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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Signal sequence receptor, alpha

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, iMpact, OUT
Papers on SSRI
The Relationship Between Plasma Cytokine Levels and Response to Selective Serotonin Reuptake Inhibitor Treatment in Children and Adolescents with Depression and/or Anxiety Disorders.
Fennig et al., Petah Tikva, Israel. In J Child Adolesc Psychopharmacol, Feb 2016
This is the first report, to our knowledge, of the relationship between response to selective serotonin reuptake inhibitor (SSRI) treatment for anxiety and/or depression and cytokine levels in children and adolescents.
Maternal pharmacokinetics and fetal disposition of (±)-citalopram during mouse pregnancy.
Bonnin et al., In Acs Chem Neurosci, Feb 2016
UNASSIGNED: While selective-serotonin reuptake inhibitor (SSRI) antidepressants are commonly prescribed in the treatment of depression, their use during pregnancy leads to fetal drug exposures.
Differential effects of vilazodone versus citalopram and paroxetine on sexual behaviors and serotonin transporter and receptors in male rats.
Tarazi et al., Utrecht, Netherlands. In Psychopharmacology (berl), Feb 2016
RATIONALE: Sexual side effects are commonly associated with selective serotonin reuptake inhibitor (SSRI) treatment.
Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial.
Kessing et al., Copenhagen, Denmark. In Nord J Psychiatry, Feb 2016
Aim Based on the AGENDA trial dataset, we analysed whether an intervention with SSRI versus placebo decreases the GRα mRNA expression in peripheral blood cells in healthy first-degree relatives of patients with major depression.
Systematic Review and Meta-Analysis: Dose-Response Relationship of Selective Serotonin Reuptake Inhibitors in Major Depressive Disorder.
Bloch et al., London, United Kingdom. In Am J Psychiatry, Dec 2015
Endpoint and tolerability analyses were analyzed using meta-regression and stratified subgroup analysis by predefined SSRI dose categories in order to assess the effect of SSRI dosing on the efficacy and tolerability of SSRIs for major depressive disorder.
Efficacy of Phosphodiesterase-5 Inhibitor in Men With Premature Ejaculation: A New Systematic Review and Meta-analysis.
Shen et al., Chengdu, China. In Urology, Nov 2015
METHODS: We searched the PubMed, Embase, and Cochrane Library databases to identify all randomized controlled trials and compared results, including intravaginal ejaculation latency time, satisfaction, side effects, and others, after treatment with PDE5i vs placebo, PDE5i vs selective serotonin reuptake inhibitor (SSRI), or combined use of PDE5i with SSRI vs SSRI alone for treating PE.
Selective serotonin reuptake inhibitors to improve outcome in acute ischemic stroke: possible mechanisms and clinical evidence.
Barlinn et al., Dresden, Germany. In Brain Behav, Oct 2015
The mechanisms of action whereby SSRI might improve recovery from acute ischemic stroke are not fully elucidated.
Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn.
Hernandez-Diaz et al., Boston, United States. In Jama, Jul 2015
IMPORTANCE: The association between selective serotonin reuptake inhibitor (SSRI) antidepressant use during pregnancy and risk of persistent pulmonary hypertension of the newborn (PPHN) has been controversial since the US Food and Drug Administration issued a public health advisory in 2006.
[Social Anxiety Disorder].
Nagata, In Seishin Shinkeigaku Zasshi, 2014
However, ten years have already passed since selective serotonin reuptake inhibitors (SSRI) were approved for the treatment of SAD in Japan, and not only laypersons but also mental health professionals still misunderstand SAD as public speech phobia.
Social anxiety disorder and the psychobiology of self-consciousness.
Stein, Cape Town, South Africa. In Front Hum Neurosci, 2014
A number of investigations of SAD have highlighted altered activity in the medial prefrontal cortex (mPFC; involved in self-representation), insula (involved in interoceptive processing), and other structures that play a role in bodily self-consciousness, as well as the potential value of interventions such as selective serotonin reuptake inhibitors (SSRI) and self-focused reappraisal in normalizing such changes.
Structural basis for action by diverse antidepressants on biogenic amine transporters.
Gouaux et al., Portland, United States. In Nature, 2013
The final LeuBAT mutant binds the SSRI sertraline with a binding constant of 18 nM and displays high-affinity binding to a range of SSRIs, SNRIs and a TCA.
SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.
Greengard et al., New York City, United States. In Cell, 2013
The SSRI fluoxetine induces expression of p11 in both cell types and increases the amount of the ternary complex of p11/annexin A2/SMARCA3.
Selective serotonin reuptake inhibitors during pregnancy and risk of stillbirth and infant mortality.
Valdimarsdóttir et al., Stockholm, Sweden. In Jama, 2013
MAIN OUTCOME MEASURES: We used logistic regression to estimate relative risks of stillbirth, neonatal death, and postneonatal death associated with SSRI use during pregnancy taking into account maternal characteristics and previous psychiatric hospitalization.
Pharmacology for the treatment of premature ejaculation.
Clèment et al., Garches, France. In Pharmacol Rev, 2012
Dapoxetine, a short-acting SSRI, is the first treatment registered for the on-demand treatment of PE.
Premature ejaculation: is there an efficient therapy?
Facio Junior et al., Ribeirão Preto, Brazil. In Einstein (sao Paulo), 2011
Dapoxetine is a short-acting SSRI formulated to treat premature ejaculation, and results seem very promising.
Mutation in the Trapalpha/Ssr1 gene, encoding translocon-associated protein alpha, results in outflow tract morphogenetic defects.
Barra et al., Paris, France. In Mol Cell Biol, 2006
TRAPalpha could be involved in translocation of factors necessary for maturation of endocardial cushions
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