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GC-rich promoter binding protein 1

SSH6, vasculin, GPBP1
This gene was originally isolated by subtractive hybridization of cDNAs expressed in atherosclerotic plaques with a thrombus, and was found to be expressed only in vascular smooth muscle cells. However, a shorter splice variant was found to be more ubiquitously expressed. This protein is suggested to play a role in the development of atherosclerosis. Studies in mice suggest that it may also function as a GC-rich promoter-specific trans-activating transcription factor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011] (from NCBI)
Top mentioned proteins: ACID, Antizyme, Cullin, GAPDH, Dsk2
Papers on SSH6
The extended AT-hook is a novel RNA binding motif.
NĂ©meth et al., Regensburg, Germany. In Rna Biol, 2014
We identified 80 human and 60 mouse eAT-hook proteins and biochemically characterized the eAT-hooks of Tip5/BAZ2A, PTOV1 and GPBP1.
Identification of novel reference genes using multiplatform expression data and their validation for quantitative gene expression analysis.
Shin et al., Seoul, South Korea. In Plos One, 2008
Here, we first selected candidate housekeeping genes (HKGs) using human gene expression data from different platforms including EST, SAGE, and microarray, and 13 novel ERGs (nERGs) (ARL8B, CTBP1, CUL1, DIMT1L, FBXW2, GPBP1, LUC7L2, OAZ1, PAPOLA, SPG21, TRIM27, UBQLN1, ZNF207) were further identified from these HKGs.
Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns.
Platzer et al., Jena, Germany. In Genome Biol, 2006
occurrence of an unusual TG 3' splice site in intron 9
Vasculin, a novel vascular protein differentially expressed in human atherogenesis.
Cleutjens et al., Maastricht, Netherlands. In Blood, 2003
Vasculin is a novel vascular protein differentially expressed in human atherogenesis
Identification of genes potentially involved in rupture of human atherosclerotic plaques.
Daemen et al., Maastricht, Netherlands. In Circ Res, 2001
Reverse transcriptase-polymerase chain reaction analysis on 10 individual ruptured and 10 individual stable plaques showed a striking consistency of expression for the clones SSH6, present in 8 ruptured and 2 stable plaques, and perilipin, expressed in 8 ruptured plaques and completely absent in stable plaques.
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.
Wiemann et al., Heidelberg, Germany. In Embo Rep, 2000
This publication discusses both human and mouse GC-rich promoter binding protein.
An insulin receptor peptide (1135-1156) stimulates guanosine 5'-[gamma-thio]triphosphate binding to the 67 kDa G-protein associated with the insulin receptor.
McDonald et al., Birmingham, United States. In Biochem J, 1993
Peptides representing two putative G-protein-binding motifs (GPBP1 and GPBP2) derived from insulin-receptor sequences were tested for their ability to stimulate guanosine 5'-[gamma-thio]-triphosphate (GTP[S]; 'GTP gamma S') binding to a preparation containing the 41 and 67 kDa G-proteins that are associated with the insulin receptor [Jo, Cha, Davis and McDonald (1992) Endocrinology (Baltimore) 131, 2855-2861].
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