gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Karyopherin alpha 2

SRP1, Srp1p, Rch1, importin alpha1, Importin alpha, KPNA2, karyopherin alpha2
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination [provided by RefSeq, Jul 2008] (from NCBI)
Papers on SRP1
The interaction between importin-α and Nup153 promotes importin-α/β-mediated nuclear import.
Yoneda et al., Suita, Japan. In Traffic, 2012
importin alpha binds to Nup153
Nuclear import of the yeast hexokinase 2 protein requires α/β-importin-dependent pathway.
Moreno et al., Oviedo, Spain. In J Biol Chem, 2012
Hxk2 as a new cargo for the alpha/beta-importin pathway of S. cerevisiae.
Nuclear retention of importin α coordinates cell fate through changes in gene expression.
Yoneda et al., Ōsaka, Japan. In Embo J, 2012
results collectively reveal that nuclear-localized importin alpha2 influences gene expression and contributes directly to cell fate outcomes including non-apoptotic cell death.
Nuclear transport of Wilms' tumour protein Wt1 involves importins α and β.
Scholz et al., Lübeck, Germany. In Cell Physiol Biochem, 2011
Nuclear translocation of Wilms' tumour protein involves importins alpha and beta, and a nuclear localisation signal in the third zinc finger
Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity.
Leaner et al., Cape Town, South Africa. In Plos One, 2010
findings suggest that the deregulated activity of E2F in cancer cells causes increased activation of the Kpnbeta1 and Kpnalpha2 promoters, leading to elevated levels of these proteins, and ultimately impacting the cancer phenotype.
share on facebooktweetadd +1mail to friends