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Serine/arginine-rich splicing factor 3

SRp20, X16, SFRS3
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants, one protein-coding and the other non-coding, have been found for this gene. [provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: CAN, 9G8, SC35, POLYMERASE, HAD
Papers using SRp20 antibodies
Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control?
Zheng Zhi-Ming et al., In International Journal of Biological Sciences, 1996
... (Tom Misteli of NCI and Javier Caceres of Edinburgh) into the pRevTRE vector to put T7-SRp20 under the control of tetracycline.Immortal rodent fibroblast NIH 3T3 and MEF 3T3 tet-off cells (Clontech) and human C33A, 786-O, ...
Papers on SRp20
A genome landscape of SRSF3-regulated splicing events and gene expression in human osteosarcoma U2OS cells.
Zheng et al., Frederick, United States. In Nucleic Acids Res, Jan 2016
We recently described serine/arginine-rich splicing factor 3 (SRSF3 or SRp20) being a proto-oncogene.
Construction and evaluation of an adenoviral vector for the liver-specific expression of the serine/arginine-rich splicing factor, SRSF3.
Salati et al., Morgantown, United States. In Plasmid, Nov 2015
Serine/arginine-rich splicing factor-3 (SRSF3), alternatively known as SRp20, is a member of the highly-conserved SR protein family of mRNA splicing factors.
Regulation of CD44E by DARPP-32-dependent activation of SRp20 splicing factor in gastric tumorigenesis.
El-Rifai et al., Nashville, United States. In Oncogene, Jul 2015
Further experiments showed that DARPP-32 regulates the expression of SRp20 splicing factor and co-exists with it in the same protein complex.
Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates.
Zheng et al., Frederick, United States. In Int J Biol Sci, 2014
In this report, transgenic mouse lines were created for conditional knockdown of Srsf3 (SRp20) expression in liver and mammary gland tissues by expressing Srsf3-specific shRNAs driven by a U6 promoter.
Attenuation of the suppressive activity of cellular splicing factor SRSF3 by Kaposi sarcoma-associated herpesvirus ORF57 protein is required for RNA splicing.
Zheng et al., Frederick, United States. In Rna, 2014
Here, we identified serine/arginine-rich splicing factor 3 (SRSF3, formerly known as SRp20) as a cellular cofactor involved in ORF57-mediated splicing of KSHV K8β RNA.
Homer1 alternative splicing is regulated by gonadotropin-releasing hormone and modulates gonadotropin gene expression.
Sealfon et al., New York City, United States. In Mol Cell Biol, 2014
Phosphorylation of the splicing regulator SRp20 was found to be induced by GnRH.
An RNAi screen for Aire cofactors reveals a role for Hnrnpl in polymerase release and Aire-activated ectopic transcription.
Benoist et al., Boston, United States. In Proc Natl Acad Sci U S A, 2014
Fifty-one functional allies were identified, with a preponderance of factors that impact transcriptional elongation compared with initiation, in particular members of the positive transcription elongation factor b (P-TEFb) involved in the release of "paused" RNA polymerases (CCNT2 and HEXIM1); mRNA processing and polyadenylation factors were also highlighted (HNRNPL/F, SFRS1, SFRS3, and CLP1).
Exon 9 skipping of apoptotic caspase-2 pre-mRNA is promoted by SRSF3 through interaction with exon 8.
Shen et al., Kwangju, South Korea. In Biochim Biophys Acta, 2014
Here we show that knockdown of SRSF3 (also known as SRp20) with siRNA induced significant increase of endogenous exon 9 inclusion.
Gammaretroviral pol sequences act in cis to direct polysome loading and NXF1/NXT-dependent protein production by gag-encoded RNA.
Luban et al., Genève, Switzerland. In Retrovirology, 2013
Finally, overexpression of SRp20, a shuttling protein that binds to NXF1 and promotes NXF1 binding to RNA, also increased gag RNA loading onto polysomes and increased Pr65Gag synthesis.
