[Progress in the molecular genetic mechanism of gonadoblastoma].
Kunming, China. In Yi Chuan, Nov 2015
Increasing studies show that the formation of GB is closely related to genes regulating sexual differentiation and determination (e.g., SRY, WT1, SOX9, Foxl2, TSPY, etc), and is affected by the interaction of genetic and epigenetic regulation.
Origins and functional evolution of Y chromosomes across mammals.
Lausanne, Switzerland. In Nature, 2014
The original placental and marsupial (therian) Y, containing the sex-determining gene SRY, emerged in the therian ancestor approximately 180 million years ago, in parallel with the first of five monotreme Y chromosomes, carrying the probable sex-determining gene AMH.
Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse.
Honolulu, United States. In Science, 2014
Here, we demonstrate that live mouse progeny can also be generated by using germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y. Sry is believed to function primarily in sex determination during fetal life.
TALEN-mediated editing of the mouse Y chromosome.
Cambridge, United States. In Nat Biotechnol, 2013
We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and insertions in two Y-linked genes--Sry and Uty.