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Sex determining region Y

This intronless gene encodes a transcription factor that is a member of the high mobility group (HMG)-box family of DNA-binding proteins. This protein is the testis-determining factor (TDF), which initiates male sex determination. Mutations in this gene give rise to XY females with gonadal dysgenesis (Swyer syndrome); translocation of part of the Y chromosome containing this gene to the X chromosome causes XX male syndrome. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, Sox, POLYMERASE, Sox2
Papers on SRY
Androgen insensitivity syndrome in a cohort of Sri Lankan children with 46, XY disorders of sex development (46, XY DSD).
Dissanayake et al., Colombo, Sri Lanka. In Ceylon Med J, Dec 2015
SRY gene mutations were also assayed.
Structural Mechanism behind Distinct Efficiency of Oct4/Sox2 Proteins in Differentially Spaced DNA Complexes.
Choi et al., Suwŏn, South Korea. In Plos One, Dec 2015
UNASSIGNED: The octamer-binding transcription factor 4 (Oct4) and sex-determining region Y (SRY)-box 2 (Sox2) proteins induce various transcriptional regulators to maintain cellular pluripotency.
Mutations in TP53 increase the risk of SOX2 copy number alterations and silencing of TP53 reduces SOX2 expression in non-small cell lung cancer.
Zienolddiny et al., Oslo, Norway. In Bmc Cancer, Dec 2015
BACKGROUND: Amplifications of the transcription factor, SRY (sex determining region Y)-box 2 (SOX2), are common in non-small cell lung cancer (NSCLC).
Vascular endothelial growth factor A: just one of multiple mechanisms for sex-specific vascular development within the testis?
Cupp et al., Lincoln, United States. In J Endocrinol, Nov 2015
However, in vivo models using mice which selectively eliminated all VEGFA isoforms: in Sertoli and germ cells (pDmrt1-Cre;Vegfa(-/-)); Sertoli and Leydig cells (Amhr2-Cre;Vegfa(-/-)) or Sertoli cells (Amh-Cre;Vegfa(-/-) and Sry-Cre;Vegfa(-/-)) displayed testes with observably normal cords and vasculature at postnatal day 0 and onwards.
[Progress in the molecular genetic mechanism of gonadoblastoma].
Xiangyang et al., Kunming, China. In Yi Chuan, Nov 2015
Increasing studies show that the formation of GB is closely related to genes regulating sexual differentiation and determination (e.g., SRY, WT1, SOX9, Foxl2, TSPY, etc), and is affected by the interaction of genetic and epigenetic regulation.
SGF29 and Sry pathway in hepatocarcinogenesis.
Tashiro et al., Hamamatsu, Japan. In World J Biol Chem, Sep 2015
We propose that the upstream regulation of SGF29 elicited by sex-determining region Y (Sry) is also augmented in HCC.
Biological factors underlying sex differences in neurological disorders.
Lee et al., Australia. In Int J Biochem Cell Biol, Aug 2015
In particular, the Y-chromosome gene, SRY (Sex-determining Region on the Y chromosome) is an interesting candidate as it is expressed in dopamine-abundant brain regions, where it regulates dopamine biosynthesis and dopamine-mediated functions such as voluntary movement in males.
Regulation of senescence associated signaling mechanisms in chondrocytes for cartilage tissue regeneration.
Lee et al., Seoul, South Korea. In Osteoarthritis Cartilage, Aug 2015
Upregulation of the genes interleukin 1 beta (IL-1β), p53, p16, p21, and p38 mitogen-activated protein kinase (MAPK) is responsible for the direct induction of senescence, whereas downregulation of the genes transforming growth factor-beta (TGF-β), bone morphogenetic protein-2 (BMP-2), SRY (sex determining region Y)-box 9 (SOX9), and insulin-like growth factor-1 (IGF-1), indirectly induces senescence.
Homozygous Ala65Pro Mutation with V89L Polymorphism in SRD5A2 Deficiency.
Karakaş Çelik et al., In J Clin Res Pediatr Endocrinol, Feb 2015
Chromosomal and SRY gene analyses were performed on the peripheral blood of all patients.
Isolation and analysis of cell-free fetal DNA from maternal peripheral blood in Chinese women.
Fu et al., China. In Genet Mol Res, 2014
The SRY gene of plasma DNA was amplified by polymerase chain reaction (PCR).
Origins and functional evolution of Y chromosomes across mammals.
Kaessmann et al., Lausanne, Switzerland. In Nature, 2014
The original placental and marsupial (therian) Y, containing the sex-determining gene SRY, emerged in the therian ancestor approximately 180 million years ago, in parallel with the first of five monotreme Y chromosomes, carrying the probable sex-determining gene AMH.
Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse.
Ward et al., Honolulu, United States. In Science, 2014
Here, we demonstrate that live mouse progeny can also be generated by using germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y. Sry is believed to function primarily in sex determination during fetal life.
Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a.
Tachibana et al., Kyoto, Japan. In Science, 2013
We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry.
TALEN-mediated editing of the mouse Y chromosome.
Jaenisch et al., Cambridge, United States. In Nat Biotechnol, 2013
We used transcription activator-like effector nuclease (TALEN)-mediated gene editing in mouse embryonic stem cells (mESCs) to produce mice with targeted gene disruptions and insertions in two Y-linked genes--Sry and Uty.
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering.
Jaenisch et al., Cambridge, United States. In Cell, 2013
We demonstrate that CRISPR/Cas-mediated gene editing allows the simultaneous disruption of five genes (Tet1, 2, 3, Sry, Uty--8 alleles) in mouse embryonic stem (ES) cells with high efficiency.
Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis.
Janknecht et al., Los Angeles, United States. In J Biol Chem, 2012
Data suggest a mechanism by which SRY induces Sox9 and Er71 transcription early in testis differentiation.
Transgenic mouse analysis of Sry expression during the pre- and peri-implantation stage.
Pilon et al., Saint-Hyacinthe, Canada. In Dev Dyn, 2012
Data propose that SRY/Sry may function as a male-specific maturation factor in the peri-implantation mammalian embryo.
Cbx2, a polycomb group gene, is required for Sry gene expression in mice.
Morohashi et al., Ōbu, Japan. In Endocrinology, 2012
This study implicates Cbx2 in testis differentiation through regulating Sry gene expression.
Synergistic effect of SRY and its direct target, WDR5, on Sox9 expression.
Zhao et al., Nanjing, China. In Plos One, 2011
findings show that WDR5 is a direct target of SRY; the interaction of WDR5 and SRY activates Sox9 expression; results suggest that, in conjunction with SRY, WDR5 plays an important role in sex determination
[SRY and SOX9: the main genetic factors of mammalian sex determination].
Kozhukhar', In Tsitologiia, 2011
Factor SRY is the key trigger of mammalian sex determination by means of initiation the autosomal gene SOX9 expression. (Review)
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