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Signal transducer and activator of transcription 1, 91kDa

STAT1, signal transducer and activator of transcription 1
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: STAT3, V1a, CAN, Interleukin-6, HAD
Papers using STAT1 antibodies
The use of nanoparticle-mediated targeted gene silencing and drug delivery to overcome tumor drug resistance
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Su Wu-Chou et al., In International Journal of Nanomedicine, 2009
... The following antibodies were used: anti-Stat3 (Tyr705), anti-Stat1, anti-α-tubulin (Cell Signaling Technology, Beverly, MA), anti-Stat3 ...
Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury.
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Dalmasso Guillaume, In PLoS ONE, 2009
... Antibodies specific for MLC and phosphorylated MLC (serine 19) (pMLC) and STAT1 (pSTAT1) were from Cell Signaling Technology (Danvers, MA) ...
Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2.
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Kremer Eric J., In PLoS ONE, 2008
... STAT1 and phosphorylated STAT1 antibodies were purchased from Santa Cruz Biotechnology and Cell Signaling, respectively ...
Interferon alpha decreases expression of human scavenger receptor class BI, a possible HCV receptor in hepatocytes
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Qi Zhong-Tian et al., In Virology Journal, 2007
... MEK, ERK, STAT1, phospho-MEK (Ser217/221), phospho-ERK (Thr202/Tyr204), phospho-SAPK/JNK (Thr183/Tyr185), phospho-p38 MAPK (Thr180/Tyr182), phospho-ATF-2 (Thr71), or phospho-STAT1 (Tyr701) were purchased from Cell Signaling Technology (Beverly, MA) ...
Inhibition of interleukin-1beta-induced group IIA secretory phospholipase A2 expression by peroxisome proliferator-activated receptors (PPARs) in rat vascular smooth muscle cells: cooperation between PPARbeta and the proto-oncogene BCL-6
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DeCoster Mark A et al., In Journal of Neuroinflammation, 2006
... Antibodies against vWF-related antigen, STAT1 siRNA [STAT1 p84/p91 shRNA (r) lentiviral particles: sc-61879-V], control shRNA lentiviral particles (sc-108080), and Polybrene® buffer (sc-134220) were purchased from Santa Cruz Biotechnology Inc ...
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Papers on STAT1
Tuberculosis antigen-induced expression of IFN-α in tuberculosis patients inhibits production of IL-1β
New
Wu et al., Shiqi, China. In Faseb J, 27 Apr 2014
Notably, we showed that IFN-α inhibited production of IL-1β through 2 distinct mechanisms: IFN-α signaling, via the STAT1 transcription factor, suppressed caspase-1-dependent IL-1β maturation, and IFN-α induced the production of IL-10 in a STAT1-dependent manner in which IL-10 reduced the abundance of IL-1β.
The role of STAT-6 as a key transcription regulator in HeLa cell death induced by IFN-γ/TNF-α co-immobilized on nanoparticles.
New
Liu et al., Guangzhou, China. In Biomaterials, 24 Apr 2014
UNLABELLED: Based on the fact that the transcription of STAT-1 plus its Serine 727 and Tyrosine 701 phosphorylation is not the pre-requisite for the cell death signal transduction in the IFN-γ signaling pathway induced by co-immobilized IFN-γ/TNF-α, we investigate both in vitro and in vivo the key transcription regulators to promote the signal transduction of HeLa cells.
A160: role of interleukin-1 in abnormal monocyte phenotype in systemic onset juvenile idiopathic arthritis.
New
Mellins et al., Stanford, United States. In Arthritis Rheumatol, 31 Mar 2014
We used real time PCR to measure M1 associated genes: Interferon Regulatory factor (IRF) family IRF5, STAT1; M2 associated genes IRF4, STAT6, Kruppel-Like Factor 4 (KLF4) and peroxisome proliferator-activated receptor-γ (PPAR-γ); IL-1 secretion related genes: RAB39, RAB27A, RAB27B, P2RX7, and IL-1β.
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity.
New
Impact
Rice et al., New York City, United States. In Nature, 02 Mar 2014
In vitro, lentiviral delivery of enzymatically active cGAS triggers a STING-dependent, IRF3-mediated antiviral program that functions independently of canonical IFN/STAT1 signalling.
T helper type 17 pathway suppression by appendicitis and appendectomy protects against colitis.
