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Serine/arginine-rich splicing factor 10

SRp38, TASR, TASR-1, TLS-associated serine-arginine protein, SRrp40
This gene product is a member of the serine-arginine (SR) family of proteins, which is involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein can influence splice site selection of adenovirus E1A pre-mRNA. It interacts with the oncoprotein TLS, and abrogates the influence of TLS on E1A pre-mRNA splicing. This gene has multiple pseudogenes. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. In addition, transcript variants utilizing alternative polyA sites exist.[provided by RefSeq, Jul 2010] (from NCBI)
Top mentioned proteins: CAN, STEP, V1a, FUS, SC35
Papers on SRp38
A new approach for annotation of transposable elements using small RNA mapping.
Jackson et al., Athens, United States. In Nucleic Acids Res, Aug 2015
We use this new approach, called TASR (for Transposon Annotation using Small RNAs), for de novo annotation of TEs in Arabidopsis, rice and soybean and demonstrate that this strategy can be successfully applied for de novo TE annotation in plants.Executable PERL is available for download from:
Decrease in olfactory and taste receptor expression in the dorsolateral prefrontal cortex in chronic schizophrenia.
Ferrer et al., Barcelona, Spain. In J Psychiatr Res, 2015
We have recently identified up- or down-regulation of the olfactory (OR) and taste (TASR) chemoreceptors in the human cortex in several neurodegenerative diseases, raising the possibility of a general deregulation of these genes in neuropsychiatric disorders.
Widespread inhibition of posttranscriptional splicing shapes the cellular transcriptome following heat shock.
Burge et al., Cambridge, United States. In Cell Rep, 2014
Splicing of several mRNAs is known to be inhibited during heat stress, often meditated by SRp38, but the extent and specificity of this effect have remained unclear.
The ribosomal protein rpl26 promoter is required for its 3' sense terminus ncRNA transcription in Schizosaccharomyces pombe, implicating a new transcriptional mechanism for ncRNAs.
Qu et al., Guangzhou, China. In Biochem Biophys Res Commun, 2014
Here, we identify a 3' sense termini-associated sRNA (TASR) downstream of rpl26 in Schizosaccharomyces pombe (S. pombe).
Dephosphorylation of NSSR1 regulates alternative splicing of the GluR-B minigene.
Peng et al., Hangzhou, China. In Genet Mol Res, 2013
Neural salient serine/arginine-rich protein 1 (NSSR1, alternatively SRp38) is an important splicing factor that can repress pre-mRNA alternative splicing in cells during heat shock and mitosis.
Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model.
Ferrer et al., l'Hospitalet de Llobregat, Spain. In Neuroscience, 2013
Recently, we have shown the expression of novel chemoreceptors corresponding to the olfactory receptor (OR) and taste receptor (TASR) families in the human brain.
Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-Associated Herpesvirus Interacts with a Translocation Liposarcoma Protein-Associated Serine-Arginine Protein.
Seo et al., Seoul, South Korea. In Osong Public Health Res Perspect, 2012
OBJECTIVES: To confirm that Kaposi's sarcoma-associated herpes virus openreading frame K9, viral interferon regulatory factor 1 (vIRF1), interacts with splicing factor, translocation liposarcoma protein-associated serine-arginine protein (TASR), in vivo and to establish whether interactions between vIRF1 and TASRs influence alternative splicing.
[Expression of neural salient serine-/arginine-rich protein 1 (NSSR1) in colorectal cancer].
Shen et al., Hangzhou, China. In Zhejiang Da Xue Xue Bao Yi Xue Ban, 2011
In colorectal cancer, NSSR1 was highly expressed in the nucleus of tumor cells.
Heat shock-induced SRSF10 dephosphorylation displays thermotolerance mediated by Hsp27.
Manley et al., New York City, United States. In Mol Cell Biol, 2011
Splicing thermotolerance is acquired through maintenance of SRSF10 phosphorylation and that this is mediated at least in part by Hsp27.
Dephosphorylated NSSR1 is induced by androgen in mouse epididymis and phosphorylated NSSR1 is increased during sperm maturation.
Chen et al., Shanghai, China. In Plos One, 2010
NSSR1 (Neural salient serine/arginine rich protein 1, alternatively SRp38) is a newly identified RNA splicing factor and predominantly expressed in neural tissues.
Role of SFRS13A in low-density lipoprotein receptor splicing.
Estus et al., Lexington, United States. In Hum Mutat, 2010
Data show that SFRS13A expression was significantly associated with LDLR splicing efficiency in vivo.
SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart.
Manley et al., New York City, United States. In Dev Cell, 2009
SRp38 is an atypical SR protein splicing regulator.
Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator.
Manley et al., New York City, United States. In Nat Struct Mol Biol, 2008
SRp38 is an atypical SR protein that functions as a general splicing repressor when dephosphorylated.
A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock.
Manley et al., New York City, United States. In Mol Cell, 2007
Results describe a complex signaling pathway that regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock.
Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins.
Manley et al., New York City, United States. In Mol Cell Biol, 2005
SRp38 contains two arginine- and serine-rich domains (RS), one of which has a unique, second-step repression activity, while both function together as a splicing repression domain.
Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.
Manley et al., New York City, United States. In Nature, 2004
SRp38 plays a crucial role in cell survival under stress conditions by inhibiting the splicing machinery
Splicing regulation: the cell cycle connection.
Blencowe, Toronto, Canada. In Curr Biol, 2003
A recent study suggests that splicing is also targeted for mitotic repression, in this case by dephosphorylation of the newly identified splicing factor SRp38.
The SR protein SRp38 represses splicing in M phase cells.
Manley et al., New York City, United States. In Cell, 2002
found to be dephosphorylated specifically in mitotic cells; show that dephosphorylated SRp38 is required for the observed splicing repression
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