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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Sjogren syndrome antigen B

SSB, single-stranded DNA binding protein
The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: CAN, SS-A, HAD, POLYMERASE, ACID
Papers using SSB antibodies
Structural diversity of the Y-family DNA polymerases
Supplier
Woodgate Roger et al., In Nucleic Acids Research, 2009
... RecA and SSB proteins were supplied by New England Biolabs, (Ipswich, MA, USA) and ...
BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT
Supplier
Tautz Diethard et al., In Frontiers in Zoology, 1998
... were considerably enhanced by the addition of Q-solution (Qiagen, Düsseldorf) and single strand binding Protein (SSB, Sigma Aldrich).
Papers on SSB
The acidic C-terminus of vaccinia virus I3 single-strand binding protein promotes proper assembly of DNA-protein complexes.
New
Evans et al., Edmonton, Canada. In Virology, Feb 2016
UNASSIGNED: The vaccinia virus I3L gene encodes a single-stranded DNA binding protein (SSB) that is essential for virus DNA replication and is conserved in all Chordopoxviruses.
SSB binds to the RecG and PriA helicases in vivo in the absence of DNA.
New
Bianco et al., Buffalo, United States. In Genes Cells, Feb 2016
UNASSIGNED: The E. coli single-stranded DNA-binding protein (SSB) binds to the fork DNA helicases RecG and PriA in vitro.
Achieving Single-Nucleotide Specificity in Direct Quantitative Analysis of Multiple microRNAs (DQAMmiR).
New
Krylov et al., In Anal Chem, Feb 2016
The second problem is further complicated by the reliance of separation in DQAMmiR on single-strand DNA binding protein (SSB) whose native structure and binding properties may be drastically affected by the elevated temperature.
Defective DNA methylation in salivary gland epithelial acini from patients with Sjögren's syndrome is associated with SSB gene expression, anti-SSB/LA detection, and lymphocyte infiltration.
New
Renaudineau et al., Brest, France. In J Autoimmun, Jan 2016
Twenty-two pSS patients and ten controls were selected, and MSG were stained with anti-(5m)C, anti-(5m)C/anti-cytokeratin (KRT)19, or with anti-SSB/La antibodies (Ab).
Making the diagnosis of Sjögren's syndrome in patients with dry eye.
Review
New
Milner et al., Westerville, United States. In Clin Ophthalmol, Dec 2015
Examination of classic SS biomarkers (SS-A/Ro, SS-B/La, antinuclear antibody, and rheumatoid factor) is a convenient and non-invasive way of evaluating patients for the presence of SS, even years prior to confirmed diagnosis, although not all SS patients will test positive, particularly those with early disease.
Beverage Consumption: Are Alcoholic and Sugary Drinks Tipping the Balance towards Overweight and Obesity?
Review
New
Poppitt, Auckland, New Zealand. In Nutrients, Aug 2015
The role that energy-containing beverages may play in the development of overweight and obesity remains highly controversial, in particular the alcoholic and sugar-sweetened beverages (SSB).
Pleural Effusion In A Patient With Primary Sjögren's Syndrome Successfully Treated With Corticosteroids.
Review
New
Ramírez-Rivera et al., In Bol Asoc Med P R, Jul 2015
We report a woman with primary Sjögren's syndrome who developed pleuritis with moderately large effusions and antibody levels for SS-A and SS-B in the serum without evidence of infection, malignancy or other collagen diseases.
I came to a fork in the DNA and there was RecG.
Review
New
Bianco, Buffalo, United States. In Prog Biophys Mol Biol, Mar 2015
A model is presented for the localization of the enzyme to the inner membrane via its binding to SSB.
[Evaluation of usefulness of Polycheck method in the detection autoantibodies in patients with systemic lupus erythematosus, Sjögren's syndrome and systemic sclerosis].