New
Grimm et al., Sydney, Australia. In Clin Exp Immunol, 28 Feb 2014
We conclude that Th17-system cytokines are kept under control by AA via down-regulation of proinflammatory CCL20, a rapid down-regulation of pro-Th17 cell differentiation genes TGF-β2 and TGF-β3, suppression of RORC-associated gene-sets, increased protective STAT1 expression and suppression of 81 'pro-Th17' system gene-sets.
STAT1-cooperative DNA binding distinguishes type 1 from type 2 interferon signaling.
New
Impact
Vinkemeier et al., Nottingham, United Kingdom. In Nat Immunol, 28 Feb 2014
STAT1 is an indispensable component of a heterotrimer (ISGF3) and a STAT1 homodimer (GAF) that function as transcription regulators in type 1 and type 2 interferon signaling, respectively.
Insights into the Role of Follicular Helper T Cells in Autoimmunity.
Review
New
Choi et al., Seoul, South Korea. In Immune Netw, 28 Feb 2014
IL-6 and IL-21 cytokine-mediated STAT signaling pathways, including STAT1 and STAT3, are crucial for inducing Bcl-6 expression and TFH cell differentiation.
Interleukin-6 signaling drives fibrosis in unresolved inflammation.
New
Impact
Jones et al., Cardiff, United Kingdom. In Immunity, 16 Feb 2014
Repeat inflammation induced IL-6-mediated T helper 1 (Th1) cell effector commitment and the emergence of STAT1 (signal transducer and activator of transcription-1) activity within the peritoneal membrane.
Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma.
New
Impact
Cao et al., Shanghai, China. In Cancer Cell, 13 Feb 2014
Mechanistically, RIG-I enhances IFN-α response by amplifying IFN-α effector signaling via strengthening STAT1 activation.
Toward a new STATe: The role of STATs in mitochondrial function.
Review
New
Larner et al., Richmond, United States. In Semin Immunol, 13 Feb 2014
Recently, other members of the STAT family (STAT1, STAT2, STAT5, and STAT6) have also been shown to be present in the mitochondria.
A Novel Artificial MicroRNA Expressing AAV Vector for Phospholamban Silencing in Cardiomyocytes Improves Ca2+ Uptake into the Sarcoplasmic Reticulum.
New
Fechner et al., Berlin, Germany. In Plos One, Dec 2013
Proteomic analysis confirmed PLB silencing of both therapeutic vectors and revealed that shPLBr, but not the amiR155-PLBr vector, increased the proinflammatory proteins STAT3, STAT1 and activated STAT1 phosphorylation at the key amino acid residue Tyr701.
STAT2 and IRF9: Beyond ISGF3.
Review
New
Grandvaux et al., Montréal, Canada. In Jakstat, Nov 2013
Among STATs, STAT2 is classically known to dimerize with STAT1 and together with IRF9 forms the ISGF3 transcription factor complex that has long been considered a hallmark of activation by type I and type III interferons.
STATs get their move on.
Review
New
Reich, Stony Brook, United States. In Jakstat, Nov 2013
Following STAT2 tyrosine phosphorylation, it can form dimers with STAT1 to affect nuclear import as the trimeric complex (ISGF3).
Diversification of dendritic cell subsets: Emerging roles for STAT proteins.
Review
New
Watowich et al., Houston, United States. In Jakstat, Nov 2013
Here, we focus on the functions of STAT1, STAT3, and STAT5 in DC generation and DC-mediated immune responses.
Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.
New
Impact
Ivashkiv et al., New York City, United States. In Immunity, Oct 2013
Rather, we found that IFN-γ induced sustained occupancy of transcription factors STAT1, IRF-1, and associated histone acetylation at promoters and enhancers at the TNF, IL6, and IL12B loci.
Extended JAK activation and delayed STAT1 dephosphorylation contribute to the distinct signaling profile of CNS neurons exposed to interferon-gamma.
GeneRIF
Rose et al., Easton, United States. In J Neuroimmunol, 2012
Experimental inactivation of JAK1/JAK2 in neurons after IFN-gamma treatment did not reverse the extended STAT1 phosphorylation phenotype.
Chronic mucocutaneous candidiasis caused by a gain-of-function mutation in the STAT1 DNA-binding domain.
