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Somatostatin receptor 4

SSTR4
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR4 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in fetal and adult brain and lung. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: somatostatin, somatostatin receptor, SSTR2, SSTR5, CAN
Papers on SSTR4
Genome-wide association study of 25(OH) Vitamin D concentrations in Punjabi Sikhs: Results of the Asian Indian diabetic heart study.
New
Sanghera et al., Oklahoma City, United States. In J Steroid Biochem Mol Biol, Jan 2016
p=4.47×10(-9)] between FOXA2 and SSTR4 was identified to be associated with 25(OH)D levels.
The somatostatin receptor 4 agonist J-2156 reduces mechanosensitivity of peripheral nerve afferents and spinal neurons in an inflammatory pain model.
New
Doods et al., Biberach an der Riß, Germany. In Eur J Pharmacol, Feb 2015
The aim of this study was to investigate whether the analgesic properties of the selective SSTR4 agonist J-2156 are mediated via peripheral and/or spinal receptors.
Expression of Somatostatin Receptors 1-5 and Dopamine Receptor 2 in Lung Carcinoids: Implications for a Therapeutic Role.
Tsolakis et al., Athens, Greece. In Neuroendocrinology, 2014
RESULTS: SSTR2A was the SSTR subtype most frequently expressed immunohistochemically (72%), followed by SSTR1 (63%), SSTR5 (40%), and SSTR3 (20%), whereas SSTR4 was negative.
Somatostatin receptor 1-5; expression profiles during rat development.
Stridsberg et al., Uppsala, Sweden. In Ups J Med Sci, 2014
In mRNA isolated from whole rat embryos SSTR1-2 and SSTR4 expression showed a peak at day 14, while SSTR3 mRNA was not present until day 15.
Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas.
Beranek et al., Hradec Králové, Czech Republic. In Physiol Res, 2014
SSTR4 and SSTR5 were detectable in 85 % and 61 % of adenomas, respectively.
Expression of somatostatin type-2 and -4 receptor and correlation with histological type in breast cancer.
Chereau et al., Paris, France. In Anticancer Res, 2014
We were interested to evaluate the somatostatin type 2 (SSTR2) and type 4 (SSTR4) receptor expression on a large sample cohort of breast cancer cases.
Molecular evolution of GPCRs: Somatostatin/urotensin II receptors.
Review
Larhammar et al., Uppsala, Sweden. In J Mol Endocrinol, 2014
In the teleost lineage, all these have been preserved with the exception of SSTR4.
Pattern of somatostatin receptors expression in normal and bladder cancer tissue samples.
Koutsilieris et al., Athens, Greece. In Anticancer Res, 2014
RESULTS: SSTR1 was expressed in 24 samples, SSTR2 in 15, SSTR3 in 23, SSTR4 in 16 and SSTR5 in all but one sample.
Regulation of somatostatin receptor 4-mediated cytostatic effects by CD26 in malignant pleural mesothelioma.
Morimoto et al., Tokyo, Japan. In Br J Cancer, 2014
RESULTS: We identify that cytostatic effects in MPM are mediated by somatostatin (SST) receptor 4 (SSTR4), being inhibited by the interaction of CD26 molecules.
Somatostatin receptors in gastrointestinal stromal tumors: new prognostic biomarker and potential therapeutic strategy.
Zhang et al., Shanghai, China. In Am J Transl Res, 2013
With IHC performed, SSTR1 and SSTR2 present high positive proportion (81.9% and 87.6%) in 453 GISTs in our study, and positive expression rates of SSTR3, SSTR4 and SSTR5 are 56.1%,
Octreotide stimulates somatostatin receptor-induced apoptosis of SW480 colon cancer cells by activation of glycogen synthase kinase-3β, A Wnt/β-catenin pathway modulator.
Long et al., In Hepatogastroenterology, 2013
SSTR1, SSTR2, SSTR3, SSTR4, and SSTR5 mRNA expression levels were confirmed by RT-PCR; β-catenin, TCF-4, cyclin D1, c-Myc, and GSK-3β protein levels were examined by Western blot.
(68)Ga-1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid-p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2
Review
Leung, Bethesda, United States. In Unknown Journal, 2012
(111)In-DTPA-OCT binds with high affinity to SSTR2 and SSTR5 and to SSTR3 to a lesser degree, but it does not bind to SSTR1 and SSTR4 (8).
(68)Ga-1,4,7-Triazacyclononane,1-glutaric acid-4,7-acetic acid-p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2
Review
Leung, Bethesda, United States. In Unknown Journal, 2012
(111)In-DTPA-OCT binds with high affinity to SSTR2 and SSTR5 and to SSTR3 to a lesser degree, but it does not bind to SSTR1 and SSTR4 (8).
(64)Cu-4,11-Bis(carboxymethyl)-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane-p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2
Review
Leung, Bethesda, United States. In Unknown Journal, 2012
(111)In-DTPA-OCT binds with high affinity to SSTR2 and SSTR5 and to SSTR3 to a lesser degree, but it does not bind to SSTR1 and SSTR4 (8).
(64)Cu-1,4,7-Triazacyclononane,1-glutaric acid-4,7-acetic acid-p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2
Review
Leung, Bethesda, United States. In Unknown Journal, 2012
(111)In-DTPA-OCT binds with high affinity to SSTR2 and SSTR5 and to SSTR3 to a lesser degree, but it does not bind to SSTR1 and SSTR4 (8).
Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver.
GeneRIF
Petersen et al., Pusan, South Korea. In Liver Int, 2012
Somatostatin stimulates the migration of hepatic oval cells within injured liver through SSTR4, and this action appears to be mediated by the PI3K pathway.
Profiling of somatostatin receptor subtype expression by quantitative PCR and correlation with clinicopathological features in pancreatic endocrine tumors.
GeneRIF
Yagihashi et al., Hirosaki, Japan. In Pancreas, 2010
Data show that the mRNA levels of SSTR1, SSTR2, SSTR3, and SSTR5 were high in PET compared with AC, whereas the expression of SSTR4 was low in PET and AC.
Modulation of voltage-gated ion channels in rat retinal ganglion cells mediated by somatostatin receptor subtype 4.
GeneRIF
Barnes et al., Halifax, Canada. In J Neurophysiol, 2010
Somatostatin receptor subtype 4 is expressed specifically in retinal ganglion cells. Action potentials are reduced during inhibition.
Somatostatin receptor subtypes in human type 2 diabetic islets.
GeneRIF
Stridsberg et al., Lisbon, Portugal. In Pancreas, 2010
Studies show that this study may be the basis for further functional studies to evaluate the role of somatostatin receptors sst1 to sst5 in the diabetic state.
A potential inhibitory role for the new truncated variant of somatostatin receptor 5, sst5TMD4, in pituitary adenomas poorly responsive to somatostatin analogs.
GeneRIF
Castaño et al., Córdoba, Spain. In J Clin Endocrinol Metab, 2010
Evaluation of the potential use of sst5TMD4 expression in surgically removed pituitary adenomas as a predictor of the subsequent response of different pituitary tumors to somatostatin therapy.
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