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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Signal sequence receptor, alpha

SSRI
The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR consists of 2 subunits, a 34-kD glycoprotein encoded by this gene and a 22-kD glycoprotein. This gene generates several mRNA species as a result of complex alternative polyadenylation. This gene is unusual in that it utilizes arrays of polyA signal sequences that are mostly non-canonical. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, AGE, iMpact, OUT
Papers on SSRI
Efficacy and tolerability of switching therapy to vortioxetine versus other antidepressants in patients with major depressive disorder.
Review
New
Takyar et al., Paris, France. In Curr Med Res Opin, Feb 2016
OBJECTIVES: To assess the relative efficacy and tolerability of vortioxetine against different antidepressant monotherapies in patients with major depressive disorder (MDD) with inadequate response to selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) therapy.
The Relationship Between Plasma Cytokine Levels and Response to Selective Serotonin Reuptake Inhibitor Treatment in Children and Adolescents with Depression and/or Anxiety Disorders.
New
Fennig et al., Petah Tikva, Israel. In J Child Adolesc Psychopharmacol, Feb 2016
This is the first report, to our knowledge, of the relationship between response to selective serotonin reuptake inhibitor (SSRI) treatment for anxiety and/or depression and cytokine levels in children and adolescents.
Maternal pharmacokinetics and fetal disposition of (±)-citalopram during mouse pregnancy.
New
Bonnin et al., In Acs Chem Neurosci, Feb 2016
UNASSIGNED: While selective-serotonin reuptake inhibitor (SSRI) antidepressants are commonly prescribed in the treatment of depression, their use during pregnancy leads to fetal drug exposures.
Differential effects of vilazodone versus citalopram and paroxetine on sexual behaviors and serotonin transporter and receptors in male rats.
New
Tarazi et al., Utrecht, Netherlands. In Psychopharmacology (berl), Feb 2016
RATIONALE: Sexual side effects are commonly associated with selective serotonin reuptake inhibitor (SSRI) treatment.
Effect of escitalopram versus placebo on GRα messenger RNA expression in peripheral blood cells of healthy individuals with a family history of depression - a secondary outcome analysis from the randomized AGENDA trial.
New
Kessing et al., Copenhagen, Denmark. In Nord J Psychiatry, Feb 2016
Aim Based on the AGENDA trial dataset, we analysed whether an intervention with SSRI versus placebo decreases the GRα mRNA expression in peripheral blood cells in healthy first-degree relatives of patients with major depression.
Rapid Onset of the Effects of Combined Selective Serotonin Reuptake Inhibitors and Electroacupuncture on Primary Depression: A Meta-Analysis.
Review
New
Chen et al., Guangzhou, China. In J Altern Complement Med, Jan 2016
METHODS: Randomized controlled trials (RCTs) were analyzed to compare therapy combining SSRIs and electroacupuncture to SSRI therapy alone.
Pharmacotherapy for Pediatric Generalized Anxiety Disorder: A Systematic Evaluation of Efficacy, Safety and Tolerability.
Review
New
Strawn et al., Cincinnati, United States. In Paediatr Drugs, Jan 2016
CONCLUSIONS: Data from five trials of SSRI/SNRI in youth with GAD, many of whom had co-occurring separation and social anxiety disorders, suggest superiority to placebo and favorable tolerability profiles.
The clinical potentials of adjunctive fluvoxamine to clozapine treatment: a systematic review.
Review
New
Nielsen et al., Aalborg, Denmark. In Psychopharmacology (berl), Jan 2016
Although depressive or obsessive-compulsive symptoms may improve, a SSRI with no CYP1A2 inhibition should rather be used (C).
Systematic Review and Meta-Analysis: Dose-Response Relationship of Selective Serotonin Reuptake Inhibitors in Major Depressive Disorder.
Review
New
Bloch et al., London, United Kingdom. In Am J Psychiatry, Dec 2015
Endpoint and tolerability analyses were analyzed using meta-regression and stratified subgroup analysis by predefined SSRI dose categories in order to assess the effect of SSRI dosing on the efficacy and tolerability of SSRIs for major depressive disorder.
Antidepressant use late in pregnancy and risk of persistent pulmonary hypertension of the newborn.
New
Impact
Hernandez-Diaz et al., Boston, United States. In Jama, Jul 2015
IMPORTANCE: The association between selective serotonin reuptake inhibitor (SSRI) antidepressant use during pregnancy and risk of persistent pulmonary hypertension of the newborn (PPHN) has been controversial since the US Food and Drug Administration issued a public health advisory in 2006.
Structural basis for action by diverse antidepressants on biogenic amine transporters.
Impact
Gouaux et al., Portland, United States. In Nature, 2013
The final LeuBAT mutant binds the SSRI sertraline with a binding constant of 18 nM and displays high-affinity binding to a range of SSRIs, SNRIs and a TCA.
SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.
Impact
Greengard et al., New York City, United States. In Cell, 2013
The SSRI fluoxetine induces expression of p11 in both cell types and increases the amount of the ternary complex of p11/annexin A2/SMARCA3.
Selective serotonin reuptake inhibitors during pregnancy and risk of stillbirth and infant mortality.
Impact
Valdimarsdóttir et al., Stockholm, Sweden. In Jama, 2013
MAIN OUTCOME MEASURES: We used logistic regression to estimate relative risks of stillbirth, neonatal death, and postneonatal death associated with SSRI use during pregnancy taking into account maternal characteristics and previous psychiatric hospitalization.
Pharmacology for the treatment of premature ejaculation.
Review
Impact
Clèment et al., Garches, France. In Pharmacol Rev, 2012
Dapoxetine, a short-acting SSRI, is the first treatment registered for the on-demand treatment of PE.
Premature ejaculation: is there an efficient therapy?
Facio Junior et al., Ribeirão Preto, Brazil. In Einstein (sao Paulo), 2011
Dapoxetine is a short-acting SSRI formulated to treat premature ejaculation, and results seem very promising.
Mutation in the Trapalpha/Ssr1 gene, encoding translocon-associated protein alpha, results in outflow tract morphogenetic defects.
GeneRIF
Barra et al., Paris, France. In Mol Cell Biol, 2006
TRAPalpha could be involved in translocation of factors necessary for maturation of endocardial cushions
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