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Testis-specific serine kinase 6

SSTK, small serine/threonine kinase, Tssk6, FKSG82
This intronless gene encodes a member of the CAMK (calcium/calmodulin-dependent) serine/threonine protein kinase family. The encoded kinase has a broad expression pattern but is described as testis-specific due to effects on fertility. Male mice which lack the gene encoding a highly similar protein are sterile and have morphologically abnormal sperm. [provided by RefSeq, Jan 2012] (from NCBI)
Top mentioned proteins: Tsk1, Tsk2, PCNA, Hsp90, Cyclin-Dependent Kinase 5
Papers on SSTK
Cloning, sequence characterization, and expression patterns of members of the porcine TSSK family.
Xiao et al., Kunming, China. In Genet Mol Res, 2014
Following comparison with TSSK4 genes in other species, BMI TSSK4 was found to contain three alternatively spliced variants, inform1, inform 3, and inform 4. BMI TSSK1 and TSSK2 are co-localized on the Sus scrofa chromosome (SSC) 14, and consist of a single exon; TSSK3, TSSK4, and TSSK6 are on SSC6, SSC7, and SSC2, and consist of two, four, and one exon, respectively.
Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility.
Johnson et al., Bethesda, United States. In J Biol Chem, 2013
TSSK1, -2, -4, and -6 (small serine/threonine kinase) were all found to associate with HSP90, and pharmacological inhibition of HSP90 function using the highly specific drugs 17-AAG, SNX-5422, or NVP-AUY922 reduced TSSK protein levels in cells.
Expression and localization of five members of the testis-specific serine kinase (Tssk) family in mouse and human sperm and testis.
Salicioni et al., Amherst Center, United States. In Mol Hum Reprod, 2011
Immunolocalization in mouse testis, and in mouse and human sperm, showed that Tssk1, Tssk2, Tssk4 and Tssk6, but not Tssk3, were present in mouse sperm and in germ cells from mouse testis.
Identification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinase.
GeneRIF
Johnson et al., Bethesda, United States. In J Biol Chem, 2010
HSP90 is essential for functional maturation of the kinase and identify SIP as a cochaperone that is critical to the HSP90-mediated activation of SSTK.
c.822+126T>G/C: a novel triallelic polymorphism of the TSSK6 gene associated with spermatogenic impairment in a Chinese population.
GeneRIF
Zhang et al., Chengdu, China. In Asian J Androl, 2010
findings, for the first time, suggested an association of c.822+126T>G/C in TSSK6 with spermatogenic impairment in humans in which allele T may be a risk factor for male infertility, while alleles C and G may decrease susceptibility to male infertility
Tssk6 is required for Izumo relocalization and gamete fusion in the mouse.
Visconti et al., Amherst Center, United States. In J Cell Sci, 2009
Here we demonstrate that sperm produced by Tssk6 (Sstk)-null mice present defects that prevent the successful fertilization of eggs in vitro and the fusion to zona-pellucida-free eggs.
Spermatozoal transcriptome profiling for bull sperm motility: a potential tool to evaluate semen quality.
Boissonneault et al., Sherbrooke, Canada. In Reproduction, 2009
With such an approach, we found that transcripts encoding a serine/threonine testis-specific protein kinase (TSSK6) and a metalloproteinase non coding RNA (ADAM5P) are associated with high-motility status (P<0.001), also confirmed by quantitative PCR (P=0.0075).
Validation of a testis specific serine/threonine kinase [TSSK] family and the substrate of TSSK1 & 2, TSKS, as contraceptive targets.
Review
Herr et al., Charlottesville, United States. In Soc Reprod Fertil Suppl, 2006
A family of testis specific serine/threonine kinases, TSSK1-4 and SSTK, in addition to the substrate of TSSK1 & 2, TSKS, have been studied during the past several years in our laboratory.
Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility.
GeneRIF
Johnson et al., Bethesda, United States. In Mol Cell Biol, 2005
results demonstrate that SSTK is required for proper postmeiotic chromatin remodeling and male fertility
Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm.
Visconti et al., Charlottesville, United States. In Mol Hum Reprod, 2004
The human and mouse homologues of TSSK 1 and TSSK 2, together with TSSK 3 and SSTK/FKSG82, constitute a kinase subfamily closely related to the calmodulin kinases and SNF/nim 1 kinase subfamilies.
Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers.
Zukerberg et al., Boston, United States. In Cancer Res, 2001
Cyclin-dependent kinase 2 (cdk2) is a small serine/threonine kinase that regulates cell cycle progression.
Cdk5 on the brain.
Review
Tsai et al., Boston, United States. In Cell Growth Differ, 2001
A small serine/threonine kinase that shows homology to cyclin-dependent kinases (Cdks) has emerged as an important regulator of neuronal migration.
Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth.
Tsai et al., Boston, United States. In Neuron, 2000
Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS.
p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton.
Tsai et al., Boston, United States. In J Cell Sci, 2000
Cyclin-dependent kinase 5 (cdk5) is a small serine/threonine kinase that displays close sequence homology to the mitotically active cyclin-dependent kinases.
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