[Stature estimation for Sichuan Han nationality female based on X-ray technology with measurement of lumbar vertebrae].
Deng et al., Beijing, China. In Fa Yi Xue Za Zhi, 2013
Group A (206 samples) consisted of all ages, group B (116 samples) were 20-45 years old and 90 samples over 45 years old were group C. All the samples were examined lumbar vertebrae through CR technology, including the parameters of five centrums (L1-L5) as anterior border, posterior border and central heights (x1-x15), total central height of lumbar spine (x16), and the real height of every sample.
SRp20: an overview of its role in human diseases.
Salvatore et al., Napoli, Italy. In Biochem Biophys Res Commun, 2013
Evidence indicates that SRp20 (SFSR3), the smallest member of the SR protein family, is involved in numerous biological processes.
Beyond secondary structure: primary-sequence determinants license pri-miRNA hairpins for processing.
Bartel et al., Cambridge, United States. In Cell, 2013
Our results confirmed the importance of pairing in the stem and revealed three primary-sequence determinants, including an SRp20-binding motif (CNNC) found downstream of most pri-miRNA hairpins in bilaterian animals, but not in nematodes.
Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease.
Kwok et al., Wollongong, Australia. In J Neurochem, 2012
This study found that significant changes in serine/arginine protein 20 (Srp20) gene expression in AD cases and confirmed this using a second cohort of control/AD.
Protein cross-talk in CD133+ colon cancer cells indicates activation of the Wnt pathway and upregulation of SRp20 that is potentially involved in tumorigenicity.
Salvatore et al., Napoli, Italy. In Proteomics, 2012
Protein extracts of colon cancer CD133+ cell stem cells were compared to protein extracts of colon cancer cell CD133- stem cells by 2D DIGE. Demonstrated a direct cause-effect relationship between Wnt pathway activation & increased SRp20 expression.
Spliceosome protein (SRp) regulation of glucocorticoid receptor isoforms and glucocorticoid response in human trabecular meshwork cells.
Clark et al., Fort Worth, United States. In Invest Ophthalmol Vis Sci, 2012
Relative levels of SRp20, SRp30c, and SRp40 in TM cells control differential expression of the two alternatively spliced isoforms of the GR and thereby regulate GC responsiveness.
The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes.
Neugebauer et al., Dresden, Germany. In Genome Biol, 2011
SRSF3 and SRSF4 proteins bind to the 3' ends of the majority of intronless histone transcripts, implicating SRSF3 and SRSF4 in histone mRNA metabolism.
Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus.
Semler et al., Irvine, United States. In Plos Pathog, 2011
a model in which SRp20 interacts with PCBP2 bound to the viral RNA, and this interaction functions to recruit ribosomes to the viral RNA in a direct or indirect manner, with the participation of additional protein-protein or protein-RNA interactions.
Human papillomavirus regulation of SR proteins.
Graham et al., Glasgow, United Kingdom. In Biochem Soc Trans, 2010
The HPV transcription/replication factor E2 (early 2) specifically up-regulates expression of the SR proteins SF2/ASF (splicing factor 2/alternative splicing factor), SRp20 and SC35 in infected epithelial cells.
[Invasive pulmonary aspergillosis following influenza A infection].
Kawabata et al., Saitama, Japan. In Nihon Kokyuki Gakkai Zasshi, 2001
The results of hemagglutination inhibition tests for influenza A (H3 N2) were x16 in September 1999, and x512 on the third day of hospitalization.
Techniques for pelvic surgery in subfertility.
Lilford et al., Ashton-under-Lyne, United Kingdom. In Cochrane Database Syst Rev, 1999
3) MAGNIFICATION FOR INFERTILITY SURGERY There was a non significant reduction in pregnancy rate when the operating microscope (magnification x4-x16) was used rather than Loupes (magnification x2-x4.5) in the only RCT to study this.
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