer and activator of transcription 1 (STAT1) and phospho-STAT1 (Tyr 701) from Cell Signaling (Beverly, MA), anti- LC3 ...
Arsenic alters the function of the glucocorticoid receptor as a transcription factor.
Supplier
In PLoS ONE, 2000
... Plasmid STAT1-YFP was generated by inserting cDNA encoding the human STAT1 protein into pEYFP-C1 (BD Biosciences Clontech, Palo ...
Signal transduction and transcription factors in rheumatic disease
Supplier
In Evidence-based Complementary and Alternative Medicine : eCAM, 1998
... Mouse anti-STAT1 monoclonal antibodies were obtained from BioLegend (CA, USA) ...
Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages
Supplier
In The Journal of General Virology, 1987
... and rabbit anti-STAT1 antiserum from Santa Cruz Biotechnology, mouse monoclonal anti-Src (clone ...
Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)
Supplier
In The Journal of Experimental Medicine, 1987
... ), and phospho-Stat1 (Tyr701) rabbit polyclonal anti–mouse antibodies were from New England Biolabs.
