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Troponin I, skeletal, slow 1

ssTnI, TNNI1
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cardiac troponin I, FasT, cTnT, HAD, Tenascin
Papers on ssTnI
TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships.
Review
New
Jin et al., Detroit, United States. In Gene, Feb 2016
Vertebrate TnI has evolved into three isoforms encoded by three homologous genes: TNNI1 for slow skeletal muscle TnI, TNNI2 for fast skeletal muscle TnI and TNNI3 for cardiac TnI, which are expressed under muscle type-specific and developmental regulations.
Combinatorial polymer matrices enhance in vitro maturation of human induced pluripotent stem cell-derived cardiomyocytes.
New
Hong et al., Nashville, United States. In Biomaterials, Oct 2015
Importantly, iPSC-CMs cultured on 4%PEG-96%PCL demonstrate troponin I (TnI) isoform switch from the fetal slow skeletal TnI (ssTnI) to the postnatal cardiac TnI (cTnI), the first report of such transition in vitro.
Epigenetic regulation of cardiac myofibril gene expression during heart development.
New
Tian et al., Chongqing, China. In Cardiovasc Toxicol, Jul 2015
In our previous studies, we have demonstrated that fetal form troponin I (ssTnI) expression in the heart is partially regulated by hormones, such as thyroid hormone.
Metabolic efficiency promotes protection from pressure overload in hearts expressing slow skeletal troponin I.
Lewandowski et al., Chicago, United States. In Circ Heart Fail, 2015
We previously found adult transgenic mouse hearts expressing the fetal troponin I isoform, (ssTnI) to be protected from ischemia by increased glycolysis.
DNA methylation regulates mouse cardiac myofibril gene expression during heart development.
Tian et al., Chongqing, China. In J Biomed Sci, 2014
Our previous studies have demonstrated that the expression of fetal troponin I gene (also called slow skeletal troponin I, ssTnI) is predominated in the fetal stage, reduced after birth and disappeared in the adulthood.
Dietary L-arginine supplementation affects the skeletal longissimus muscle proteome in finishing pigs.
Jiang et al., Guangzhou, China. In Plos One, 2014
The increase in IMF content was positively correlated with the increased abundance of slow twitch troponin I (TNNI1) protein and negatively correlated with myosin heavy chain IIb (MyHC IIb) protein content.
Balanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes.
Trafford et al., Chicago, United States. In Cardiovasc Res, 2014
METHODS AND RESULTS: Ca buffering was studied in cardiac myocytes from mice: wild-type (WT), phospholamban-knockout (PLN-KO), and mice expressing slow skeletal troponin I (ssTnI) that is not protein kinase A phosphorylatable.
Acquisition of a quantitative, stoichiometrically conserved ratiometric marker of maturation status in stem cell-derived cardiac myocytes.
Metzger et al., Minneapolis, United States. In Stem Cell Reports, 2014
In the mammalian heart, inactivation of the "fetal" TNNI gene, TNNI1 (ssTnI), together in temporal concert with its stoichiometric replacement by the adult TNNI gene product, TNNI3 (cTnI), represents a quantifiable ratiometric maturation signature.
Validation of biomarkers for loin meat quality (M. longissimus) of pigs.
te Pas et al., Lelystad, Netherlands. In J Anim Breed Genet, 2014
Ten genes (CARP, MB, CSRP3, TNNC1, VAPB, TNNI1, HSPB1, TNNT1, TIMP-1, RAD-like) were chosen from the original microarray study on the basis of the association between gene expression levels and the meat quality traits meat %, back fat, pH24, drip loss %, colour a*, colour b*, colour L*, WB-SF, SFA, MUFA, PUFA.
Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes.
Solaro et al., Davis, United States. In Arch Biochem Biophys, 2014
Comparisons were made from ventricular myocytes isolated from non-transgenic (NTG) controls and transgenic mice expressing the fetal, slow skeletal troponin I (TG-ssTnI) in place of cardiac TnI (cTnI).
Molecular determinants of cardiac myocyte performance as conferred by isoform-specific TnI residues.
Metzger et al., Minneapolis, United States. In Biophys J, 2014
The fetal heart expresses the slow skeletal TnI (ssTnI) isoform and shortly after birth ssTnI is completely and irreversibly replaced by the adult cardiac TnI (cTnI) isoform.
Changes in serum fast and slow skeletal troponin I concentration following maximal eccentric contractions.
Nosaka et al., Australia. In J Sci Med Sport, 2013
OBJECTIVES: We tested the hypothesis that fast skeletal muscle troponin I (fsTnI) concentration in serum would increase more than those of slow skeletal muscle troponin I (ssTnI) after eccentric exercise of the elbow flexors using a sensitive blood marker to track fibre specific muscle damage.
The effects of slow skeletal troponin I expression in the murine myocardium are influenced by development-related shifts in myosin heavy chain isoform.
Chandra et al., Pullman, United States. In J Physiol, 2013
Adult transgenic (TG) mice that express the embryonic isoform of TnI, slow skeletal TnI (ssTnI), were treated with propylthiouracil (PTU) to revert MHC expression from adult (α-MHC) to embryonic (β-MHC) isoforms.
Induction of cardiac myogenic lineage development differs between mesenchymal and satellite cells and is accelerated by bone morphogenetic protein-4.
Geenen et al., Chicago, United States. In J Mol Cell Cardiol, 2012
MSC also expressed skeletal genes (MyoG, ssTnI, Sk-Act) early in culture but their expression was suppressed when BMP4 was added from day 0 to day 6 (p<0.05).
Cardiac biomarkers are associated with an increased risk of stroke and death in patients with atrial fibrillation: a Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) substudy.
GeneRIF
Wallentin et al., Uppsala, Sweden. In Circulation, 2012
Elevations of troponin I and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are common in patients with atrial fibrillation and independently related to increased risks of stroke and mortality.
Impact of troponin 1 on long-term mortality after emergency orthopaedic surgery in older patients.
GeneRIF
Lim et al., Australia. In Intern Med J, 2010
Elevated post-operative troponin 1 levels predict long-term mortality in older patients undergoing emergency orthpedic surgery.
Analysis of the sarcomere protein gene mutation on cardiomyopathy - Mutations in the cardiac troponin I gene.
GeneRIF
Kurihara et al., Sagamihara, Japan. In Leg Med (tokyo), 2010
Evaluated the prevalence of TNN13 gene mutations in sudden death caused by cardiomyopathy (CM); in dilated CM cases, a new missense mutation Pro16Thr was detected. A single nucleotide polymorphism at -8 position of intron 3 was identified.
The molecular structures and expression patterns of zebrafish troponin I genes.
GeneRIF
Tsai et al., Taipei, Taiwan. In Gene Expr Patterns, 2009
Data show thattnni1 and tnni2 transcripts were not detectable in the somites until 16 h post-fertilization (hpf), after which they were identified as slow-and fast muscle-specific, respectively.
Reduced troponin I phosphorylation and increased Ca(2+)-dependent ATP-consumption in triton X-skinned fiber preparations from Galphaq overexpressor mice.
GeneRIF
Brixius et al., Münster, Germany. In Mol Cell Biochem, 2008
Phosphorylation of troponin I was significantly reduced in Galphaq-overexpressing mice compared to wild type.
The miscommunicative cardiac cell: when good proteins go bad.
Review
Potter et al., Miami, United States. In Ann N Y Acad Sci, 2005
In cardiac muscle, TnI can exist as two isoforms, slow skeletal TnI (ssTnI) or cardiac TnI (cTnI), whereas TnT occurs as multiple isoforms.
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