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Serine/arginine-rich splicing factor 9

SRp30c, SFRS9
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two pseudogenes, one on chromosome 15 and the other on chromosome 21, have been found for this gene. [provided by RefSeq, Sep 2010] (from NCBI)
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Top mentioned proteins: CAN, V1a, SRp20, HAD, E1A
Papers on SRp30c
Heterogeneous Nuclear Ribonucleoprotein C Proteins Interact with the Human Papillomavirus Type 16 (HPV16) Early 3'-Untranslated Region and Alleviate Suppression of HPV16 Late L1 mRNA Splicing.
Schwartz et al., Lund, Sweden. In J Biol Chem, Jun 2015
These cells either contained a novel spliced variant of the L1 mRNAs that bypassed the suppressed HPV16 late, 5'-splice site SD3632; produced elevated levels of RNA-binding proteins SRSF1 (ASF/SF2), SRSF9 (SRp30c), and HuR that are known to regulate HPV16 late gene expression; or were shown by a gene expression array analysis to overexpress the RALYL RNA-binding protein of the heterogeneous nuclear ribonucleoprotein C (hnRNP C) family.
Expression of glucocorticoid receptor isoforms and associations with serine/arginine-rich protein 30c and 40 in patients with systemic lupus erythematosus.
Fang et al., Dalian, China. In Clin Exp Rheumatol, Mar 2015
Transcript levels of GRα, GRβ, GRγ, GR-P, SRp30c and SRp40 in peripheral blood mononuclear cells (PBMCs) were determined by real-time PCR.
Genetic variants in Ser-Arg protein-coding genes are associated with the risk of nonobstructive azoospermia in Chinese men.
Hu et al., Nanjing, China. In Fertil Steril, 2014
RESULT(S): Rs17431717 near SFRS9 and rs12046213 near SFRS4 were significantly associated with a decreased risk of NOA, whereas rs10849753 near SFRS9 and rs6103330 in SFRS6 were associated with an increased risk of NOA.
RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation.
Jantsch et al., Vienna, Austria. In Nucleic Acids Res, 2013
The three proteins RPS14, SFRS9 and DDX15 interact with RNA.
Development and validation of a novel reporter assay for human papillomavirus type 16 late gene expression.
Schwartz et al., Dublin, Ireland. In J Virol Methods, 2012
For example, overexpression of adenovirus E4orf4 protein (E4orf4), polypyrimidine tract binding protein (PTB), arginine/serine-rich SRp30c protein (SRp30c) or alternative splicing factor/splicing factor 2 (ASF/SF2) induced an increased expression of CAT or GFP.
Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells.
Clark et al., Fort Worth, United States. In Invest Ophthalmol Vis Sci, 2012
Relative levels of SRp20, SRp30c, and SRp40 in TM cells control differential expression of the two alternatively spliced isoforms of the GR and thereby regulate GC responsiveness.
Tumor suppressive microRNA-1 mediated novel apoptosis pathways through direct inhibition of splicing factor serine/arginine-rich 9 (SRSF9/SRp30c) in bladder cancer.
Nakagawa et al., Kagoshima, Japan. In Biochem Biophys Res Commun, 2012
these data indicated that tumor suppressive miR-1 induces apoptosis through direct inhibition of SRSF9 in bladder cancer.
Splicosomal and serine and arginine-rich splicing factors as targets for TGF-β.
Westergren-Thorsson et al., Lund, Sweden. In Fibrogenesis Tissue Repair, 2011
Specifically, TGF-β1 significantly induced expression of SRp20, and reduced the expression of SRp30C, which has been suggested to be a prerequisite for generation of alternatively spliced fibronectin.
[Dissecting molecular mechanism of spinocerebellar ataxia type 31].
Mizusawa et al., Tokyo, Japan. In Rinsho Shinkeigaku, 2011
In situ hybridization analysis in patients' Purkinje cells demonstrated that pentanucleotide repeats transcribed in BEAN direction form RNA aggregates ("RNA foci"), and essential splicing factors, SFRS1 and SFRS9, bind to (UGGAA)(n), the transcript of (TGGAA)(n)in vitro.
Serine/arginine-rich protein 30c activates human papillomavirus type 16 L1 mRNA expression via a bimodal mechanism.
Schwartz et al., Uppsala, Sweden. In J Gen Virol, 2011
These results suggest that SRp30c can activate human papillomavirus type 16 L1 mRNA expression via a bimodal mechanism: directly by stimulating splicing to late splice sites and indirectly by inhibiting competing early splice sites.
Super-high-dose methylprednisolone does not improve efficacy or induce glucocorticoid resistance in experimental allergic encephalomyelitis.
Huang et al., Guangzhou, China. In Neuroimmunomodulation, 2010
Immunohistochemistry and RT-PCR were used to investigate the expression of GC receptor (GR) isoforms and splicing factor SRp30c.
[Spinocerebellar ataxia type 31].
Mizusawa et al., Tokyo, Japan. In Rinsho Shinkeigaku, 2010
We further found that splicing factors, SFRS1 and SFRS9, binds to (UGGAA)(n), the transcript of (TGGAA)(n) in vitro.
Proteomic analysis of nuclei isolated from cancer cell lines treated with indenoisoquinoline NSC 724998, a novel topoisomerase I inhibitor.
Newton et al., Frederick, United States. In J Proteome Res, 2010
Importantly, 12 differentially expressed proteins (ETFA, HCC1, HNRCL, KAP1, NPM, NUCL, PRDX1, PRP19, PSB6, RAE1L, RU2A, and SFRS9) were common to both cell lines.
Assessment of SNPs associated with the human glucocorticoid receptor in primary open-angle glaucoma and steroid responders.
Clark et al., Iowa City, United States. In Mol Vis, 2009
Genotyping of DNA samples for 48 SNPs in SFRS3, SFRS5, SFRS9, FKBP4, FKBP5, and NR3C1 was done at GeneSeek using a mass spectroscopy based system.
Spinocerebellar ataxia type 31 is associated with "inserted" penta-nucleotide repeats containing (TGGAA)n.
Mizusawa et al., Tokyo, Japan. In Am J Hum Genet, 2009
An electrophoretic mobility-shift assay showed that essential splicing factors, serine/arginine-rich splicing factors SFRS1 and SFRS9, bind to (UGGAA)n in vitro.
Arginine methylation analysis of the splicing-associated SR protein SFRS9/SRP30C.
Kobarg et al., Campinas, Brazil. In Cell Mol Biol Lett, 2008
findings indicate the importance of arginine methylation for the subnuclear localization of SFRS9.
Antagonistic effects of the SRp30c protein and cryptic 5' splice sites on the alternative splicing of the apoptotic regulator Bcl-x.
Chabot et al., Sherbrooke, Canada. In J Biol Chem, 2008
SRp30c stimulates splicing to the downstream 5' splice site of Bcl-x(L), thereby attenuating the repressive effect of upstream U1 snRNP binding sit
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