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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

RAR-related orphan receptor alpha

Staggerer, Ror1, Rora, NR1F1
The protein encoded by this gene is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. It is a type I membrane protein and belongs to the ROR subfamily of cell surface receptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, CLOCK, AGE, RORalpha
Papers on Staggerer
Wnt5a induces ROR1/ROR2 heterooligomerization to enhance leukemia chemotaxis and proliferation.
New
Kipps et al., In J Clin Invest, Jan 2016
Treatment of CLL cells with Wnt5a induced ROR1 to oligomerize with ROR2 and recruit guanine exchange factors (GEFs), which activated Rac1 and RhoA; siRNA-mediated silencing of either ROR1 or ROR2 or treatment with UC-961 inhibited these effects.
Receptor tyrosine kinase gene expression profiles of Ewing sarcomas reveal ROR1 as a potential therapeutic target in metastatic disease.
New
Dirksen et al., Münster, Germany. In Mol Oncol, Jan 2016
Of these, ROR1 is being pursued as therapeutic target in leukemias and carcinomas, but un-characterized in sarcomas.
ROR1, a target of NKX2-1/TTF-1 lineage-survival oncogene, inhibits ASK1-mediated pro-apoptotic signaling in lung adenocarcinoma.
New
Takahashi et al., Nagoya, Japan. In Cancer Sci, Jan 2016
UNASSIGNED: We previously identified receptor tyrosine kinase-like orphan receptor 1 (ROR1) as a transcriptional target of the NKX2-1/TTF-1 lineage-survival oncogene in lung adenocarcinoma.
ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1.
New
Takahashi et al., Nagoya, Japan. In Nat Commun, Dec 2015
The receptor tyrosine kinase-like orphan receptor 1 (ROR1) sustains prosurvival signalling directly downstream of the lineage-survival oncogene NKX2-1/TTF-1 in lung adenocarcinoma.
[Circadian markers and genes in bipolar disorder].
New
Belliviera et al., Paris, France. In Encephale, Sep 2015
Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε.
Receptor tyrosine kinase-like orphan receptor 1: a novel target for cancer immunotherapy.
Review
New
Shokri et al., Tehrān, Iran. In Expert Opin Ther Targets, Jul 2015
INTRODUCTION: Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the receptor tyrosine kinase family.
Pre-clinical Specificity and Safety of UC-961, a First-In-Class Monoclonal Antibody Targeting ROR1.
Review
New
Kipps et al., San Diego, United States. In Clin Lymphoma Myeloma Leuk, Jun 2015
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an oncoembryonic antigen.
Impaired adipose tissue expandability and lipogenic capacities as ones of the main causes of metabolic disorders.
Review
Tinahones et al., Málaga, Spain. In J Diabetes Res, 2014
Thus, we suggest that this tissue ceases fulfilling its main function, the storage of excess fat, thereby affecting some of the key factors involved in lipogenesis, some of which are reviewed in this paper (PPARγ, ROR1, FASN, SCD1, Rab18, BrCa1, ZAG, and FABP4).
The receptor tyrosine kinase ROR1--an oncofetal antigen for targeted cancer therapy.
Review
Mellstedt et al., Stockholm, Sweden. In Semin Cancer Biol, 2014
ROR1 is a transmembrane RTK of importance during the normal embryogenesis for the central nervous system, heart, lung and skeletal systems, but is not expressed in normal adult tissues.
From mice to men: lessons from mutant ataxic mice.
Review
Cendelin, Plzeň, Czech Republic. In Cerebellum Ataxias, 2013
Lurcher, Hot-foot, Purkinje cell degeneration, Nervous, Staggerer, Weaver, Reeler, and Scrambler mouse models and mouse models of SCA1, SCA2, SCA3, SCA6, SCA7, SCA23, DRPLA, Niemann-Pick disease and Friedreich ataxia are reviewed with special regard to cerebellar pathology, pathogenesis, functional changes and possible therapeutic influences, if any.
Induction of multipotential hematopoietic progenitors from human pluripotent stem cells via respecification of lineage-restricted precursors.
Impact
Daley et al., Boston, United States. In Cell Stem Cell, 2013
HOXA9, ERG, and RORA conferred self-renewal and multilineage potential in vitro and maintained primitive CD34(+)CD38(-) cells.
The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression.
Impact
Jeker et al., San Francisco, United States. In Nat Immunol, 2013
In a viral infection model, miR-17∼92 restrained the expression of genes 'inappropriate' to the TFH cell subset, including the direct miR-17∼92 target Rora.
Crosstalk between ROR1 and the Pre-B cell receptor promotes survival of t(1;19) acute lymphoblastic leukemia.
Impact
Tyner et al., Portland, United States. In Cancer Cell, 2012
We report that t(1;19) ALL cells universally exhibit expression of and dependence on the cell surface receptor ROR1.
Retinoic acid-related orphan receptor-α is induced in the setting of DNA damage and promotes pulmonary emphysema.
GeneRIF
Morse et al., Boston, United States. In Am J Respir Crit Care Med, 2012
Rora expression was induced by cigarette smoke in mice and cell culture. Rora-deficient mice were protected from smoke induced airspace enlargement. DNA damage may contribute to pathogenesis of emphysema and Rora has a role in responses to genotoxicity
Detection of orphan receptor tyrosine kinase (ROR-1) expression in Egyptian pediatric acute lymphoblastic leukemia.
GeneRIF
Ibrahim et al., Cairo, Egypt. In Fetal Pediatr Pathol, 2012
ROR1 was overexpressed in acute lymphoblastic leukemia
Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα.
Impact
GeneRIF
McHeyzer-Williams et al., Los Angeles, United States. In Nat Immunol, 2012
RORalpha regulates survival and BCR expression in IgA+ memory B cells.
Gene expression analysis on a single cell level in Purkinje cells of Huntington's disease transgenic mice.
GeneRIF
Zucker et al., Freiburg, Germany. In Neurosci Lett, 2012
Retinoid acid receptor-related orphan receptor (ROR)alpha's transcriptional dysregulation is found in the R6/2 mouse model for Huntington's Disease and in a model for spinocerebellar ataxia type 1 disease.
NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
Impact
Takahashi et al., Nagoya, Japan. In Cancer Cell, 2012
Here we show that NKX2-1 induces the expression of the receptor tyrosine kinase-like orphan receptor 1 (ROR1), which in turn sustains a favorable balance between prosurvival PI3K-AKT and pro-apoptotic p38 signaling, in part through ROR1 kinase-dependent c-Src activation, as well as kinase activity-independent sustainment of the EGFR-ERBB3 association, ERBB3 phosphorylation, and consequential PI3K activation.
ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth.
GeneRIF
Kipps et al., San Diego, United States. In Plos One, 2011
ROR1 is expressed in human breast cancers and has biological and clinical significance
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Impact
Kooner et al., London, United Kingdom. In Nat Genet, 2011
We identified 69 candidate genes, including genes involved in biliary transport (ATP8B1 and ABCB11), glucose, carbohydrate and lipid metabolism (FADS1, FADS2, GCKR, JMJD1C, HNF1A, MLXIPL, PNPLA3, PPP1R3B, SLC2A2 and TRIB1), glycoprotein biosynthesis and cell surface glycobiology (ABO, ASGR1, FUT2, GPLD1 and ST3GAL4), inflammation and immunity (CD276, CDH6, GCKR, HNF1A, HPR, ITGA1, RORA and STAT4) and glutathione metabolism (GSTT1, GSTT2 and GGT), as well as several genes of uncertain or unknown function (including ABHD12, EFHD1, EFNA1, EPHA2, MICAL3 and ZNF827).
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