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Synovial sarcoma, X breakpoint 4

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SSX2, NY-ESO-1, SYT-SSX, MAGE-3, POLYMERASE
Papers on SSX4
SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma.
Hartmann et al., Köln, Germany. In Oncogene, 2014
Synovial sarcoma is a high-grade soft tissue malignancy characterized by a specific reciprocal translocation t(X;18), which leads to the fusion of the SS18 (SYT) gene to one of three SSX genes (SSX1, SSX2 or SSX4).
SSX2-4 expression in early-stage non-small cell lung cancer.
Gjerstorff et al., Odense, Denmark. In Tissue Antigens, 2014
The expression of cancer/testis antigens SSX2, SSX3, and SSX4 in non-small cell lung cancers (NSCLC) was examined, since they are considered promising targets for cancer immunotherapy due to their immunogenicity and testis-restricted normal tissue expression.
Expression of cancer-testis antigen in multiple myeloma.
Ma et al., Wuhan, China. In J Huazhong Univ Sci Technolog Med Sci, 2014
Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to detect the mRNA expression of MAGE-C1/CT7, SSX1, SSX2 and SSX4 in MM cell lines of RPMI-8226 and U266, and bone marrow (BM) cells of 25 MM patients and 18 healthy volunteers.
EBV-transformed lymphoblastoid cell lines as vaccines against cancer testis antigen-positive tumors.
Kubuschok et al., Homburg, Germany. In Cancer Immunol Immunother, 2013
The most frequently expressed CT genes were SSX4 (50 %), followed by GAGE (45 %), SSX1 (40 %), MAGE-A3 and SSX2 (25 %), SCP1, HOM-TES-85, MAGE-C1, and MAGE-C2 (15 %).
A novel fluorescence in situ hybridization assay for synovial sarcoma.
Tanaka et al., Yokohama, Japan. In Pathol Res Pract, 2013
We used two sets of two-color break-apart FISH probes, flanking either the SSX1/SSX4 or SSX2 locus.
Effects of CT-Xp gene knock down in melanoma cell lines.
Simpson et al., New York City, United States. In Oncotarget, 2013
We found that of these, those specific to GAGE and XAGE1 most significantly impeded melanoma cell migration and invasion and those specific to SSX4 and XAGE1 decreased the clonogenic survival of melanoma cells.
Identification and functional characterization of glioma-specific promoters and their application in suicide gene therapy.
Shimizu et al., Kōchi, Japan. In J Neurooncol, 2011
we found that the SSX4 and MAGE-A3 genes are frequently expressed in brain tumor cell lines
Pattern and clinical significance of cancer-testis gene expression in head and neck squamous cell carcinoma.
Rimoldi et al., Genève, Switzerland. In Int J Cancer, 2011
The pattern and level of expression of 12 CT genes (MAGE-A1, MAGE-A3, MAGE-A4, MAGE-A10, MAGE-C2, NY-ESO-1, LAGE-1, SSX-2, SSX-4, BAGE, GAGE-1/2, GAGE-3/4) and the tumor-associated antigen encoding genes PRAME, HERV-K-MEL, and NA-17A were evaluated by RT-PCR in a panel of 57 primary HNSCC.
Novel SYT-SSX fusion transcript variants in synovial sarcoma.
Trangas et al., Athens, Greece. In Cancer Genet Cytogenet, 2009
SYT4-SSX1 is the most common fusion subtype, present in approximately two thirds of the cases, followed by SYT4-SSX2 and, very rarely, SYT4-SSX4.
Cryptic chromosome rearrangement resulting in SYT-SSX2 fusion gene in a monophasic synovial sarcoma.
Teixeira et al., Porto, Portugal. In Cancer Genet Cytogenet, 2008
which results in the fusion of the SYT gene from chromosome 18 (18q11) with one of the genes from the X chromosome (Xp11) SSX1, SSX2, or SSX4.
Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma.
Nielsen et al., Vancouver, Canada. In Cancer Res, 2008
Synovial sarcoma is a soft tissue malignancy characterized by the fusion of SS18 to either SSX1, SSX2, or SSX4 genes.
Expression of cancer-testis genes in brain tumors.
Kim et al., Taegu, South Korea. In J Korean Neurosurg Soc, 2008
METHODS: We investigated the expression of 6 CT genes (MAGE-E1, SOX-6, SCP-1, SSX-2, SSX-4, and HOM-TES-85) using reverse-transcription polymerase chain reaction in 26 meningiomas and 32 other various brain tumor specimens, obtained from the patients during tumor surgery from 2000 to 2005.
Potential target antigens for immunotherapy in human pancreatic cancer.
Z'graggen et al., Heidelberg, Germany. In Cancer Lett, 2007
Tumor-associated antigen expression of MAGE-A1, MAGE-A3, MAGE-A4, MAGE-A10, LAGE-1, NY-ESO-1, SCP-1, SSX-2, SSX-4 and HERV-K-MEL was assessed by PCR.
Detection of lung cancer using MAGE A1-6 and SSX4 RT-PCR expression profiles in the bronchial wash fluid.
Jeon et al., Taegu, South Korea. In Cancer Res Treat, 2007
To increase the detection rates, we performed molecular analysis with using MAGE A1-6 and SSX4 RT-PCR on bronchial wash fluid specimens.
Detection of SS18-SSX fusion transcripts in formalin-fixed paraffin-embedded neoplasms: analysis of conventional RT-PCR, qRT-PCR and dual color FISH as diagnostic tools for synovial sarcoma.
Flanagan et al., São Paulo, Brazil. In Mod Pathol, 2007
Synovial Sarcoma consistently harbors t(X;18) resulting in SS18-SSX1, SS18-SSX2 and rarely SS18-SSX4 fusion transcripts.
CD4+ T cell responses to SSX-4 in melanoma patients.
Valmori et al., New York City, United States. In J Immunol, 2005
existence of CD4+ T cells specific for multiple SSX-4 derived sequences in circulating lymphocytes from melanoma patients
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