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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Src homology three

Top mentioned proteins: CAN, AGE, Sir2, iMpact, ACID
Papers on STAC
Reverse chemomodulatory effects of the SIRT1 activators resveratrol and SRT1720 in Ewing's sarcoma cells: resveratrol suppresses and SRT1720 enhances etoposide- and vincristine-induced anticancer activity.
Beck et al., Jena, Germany. In J Cancer Res Clin Oncol, Jan 2016
However, the best-studied STAC, the naturally occurring compound resveratrol, is reported to have contradictory effects in combination chemotherapy regimens: It has been shown both to increase and to decrease the action of anticancer agents.
Sirt1 Activation Markedly Alters Transcription Profiles and Improves Outcome in Experimental Sepsis.
Kessimian et al., Cambridge, United States. In Shock, Dec 2015
We tested the therapeutic potential of the STAC SRT3025 in two preclinical models of severe infection, the murine cecal ligation and puncture (CLP) model to induce peritonitis and intra-tracheal installation of Streptococcus pneumoniae to induce severe bacterial pneumonia.
STAC--A New Domain Associated with Transmembrane Solute Transport and Two-Component Signal Transduction Systems.
Lupas et al., Tübingen, Germany. In J Mol Biol, Nov 2015
We propose that this newly identified domain family mediates signal transduction in systems regulating transport processes and name it STAC, for SLC and TCST-Associated Component.
Obesity and Aging: Consequences for Cognition, Brain Structure, and Brain Function.
Park et al., Dallas, United States. In Psychosom Med, Jul 2015
The topics covered are guided by the Scaffolding Theory of Aging and Cognition (STAC [Park and Reuter-Lorenz.
Genetic risk for Alzheimer's disease alters the five-year trajectory of semantic memory activation in cognitively intact elders.
Durgerian et al., Cleveland, United States. In Neuroimage, Jun 2015
The Scaffolding Theory of Aging and Cognition (STAC) (Park and Reuter-Lorenz, 2009; Reuter-Lorenz and Park, 2014) posits that compensatory brain processes are responsible for maintaining normal cognitive performance in older adults, despite accumulation of aging-related neural damage.
Stac gets the skeletal L-type calcium channel unstuck.
Weiss, Praha, Czech Republic. In Gen Physiol Biophys, Apr 2015
Commentary to: Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca²⁺ channels.
Stac adaptor proteins regulate trafficking and function of muscle and neuronal L-type Ca2+ channels.
Beam et al., Aurora, United States. In Proc Natl Acad Sci U S A, Feb 2015
Excitation-contraction (EC) coupling in skeletal muscle depends upon trafficking of CaV1.1, the principal subunit of the dihydropyridine receptor (DHPR) (L-type Ca(2+) channel), to plasma membrane regions at which the DHPRs interact with type 1 ryanodine receptors (RyR1) in the sarcoplasmic reticulum.
Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.
Ellis et al., Cambridge, United States. In Nat Commun, 2014
Using this construct, we solved the crystal structure of a mini-hSIRT1-STAC complex, which revealed the STAC-binding site within the N-terminal domain of hSIRT1.
Transcription profiles of the ductus arteriosus in Brown-Norway rats with irregular elastic fiber formation.
Minamisawa et al., In Circ J, 2013
Among these genes, 8 (Tbx20, Scn3b, Stac, Sphkap, Trpm8, Rup2, Slc37a2, and RGD1561216) are located in chromosomes 8 and 9. Interestingly, it was also suggested that the significant decrease in the expression levels of the PGE2-specfic receptor, EP4, plays a critical role in elastogenesis in the DA.
Recurrent genetic alterations in hepatitis C-associated hepatocellular carcinoma detected by genomic microarray: a genetic, clinical and pathological correlation study.
Yeh et al., Seattle, United States. In Mol Cytogenet, 2013
Statistically significant smaller copy number alterations (3.9 kb to 644 kb) were identified using STAC algorithm, including losses of FGFR3, RECQL4, NOTCH1, PTEN, TSC2, and/or ASPSCR1 and gains of ETV1and/or MAF.
Efficacy of sotrastaurin plus tacrolimus after de novo kidney transplantation: randomized, phase II trial results.
Budde et al., Adelaide, Australia. In Am J Transplant, 2013
plus standard tacrolimus (sTAC; 5-12 ng/mL), sotrastaurin 300 mg (n = 75) b.i.d.
Evidence for a common mechanism of SIRT1 regulation by allosteric activators.
Sinclair et al., Boston, United States. In Science, 2013
A single amino acid in SIRT1, Glu(230), located in a structured N-terminal domain, was critical for activation by all previously reported STAC scaffolds and a new class of chemically distinct activators.
Functional magnetic resonance imaging in aging and dementia: detection of age-related cognitive changes and prediction of cognitive decline.
Sugarman et al., Detroit, United States. In Curr Top Behav Neurosci, 2011
We also discuss models that account for cognitive aging processes, including the hemispheric asymmetry reduction in older adults (HAROLD) and scaffolding theory of aging and cognition (STAC) models.
stac1 and stac2 genes define discrete and distinct subsets of dorsal root ganglia neurons.
Moqrich et al., Marseille, France. In Gene Expr Patterns, 2010
found STAC1 and STAC2 expressed in mutually exclusive fashion in adult DRG neurons; STAC1 marks peptidergic nociceptive neurons; STAC2 is expressed in subset of nonpeptidergic nociceptors, all trkB+ neurons and a subpopulation of proprioceptive neurons
The adaptive brain: aging and neurocognitive scaffolding.
Reuter-Lorenz et al., Dallas, United States. In Annu Rev Psychol, 2008
To account for these joint phenomena, we propose the scaffolding theory of aging and cognition (STAC).
Advances in interleukin 2 receptor targeted treatment.
Waldmann et al., Bethesda, United States. In Ann Rheum Dis, 2000
The IL2Ralpha is shed from the cell surface and is measurable in the serum as a 45 kDa soluble form (s-Tac or s-IL2Ralpha).
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