Grzywnowicz et al., In Wiad Lek, 2014
RESULTS: In our study we found thatthe frequency of antibodies characteristic of the SS: anti-SS-A/Ro 52, anti-SS-A Ro 60 and anti-SS-B/La was significantly higher in patients with SS group compared to TRU, TU, and GK (p <0.05); concentrations of Ab were lower in TRU and in SSc group.
Efficiency of a solid-phase chemiluminescence immunoassay for detection of antinuclear and cytoplasmic autoantibodies compared with gold standard immunoprecipitation.
Review
Roldan et al., Barcelona, Spain. In Auto Immun Highlights, 2014
PURPOSE: The aim of this study was to compare the degree of agreement of a novel Zenit RA chemiluminescent immunoassay (CLIA) from A. Menarini Diagnostics (Florence, Italy) and the gold standard immunoprecipitation assay to screen for the presence of specific anti-U1snRNP, anti-Sm, anti-Ro/SS-A, anti-La/SS-B, anti-Jo-1((his)tRNA-Synthetase) and anti-Scl-70(Topo I) antibodies.
The cotranslational function of ribosome-associated Hsp70 in eukaryotic protein homeostasis.
Impact
Frydman et al., Stanford, United States. In Cell, 2013
Here, we use a sensitive and global approach to define the cotranslational substrate specificity of the yeast Hsp70 SSB.
Direct imaging of RecA nucleation and growth on single molecules of SSB-coated ssDNA.
Impact
Kowalczykowski et al., Davis, United States. In Nature, 2012
To function, filaments of RecA must nucleate and grow on single-stranded DNA (ssDNA) in direct competition with ssDNA-binding protein (SSB), which rapidly binds and continuously sequesters ssDNA, kinetically blocking RecA assembly.
Regulation of hepatitis C virus translation initiation by iron: role of eIF3 and La protein.
GeneRIF
Li et al., Hangzhou, China. In Virus Res, 2012
Iron promotes the translation initiation of hepatitis C virus by stimulating the expression of eIF3A and La proteins.
La autoantigen mediates oxidant induced de novo Nrf2 protein translation.
GeneRIF
Chen et al., Tucson, United States. In Mol Cell Proteomics, 2012
oxidants cause nuclear export of La/SSB protein and subsequent association of La/SSB with Nrf2 untranslated regions and ribosomes
RNA chaperone activity of human La protein is mediated by variant RNA recognition motif.
GeneRIF
Bayfield et al., Toronto, Canada. In J Biol Chem, 2012
the structural elements required for La-mediated RNA chaperone activity
Polymerase exchange during Okazaki fragment synthesis observed in living cells.
Impact
Allemand et al., Gif-sur-Yvette, France. In Science, 2012
Fluctuations in the amount of DNA-bound single-stranded DNA-binding protein (SSB) reflect different speeds for the leading- and lagging-strand DNA polymerases.
Autoantigen La promotes efficient RNAi, antiviral response, and transposon silencing by facilitating multiple-turnover RISC catalysis.
GeneRIF
Liu et al., Dallas, United States. In Mol Cell, 2011
Autoantigen La promotes efficient RNAi, antiviral response, and transposon silencing by facilitating multiple-turnover RNA-induced silencing complex catalysis.
SSB functions as a sliding platform that migrates on DNA via reptation.
Impact
Ha et al., Champaign, United States. In Cell, 2011
SSB proteins bind to and control the accessibility of single-stranded DNA (ssDNA), likely facilitated by their ability to diffuse on ssDNA.
Implication of RNA-binding protein La in proliferation, migration and invasion of lymph node-metastasized hypopharyngeal SCC cells.
GeneRIF
Heise et al., Charleston, United States. In Plos One, 2010
function of the RNA-binding protein La in promoting tumor progression of head and neck squamous cell carcinoma
SSB protein diffusion on single-stranded DNA stimulates RecA filament formation.
Impact
Ha et al., Champaign, United States. In Nature, 2009
Single-stranded DNA generated in the cell during DNA metabolism is stabilized and protected by binding of ssDNA-binding (SSB) proteins.
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