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Membrane protein, palmitoylated 5

Stardust, Pals1, MPP5
This gene encodes a member of the p55-like subfamily of the membrane-associated guanylate kinase (MAGUK) gene superfamily. The encoded protein participates in the polarization of differentiating cells, has been shown to regulate myelinating Schwann cells (PMID: 20237282), and is one of the components of the Crumbs complex in the retina. Mice which express lower levels of the orthologous protein have retinal degeneration and impaired vision (PMID: 22114289). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: PATJ, Par6, CAN, CRB1, iMpact
Papers using Stardust antibodies
The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost
Supplier
Margolis Ben et al., In The Journal of Cell Biology, 1994
... Truncation mutations in Pals1 were generated by PCR and cloned into pRK5Myc and pEYFP-N1 (CLONTECH Laboratories, Inc.) ...
Papers on Stardust
The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.
New
Kim et al., Philadelphia, United States. In Development, Feb 2016
Deletion of the apical polarity complex protein Pals1 in the developing cerebellum results in a remarkably undersized cerebellum with disrupted layers in poorly formed folia and strikingly reduced granule cell production.
AP-2-complex-mediated endocytosis of Drosophila Crumbs regulates polarity by antagonizing Stardust.
New
Knust et al., Dresden, Germany. In J Cell Sci, Jan 2016
The adaptor protein 2 (AP-2) complex binds to a motif in the cytoplasmic tail of Crumbs that overlaps with the binding site of Stardust, a protein known to stabilize Crumbs on the surface.
GRANULAR HYPERREFLECTIVE SPECKS BY SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY AS SIGNS OF WEST NILE VIRUS INFECTION: THE STARDUST SIGN.
New
Brown et al., Houston, United States. In Retin Cases Brief Rep, Jan 2016
PURPOSE: To report the retinal findings and evolution of a visually symptomatic case of West Nile virus meningoencephalitis.
Space science applications for conducting polymer particles: synthetic mimics for cosmic dust and micrometeorites.
New
Armes et al., Canterbury, United Kingdom. In Chem Commun (camb), Jan 2016
In this case, the sacrificial polypyrrole overlayer simply provides a sensitive spectroscopic signature (rather than a conductive overlayer), and the scientific findings have important implications for the detection of organic dust grains during the Stardust space mission.
The Polarity Protein Pals1 Regulates Radial Sorting of Axons.
New
Rasband et al., Houston, United States. In J Neurosci, Aug 2015
Intriguingly, polarity proteins, such as Pals1/Mpp5, are highly enriched in some of these domains, suggesting that they may regulate the polarity of Schwann cells and myelination.
Interstellar dust. Evidence for interstellar origin of seven dust particles collected by the Stardust spacecraft.
Impact
30714 Stardust@home dusters et al., Berkeley, United States. In Science, 2014
Seven particles captured by the Stardust Interstellar Dust Collector and returned to Earth for laboratory analysis have features consistent with an origin in the contemporary interstellar dust stream.
Colorectal cancer progression: lessons from Drosophila?
Review
Thompson et al., London, United Kingdom. In Semin Cell Dev Biol, 2014
In contrast, adenocarcinomas retain expression of E-cadherin and disruption of the epithelium occurs through formation of progressively smaller epithelial cysts with apical Crumbs/CRB3, Stardust/PALS1, and Bazooka/PAR3 localised to the inner lumen.
Function and cancer genomics of FAT family genes (review).
Review
Katoh, Tokyo, Japan. In Int J Oncol, 2012
FAT4 directly interacts with MPDZ/MUPP1 to recruit membrane‑associated guanylate kinase MPP5/PALS1.
Genetic ablation of Pals1 in retinal progenitor cells models the retinal pathology of Leber congenital amaurosis.
GeneRIF
Kim et al., Houston, United States. In Hum Mol Genet, 2012
Data show the deletion of Pals1 leads to the disruption of the apical localization of Crb polarity complex proteins Crb1, Crb2 and Crb3 in retinal progenitors and the adult retina.