GeneRIF
Ariga et al., Sapporo, Japan. In J Immunol, 2012
This is the first report of a mutation affecting the DNA-binding domain of STAT1 as the genetic cause of sporadic chronic mucocutaneous candidiasis in two unrelated Japanese patients.
Herpes in STAT1 gain-of-function mutation [corrected].
Impact
GeneRIF
Maródi et al., Debrecen, Hungary. In Lancet, 2012
individuals carrying STAT1 mutations might also be susceptible to viral diseases. The mechanism underlying reactivation disease in patients with STAT1 mutations and chronic mucocutaneous candidosis could involve the impairment of memory T cells
Mathematical modelling unravels regulatory mechanisms of interferon-γ-induced STAT1 serine-phosphorylation and MUC4 expression in pancreatic cancer cells.
GeneRIF
Rateitschak et al., Rostock, Germany. In Iet Syst Biol, 2012
In addition, our results propose that unphosphorylated or serine-phosphorylated STAT1 can act as transcription factors of MUC4.
Involvement of Stat1 in the phagocytosis of M. avium.
GeneRIF
Brandi et al., Urbino, Italy. In Clin Dev Immunol, 2011
we demonstrate that opsonized live M. avium is phagocytosed by macrophages involving membrane receptors not related with JAK/STAT1 signalling pathway.
More papers using STAT1 antibodies
Computational processing and error reduction strategies for standardized quantitative data in biological networks
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Jaster Robert et al., In Molecular Cancer, 2004
... Primary antibodies were from BD Biosciences (Franklin Lakes, NJ, USA; anti-pY701-STAT1; mouse monoclonal), Upstate Cell Signaling Solutions (Billerica, MA, USA; ...
Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs.
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Virgin Skip W., In PLoS Biology, 2004
... Antibodies for the following targets were used: STAT1 (BD Biosciences Franklin Lakes, NJ, USA), ...
Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas
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Kirchmair Rudolf, In PLoS ONE, 2003
... ) and STAT1(total and Y701P), were from New England Biolabs (Herts, UK), MMP-14 (AB8221), ...
Genetic Disruption of Cortical Interneuron Development Causes Region- and GABA Cell Type Specific Deficits, Epilepsy, and Behavioral Dysfunction
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Ploplis Victoria A et al., In Vascular Cell, 2002
... rabbit anti-human-total paxillin, rabbit anti-human-phospho-FAK, rabbit anti-human RhoA, rabbit anti-human Rac1/2/3 (L129), and rabbit anti-human STAT1 were from Cell Signaling Technology (Danvers, MA) ...
Using the transcriptome to annotate the genome.
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Rénia Laurent, In PLoS ONE, 2001
... heterozygous (N = 19); LMP2 knockout/IFNγ transgenic (N = 46); LMP2 heterozygous/IFNγ transgenic (N = 19); LMP7 knockout/IFNγ transgenic (N = 5); and STAT1 knockout/IFNγ transgenic (N = 3) ...
Arsenic alters the function of the glucocorticoid receptor as a transcription factor.
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Mellone Barbara, In PLoS ONE, 2000
... Plasmid STAT1-YFP was generated by inserting cDNA encoding the human STAT1 protein into pEYFP-C1 (BD Biosciences Clontech, Palo ...
Cathepsin B acts as a dominant execution protease in tumor cell apoptosis induced by tumor necrosis factor.
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Linden Rafael, In PLoS ONE, 2000
... The antisera used were: anti-signal transducer and activator of transcription 1 (STAT1) and phospho-STAT1 (Tyr 701) from Cell Signaling (Beverly, MA), anti- LC3 ...
Signal transduction and transcription factors in rheumatic disease
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Peng Daizhi et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 1998
... Mouse anti-STAT1 monoclonal antibodies were obtained from BioLegend (CA, USA) ...
Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)
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Marrack Philippa et al., In The Journal of Experimental Medicine, 1987
... ), and phospho-Stat1 (Tyr701) rabbit polyclonal anti–mouse antibodies were from New England Biolabs.
Src family kinases participate in the regulation of encephalomyocarditis virus-induced cyclooxygenase-2 expression by macrophages
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Corbett John A. et al., In The Journal of General Virology, 1987
... and rabbit anti-STAT1 antiserum from Santa Cruz Biotechnology, mouse monoclonal anti-Src (clone ...
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