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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Signal recognition particle 72kDa

SRP72, Srp72p
The SRP72 gene encodes the 72-kD subunit of the signal recognition particle (SRP), a ribonucleoprotein complex that mediates the targeting of proteins to the endoplasmic reticulum (ER) (summarized by Lutcke et al., 1993 [PubMed 8388879]). The complex consists of a 7S (or 7SL) RNA and 6 different proteins, SRP9 (MIM 600707), SRP14 (MIM 600708), SRP19 (MIM 182175), SRP54 (MIM 604857), SRP68 (MIM 604858), and SRP72. The proteins are bound to the 7S RNA as monomers (SRP19 and SRP54) or heterodimers (SRP9/SRP14 and SRP68/SRP72). SRP9 and SRP14 constitute the Alu domain of 7S, whereas the other 4 proteins belong to the S domain. SRP has at least 3 distinct functions that can be associated with the protein subunits: signal recognition, translational arrest, and ER membrane targeting by interaction with the docking protein.[supplied by OMIM, Mar 2010] (from NCBI)
Top mentioned proteins: SRP54, SRP19, SRP14, ACID, CAN
Papers on SRP72
An integrated analysis of cancer genes in thyroid cancer.
New
Lv et al., Shanghai, China. In Oncol Rep, Feb 2016
Two genes, FHOD3 and SRP72, were hypomethylated, overexpressed and involved in major deletions in thyroid cancer.
Genetic predisposition to myelodysplastic syndrome and acute myeloid leukemia in children and young adults.
New
Olson et al., Philadelphia, United States. In Leuk Lymphoma, Jan 2016
Here, we provide a practical algorithm for approaching a patient with a suspected MDS/AML predisposition, and provide an in-depth review of the established and emerging familial MDS/AML syndromes caused by mutations in the ANKRD26, CEBPA, DDX41, ETV6, GATA2, RUNX1, SRP72 genes.
SRP-IgG detected incidentally associates with autoimmune myopathy.
New
Lennon et al., Rochester, United States. In Muscle Nerve, Dec 2015
Recombinant antigens confirmed SRP54-IgG-specificity alone (17), SRP72-IgG-specificity alone (3), both (32), neither (2).
Genetic predisposition syndromes: when should they be considered in the work-up of MDS?
Review
New
Bessler et al., Philadelphia, United States. In Best Pract Res Clin Haematol, Mar 2015
In addition to the classic hereditary bone marrow failure syndromes (BMFS) such as Fanconi Anemia and Dyskeratosis Congenita, in recent years there has been an increased awareness of non-syndromic familial MDS/AML predisposition syndromes such as those caused by mutations in GATA2, RUNX1, CEBPA, and SRP72 genes.
SRP RNA remodeling by SRP68 explains its role in protein translocation.
Impact
Sinning et al., Heidelberg, Germany. In Science, 2014
In eukaryotes, SRP function relies on the SRP68-SRP72 heterodimer.
Plasmodium falciparum signal recognition particle components and anti-parasitic effect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP.
Tuteja et al., New Delhi, India. In Cell Death Dis, 2013
Here we report that Plasmodium falciparum SRP is composed of six polypeptides; SRP9, SRP14, SRP19, SRP54, SRP68 and SRP72 and a 303nt long SRP RNA.
A novel histone H4 arginine 3 methylation-sensitive histone H4 binding activity and transcriptional regulatory function for signal recognition particle subunits SRP68 and SRP72.
Wong et al., Shanghai, China. In J Biol Chem, 2012
These proteins were identified as the SRP68 and SRP72 heterodimers (SRP68/72), the components of the signal recognition particle (SRP).
Exome sequencing identifies autosomal-dominant SRP72 mutations associated with familial aplasia and myelodysplasia.
GeneRIF
Dokal et al., London, United Kingdom. In Am J Hum Genet, 2012
A heterozygous mutation in SRP72 has a role in familial aplasia and myelodysplasia.
Ribosomal protein S6 interacts with the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus.
Dittmer et al., Chapel Hill, United States. In J Virol, 2011
Three classes of proteins survived our stringent four-step purification procedure (size, heparin, anion, and immunoaffinity chromatography): two heat shock proteins (Hsp70 and Hsp96 precursor), signal recognition particle 72 (SRP72), and 10 different ribosomal proteins.
Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells.
GeneRIF
Vázquez-Del Mercado et al., Guadalajara, Mexico. In J Biol Chem, 2010
Inhibitors of MAPK pathway ERK1/2 or p38 prevent the IL-1{beta}-induced up-regulation of SRP72 autoantigen in Jurkat cells.
Archaea signal recognition particle shows the way.
Review
Bhuiyan et al., Tyler, United States. In Archaea, 2009
The 5e motif, which in eukaryotes binds a 72 kilodalton protein, is preserved in most archaea SRP RNAs despite the lack of an archaea SRP72 homolog.
Identification of amino acid residues in protein SRP72 required for binding to a kinked 5e motif of the human signal recognition particle RNA.
GeneRIF
Zwieb et al., Tyler, United States. In Bmc Mol Biol, 2009
The study delineated the minimal region of SRP72 capable of forming a stable complex with an signal recognition particle RNA fragment.
[Histological and molecular alterations in inflammatory myopathies].
Aguilar Arreola et al., Guadalajara, Mexico. In Reumatol Clin, 2009
In this chapter we will review the histological and molecular findings of inflammatory myopathies but we will also discuss a special group of myopathies related to the presence of antibodies against the SRP complex, in particular the SRP72 and SRP54 antibodies, which are associated with a poor prognosis and clinical outcome and present an inadequate response to conventional treatment.
Characterization of the SRP68/72 interface of human signal recognition particle by systematic site-directed mutagenesis.
Zwieb et al., Tyler, United States. In Protein Sci, 2009
Among the six proteins of the eukaryotic SRP, the two largest, SRP68 and SRP72, form a stable SRP68/72 heterodimer of unknown structure which is required for SRP function.
Anti-cooperative assembly of the SRP19 and SRP68/72 components of the signal recognition particle.
Weeks et al., Chapel Hill, United States. In Biochem J, 2008
In the present study we analysed the interdependent interactions between the SRP19, SRP68 and SRP72 proteins and the SRP RNA.
The 5e motif of eukaryotic signal recognition particle RNA contains a conserved adenosine for the binding of SRP72.
GeneRIF
Zwieb et al., Tyler, United States. In Rna, 2008
Human signal recognition particle RNA with a single A240G change was unable to form a complex with full-length human SRP72.
Roles for Srp72p in assembly, nuclear export and function of the signal recognition particle.
GeneRIF
Brown et al., Newcastle upon Tyne, United Kingdom. In Rna Biol, 2008
Srp72p has at least two functions that are individually redundant and that the conformation of the complex is critical for efficient completion of its biogenesis.
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