Colorectal cancer progression: lessons from Drosophila?
London, United Kingdom. In Semin Cell Dev Biol, 2014
In contrast, adenocarcinomas retain expression of E-cadherin and disruption of the epithelium occurs through formation of progressively smaller epithelial cysts with apical Crumbs/CRB3, Stardust/PALS1, and Bazooka/PAR3 localised to the inner lumen.
The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival.
Toronto, Canada. In Annu Rev Cell Dev Biol, 2011
APRs compose a diverse set of molecules including a transmembrane protein (Crumbs), a serine/threonine kinase (aPKC), a lipid phosphatase (PTEN), a small GTPase (Cdc42), FERM domain proteins (Moesin, Yurt), and several adaptor or scaffolding proteins (Bazooka/Par3, Par6, Stardust, Patj).
Stardust in meteorites.
Chicago, United States. In Proc Natl Acad Sci U S A, 2011
The properties of stardust grains are used to constrain models of nucleosynthesis in red giant stars and supernovae, the dominant sources of dust grains that are recycled into the interstellar medium by stars.
Protein complexes that control renal epithelial polarity.
Ann Arbor, United States. In Am J Physiol Renal Physiol, 2011
The apical Crumbs complex consists of three proteins, Crumbs, PALS1, and PATJ, whereas the apical Par complex consists of Par-3, Par-6, and atypical protein kinase C. The lateral Scribble complex consists of Scribble, discs large, and lethal giant larvae.