Structure of an L27 domain heterotrimer from cell polarity complex Patj/Pals1/Mals2 reveals mutually independent L27 domain assembly mode.
GeneRIF
Long et al., Tianjin, China. In J Biol Chem, 2012
the crystal structure of a 4-L27 domain-containing heterotrimer derived from the tripartite complex Patj/Pals1/Mals2
The apical polarity protein network in Drosophila epithelial cells: regulation of polarity, junctions, morphogenesis, cell growth, and survival.
Review
Tepass, Toronto, Canada. In Annu Rev Cell Dev Biol, 2011
APRs compose a diverse set of molecules including a transmembrane protein (Crumbs), a serine/threonine kinase (aPKC), a lipid phosphatase (PTEN), a small GTPase (Cdc42), FERM domain proteins (Moesin, Yurt), and several adaptor or scaffolding proteins (Bazooka/Par3, Par6, Stardust, Patj).
Stardust in meteorites.
Review
Davis, Chicago, United States. In Proc Natl Acad Sci U S A, 2011
The properties of stardust grains are used to constrain models of nucleosynthesis in red giant stars and supernovae, the dominant sources of dust grains that are recycled into the interstellar medium by stars.
PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.
GeneRIF
Wijnholds et al., Amsterdam, Netherlands. In J Neurosci, 2011
Small irregularly shaped spots are detected throughout the Pals1-deficient retina of conditional knockdown mice by confocal scanning laser ophthalmoscopy and spectral domain optical coherence tomography.
Crystallization and preliminary X-ray data collection of the L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) tripartite complex.
GeneRIF
Long et al., Tianjin, China. In Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011
Crystals of tripartite complex 1 of L27(PATJ)-(L27N,L27C)(Pals1)-L27(MALS) diffracted to 2.05 A resolution
A tight junction-associated Merlin-angiomotin complex mediates Merlin's regulation of mitogenic signaling and tumor suppressive functions.
Impact
Kissil et al., Philadelphia, United States. In Cancer Cell, 2011
We have identified a tight-junction-associated protein complex comprising Merlin, Angiomotin, Patj, and Pals1.
Protein complexes that control renal epithelial polarity.
Review
Margolis et al., Ann Arbor, United States. In Am J Physiol Renal Physiol, 2011
The apical Crumbs complex consists of three proteins, Crumbs, PALS1, and PATJ, whereas the apical Par complex consists of Par-3, Par-6, and atypical protein kinase C. The lateral Scribble complex consists of Scribble, discs large, and lethal giant larvae.
Participation of the cell polarity protein PALS1 to T-cell receptor-mediated NF-κB activation.
GeneRIF
Bidère et al., Villejuif, France. In Plos One, 2010
The cell polarity protein PALS1 is expressed in T lymphocytes and participates to the optimal activation of NF-kappaB following TCR stimulation.
Extreme deuterium excesses in ultracarbonaceous micrometeorites from central Antarctic snow.
Impact
Robert et al., Orsay, France. In Science, 2010
The masses of the particles range from a few tenths of a microgram to a few micrograms, exceeding by more than an order of magnitude those of the dust fragments from comet 81P/Wild 2 returned by the Stardust mission.
Constraints on the formation age of cometary material from the NASA Stardust mission.
Impact
MacPherson et al., Livermore, United States. In Science, 2010
We measured the 26Al-26Mg isotope systematics of a approximately 5-micrometer refractory particle, Coki, returned from comet 81P/Wild 2 in order to relate the time scales of formation of cometary inclusions to their meteoritic counterparts.
Chondrulelike objects in short-period comet 81P/Wild 2.
Impact
Nakano et al., Fukuoka, Japan. In Science, 2008
The Stardust spacecraft returned cometary samples that contain crystalline material, but the origin of the material is not yet well understood.
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