[Progress in the molecular genetic mechanism of gonadoblastoma].
Kunming, China. In Yi Chuan, Nov 2015
Increasing studies show that the formation of GB is closely related to genes regulating sexual differentiation and determination (e.g., SRY, WT1, SOX9, Foxl2, TSPY, etc), and is affected by the interaction of genetic and epigenetic regulation.
Biological factors underlying sex differences in neurological disorders.
Australia. In Int J Biochem Cell Biol, Aug 2015
In particular, the Y-chromosome gene, SRY (Sex-determining Region on the Y chromosome) is an interesting candidate as it is expressed in dopamine-abundant brain regions, where it regulates dopamine biosynthesis and dopamine-mediated functions such as voluntary movement in males.
Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration.
Seoul, South Korea. In Osteoarthritis Cartilage, Aug 2015
Upregulation of the genes interleukin 1 beta (IL-1β), p53, p16, p21, and p38 mitogen-activated protein kinase (MAPK) is responsible for the direct induction of senescence, whereas downregulation of the genes transforming growth factor-beta (TGF-β), bone morphogenetic protein-2 (BMP-2), SRY (sex determining region Y)-box 9 (SOX9), and insulin-like growth factor-1 (IGF-1), indirectly induces senescence.
Origins and functional evolution of Y chromosomes across mammals.
Lausanne, Switzerland. In Nature, 2014
The original placental and marsupial (therian) Y, containing the sex-determining gene SRY, emerged in the therian ancestor approximately 180 million years ago, in parallel with the first of five monotreme Y chromosomes, carrying the probable sex-determining gene AMH.
Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse.
Honolulu, United States. In Science, 2014
Here, we demonstrate that live mouse progeny can also be generated by using germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y. Sry is believed to function primarily in sex determination during fetal life.
TALEN-mediated editing of the mouse Y chromosome.
Cambridge, United States. In Nat Biotechnol, 2013
We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and insertions in two Y-linked genes--Sry and Uty.